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The map label for this gene is clpB2 [H]

Identifier: 78048880

GI number: 78048880

Start: 3802293

End: 3804878

Strand: Reverse

Name: clpB2 [H]

Synonym: XCV3324

Alternate gene names: 78048880

Gene position: 3804878-3802293 (Counterclockwise)

Preceding gene: 78048881

Following gene: 78048879

Centisome position: 73.48

GC content: 64.54

Gene sequence:

>2586_bases
ATGCGGATGGACAAGCTCACCTCGCGGTTCCAGCAGGCGCTGGCCGACGCGCAGTCGCTGGCTGTGGGCCGCGACCACAA
CATCATCGAGCCGGTGCACGTGCTGGCCGCGCTGCTCGACCAGAGCGGCGGCAGCACGCGCCCGCTGCTGTCGCAGGCCG
GCGTCAACGTGCCGCTGCTGCGCGAGCGCCTGGGCGAGGCGCTGGACACGCTGCCCAAGGTGTCCGGGCAGGAAGGCAAT
CTGTCGATCGGCAACGATCTCAATCGCCTGCTCAACCAGACCGACAAGCTCGCCCAGCAACATGGCGACGCGTTCATCGC
CAGCGAGTGGTTCGTGCTGGCCGCTGCCGACGATGCCAGCCCGCTGGGCGTGGCGTTGCGCGCGGCCGGTGGCGACAAGA
AGAAGATCGAAGCGGCCATCGACAAGCTGCGTGGCGGGGAAACCGTGCAGTCTGAAAACGCCGAAGAACAGCGCCAGGCG
CTGGAGAAATACACCATCGACCTGACCGCACGCGCCGAGAGCGGCAAGCTCGATCCGGTGATCGGCCGCGACGAGGAAAT
CCGCCGCACCATCCAGGTGCTGCAACGGCGCACCAAGAACAACCCGGTGCTGATCGGCGAGCCCGGCGTGGGCAAGACCG
CCATTGTCGAAGGCCTGGCCCAGCGCATCATCAACGGCGAAGTGCCCGAAGGCCTGCGCGGCAAGCGCGTGCTCTCGCTG
GACATGGGCGCGTTGATCGCCGGCGCCAAATTCCGCGGCGAATTCGAAGAGCGCCTGAAGGCCGTGCTCAGCGACCTGTC
GAAGAACGAGGGCCAGATCATCCTGTTCATCGACGAGCTGCACACCATGGTCGGGGCCGGCAAGGCCGATGGCGCGATGG
ATGCCGGCAACATGCTCAAGCCGGCGCTGGCACGCGGCGAGCTGCATTGCATCGGCGCCACCACGCTGGACGAATACCGC
AAGTACATCGAAAAAGACGCCGCACTGGAGCGCCGTTTCCAGAAAGTGTTCGTGGGCGAGCCGACGGTGGAAGACACCAT
CGCGATCCTGCGCGGCCTGAAGGAGCGCTACGCGGTGCATCACGGCGTGGAGATCACCGACCCGGCCATCGTGGCCGCGG
CCACGCTGTCCAACCGCTACATCACCGACCGCCAGCTGCCGGACAAGGCCATCGACCTAATGGACGAAGCGGCCTCGCGT
ATCCGCATGGAGATCGACTCCAAGCCCGAAGAACTCGACCGCCTGGAGCGCCGCCTGATCCAGCTCAAGATCCAGCGCGA
GATGCTCAAGAAGGAAAAGGACGAGGCCTCGCGGCAGCGCCTGGCCGATCTGGAAAGCGATATCGACAAGCTCGAACGCG
AGTTTTCCGACCTCAATGAAGTGTGGAAGTCGGAAAAGGCCGCGCTGCAGGGCACCACCAAGATCAAGGAGCAGATCGAG
CACGCAAAGCTGGAACTGGAGGCCGCACAGCGCCGCCAGGACTACGCCAAGATGAGCGAGATCCAGTACGGCGTGCTGCC
GCAACTGGAAAAGCAGATGCTGCTGGCCAACGAGGTGGAACACCACGATTTCAAGCTGGTGCAGGACCGCGTGACCGCCG
AGGAAATCGCCGAAGTGGTGTCGCGCTGGACCGGCATTCCGGTCAACAAGATGCTCGAAGGCGAGCGCGACAAGTTGTTG
CGCATGGAAGACGACTTGCATCATCGCGTGGTCGGTCAGAACGAGGCGATCAAGGTGGTGTCCGATGCGGTGCGCCGCTC
GCGTGCCGGCCTGTCCGACCCGAACCGCCCCAGTGGCTCGTTCCTGTTCTTAGGTCCCACCGGCGTGGGCAAGACCGAGC
TGTGCAAGGCGTTGGCGGATTTCCTGTTCGACAGCACCGAGGCGATGATCCGCATCGACATGAGCGAGTTCATGGAGAAG
CATTCGGTCGCACGCCTGATCGGCGCGCCTCCGGGCTATGTGGGCTACGAAGAGGGCGGTTACCTCACCGAGGCCGTGCG
TCGTCGTCCGTATTCGCTGATCCTGCTGGACGAAGTGGAAAAGGCGCATCCGGATGTATTCAACATCCTGCTGCAGGTAC
TCGACGATGGCCGCCTGACCGATGGCCAGGGCCGCACCGTGGACTTCCGCAATACCGTCATCGTGATGACCTCCAACCTG
GGCTCGCACCAGATCCAGGAGCTGTCCGGCGACGATAGCGCCGAGGCGTATACGCAGATGAAGGCCGCGGTGATGGGCGT
GGTGCAGGCGCACTTCCGCCCGGAGTTCATCAACCGGCTGGACGACATCGTGGTGTTCCATCCGCTGGACAAGGCGCAGA
TCAAGTCGATTGCGCGCATCCAGTTGCAAGGCCTGGAAAAACGCCTGGCCGAGCGCGGACTCAAGCTGGACCTGGACGAT
GCGGCGCTGGAGGTGCTGGGCAATGTCGGCTTCGATCCGGTGTACGGCGCGCGCCCGCTCAAACGCGCGATCCAGTCGCA
GGTGGAGAACCCGTTGGCGCAGCAGATCCTGTCCGGCCAGTATCTCAGCGGCGAGAGCGTGCGCGTGCGCGCCGACGGCG
GGCGGCTGGTGTTTACCAAGGACTGA

Upstream 100 bases:

>100_bases
CGCTTGCATCTCCAGCACCGGCAAACCTTGAAACCTCGCTCGCCAACCGCATTTGCACGGTATCGCCGGCGGTGCCGGCC
ACCTGTTCAGAGGATCTCCC

Downstream 100 bases:

>100_bases
GTACGCGGCCCGCACGGCGTAGGAGCGCACGTGGGCGATGGCTTTACCGGGAACGCCCATCGCGCCCAGGTGCGCTCCTA
CGTCGAGCTGGAACGTGCCT

Product: ATP-dependent Clp protease subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 861; Mature: 861

Protein sequence:

>861_residues
MRMDKLTSRFQQALADAQSLAVGRDHNIIEPVHVLAALLDQSGGSTRPLLSQAGVNVPLLRERLGEALDTLPKVSGQEGN
LSIGNDLNRLLNQTDKLAQQHGDAFIASEWFVLAAADDASPLGVALRAAGGDKKKIEAAIDKLRGGETVQSENAEEQRQA
LEKYTIDLTARAESGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLRGKRVLSL
DMGALIAGAKFRGEFEERLKAVLSDLSKNEGQIILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCIGATTLDEYR
KYIEKDAALERRFQKVFVGEPTVEDTIAILRGLKERYAVHHGVEITDPAIVAAATLSNRYITDRQLPDKAIDLMDEAASR
IRMEIDSKPEELDRLERRLIQLKIQREMLKKEKDEASRQRLADLESDIDKLEREFSDLNEVWKSEKAALQGTTKIKEQIE
HAKLELEAAQRRQDYAKMSEIQYGVLPQLEKQMLLANEVEHHDFKLVQDRVTAEEIAEVVSRWTGIPVNKMLEGERDKLL
RMEDDLHHRVVGQNEAIKVVSDAVRRSRAGLSDPNRPSGSFLFLGPTGVGKTELCKALADFLFDSTEAMIRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSLILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVIVMTSNL
GSHQIQELSGDDSAEAYTQMKAAVMGVVQAHFRPEFINRLDDIVVFHPLDKAQIKSIARIQLQGLEKRLAERGLKLDLDD
AALEVLGNVGFDPVYGARPLKRAIQSQVENPLAQQILSGQYLSGESVRVRADGGRLVFTKD

Sequences:

>Translated_861_residues
MRMDKLTSRFQQALADAQSLAVGRDHNIIEPVHVLAALLDQSGGSTRPLLSQAGVNVPLLRERLGEALDTLPKVSGQEGN
LSIGNDLNRLLNQTDKLAQQHGDAFIASEWFVLAAADDASPLGVALRAAGGDKKKIEAAIDKLRGGETVQSENAEEQRQA
LEKYTIDLTARAESGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLRGKRVLSL
DMGALIAGAKFRGEFEERLKAVLSDLSKNEGQIILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCIGATTLDEYR
KYIEKDAALERRFQKVFVGEPTVEDTIAILRGLKERYAVHHGVEITDPAIVAAATLSNRYITDRQLPDKAIDLMDEAASR
IRMEIDSKPEELDRLERRLIQLKIQREMLKKEKDEASRQRLADLESDIDKLEREFSDLNEVWKSEKAALQGTTKIKEQIE
HAKLELEAAQRRQDYAKMSEIQYGVLPQLEKQMLLANEVEHHDFKLVQDRVTAEEIAEVVSRWTGIPVNKMLEGERDKLL
RMEDDLHHRVVGQNEAIKVVSDAVRRSRAGLSDPNRPSGSFLFLGPTGVGKTELCKALADFLFDSTEAMIRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSLILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVIVMTSNL
GSHQIQELSGDDSAEAYTQMKAAVMGVVQAHFRPEFINRLDDIVVFHPLDKAQIKSIARIQLQGLEKRLAERGLKLDLDD
AALEVLGNVGFDPVYGARPLKRAIQSQVENPLAQQILSGQYLSGESVRVRADGGRLVFTKD
>Mature_861_residues
MRMDKLTSRFQQALADAQSLAVGRDHNIIEPVHVLAALLDQSGGSTRPLLSQAGVNVPLLRERLGEALDTLPKVSGQEGN
LSIGNDLNRLLNQTDKLAQQHGDAFIASEWFVLAAADDASPLGVALRAAGGDKKKIEAAIDKLRGGETVQSENAEEQRQA
LEKYTIDLTARAESGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLRGKRVLSL
DMGALIAGAKFRGEFEERLKAVLSDLSKNEGQIILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCIGATTLDEYR
KYIEKDAALERRFQKVFVGEPTVEDTIAILRGLKERYAVHHGVEITDPAIVAAATLSNRYITDRQLPDKAIDLMDEAASR
IRMEIDSKPEELDRLERRLIQLKIQREMLKKEKDEASRQRLADLESDIDKLEREFSDLNEVWKSEKAALQGTTKIKEQIE
HAKLELEAAQRRQDYAKMSEIQYGVLPQLEKQMLLANEVEHHDFKLVQDRVTAEEIAEVVSRWTGIPVNKMLEGERDKLL
RMEDDLHHRVVGQNEAIKVVSDAVRRSRAGLSDPNRPSGSFLFLGPTGVGKTELCKALADFLFDSTEAMIRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSLILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVIVMTSNL
GSHQIQELSGDDSAEAYTQMKAAVMGVVQAHFRPEFINRLDDIVVFHPLDKAQIKSIARIQLQGLEKRLAERGLKLDLDD
AALEVLGNVGFDPVYGARPLKRAIQSQVENPLAQQILSGQYLSGESVRVRADGGRLVFTKD

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=309, Percent_Identity=38.5113268608414, Blast_Score=207, Evalue=4e-53,
Organism=Escherichia coli, GI1788943, Length=857, Percent_Identity=70.4784130688448, Blast_Score=1245, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=398, Percent_Identity=40.9547738693467, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6320464, Length=707, Percent_Identity=54.4554455445545, Blast_Score=774, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=867, Percent_Identity=42.6758938869666, Blast_Score=677, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95569; Mature: 95569

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMDKLTSRFQQALADAQSLAVGRDHNIIEPVHVLAALLDQSGGSTRPLLSQAGVNVPLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHH
RERLGEALDTLPKVSGQEGNLSIGNDLNRLLNQTDKLAQQHGDAFIASEWFVLAAADDAS
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCC
PLGVALRAAGGDKKKIEAAIDKLRGGETVQSENAEEQRQALEKYTIDLTARAESGKLDPV
CCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCC
IGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLRGKRVLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALIAGAKFRGEFEERLKAVLSDLSKNEGQIILFIDELHTMVGAGKADGAMDAGNMLK
CHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCHHH
PALARGELHCIGATTLDEYRKYIEKDAALERRFQKVFVGEPTVEDTIAILRGLKERYAVH
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HGVEITDPAIVAAATLSNRYITDRQLPDKAIDLMDEAASRIRMEIDSKPEELDRLERRLI
CCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QLKIQREMLKKEKDEASRQRLADLESDIDKLEREFSDLNEVWKSEKAALQGTTKIKEQIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAKLELEAAQRRQDYAKMSEIQYGVLPQLEKQMLLANEVEHHDFKLVQDRVTAEEIAEVV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SRWTGIPVNKMLEGERDKLLRMEDDLHHRVVGQNEAIKVVSDAVRRSRAGLSDPNRPSGS
HHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKALADFLFDSTEAMIRIDMSEFMEKHSVARLIGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHHCCCHHHEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSLILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVIVMTSNL
HHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSHQIQELSGDDSAEAYTQMKAAVMGVVQAHFRPEFINRLDDIVVFHPLDKAQIKSIARI
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCHHHHHHHHHH
QLQGLEKRLAERGLKLDLDDAALEVLGNVGFDPVYGARPLKRAIQSQVENPLAQQILSGQ
HHHHHHHHHHHCCCEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCC
YLSGESVRVRADGGRLVFTKD
CCCCCCEEEEECCCEEEEECC
>Mature Secondary Structure
MRMDKLTSRFQQALADAQSLAVGRDHNIIEPVHVLAALLDQSGGSTRPLLSQAGVNVPLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHH
RERLGEALDTLPKVSGQEGNLSIGNDLNRLLNQTDKLAQQHGDAFIASEWFVLAAADDAS
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCC
PLGVALRAAGGDKKKIEAAIDKLRGGETVQSENAEEQRQALEKYTIDLTARAESGKLDPV
CCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCC
IGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLRGKRVLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALIAGAKFRGEFEERLKAVLSDLSKNEGQIILFIDELHTMVGAGKADGAMDAGNMLK
CHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCHHH
PALARGELHCIGATTLDEYRKYIEKDAALERRFQKVFVGEPTVEDTIAILRGLKERYAVH
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HGVEITDPAIVAAATLSNRYITDRQLPDKAIDLMDEAASRIRMEIDSKPEELDRLERRLI
CCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QLKIQREMLKKEKDEASRQRLADLESDIDKLEREFSDLNEVWKSEKAALQGTTKIKEQIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAKLELEAAQRRQDYAKMSEIQYGVLPQLEKQMLLANEVEHHDFKLVQDRVTAEEIAEVV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SRWTGIPVNKMLEGERDKLLRMEDDLHHRVVGQNEAIKVVSDAVRRSRAGLSDPNRPSGS
HHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKALADFLFDSTEAMIRIDMSEFMEKHSVARLIGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHHCCCHHHEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSLILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVIVMTSNL
HHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSHQIQELSGDDSAEAYTQMKAAVMGVVQAHFRPEFINRLDDIVVFHPLDKAQIKSIARI
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCHHHHHHHHHH
QLQGLEKRLAERGLKLDLDDAALEVLGNVGFDPVYGARPLKRAIQSQVENPLAQQILSGQ
HHHHHHHHHHHCCCEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCC
YLSGESVRVRADGGRLVFTKD
CCCCCCEEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]