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The map label for this gene is yjcE [H]

Identifier: 78049379

GI number: 78049379

Start: 4405373

End: 4407010

Strand: Reverse

Name: yjcE [H]

Synonym: XCV3823

Alternate gene names: 78049379

Gene position: 4407010-4405373 (Counterclockwise)

Preceding gene: 78049381

Following gene: 78049378

Centisome position: 85.1

GC content: 65.45

Gene sequence:

>1638_bases
ATGCATTCGATCGATGTCGTCCTCGCCATGTTGCTGGCGGTCGCGGCCAGCGGTTACCTCATCCGCATCCTGCCGTTTTC
GCTGCCGCTGCCGTTGGTCCAGATCGCGCTGGGCGCGGTGGTCTCCGGCGTCTTCGATGCCGGGCACGAGCTGGAACCGG
AGCTGTTCTTCCTGTTGTTCCTGCCGCCACTGCTGTTTCTGGATGGCTGGCGCATTCCCAAGCAGGGCCTGTTCCGCGAC
AAGGCGGCCATTCTGGAACTGGCGTTGGGGCTGGTCATCTTCACCGTGATTGGTGCCGGCTTCTTCATCCATTGGCTGAT
ACCGGCGATGCCGCTGGCCGTGGCGTTTGCGCTGGCAGCGATCATTTCGCCGACCGACCCGGTGGCGGTGTCCTCGATCG
CCTCCAAGGTGCCGATCCCCAAGCGCCTGATGCACATTCTGGAAGGCGAGTCGCTGCTCAACGACGCCTCGGGCCTGGTG
TGTTTCCAGTTCGCGGTGGCGGCGGTGCTGACCGGCACCTTCTCGGTGGCGGCCGCTTCGCTGACCTTTCTGTGGGTGGC
GCTGGCCGGCCTGGCCTTGGGCGTGGCGACGACCTTTGGGTTGAGCCGCATCCAGGCCTGGATCTGGCGGCATTTCGGCG
AGGAGCCCGGTTCGGCGATCCTGGTCAACCTGCTTACCCCATTTGCGGCGTATCTGCTGGCCGAAGCCTTCCATGCCTCC
GGCATCCTGGCCGCAGTGGCCGCCGGCATCACCATGAGCTACGTGGAAATGGCCGGCAACGCCCCGGGCAATATGCGCCT
GCAGCGTTCGGCGGTGTGGGACACGGTGCAGTTCACCTTCAACGGCATCATCTTCGTGCTGCTGGGCGAGCAGTTGCCGG
GCATCCTGGACGGTGCGGTGCGCAGCGTGCAGGAGGCCGGGCACCTCAATCCCTGGTGGCTGGCGGTGTACGTGGCCACC
ATCAGTCTCAGCCTGATGGCGTTGCGTTTTGTGTGGGTGTTCCTGTCGTTGCGCTGGAATATCTTCAAGGCGCAGCGACG
CGGCGAGGCGCATGTCAGCCCGCCGTGGCGCATCGTGGTGGCGGTGTCGCTGGCCGGCGTGCGCGGTGCGATCACCCTGG
CCGGCGTGCTCACGCTGCCGTTGATGCTGGAGGACGGCTCGCCCTTCCCGGCCCGTCAGTTGGCGATCTTCCTGGCGGCC
TCGGTCATTCTGGTGTCGTTGCTGGTGGCCAGCGTCGCGTTGCCGCGGCTGTTGCGTGGGCTGGAGTTGCCCGAAGAAGA
AGACGAGCAGCTCAAGGAAGACCTGGCCGTCAAAGCCGCTTCGCAGGCGGCGCTGGATGCAGTGGAAAAGCTGCGCCAGC
GGCTGGTGGAAGACAGCAAGCATGCCGAGCGCTACAACGCGGCGGCCAACCAGGTGAGCCAGCGCTATCAGCGCAAGCTC
GGCGCGGTGGACATGGCCGAGACCGATCCGGAAGAGGCGGTTGCTTACGAAAAGGCGCTGCGCCAGTTTCGCCATGCGGC
CTTGGTGGCCGAGCGCAATGAGCTGTTCAAGCTTGCGCGACGACGCGAAATTTCCGACGACCTGTCGCGGCGGCTGGTGC
GCAATCTGGATCTGATCGAGTCGCGCAAGCGCGCGTGA

Upstream 100 bases:

>100_bases
TCATCACCGGGTGCAACACGGTATGGTCCGGTAGGTGCGTTGTTGTGCGTCGCAATATGCGATGCCGCGCGTGCGGCCGT
TTCTTCATTCCGGGTTTTTC

Downstream 100 bases:

>100_bases
ATCGGGAATCGGGAGTGGGGAATCGCAAGAGCCAAGGCGGTTGCCATGTTTTGGTAGGAGCGCACCTGGGCGCGATGGGG
CATTGGCGGGAAAGCCCCAT

Product: monovalent cation:proton antiporter-1 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLFLPPLLFLDGWRIPKQGLFRD
KAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAAIISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLV
CFQFAVAAVLTGTFSVAAASLTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
GILAAVAAGITMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAVRSVQEAGHLNPWWLAVYVAT
ISLSLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVVAVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAA
SVILVSLLVASVALPRLLRGLELPEEEDEQLKEDLAVKAASQAALDAVEKLRQRLVEDSKHAERYNAAANQVSQRYQRKL
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIESRKRA

Sequences:

>Translated_545_residues
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLFLPPLLFLDGWRIPKQGLFRD
KAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAAIISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLV
CFQFAVAAVLTGTFSVAAASLTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
GILAAVAAGITMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAVRSVQEAGHLNPWWLAVYVAT
ISLSLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVVAVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAA
SVILVSLLVASVALPRLLRGLELPEEEDEQLKEDLAVKAASQAALDAVEKLRQRLVEDSKHAERYNAAANQVSQRYQRKL
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIESRKRA
>Mature_545_residues
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLFLPPLLFLDGWRIPKQGLFRD
KAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAAIISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLV
CFQFAVAAVLTGTFSVAAASLTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
GILAAVAAGITMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAVRSVQEAGHLNPWWLAVYVAT
ISLSLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVVAVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAA
SVILVSLLVASVALPRLLRGLELPEEEDEQLKEDLAVKAASQAALDAVEKLRQRLVEDSKHAERYNAAANQVSQRYQRKL
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIESRKRA

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=508, Percent_Identity=22.8346456692913, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI15529998, Length=573, Percent_Identity=23.5602094240838, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI41872703, Length=467, Percent_Identity=25.6959314775161, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI27777632, Length=504, Percent_Identity=25.7936507936508, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4759144, Length=257, Percent_Identity=31.9066147859922, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI27734935, Length=425, Percent_Identity=23.0588235294118, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194239733, Length=432, Percent_Identity=24.537037037037, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI110227626, Length=258, Percent_Identity=26.7441860465116, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI294997330, Length=258, Percent_Identity=26.7441860465116, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI14211919, Length=416, Percent_Identity=23.3173076923077, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI5454070, Length=258, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790501, Length=543, Percent_Identity=41.804788213628, Blast_Score=378, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71987559, Length=438, Percent_Identity=25.3424657534247, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71987545, Length=438, Percent_Identity=25.3424657534247, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25150332, Length=475, Percent_Identity=23.5789473684211, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71993582, Length=404, Percent_Identity=26.7326732673267, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71993590, Length=404, Percent_Identity=26.7326732673267, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71999817, Length=514, Percent_Identity=22.1789883268482, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980847, Length=532, Percent_Identity=23.1203007518797, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999821, Length=483, Percent_Identity=22.5672877846791, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71999819, Length=514, Percent_Identity=22.1789883268482, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25147678, Length=404, Percent_Identity=23.7623762376238, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71987535, Length=523, Percent_Identity=22.1797323135755, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71987537, Length=523, Percent_Identity=22.1797323135755, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=339, Percent_Identity=23.598820058997, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71992107, Length=339, Percent_Identity=23.598820058997, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320663, Length=256, Percent_Identity=27.34375, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510738, Length=499, Percent_Identity=23.8476953907816, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221510734, Length=421, Percent_Identity=24.9406175771971, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221510736, Length=428, Percent_Identity=26.1682242990654, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221510732, Length=428, Percent_Identity=26.1682242990654, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585580, Length=428, Percent_Identity=25.7009345794392, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585578, Length=428, Percent_Identity=25.7009345794392, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221510740, Length=428, Percent_Identity=25.7009345794392, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360447, Length=288, Percent_Identity=28.4722222222222, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281364513, Length=434, Percent_Identity=24.1935483870968, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221473212, Length=407, Percent_Identity=24.5700245700246, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221473222, Length=429, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221473215, Length=407, Percent_Identity=24.5700245700246, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59287; Mature: 59287

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLF
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPPLLFLDGWRIPKQGLFRDKAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLVCFQFAVAAVLTGTFSVAAAS
HHCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILAAVAAGITMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHH
RSVQEAGHLNPWWLAVYVATISLSLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
AVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAASVILVSLLVASVALPRLLRG
EEHHHCHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LELPEEEDEQLKEDLAVKAASQAALDAVEKLRQRLVEDSKHAERYNAAANQVSQRYQRKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKRA
HCCCC
>Mature Secondary Structure
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLF
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPPLLFLDGWRIPKQGLFRDKAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLVCFQFAVAAVLTGTFSVAAAS
HHCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILAAVAAGITMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHH
RSVQEAGHLNPWWLAVYVATISLSLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
AVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAASVILVSLLVASVALPRLLRG
EEHHHCHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LELPEEEDEQLKEDLAVKAASQAALDAVEKLRQRLVEDSKHAERYNAAANQVSQRYQRKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKRA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]