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The map label for this gene is ttcA [H]

Identifier: 78049884

GI number: 78049884

Start: 4975895

End: 4977004

Strand: Reverse

Name: ttcA [H]

Synonym: XCV4328

Alternate gene names: 78049884

Gene position: 4977004-4975895 (Counterclockwise)

Preceding gene: 78049888

Following gene: 78049883

Centisome position: 96.11

GC content: 67.84

Gene sequence:

>1110_bases
GTGGTTACCTGGCAACGGCCGCAGGACACCATGTCCAGGCAACAGGTCTGCATCGACCGGCGCCATTGCAGCCGTCCGTG
CCGCTGCCGCGTCAACGTCCAATGCGTCACAAGGGCTGCGTGTCGGCGTGCCACCCCCGCGCGCAGCCAACCCCGTCGCC
TGCCAGCCCCCGGCAGCTACAATGGCCGGCTTATGACCGCTGTCCTGCCGCTGCCGCAACCCCTGGCCGACCCCGCACCG
CGCGACCCGCGCCAGCGGTTGCAGCGCGAACAGCTGCGCCTGGGCAAACGCCTGCAGCGCCAGGTCGGCCAGGCGATTGC
CGATTTCGGCATGATCGCACCCGGCGACAAGGTCATGGTCTGTCTGTCGGGCGGCAAGGACAGCTACACCTTGTTGGACA
TGCTGCTGCAGTTGCAGCGCAAGGCGCCGGTGCCGTTCAGCCTGGTGGCGGTTAACCTGGACCAGAAACAGCCCGACTTT
CCCGCCCATGTGCTGCCGGCCTACCTGCGCGGGCTGGGGGTGCCGTTCGATATCGTCGAGCAGGACACCTATTCGGTGGT
CAGCCGGGTGATTCCAGCCGGCAAGACGATGTGTTCGCTGTGCTCGCGGCTGCGGCGCGGCGCGCTGTATGCCTACGCGC
AGACGCATGGCGTGACCAAGATCGCGCTCGGCCATCACCGCGACGACATCGTGGCCACCTTCTTCATGAACCTGTTTCAC
CACGCGCGGCTGGCGGCGATGGCGCCCAAGCTACGCAGCGACGACGGCGCGCATGTGGTGATCCGCCCGCTGGCCTATGT
GCGCGAAGCCGACATCGCGGCGTACGCGCAGGCGCGGCAGTTCCCGATCATTCCGTGCAACCTGTGCGGCAGCCAGGAAA
ACCTGCAGCGCCAGCAGGTCGGCAAGCTGTTGCAGCAATGGGACCGCGAGTTCCCCGGCCGCGTGGAGCAGATCGCCCGC
GCCTTGGGCGATGTCCGCCCCGAGCAATTGGCCGATCGCACGTTGTTCGATTTCCTGGCGCTGGGCCGCAGCGGCGATGC
GCCGAGCGATGTTGATCCCGATCCCAGCGCGTGGCTGTCCGCCAGCCACGCCCCCCACGACAGCGACTGA

Upstream 100 bases:

>100_bases
CAATGGAGGCGGCCCGCAAGTAACAATGCGCGCAGCTACCGTGCGCATTGCACGCTGACGACTGCATGCATCTGCGGACA
AAAAGCCGGACTGCCGGCAA

Downstream 100 bases:

>100_bases
CGCCGCCGCTCCGGCTGCCGGCAGTCTTCCACCCTCCACGTTTTTCTTCATTCGGTCCAACGCATGTTCTTTCGCAACCT
CACCCTGTTCCGCTTTCCCA

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MVTWQRPQDTMSRQQVCIDRRHCSRPCRCRVNVQCVTRAACRRATPARSQPRRLPAPGSYNGRLMTAVLPLPQPLADPAP
RDPRQRLQREQLRLGKRLQRQVGQAIADFGMIAPGDKVMVCLSGGKDSYTLLDMLLQLQRKAPVPFSLVAVNLDQKQPDF
PAHVLPAYLRGLGVPFDIVEQDTYSVVSRVIPAGKTMCSLCSRLRRGALYAYAQTHGVTKIALGHHRDDIVATFFMNLFH
HARLAAMAPKLRSDDGAHVVIRPLAYVREADIAAYAQARQFPIIPCNLCGSQENLQRQQVGKLLQQWDREFPGRVEQIAR
ALGDVRPEQLADRTLFDFLALGRSGDAPSDVDPDPSAWLSASHAPHDSD

Sequences:

>Translated_369_residues
MVTWQRPQDTMSRQQVCIDRRHCSRPCRCRVNVQCVTRAACRRATPARSQPRRLPAPGSYNGRLMTAVLPLPQPLADPAP
RDPRQRLQREQLRLGKRLQRQVGQAIADFGMIAPGDKVMVCLSGGKDSYTLLDMLLQLQRKAPVPFSLVAVNLDQKQPDF
PAHVLPAYLRGLGVPFDIVEQDTYSVVSRVIPAGKTMCSLCSRLRRGALYAYAQTHGVTKIALGHHRDDIVATFFMNLFH
HARLAAMAPKLRSDDGAHVVIRPLAYVREADIAAYAQARQFPIIPCNLCGSQENLQRQQVGKLLQQWDREFPGRVEQIAR
ALGDVRPEQLADRTLFDFLALGRSGDAPSDVDPDPSAWLSASHAPHDSD
>Mature_369_residues
MVTWQRPQDTMSRQQVCIDRRHCSRPCRCRVNVQCVTRAACRRATPARSQPRRLPAPGSYNGRLMTAVLPLPQPLADPAP
RDPRQRLQREQLRLGKRLQRQVGQAIADFGMIAPGDKVMVCLSGGKDSYTLLDMLLQLQRKAPVPFSLVAVNLDQKQPDF
PAHVLPAYLRGLGVPFDIVEQDTYSVVSRVIPAGKTMCSLCSRLRRGALYAYAQTHGVTKIALGHHRDDIVATFFMNLFH
HARLAAMAPKLRSDDGAHVVIRPLAYVREADIAAYAQARQFPIIPCNLCGSQENLQRQQVGKLLQQWDREFPGRVEQIAR
ALGDVRPEQLADRTLFDFLALGRSGDAPSDVDPDPSAWLSASHAPHDSD

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=275, Percent_Identity=57.4545454545455, Blast_Score=337, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI193211090, Length=250, Percent_Identity=34, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17540090, Length=200, Percent_Identity=27, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 41158; Mature: 41158

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTWQRPQDTMSRQQVCIDRRHCSRPCRCRVNVQCVTRAACRRATPARSQPRRLPAPGSY
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NGRLMTAVLPLPQPLADPAPRDPRQRLQREQLRLGKRLQRQVGQAIADFGMIAPGDKVMV
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CLSGGKDSYTLLDMLLQLQRKAPVPFSLVAVNLDQKQPDFPAHVLPAYLRGLGVPFDIVE
EEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHH
QDTYSVVSRVIPAGKTMCSLCSRLRRGALYAYAQTHGVTKIALGHHRDDIVATFFMNLFH
HHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEHHHHCCCEEEECCCCHHHHHHHHHHHHHH
HARLAAMAPKLRSDDGAHVVIRPLAYVREADIAAYAQARQFPIIPCNLCGSQENLQRQQV
HHHHHHHCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHH
GKLLQQWDREFPGRVEQIARALGDVRPEQLADRTLFDFLALGRSGDAPSDVDPDPSAWLS
HHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHC
ASHAPHDSD
CCCCCCCCC
>Mature Secondary Structure
MVTWQRPQDTMSRQQVCIDRRHCSRPCRCRVNVQCVTRAACRRATPARSQPRRLPAPGSY
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NGRLMTAVLPLPQPLADPAPRDPRQRLQREQLRLGKRLQRQVGQAIADFGMIAPGDKVMV
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CLSGGKDSYTLLDMLLQLQRKAPVPFSLVAVNLDQKQPDFPAHVLPAYLRGLGVPFDIVE
EEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHH
QDTYSVVSRVIPAGKTMCSLCSRLRRGALYAYAQTHGVTKIALGHHRDDIVATFFMNLFH
HHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEHHHHCCCEEEECCCCHHHHHHHHHHHHHH
HARLAAMAPKLRSDDGAHVVIRPLAYVREADIAAYAQARQFPIIPCNLCGSQENLQRQQV
HHHHHHHCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHH
GKLLQQWDREFPGRVEQIARALGDVRPEQLADRTLFDFLALGRSGDAPSDVDPDPSAWLS
HHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHC
ASHAPHDSD
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]