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The map label for this gene is macA [H]

Identifier: 78064880

GI number: 78064880

Start: 261542

End: 262747

Strand: Reverse

Name: macA [H]

Synonym: Bcep18194_A3403

Alternate gene names: 78064880

Gene position: 262747-261542 (Counterclockwise)

Preceding gene: 78064882

Following gene: 78064879

Centisome position: 7.11

GC content: 70.23

Gene sequence:

>1206_bases
TTGCCCGATCACAATCTGGACAAACTGAAGATCGACCGGCGTCCGCTCGCACCGGCACCCCGCCGGCGCCGGTGGCTCCG
CTATGCGGTCGCCGCCGCGGTCGTCATCGGCGCGATCGTCGCCGGCCTCGCGCTCACCGGCCGGCCGGCCGTCGAAACCA
CCGCCGTCACGTCCGCCTACCCGTACCAGAACGACACGCAGCTCAATGCGACCGGCTACGTCGTGCCGCAGCGCAAGGCC
GCGGTCGCGTCGAAGGGCCAGGGACGCGTCGAATGGCTCGGCGTGCTCGAAGGCACGCGCGTGAAGAAAGATGAGATCAT
CGCCCGCCTCGAAAGCCGTGACGTCGAGGCCTCGCTGGCACAGGCGCTCGCACAGGTGAAGGTCGCCCGCGCCAACCTCG
GCGTCGAGCAGGCCGAACTGAAGGACGCCGAGATCGCGTTGCGCCGCACCTCGGTGCTCGCGCCCAAGGGCGCCGTGCCG
GCCGCGCAGCTCGACACCGACACGGCCCGCGTGAACAAGGCGCGCGCGTCGGTCAACAGCGACCAGGCCGCCATCACGTC
CGCCGAAGCCAACGCGCAAGCCGCGCAGGTCGCGGTCGACCAGACGGTGATCCGCGCCCCGTTCGACGGCATCGTGCTCG
CGAAGCACGCGAACGTCGGCGACAACATCACGCCGTTCTCGTCCGCATCGGACAGCAAGGGTGCGGTCGTGACGATTGCC
GACATGGACACGCTCGAGGTCGAGGCCGACGTCGCCGAATCGAACATCGCGAAGATCCGCGCCGAGCAGCCGTGCGAGAT
CCAGCTCGACGCGCTGCCCGACACGCGCTTCGCGGGCCGCGTGTCGCGCATCGTGCCGACCGTCGACCGCTCGAAGGCCA
CCGTGCTCGTGAAAGTACGCTTCGTCGACCGCGACGACCGCGTGCTGCCCGACATGAGCGCGAAGATCGCGTTCCTGTCG
AAGCCCGCGTCGGCGCAGGACCGGCAGCCCGTGACGGCCGTGCAGGCAAGCGCGGTCGTGGAACGCGACGGCCGGCCGGT
CGTGTTCGTCGTGAAGGACGACACCGTGCGCGCCGTGGGCGTGACGCGGGGCGAGCGGATCGGCGAACTCATCGCGATCC
GCGGCGTGAAGCCCGGCGACACGGTCGTGCTCGCGCCGGACGCGAAGCTGAAGGACGGCGCGAAAGTGACCGTCGCGAAG
AAGTAG

Upstream 100 bases:

>100_bases
CGCCGTCGGGGCGACGCTTATACTGGCGTCCATCCGTCCCTTTCCCCGGAAACCGGATCGCGGCCGGTCGTCAGACCGCC
GCCGTCTCGAGGCGCTCAAA

Downstream 100 bases:

>100_bases
CGCACGCGTGAACGACGCCCCGCCGCCCCTCGTCGAGATCAGCCACGTCGCGAAGTCGTACCGGCGCGGCAACCAGATCG
TGCCCGTGCTGACCGACATC

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MPDHNLDKLKIDRRPLAPAPRRRRWLRYAVAAAVVIGAIVAGLALTGRPAVETTAVTSAYPYQNDTQLNATGYVVPQRKA
AVASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLAQALAQVKVARANLGVEQAELKDAEIALRRTSVLAPKGAVP
AAQLDTDTARVNKARASVNSDQAAITSAEANAQAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIA
DMDTLEVEADVAESNIAKIRAEQPCEIQLDALPDTRFAGRVSRIVPTVDRSKATVLVKVRFVDRDDRVLPDMSAKIAFLS
KPASAQDRQPVTAVQASAVVERDGRPVVFVVKDDTVRAVGVTRGERIGELIAIRGVKPGDTVVLAPDAKLKDGAKVTVAK
K

Sequences:

>Translated_401_residues
MPDHNLDKLKIDRRPLAPAPRRRRWLRYAVAAAVVIGAIVAGLALTGRPAVETTAVTSAYPYQNDTQLNATGYVVPQRKA
AVASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLAQALAQVKVARANLGVEQAELKDAEIALRRTSVLAPKGAVP
AAQLDTDTARVNKARASVNSDQAAITSAEANAQAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIA
DMDTLEVEADVAESNIAKIRAEQPCEIQLDALPDTRFAGRVSRIVPTVDRSKATVLVKVRFVDRDDRVLPDMSAKIAFLS
KPASAQDRQPVTAVQASAVVERDGRPVVFVVKDDTVRAVGVTRGERIGELIAIRGVKPGDTVVLAPDAKLKDGAKVTVAK
K
>Mature_400_residues
PDHNLDKLKIDRRPLAPAPRRRRWLRYAVAAAVVIGAIVAGLALTGRPAVETTAVTSAYPYQNDTQLNATGYVVPQRKAA
VASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLAQALAQVKVARANLGVEQAELKDAEIALRRTSVLAPKGAVPA
AQLDTDTARVNKARASVNSDQAAITSAEANAQAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIAD
MDTLEVEADVAESNIAKIRAEQPCEIQLDALPDTRFAGRVSRIVPTVDRSKATVLVKVRFVDRDDRVLPDMSAKIAFLSK
PASAQDRQPVTAVQASAVVERDGRPVVFVVKDDTVRAVGVTRGERIGELIAIRGVKPGDTVVLAPDAKLKDGAKVTVAKK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=364, Percent_Identity=25.8241758241758, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082036, Length=357, Percent_Identity=26.890756302521, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42637; Mature: 42506

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDHNLDKLKIDRRPLAPAPRRRRWLRYAVAAAVVIGAIVAGLALTGRPAVETTAVTSAY
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PYQNDTQLNATGYVVPQRKAAVASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLA
CCCCCCEECEEEEEECCHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHH
QALAQVKVARANLGVEQAELKDAEIALRRTSVLAPKGAVPAAQLDTDTARVNKARASVNS
HHHHHHHHHHHHCCCCHHHCCHHHHEEEHHHEECCCCCCCCHHCCCCHHHHHHHHHCCCC
DQAAITSAEANAQAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIA
CCCEEEECCCCCHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEE
DMDTLEVEADVAESNIAKIRAEQPCEIQLDALPDTRFAGRVSRIVPTVDRSKATVLVKVR
CCCEEEEEHHHHHCCHHEEECCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEEE
FVDRDDRVLPDMSAKIAFLSKPASAQDRQPVTAVQASAVVERDGRPVVFVVKDDTVRAVG
EECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEE
VTRGERIGELIAIRGVKPGDTVVLAPDAKLKDGAKVTVAKK
CCCCHHCCCEEEEECCCCCCEEEECCCCCCCCCCEEEEECC
>Mature Secondary Structure 
PDHNLDKLKIDRRPLAPAPRRRRWLRYAVAAAVVIGAIVAGLALTGRPAVETTAVTSAY
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PYQNDTQLNATGYVVPQRKAAVASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLA
CCCCCCEECEEEEEECCHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHH
QALAQVKVARANLGVEQAELKDAEIALRRTSVLAPKGAVPAAQLDTDTARVNKARASVNS
HHHHHHHHHHHHCCCCHHHCCHHHHEEEHHHEECCCCCCCCHHCCCCHHHHHHHHHCCCC
DQAAITSAEANAQAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIA
CCCEEEECCCCCHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEE
DMDTLEVEADVAESNIAKIRAEQPCEIQLDALPDTRFAGRVSRIVPTVDRSKATVLVKVR
CCCEEEEEHHHHHCCHHEEECCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEEE
FVDRDDRVLPDMSAKIAFLSKPASAQDRQPVTAVQASAVVERDGRPVVFVVKDDTVRAVG
EECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEE
VTRGERIGELIAIRGVKPGDTVVLAPDAKLKDGAKVTVAKK
CCCCHHCCCEEEEECCCCCCEEEECCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]