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The map label for this gene is hisI

Identifier: 78065007

GI number: 78065007

Start: 395867

End: 396283

Strand: Direct

Name: hisI

Synonym: Bcep18194_A3530

Alternate gene names: 78065007

Gene position: 395867-396283 (Clockwise)

Preceding gene: 78065006

Following gene: 78065008

Centisome position: 10.72

GC content: 62.35

Gene sequence:

>417_bases
ATGAATACGGAAACGAATGCATTGCCCGCGTGGCTCGACAAGGTCCGCTGGGACGACAACGGCCTCGTGCCGGTGATCGC
GCAGGAAGCGTCGACGAACGACGTGCTGATGTTCGCGTGGATGAACCGCGAGGCACTGGCGAAGACGATCGAGACGCAGC
GCGCGGTCTACTATTCGCGCTCGCGCAAGCGCCTATGGTTCAAGGGCGAGGAGTCGGGCCACGTGCAGCACGTGCACGAG
GTGCGGCTCGACTGCGACGAGGACGTCGTGCTGCTGAAGGTCGAGCAGGTGTCGGGCATCGCGTGCCACACCGGCCGGCA
TTCGTGCTTCTTCCAGAAATTCGAAGGCACCGTCGACAACGGCGACTGGGTCGCGGTCGAACCGGTGCTGAAAGATCCCG
AACACATCTACAAATGA

Upstream 100 bases:

>100_bases
CCGACGCGGTGCTGGCCGCGAGTATCTTCCACTACGGCGAGCACACGGTCGGCGAGGCAAAGCGCTTCATGGCCGACCAG
GGCATCCCGGTGAGGCTGTG

Downstream 100 bases:

>100_bases
CGCAATCGACCGAAGACACGCTGCTGCGCCTCGCGGCCGTGATCGATAGCCGCAAGGGCGGCGACCCCGATCAATCGTAC
GTATCGCGCCTGTTCCACAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MNTETNALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGEESGHVQHVHE
VRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVEPVLKDPEHIYK

Sequences:

>Translated_138_residues
MNTETNALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGEESGHVQHVHE
VRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVEPVLKDPEHIYK
>Mature_138_residues
MNTETNALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGEESGHVQHVHE
VRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVEPVLKDPEHIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=45.0549450549451, Blast_Score=91, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=107, Percent_Identity=37.3831775700935, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 15900; Mature: 15900

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTETNALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSR
CCCCCCCCHHHHHHEEECCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
SRKRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDN
CCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCEEEEECCCCCCC
GDWVAVEPVLKDPEHIYK
CCEEEECCCCCCHHHHCC
>Mature Secondary Structure
MNTETNALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSR
CCCCCCCCHHHHHHEEECCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
SRKRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDN
CCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCEEEEECCCCCCC
GDWVAVEPVLKDPEHIYK
CCEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA