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The map label for this gene is hisA [H]

Identifier: 78065005

GI number: 78065005

Start: 394231

End: 394986

Strand: Direct

Name: hisA [H]

Synonym: Bcep18194_A3528

Alternate gene names: 78065005

Gene position: 394231-394986 (Clockwise)

Preceding gene: 78065004

Following gene: 78065006

Centisome position: 10.67

GC content: 63.62

Gene sequence:

>756_bases
ATGTTGCTGATTCCGGCCATCGATCTCAAAGACGGTCAGTGTGTGCGCCTTAAACAGGGCGATATGGACCAGGCTACGAT
TTTCTCCGAGGACCCGGCGGCGATGGCCCGCAAGTGGGTCGATCTCGGCGCCCGGCGGCTCCATCTCGTCGACCTGAACG
GCGCATTCGCCGGCAAGCCGAAGAATCTCGAGGCGATCGAAGCGATCCTCGACGAAGTCGGCGATGAAATCCCCGTACAG
CTCGGCGGCGGCATCCGCAGCCTCGAGACGATCGAGAAGTATCTCGACGCGGGCCTGTCCTACGTGATCATCGGCACGGC
GGCCGTGAAGGATCCAGGCTTCCTGCAGGACGCGTGCACCGCGTTCGCCGGCAGCATCATCGTCGGGCTGGACGCGAAGG
ACGGCAAGGTCGCGACCGACGGCTGGAGCAAGCTCACCGGCCACGAAGTGATCGATCTCGCGCAGAAGTTCGAGGACTAC
GGCGTCGAATCGATCGTCTACACGGACATCGGCCGCGACGGGATGCTGCAGGGCATCAACATCGAGGCGACCGTGAAACT
CGCGCAGGCGGTCGGCATCCCGGTGATCGCCAGCGGCGGCCTGTCGAACCTCGTGGACATCGAGAACCTGTGCGAAGTGG
AAGAGCAGGGCGTCGAAGGCGTGATCTGCGGCCGTGCGATCTACTCCGGCGATCTCGATTTCGCGGCCGCGCAAAAGCGC
GCGGACGAACTGAACGGCGAACTCGACAACGCGTAA

Upstream 100 bases:

>100_bases
AGCGCCGAAAGAGTTGTACTAAACTAGCGAGACGGCGCGGTACCGGATTGGCCGGTACGCGCCGGATTCTTTTCTTTTTC
CACGACGATACCCGATTGCT

Downstream 100 bases:

>100_bases
GCGCGGTTGTCCCGCTCGCCGGGGCTGCCTGCAGGCGGCCCCGACCGGAAGCCTCGCGCGAGGCTTTCCGTAACCGGCCG
TCCCATCGCGGCATTTGGCG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILDEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACTAFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLVDIENLCEVEEQGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA

Sequences:

>Translated_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILDEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACTAFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLVDIENLCEVEEQGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA
>Mature_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILDEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACTAFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLVDIENLCEVEEQGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=32.9218106995885, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788336, Length=213, Percent_Identity=26.2910798122066, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26589; Mature: 26589

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLEAIEAILDEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACT
CCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDYGVESIVYTDIGRDGMLQGIN
HHHCCEEEEECCCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IEATVKLAQAVGIPVIASGGLSNLVDIENLCEVEEQGVEGVICGRAIYSGDLDFAAAQKR
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDNA
HHHHCCCCCCC
>Mature Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLEAIEAILDEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACT
CCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDYGVESIVYTDIGRDGMLQGIN
HHHCCEEEEECCCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IEATVKLAQAVGIPVIASGGLSNLVDIENLCEVEEQGVEGVICGRAIYSGDLDFAAAQKR
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDNA
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA