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The map label for this gene is proA [H]

Identifier: 78048097

GI number: 78048097

Start: 2868635

End: 2869879

Strand: Reverse

Name: proA [H]

Synonym: XCV2541

Alternate gene names: 78048097

Gene position: 2869879-2868635 (Counterclockwise)

Preceding gene: 78048098

Following gene: 78048095

Centisome position: 55.42

GC content: 66.67

Gene sequence:

>1245_bases
ATGACCATCAAAACCCTCGCTCTGCAATGCCGTGACGCCGCGCAGGTGGTGTCGCAATTGTCTGCACCGGCCAAGCATGC
CTTGCTGGACGCGATGGCGGCCGCGCTGGAAGCCGATGCGGCGGCGATTCTGGCCGCCAATGCGCGCGATCTGGAGGCCG
CGCGTGCCAAGGGCACCGGCAGTGCCATGCTCGATCGGCTGGCGCTGGACGACAAGCGCCTGGCCGGCATCGCGGCCGCA
TTGCGCGAGGTGGCGCAGCTGCCCGACCCGGTGGGTCGGATCACCCGCGAAGATGTGCGCCCCAACGGGATTCGCGTGCA
GAAGGTGCGTGTGCCGCTGGGCGTGATCGCGATGATCTACGAGGCGCGGCCCAACGTCACGGCTGACGCTGCGGCGCTGT
GCATCAAAGCCGGCAATGGCGTGATCCTGCGCGGTGGCTCGGAGGCGATCCATTCCAATACCGCCATTGCGCGCGCACTG
CAGCGGGCCTTGCGCGAGGCCAATGTGCCGGACGCGGCGCTGACCCTGGTCGAGGATCTGCGCCGCGAGACCATGCTGGA
ACTGCTGCAGCTTAACGATATCGTCGATCTGGCGATTCCGCGCGGCGGCGAAGGCCTGATCCGGTTTGTCGCCGAGCACG
CGCGCGTGCCGGTGATCAAGCACTACAAGGGGGTGTGCCACCTGTTTGTGGATGCATCCGCCGAGATGGAGCTTGCGCTG
CGCCTGCTGATCGATGGCAAGGCGACGCGGCCGTCGGCCTGTAATTCGCTGGAGACCTTGCTGGTGCATGCAGGCATCGC
CGAGCGCTTCTTGCCGCTTGCCGCGCAGGCATTGCGCGAACGCAAGGTTGAACTGCGTGGCGATGCGGCGACGCAGGCGG
TGCTGCCGGACATCGCTGCTGCCAGCGACGACGACTATGCCGCGGAATTCCTGGATCTGATTCTGGCCATCCGCGTGGTG
CCGGACCTGGACACGGCGCTGGCGCACATCCGCCAGTACGGCTCGGACCACACCGAAGTCATCGCCACGCAGGATGCCGA
CAACGCCGAGCGATTCGTGCAGTCGCTACGCTCTGCGGTGGTGATGGTGAACGCCTCCTCGCGCTTTTCCGATGGCGGTG
AACTGGGCCTGGGCGCGGAGATCGGCATCTCCACCACACGCCTGCATTCCTATGGCCCCATGGGCCTGGAAGCGCTGACG
GTGGAGCGCTTCGTGGTGCGTGGCGAAGGCCAGGTGCGGCATTAG

Upstream 100 bases:

>100_bases
TTTGCCGCTTTGTTACAGTGAATGAGTCCGTTGTGCTAATAAAACGATGTCGCCTGCTTTTGCAAATCTCCAATCCCGAC
TCCCAAATCCCGGCCCCCAA

Downstream 100 bases:

>100_bases
GAAAGCTGGACACCCCTAGCGAACACCCATCAAGGGCCGCCACGCAGACGCCGCCTGCAACGGCGTCATGCTGCAGGCGC
TGCCGGCCTGCGGGGCCGGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTIKTLALQCRDAAQVVSQLSAPAKHALLDAMAAALEADAAAILAANARDLEAARAKGTGSAMLDRLALDDKRLAGIAAA
LREVAQLPDPVGRITREDVRPNGIRVQKVRVPLGVIAMIYEARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARAL
QRALREANVPDAALTLVEDLRRETMLELLQLNDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASAEMELAL
RLLIDGKATRPSACNSLETLLVHAGIAERFLPLAAQALRERKVELRGDAATQAVLPDIAAASDDDYAAEFLDLILAIRVV
PDLDTALAHIRQYGSDHTEVIATQDADNAERFVQSLRSAVVMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALT
VERFVVRGEGQVRH

Sequences:

>Translated_414_residues
MTIKTLALQCRDAAQVVSQLSAPAKHALLDAMAAALEADAAAILAANARDLEAARAKGTGSAMLDRLALDDKRLAGIAAA
LREVAQLPDPVGRITREDVRPNGIRVQKVRVPLGVIAMIYEARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARAL
QRALREANVPDAALTLVEDLRRETMLELLQLNDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASAEMELAL
RLLIDGKATRPSACNSLETLLVHAGIAERFLPLAAQALRERKVELRGDAATQAVLPDIAAASDDDYAAEFLDLILAIRVV
PDLDTALAHIRQYGSDHTEVIATQDADNAERFVQSLRSAVVMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALT
VERFVVRGEGQVRH
>Mature_413_residues
TIKTLALQCRDAAQVVSQLSAPAKHALLDAMAAALEADAAAILAANARDLEAARAKGTGSAMLDRLALDDKRLAGIAAAL
REVAQLPDPVGRITREDVRPNGIRVQKVRVPLGVIAMIYEARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARALQ
RALREANVPDAALTLVEDLRRETMLELLQLNDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASAEMELALR
LLIDGKATRPSACNSLETLLVHAGIAERFLPLAAQALRERKVELRGDAATQAVLPDIAAASDDDYAAEFLDLILAIRVVP
DLDTALAHIRQYGSDHTEVIATQDADNAERFVQSLRSAVVMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALTV
ERFVVRGEGQVRH

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=416, Percent_Identity=37.2596153846154, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI62912457, Length=416, Percent_Identity=37.2596153846154, Blast_Score=262, Evalue=5e-70,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=44.8192771084337, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=35.2657004830918, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=35.2657004830918, Blast_Score=252, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6324899, Length=429, Percent_Identity=32.1678321678322, Blast_Score=252, Evalue=7e-68,
Organism=Drosophila melanogaster, GI21357643, Length=413, Percent_Identity=35.5932203389831, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44148; Mature: 44017

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKTLALQCRDAAQVVSQLSAPAKHALLDAMAAALEADAAAILAANARDLEAARAKGTG
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHCCCCH
SAMLDRLALDDKRLAGIAAALREVAQLPDPVGRITREDVRPNGIRVQKVRVPLGVIAMIY
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHH
EARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARALQRALREANVPDAALTLVEDL
HCCCCCCHHHHHHEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RRETMLELLQLNDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASAEMELAL
HHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHCCEEEEEECCCCHHHHHH
RLLIDGKATRPSACNSLETLLVHAGIAERFLPLAAQALRERKVELRGDAATQAVLPDIAA
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCHHHC
ASDDDYAAEFLDLILAIRVVPDLDTALAHIRQYGSDHTEVIATQDADNAERFVQSLRSAV
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHE
VMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALTVERFVVRGEGQVRH
EEEECCCCCCCCCCCCCCCCCCCEEHEECCCCCCCHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
TIKTLALQCRDAAQVVSQLSAPAKHALLDAMAAALEADAAAILAANARDLEAARAKGTG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHCCCCH
SAMLDRLALDDKRLAGIAAALREVAQLPDPVGRITREDVRPNGIRVQKVRVPLGVIAMIY
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHH
EARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARALQRALREANVPDAALTLVEDL
HCCCCCCHHHHHHEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RRETMLELLQLNDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASAEMELAL
HHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHCCEEEEEECCCCHHHHHH
RLLIDGKATRPSACNSLETLLVHAGIAERFLPLAAQALRERKVELRGDAATQAVLPDIAA
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCHHHC
ASDDDYAAEFLDLILAIRVVPDLDTALAHIRQYGSDHTEVIATQDADNAERFVQSLRSAV
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHE
VMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALTVERFVVRGEGQVRH
EEEECCCCCCCCCCCCCCCCCCCEEHEECCCCCCCHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]