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The map label for this gene is trpC

Identifier: 78065094

GI number: 78065094

Start: 492357

End: 493142

Strand: Reverse

Name: trpC

Synonym: Bcep18194_A3618

Alternate gene names: 78065094

Gene position: 493142-492357 (Counterclockwise)

Preceding gene: 78065095

Following gene: 78065093

Centisome position: 13.35

GC content: 65.39

Gene sequence:

>786_bases
ATGAGCGACATTCTCGACCGAATCATCGCCGTCAAGCGCGAAGAAGTCGCAGCGGCCATGCGCAGCGCGCCGCTCGAGGC
ACTGAAACTGGAAGCATCGGCACGCGACCTGCGCGACTTCGTCGGCGCACTGCGCGCGAAGCATGCGGCCGGCCACGCGG
CCGTGATTTCCGAAATCAAGAAAGCCAGCCCGTCGAAAGGCGTGCTGCGCGAGCATTTCGTGCCGGCCGACATCGCGCGT
TCGTATGCCGAGCACGGCGCCGCGTGCCTGTCGGTGCTGACCGACGAACAGTTCTTCCAGGGCAGCGTCCGCTACCTCGA
GGAAGCGCGCGCGGCCTGCACGCTGCCGGTGCTGCGCAAGGACTTCATCGTCGACGCGTACCAGATCATGGAAGCGCGCG
CGATGGGCGCCGACGCGATCCTGCTGATCGCCGCCGCGCTCGACACGCCGCTGATGCAGGATCTCGAAGCGTATGCGCAC
TCGCTCGGCCTCGCGGTGCTGGTCGAAGTCCACGACCGCAACGAGATGGAACAGGCGCTGACGCTCAAGACGCCGCTGCT
CGGCATCAACAACCGCAACCTGCGCACGTTCGAGACGTCGATCCAGACCACGCTCGACATGCTCGACATGATTCCGTCTG
ACCGCATCGTCGTGACCGAATCGGGCATCCTGTCGCGCACCGACGTCGACACGATGCGTGCGGCGAACGTGAACACGTTC
CTCGTCGGCGAAGCATTCATGCGCGCCGACCAGCCGGGCGAAGAGCTCGCGCGGATGTTCTTCTGA

Upstream 100 bases:

>100_bases
CGATCGCGAGCGGCAAGGCCCGCGCGAAAGTCGACGAACTCGTGCGCTTCACGCAGCAGTTCAAGCGCTGACTCCCCTTA
CGAATCAAGCAGGAATCCAC

Downstream 100 bases:

>100_bases
TGGCGATCGAAAAGGAAATCAAGCTCGCGCTGCCGGCCGGCCAGGCCGACGCCGCGCGACGCTTCTTCGAGACGCTGACC
GGCGAACCCGGTCACGACAT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSDILDRIIAVKREEVAAAMRSAPLEALKLEASARDLRDFVGALRAKHAAGHAAVISEIKKASPSKGVLREHFVPADIAR
SYAEHGAACLSVLTDEQFFQGSVRYLEEARAACTLPVLRKDFIVDAYQIMEARAMGADAILLIAAALDTPLMQDLEAYAH
SLGLAVLVEVHDRNEMEQALTLKTPLLGINNRNLRTFETSIQTTLDMLDMIPSDRIVVTESGILSRTDVDTMRAANVNTF
LVGEAFMRADQPGEELARMFF

Sequences:

>Translated_261_residues
MSDILDRIIAVKREEVAAAMRSAPLEALKLEASARDLRDFVGALRAKHAAGHAAVISEIKKASPSKGVLREHFVPADIAR
SYAEHGAACLSVLTDEQFFQGSVRYLEEARAACTLPVLRKDFIVDAYQIMEARAMGADAILLIAAALDTPLMQDLEAYAH
SLGLAVLVEVHDRNEMEQALTLKTPLLGINNRNLRTFETSIQTTLDMLDMIPSDRIVVTESGILSRTDVDTMRAANVNTF
LVGEAFMRADQPGEELARMFF
>Mature_260_residues
SDILDRIIAVKREEVAAAMRSAPLEALKLEASARDLRDFVGALRAKHAAGHAAVISEIKKASPSKGVLREHFVPADIARS
YAEHGAACLSVLTDEQFFQGSVRYLEEARAACTLPVLRKDFIVDAYQIMEARAMGADAILLIAAALDTPLMQDLEAYAHS
LGLAVLVEVHDRNEMEQALTLKTPLLGINNRNLRTFETSIQTTLDMLDMIPSDRIVVTESGILSRTDVDTMRAANVNTFL
VGEAFMRADQPGEELARMFF

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=250, Percent_Identity=40, Blast_Score=156, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322638, Length=261, Percent_Identity=37.1647509578544, Blast_Score=168, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28657; Mature: 28526

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDRIIAVKREEVAAAMRSAPLEALKLEASARDLRDFVGALRAKHAAGHAAVISEIK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KASPSKGVLREHFVPADIARSYAEHGAACLSVLTDEQFFQGSVRYLEEARAACTLPVLRK
HCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFIVDAYQIMEARAMGADAILLIAAALDTPLMQDLEAYAHSLGLAVLVEVHDRNEMEQAL
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHEEEEECCHHHHHHHH
TLKTPLLGINNRNLRTFETSIQTTLDMLDMIPSDRIVVTESGILSRTDVDTMRAANVNTF
HHHCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHCCCCEE
LVGEAFMRADQPGEELARMFF
EHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
SDILDRIIAVKREEVAAAMRSAPLEALKLEASARDLRDFVGALRAKHAAGHAAVISEIK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KASPSKGVLREHFVPADIARSYAEHGAACLSVLTDEQFFQGSVRYLEEARAACTLPVLRK
HCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFIVDAYQIMEARAMGADAILLIAAALDTPLMQDLEAYAHSLGLAVLVEVHDRNEMEQAL
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHEEEEECCHHHHHHHH
TLKTPLLGINNRNLRTFETSIQTTLDMLDMIPSDRIVVTESGILSRTDVDTMRAANVNTF
HHHCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHCCCCEE
LVGEAFMRADQPGEELARMFF
EHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA