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The map label for this gene is bioD [H]

Identifier: 78049292

GI number: 78049292

Start: 4317515

End: 4318189

Strand: Reverse

Name: bioD [H]

Synonym: XCV3736

Alternate gene names: 78049292

Gene position: 4318189-4317515 (Counterclockwise)

Preceding gene: 78049295

Following gene: 78049288

Centisome position: 83.39

GC content: 70.07

Gene sequence:

>675_bases
ATGCAGCATCCAGCTTTTTATGTCACCGGCACCGATACCGGCATCGGCAAGACCATGGGAAGCACCGCGCTGTTGCACGC
CTTGCGCGCACGCGGCCATCGCGCCGTCGGCATGAAGCCGGTGGCCAGCGGCTGCGAGCACACGCCGCAGGGTTGGCGTA
ACGAAGACGCGCTGGCGCTGCAGGCGGCCAGCGATCCGCAGCCGGACTACGCCACGCTCAATCCCTACGCCTTGCCGGCG
CCGCTGGCACCGGAACTGGCGGCGGCCGATGTCGGCGTAACGCTGGCGCTGGAGCCCATCGCACACGCGTTCGCGCAATT
GCTCACGCAGGCCGAGGTGGTGGTGGTGGAAGGGGTGGGCGGGTGGGCCGCGCCGCTGAGCGCGACCCTGGACCAAGCCG
ATCTGGTGCGCGCCTTGCAGCTGCCGGTGGTGCTGGTGGTCGGCGTGCGGCTGGGCTGCATCAACCACGCGCGGCTCACT
GCTGCGGCCATCGCCGCCGATGGGCTGCAGTGCATCGGGTGGATCGCCAATGAAATCGATCCGCAGATGGAGCGCATCGA
AGAGAACATCGGCATGCTGCGCCAGCGCCTGGCGATGCCGTGCTGGGGCCGGATCCCGTGGCGGCCGGGCGCCGACGCTG
CCGCCCAGGCACACGGGCTGCAGTTGCCGCGCTAG

Upstream 100 bases:

>100_bases
CGCAGGCAAACGACACCAACTGTCCTCAGCCGCACGTGCAGCGCGCACGGTATGCTGCGCGCCCTCACGGCAATGGCGGC
GCGGCCGCAGGATCAGGCGT

Downstream 100 bases:

>100_bases
CTGGCACGGCGCGCTCGCGCGGGCAATAAAAAAGCCCGACAGAGGGAGGGATCTGTCGGGCCGGATTGCACGGGGGGAGG
GACCCATGCAAAGACGCTGA

Product: dithiobiotin synthetase

Products: NA

Alternate protein names: DTB synthetase; DTBS; Dethiobiotin synthase [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MQHPAFYVTGTDTGIGKTMGSTALLHALRARGHRAVGMKPVASGCEHTPQGWRNEDALALQAASDPQPDYATLNPYALPA
PLAPELAAADVGVTLALEPIAHAFAQLLTQAEVVVVEGVGGWAAPLSATLDQADLVRALQLPVVLVVGVRLGCINHARLT
AAAIAADGLQCIGWIANEIDPQMERIEENIGMLRQRLAMPCWGRIPWRPGADAAAQAHGLQLPR

Sequences:

>Translated_224_residues
MQHPAFYVTGTDTGIGKTMGSTALLHALRARGHRAVGMKPVASGCEHTPQGWRNEDALALQAASDPQPDYATLNPYALPA
PLAPELAAADVGVTLALEPIAHAFAQLLTQAEVVVVEGVGGWAAPLSATLDQADLVRALQLPVVLVVGVRLGCINHARLT
AAAIAADGLQCIGWIANEIDPQMERIEENIGMLRQRLAMPCWGRIPWRPGADAAAQAHGLQLPR
>Mature_224_residues
MQHPAFYVTGTDTGIGKTMGSTALLHALRARGHRAVGMKPVASGCEHTPQGWRNEDALALQAASDPQPDYATLNPYALPA
PLAPELAAADVGVTLALEPIAHAFAQLLTQAEVVVVEGVGGWAAPLSATLDQADLVRALQLPVVLVVGVRLGCINHARLT
AAAIAADGLQCIGWIANEIDPQMERIEENIGMLRQRLAMPCWGRIPWRPGADAAAQAHGLQLPR

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1786995, Length=202, Percent_Identity=50, Blast_Score=191, Evalue=3e-50,
Organism=Escherichia coli, GI87081944, Length=207, Percent_Identity=43.4782608695652, Blast_Score=165, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324385, Length=180, Percent_Identity=35, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004472
- InterPro:   IPR002586 [H]

Pfam domain/function: PF01656 CbiA [H]

EC number: =6.3.3.3 [H]

Molecular weight: Translated: 23613; Mature: 23613

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHPAFYVTGTDTGIGKTMGSTALLHALRARGHRAVGMKPVASGCEHTPQGWRNEDALAL
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCEEE
QAASDPQPDYATLNPYALPAPLAPELAAADVGVTLALEPIAHAFAQLLTQAEVVVVEGVG
EECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEECCC
GWAAPLSATLDQADLVRALQLPVVLVVGVRLGCINHARLTAAAIAADGLQCIGWIANEID
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
PQMERIEENIGMLRQRLAMPCWGRIPWRPGADAAAQAHGLQLPR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MQHPAFYVTGTDTGIGKTMGSTALLHALRARGHRAVGMKPVASGCEHTPQGWRNEDALAL
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCEEE
QAASDPQPDYATLNPYALPAPLAPELAAADVGVTLALEPIAHAFAQLLTQAEVVVVEGVG
EECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEECCC
GWAAPLSATLDQADLVRALQLPVVLVVGVRLGCINHARLTAAAIAADGLQCIGWIANEID
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
PQMERIEENIGMLRQRLAMPCWGRIPWRPGADAAAQAHGLQLPR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]