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The map label for this gene is metL [H]

Identifier: 78048731

GI number: 78048731

Start: 3607003

End: 3608091

Strand: Reverse

Name: metL [H]

Synonym: XCV3175

Alternate gene names: 78048731

Gene position: 3608091-3607003 (Counterclockwise)

Preceding gene: 78048732

Following gene: 78048728

Centisome position: 69.67

GC content: 68.6

Gene sequence:

>1089_bases
GTGAGCAATGTCCTGCCCGTTTCGCGCCGCGCTCCGGTCGCTGCAGTGACGCCCACACCGCGCCTAGCCTTGCTGGGGAC
CGGCACCGTGGGGCGCGCGTTCGTGACGCGCTACACCGCGCTGCAGCAGCGCCAACTGCGCTTGCCGCGCTTCGATTGGC
TGGCCAATTCGCGTGTTGCGCAGGATTGTGGCGTCAGCGCCGAGCAGGCCCTGCAGCACGCCAATGCGGCGCCGCGCTGG
CAAACGCTCTTGCAGCCCTGGGCGGAAACCACCGCACTGCGTGCCGGCGATGTACTGGTGGATGCGACTGCCAGCGATGT
CGTGGCCGATTGGCATGTCGAATGGTTGCAGCGCGGTGTGCATGTGGTCACCGCCAACAAACTGGGCCAGGGCACCGCGT
TGTCGCGTGCGCAGGCGCTGCATGCGGCCCGCCATGCCAGCGGCGCGTATTACGGCGACAGCGCCACTGTGGGCGCCGGG
CTACCGGTGTTGAGCAGCGTGCGCGCCTTGGTCGCCGGTGGGGATCGCATTCATTCGATCGAAGGCGTGTTGTCCGGATC
GTTGGCGTGGCTGTTTCATCGCTACGACGGCAGTGGCGCGTTTTCCGCCTGCGTGCGCGAAGCGATGGCGGCTGGTTATA
CCGAGCCGGATCCACGCATCGATCTCTCTGGCGAGGATGTGCGGCGCAAGCTGCTGATCCTGGCGCGTGCCGCGGGGTGG
CAACTGGAGGCCGAGCAGGTGCATGTGGAATCGCTGGTGCCTGCCGTCATTGCCAAGGCGCCGCTTGCTGAACTGGATGC
GCAGTTGGGCGCGCTGGATGCGGTGGTGGGCGCGCGGTGGCAACAGGCGCGTGCGGCAGGGCGTTGCCTGCGCTTTGTCG
GCCGTGTGGACGCGCATGGTGCAAGCGTGGGATTGCGTGAGCTGGCGCTGGACCACCCCCTGGCCGGCGGTGCCGGGACC
GACAACCGCGTGGCGATCAGCAGTGACCGCTATCGCGCGCAGCCGCTGCTGATCCAGGGCCCGGGCGCGGGCGCCGAGGT
GACTGCAGCGGCGTTGCTGGATGACGTGTTGCGGATCGTGGCCGGCTGA

Upstream 100 bases:

>100_bases
TCGGGATCGAATCGGCCGACGATCTGCTGATCGATCTGCGCGCCGGCCTGGCCCGTGCCGAAGCGACCCTGACCGCCGCC
AGCCGCAAACAGGTCGACGC

Downstream 100 bases:

>100_bases
TGGCGCGACCGAGCTGACGCCGGTGCGTTGCCGTGCGCCTTGCGGCACTGGAGTGTGCGATCTGCCCATCGGTGCTGGCT
GCAGCCGGTTTCGACCGGCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: Aspartokinase II/homoserine dehydrogenase II; AKII-HDII; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSNVLPVSRRAPVAAVTPTPRLALLGTGTVGRAFVTRYTALQQRQLRLPRFDWLANSRVAQDCGVSAEQALQHANAAPRW
QTLLQPWAETTALRAGDVLVDATASDVVADWHVEWLQRGVHVVTANKLGQGTALSRAQALHAARHASGAYYGDSATVGAG
LPVLSSVRALVAGGDRIHSIEGVLSGSLAWLFHRYDGSGAFSACVREAMAAGYTEPDPRIDLSGEDVRRKLLILARAAGW
QLEAEQVHVESLVPAVIAKAPLAELDAQLGALDAVVGARWQQARAAGRCLRFVGRVDAHGASVGLRELALDHPLAGGAGT
DNRVAISSDRYRAQPLLIQGPGAGAEVTAAALLDDVLRIVAG

Sequences:

>Translated_362_residues
MSNVLPVSRRAPVAAVTPTPRLALLGTGTVGRAFVTRYTALQQRQLRLPRFDWLANSRVAQDCGVSAEQALQHANAAPRW
QTLLQPWAETTALRAGDVLVDATASDVVADWHVEWLQRGVHVVTANKLGQGTALSRAQALHAARHASGAYYGDSATVGAG
LPVLSSVRALVAGGDRIHSIEGVLSGSLAWLFHRYDGSGAFSACVREAMAAGYTEPDPRIDLSGEDVRRKLLILARAAGW
QLEAEQVHVESLVPAVIAKAPLAELDAQLGALDAVVGARWQQARAAGRCLRFVGRVDAHGASVGLRELALDHPLAGGAGT
DNRVAISSDRYRAQPLLIQGPGAGAEVTAAALLDDVLRIVAG
>Mature_361_residues
SNVLPVSRRAPVAAVTPTPRLALLGTGTVGRAFVTRYTALQQRQLRLPRFDWLANSRVAQDCGVSAEQALQHANAAPRWQ
TLLQPWAETTALRAGDVLVDATASDVVADWHVEWLQRGVHVVTANKLGQGTALSRAQALHAARHASGAYYGDSATVGAGL
PVLSSVRALVAGGDRIHSIEGVLSGSLAWLFHRYDGSGAFSACVREAMAAGYTEPDPRIDLSGEDVRRKLLILARAAGWQ
LEAEQVHVESLVPAVIAKAPLAELDAQLGALDAVVGARWQQARAAGRCLRFVGRVDAHGASVGLRELALDHPLAGGAGTD
NRVAISSDRYRAQPLLIQGPGAGAEVTAAALLDDVLRIVAG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=263, Percent_Identity=45.2471482889734, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786183, Length=326, Percent_Identity=36.8098159509202, Blast_Score=193, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6322599, Length=371, Percent_Identity=32.3450134770889, Blast_Score=172, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 38122; Mature: 37990

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVLPVSRRAPVAAVTPTPRLALLGTGTVGRAFVTRYTALQQRQLRLPRFDWLANSRVA
CCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHH
QDCGVSAEQALQHANAAPRWQTLLQPWAETTALRAGDVLVDATASDVVADWHVEWLQRGV
HHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCC
HVVTANKLGQGTALSRAQALHAARHASGAYYGDSATVGAGLPVLSSVRALVAGGDRIHSI
EEEEECCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHCCCHHHHH
EGVLSGSLAWLFHRYDGSGAFSACVREAMAAGYTEPDPRIDLSGEDVRRKLLILARAAGW
HHHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
QLEAEQVHVESLVPAVIAKAPLAELDAQLGALDAVVGARWQQARAAGRCLRFVGRVDAHG
EECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ASVGLRELALDHPLAGGAGTDNRVAISSDRYRAQPLLIQGPGAGAEVTAAALLDDVLRIV
CHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
AG
CC
>Mature Secondary Structure 
SNVLPVSRRAPVAAVTPTPRLALLGTGTVGRAFVTRYTALQQRQLRLPRFDWLANSRVA
CCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHH
QDCGVSAEQALQHANAAPRWQTLLQPWAETTALRAGDVLVDATASDVVADWHVEWLQRGV
HHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCC
HVVTANKLGQGTALSRAQALHAARHASGAYYGDSATVGAGLPVLSSVRALVAGGDRIHSI
EEEEECCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHCCCHHHHH
EGVLSGSLAWLFHRYDGSGAFSACVREAMAAGYTEPDPRIDLSGEDVRRKLLILARAAGW
HHHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
QLEAEQVHVESLVPAVIAKAPLAELDAQLGALDAVVGARWQQARAAGRCLRFVGRVDAHG
EECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ASVGLRELALDHPLAGGAGTDNRVAISSDRYRAQPLLIQGPGAGAEVTAAALLDDVLRIV
CHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6298218; 8346018; 9278503 [H]