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The map label for this gene is hisC3 [H]

Identifier: 78049094

GI number: 78049094

Start: 4052893

End: 4054095

Strand: Reverse

Name: hisC3 [H]

Synonym: XCV3538

Alternate gene names: 78049094

Gene position: 4054095-4052893 (Counterclockwise)

Preceding gene: 78049095

Following gene: 78049093

Centisome position: 78.29

GC content: 64.59

Gene sequence:

>1203_bases
ATGAACACTGCTCTTTCGCGCCGCGCGTTTCTACGCGACTCCGCGTTGTTTGCCGGCGCCGCCGGTGCCGGCAGCTTGCC
GCTGTTGGCCAGCGGCTTCGAACGCGCCACTGCCATCGCGCCCGCATCGGCAACGGCGCTGGCACCGGTGATGATCGACT
CCAATGAATTTCCGGATGGACCGTCGGCTGCCGCAGTAAAGGCCATCGCGCAGATCGCCCCGCAAGGCGGGCGGTATTTG
CGGCAGGTACAGATGGAATTGATGACCACCCTGGCTGCCGAGCTCGCGCTGCCGGTCGATCACCTGATGGCGTATGCCGG
GTCCACCGAACCGCTCGACTACACGATGCTGGCATTTACTTCGCCCAGCGCCGCGTTGGTCACAGCCGACCCCACCTACG
AATCCGGTTGGCGTGCGGCAACCCGCAATGGCGCGCGCCTGATCAAGGTGCCGCTGCGCAAGGACTTTTCGCACGATGTA
CAGGCCATGTGCGCGGCGGACGCCAACGCGGGCGTGATCTACATCTGCAACCCCAACAATCCCACCGGTTCGGTCACCGC
ACGCAAGGATCTGGACTACGCGTTGGCGCACAAGCCCAAAGGCAGCGTGTTGGTGGTGGATGAGGCGTATATCCACTTCG
CGCAAAACACGCGCAGCATGGTCGACATGGTTGCTGCAGGCGAAGACGTGGTGGTGTTGCGCACCTTCTCCAAACTCTAT
GGCATGGCCGGCATCCGCCTGGGCTATGCGGCCGCGCGTCCGGACCTGCTGGCCAAGCTGAAGTTCTACAGCGTCAACAG
CTTGCCGGTCACCGCCGCCGCTGCCGGGCTGGCCAGCCTGCGTGATCCTGCACTGGTGCCGCAACGGCGCGCACGTACGG
CCGCGACGCGCACGGATGTGATGGACTTTCTCGCCAGGCAGGGCTATGCGTGCACTGCCTCGGAGAGCAACTGCTTCATG
GTGGATGTAAAGCGGCCTGCCGCCGGCTTCAAGGACGCCATGGCCACCCATGGCGTGTTCATCGGCCGCAGCTGGCCGGT
GTGGCCAACCTGGTCGCGGATCACTGTGGGCACCGATGCGGAGATGGCGCGTTTCAAGCAGGCGTTCGTACAAGTGATCG
CCGGTAAGCGCGGCCCGTTGCCGGTGCCGGCCATCGCGTCCGCAGCAGCAGATCCGATGGATGCGTTTTTCCGTTACGCG
TGA

Upstream 100 bases:

>100_bases
ATTCCAGATCGCAGCGCTGGGTAACCCGCTGTACCGGGTCGAGATCGAAGTGGTTGCCGTGCGTCCCTGAATCCGCGTTG
TCATCCTGCTGGAGGTTGTC

Downstream 100 bases:

>100_bases
AGCACGCATGCGGCCGAAGGTCTGCTTGCAATCAGCAGGGCGCCTGGCATCGTTGGTCGATGCGCGAGCGCATGCAGTGG
GCTGGCGCGTGATGCCCTGT

Product: putative aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNTALSRRAFLRDSALFAGAAGAGSLPLLASGFERATAIAPASATALAPVMIDSNEFPDGPSAAAVKAIAQIAPQGGRYL
RQVQMELMTTLAAELALPVDHLMAYAGSTEPLDYTMLAFTSPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDV
QAMCAADANAGVIYICNPNNPTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQNTRSMVDMVAAGEDVVVLRTFSKLY
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDVMDFLARQGYACTASESNCFM
VDVKRPAAGFKDAMATHGVFIGRSWPVWPTWSRITVGTDAEMARFKQAFVQVIAGKRGPLPVPAIASAAADPMDAFFRYA

Sequences:

>Translated_400_residues
MNTALSRRAFLRDSALFAGAAGAGSLPLLASGFERATAIAPASATALAPVMIDSNEFPDGPSAAAVKAIAQIAPQGGRYL
RQVQMELMTTLAAELALPVDHLMAYAGSTEPLDYTMLAFTSPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDV
QAMCAADANAGVIYICNPNNPTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQNTRSMVDMVAAGEDVVVLRTFSKLY
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDVMDFLARQGYACTASESNCFM
VDVKRPAAGFKDAMATHGVFIGRSWPVWPTWSRITVGTDAEMARFKQAFVQVIAGKRGPLPVPAIASAAADPMDAFFRYA
>Mature_400_residues
MNTALSRRAFLRDSALFAGAAGAGSLPLLASGFERATAIAPASATALAPVMIDSNEFPDGPSAAAVKAIAQIAPQGGRYL
RQVQMELMTTLAAELALPVDHLMAYAGSTEPLDYTMLAFTSPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDV
QAMCAADANAGVIYICNPNNPTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQNTRSMVDMVAAGEDVVVLRTFSKLY
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDVMDFLARQGYACTASESNCFM
VDVKRPAAGFKDAMATHGVFIGRSWPVWPTWSRITVGTDAEMARFKQAFVQVIAGKRGPLPVPAIASAAADPMDAFFRYA

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=336, Percent_Identity=26.1904761904762, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322075, Length=260, Percent_Identity=27.6923076923077, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 42457; Mature: 42457

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTALSRRAFLRDSALFAGAAGAGSLPLLASGFERATAIAPASATALAPVMIDSNEFPDG
CCCCHHHHHHHHHCHHEECCCCCCCCCHHHCCHHHHHEECCCCCHHEEEEEECCCCCCCC
PSAAAVKAIAQIAPQGGRYLRQVQMELMTTLAAELALPVDHLMAYAGSTEPLDYTMLAFT
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEC
SPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDVQAMCAADANAGVIYICNPNN
CCCCEEEECCCCCCCCCCHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCC
PTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQNTRSMVDMVAAGEDVVVLRTFSKLY
CCCCEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHH
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDV
CCCCCEECHHHCCCHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
MDFLARQGYACTASESNCFMVDVKRPAAGFKDAMATHGVFIGRSWPVWPTWSRITVGTDA
HHHHHHCCCEEECCCCCEEEEEECCCCCCHHHHHHHCCEEECCCCCCCCCCCEEEECCCH
EMARFKQAFVQVIAGKRGPLPVPAIASAAADPMDAFFRYA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MNTALSRRAFLRDSALFAGAAGAGSLPLLASGFERATAIAPASATALAPVMIDSNEFPDG
CCCCHHHHHHHHHCHHEECCCCCCCCCHHHCCHHHHHEECCCCCHHEEEEEECCCCCCCC
PSAAAVKAIAQIAPQGGRYLRQVQMELMTTLAAELALPVDHLMAYAGSTEPLDYTMLAFT
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEC
SPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDVQAMCAADANAGVIYICNPNN
CCCCEEEECCCCCCCCCCHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCC
PTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQNTRSMVDMVAAGEDVVVLRTFSKLY
CCCCEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHH
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDV
CCCCCEECHHHCCCHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
MDFLARQGYACTASESNCFMVDVKRPAAGFKDAMATHGVFIGRSWPVWPTWSRITVGTDA
HHHHHHCCCEEECCCCCEEEEEECCCCCCHHHHHHHCCEEECCCCCCCCCCCEEEECCCH
EMARFKQAFVQVIAGKRGPLPVPAIASAAADPMDAFFRYA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA