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The map label for this gene is macB [H]

Identifier: 78064877

GI number: 78064877

Start: 258485

End: 259651

Strand: Reverse

Name: macB [H]

Synonym: Bcep18194_A3400

Alternate gene names: 78064877

Gene position: 259651-258485 (Counterclockwise)

Preceding gene: 78064878

Following gene: 78064874

Centisome position: 7.03

GC content: 67.69

Gene sequence:

>1167_bases
ATGGCGATCCCGCTCAACTACATCGCGCGCAACCTGTGGACCCGGCGGCTCACCACCGCGCTGACCGCCGGCGGGATGGC
GCTCGTGATCTTCGTGTTCGCGACCGTGCAGATGCTCGACGCGGGGCTCACGAAGACGCTCGTGTCGACCGGCGAGCCCG
ACAACGCGGTGGTGATCCGCAAGGGCGCCGAAACCGAGATCCAGAGCTCGATCGACCACCAGCAGGCCAATGCGCTCGAG
ATGCACCCGGCCGTCGCGCTCGGCCCCGACGGCCGGCCGCTCGTGTCGAAGGAAGCGGTCGTGCTGATCTCGCTGGTGAA
GACCTCGTCCGGCAAGCCGTCGAACGTCGTGATCCGCGGCGTGTCGCCGGCCGGCCTCGCGCTGCGCCCGCACGTGAAGC
TCGTCGGGGGCCGCATGTTCACGCCCGGCTCGTCGGAAATCATCGTCGGCAGCGCGATCGCGAAAGGGTTCAGCGGCACG
CAGCTCGGCGACAGCCTGCATTTCGCGCAGCGCGACTGGACCATCGTCGGCATCTTCGACGCGGGCGGCAGCGGCTTCGA
TTCGGAGATCTGGGGCGACGTCGACCAGCTGATGCAGTCGTTCCGGCGCACCAGCTATTCGTCGATGGTGCTGCGCATCC
CGAGCGCCGACGGCTTCGCACGCTTCAAGGCCGACATCGACGTCGACCCGCGGCTCACCGACGAGGCGAAACGCGAGCAG
ACCTTCTACGGCGACCAGTCGAAGGCGCTGTCGACGTTCATCAACATCCTCGGCATCACGCTGTCGACGATCTTCTCGAT
CGCCGCGATGATCGGCGCGATGATCACGATGTATGCGTCGGTCGCGAACCGCGTCGCCGAGATCGGCACGCTGCGCGCGC
TCGGCTTCAAGCGCCTGAACGTGCTCGCCGCGTTCCTGCTGGAAGCGCTGCTGCTCGGCTTCGTCGGCGGCGTCGCGGGG
CTCGCGTGTGCGTCGCTGATGCAGTTCGCGTCGTTCTCGACGACCAACTTCCAGACCTTCGCGGACCTGTCGTTCCGCTT
CGTGCTGACGCCCGCGATCGTCGTGAAGACGCTGCTGTTCTCGCTCGTGATGGGGCTGGTCGGCGGGTTCCTGCCGGCGA
TGCGCGCCGCGCGGCTGAAGATCGTCGACGCGCTGCGCGCACAGTGA

Upstream 100 bases:

>100_bases
GCTCGGTCGCGGTCGGCTTCGCGGCGGCGATCGTGCCGGCGTGGCAGGCGGCGCGCGTGCGCGTGGTCGAAGGCCTCAGG
GCAATCGGTTAGGTTTGCAC

Downstream 100 bases:

>100_bases
CGCGCCGCCCCGCCGCTCAGTGCTCGCGCGGCACCCACGCGCCGTGGAACCCGGCCGGCACGCGGCGCGGCAGGTGCACG
GTCGCGACCGGCCCCGCGTC

Product: ABC efflux pump, inner membrane subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MAIPLNYIARNLWTRRLTTALTAGGMALVIFVFATVQMLDAGLTKTLVSTGEPDNAVVIRKGAETEIQSSIDHQQANALE
MHPAVALGPDGRPLVSKEAVVLISLVKTSSGKPSNVVIRGVSPAGLALRPHVKLVGGRMFTPGSSEIIVGSAIAKGFSGT
QLGDSLHFAQRDWTIVGIFDAGGSGFDSEIWGDVDQLMQSFRRTSYSSMVLRIPSADGFARFKADIDVDPRLTDEAKREQ
TFYGDQSKALSTFINILGITLSTIFSIAAMIGAMITMYASVANRVAEIGTLRALGFKRLNVLAAFLLEALLLGFVGGVAG
LACASLMQFASFSTTNFQTFADLSFRFVLTPAIVVKTLLFSLVMGLVGGFLPAMRAARLKIVDALRAQ

Sequences:

>Translated_388_residues
MAIPLNYIARNLWTRRLTTALTAGGMALVIFVFATVQMLDAGLTKTLVSTGEPDNAVVIRKGAETEIQSSIDHQQANALE
MHPAVALGPDGRPLVSKEAVVLISLVKTSSGKPSNVVIRGVSPAGLALRPHVKLVGGRMFTPGSSEIIVGSAIAKGFSGT
QLGDSLHFAQRDWTIVGIFDAGGSGFDSEIWGDVDQLMQSFRRTSYSSMVLRIPSADGFARFKADIDVDPRLTDEAKREQ
TFYGDQSKALSTFINILGITLSTIFSIAAMIGAMITMYASVANRVAEIGTLRALGFKRLNVLAAFLLEALLLGFVGGVAG
LACASLMQFASFSTTNFQTFADLSFRFVLTPAIVVKTLLFSLVMGLVGGFLPAMRAARLKIVDALRAQ
>Mature_387_residues
AIPLNYIARNLWTRRLTTALTAGGMALVIFVFATVQMLDAGLTKTLVSTGEPDNAVVIRKGAETEIQSSIDHQQANALEM
HPAVALGPDGRPLVSKEAVVLISLVKTSSGKPSNVVIRGVSPAGLALRPHVKLVGGRMFTPGSSEIIVGSAIAKGFSGTQ
LGDSLHFAQRDWTIVGIFDAGGSGFDSEIWGDVDQLMQSFRRTSYSSMVLRIPSADGFARFKADIDVDPRLTDEAKREQT
FYGDQSKALSTFINILGITLSTIFSIAAMIGAMITMYASVANRVAEIGTLRALGFKRLNVLAAFLLEALLLGFVGGVAGL
ACASLMQFASFSTTNFQTFADLSFRFVLTPAIVVKTLLFSLVMGLVGGFLPAMRAARLKIVDALRAQ

Specific function: Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787105, Length=128, Percent_Identity=36.71875, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017911
- InterPro:   IPR003593
- InterPro:   IPR003838 [H]

Pfam domain/function: PF00005 ABC_tran; PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 41357; Mature: 41226

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPLNYIARNLWTRRLTTALTAGGMALVIFVFATVQMLDAGLTKTLVSTGEPDNAVVIR
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KGAETEIQSSIDHQQANALEMHPAVALGPDGRPLVSKEAVVLISLVKTSSGKPSNVVIRG
CCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHEEEEHHCCCCCCCCEEEEE
VSPAGLALRPHVKLVGGRMFTPGSSEIIVGSAIAKGFSGTQLGDSLHFAQRDWTIVGIFD
CCCCCCEECCCCEEECCEEECCCCCCEEEEHHHHCCCCCCCCCCCHHHHCCCEEEEEEEE
AGGSGFDSEIWGDVDQLMQSFRRTSYSSMVLRIPSADGFARFKADIDVDPRLTDEAKREQ
CCCCCCCHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHH
TFYGDQSKALSTFINILGITLSTIFSIAAMIGAMITMYASVANRVAEIGTLRALGFKRLN
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAAFLLEALLLGFVGGVAGLACASLMQFASFSTTNFQTFADLSFRFVLTPAIVVKTLLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHH
SLVMGLVGGFLPAMRAARLKIVDALRAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIPLNYIARNLWTRRLTTALTAGGMALVIFVFATVQMLDAGLTKTLVSTGEPDNAVVIR
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KGAETEIQSSIDHQQANALEMHPAVALGPDGRPLVSKEAVVLISLVKTSSGKPSNVVIRG
CCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHEEEEHHCCCCCCCCEEEEE
VSPAGLALRPHVKLVGGRMFTPGSSEIIVGSAIAKGFSGTQLGDSLHFAQRDWTIVGIFD
CCCCCCEECCCCEEECCEEECCCCCCEEEEHHHHCCCCCCCCCCCHHHHCCCEEEEEEEE
AGGSGFDSEIWGDVDQLMQSFRRTSYSSMVLRIPSADGFARFKADIDVDPRLTDEAKREQ
CCCCCCCHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHH
TFYGDQSKALSTFINILGITLSTIFSIAAMIGAMITMYASVANRVAEIGTLRALGFKRLN
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAAFLLEALLLGFVGGVAGLACASLMQFASFSTTNFQTFADLSFRFVLTPAIVVKTLLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHH
SLVMGLVGGFLPAMRAARLKIVDALRAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA