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The map label for this gene is guaB [H]

Identifier: 78048042

GI number: 78048042

Start: 2805672

End: 2807129

Strand: Reverse

Name: guaB [H]

Synonym: XCV2486

Alternate gene names: 78048042

Gene position: 2807129-2805672 (Counterclockwise)

Preceding gene: 78048043

Following gene: 78048041

Centisome position: 54.21

GC content: 64.54

Gene sequence:

>1458_bases
ATGCTACGCATCCAGGCTGAAGCTCTCACCTACGACGACGTTTCGCTCGTCCCCGCTCATTCGATCGTCCTGCCCAAGGA
CGTCAGCCTGGAAACCCGGCTGACGCGCGACCTGCGCCTGAAACTGCCGATTCTGTCGGCGGCAATGGACACAGTGACCG
AACACCGTCTTGCGGTGGCCATGGCCCAGCTGGGCGGCATCGGCATCATCCACAAGAACCTGACCCCGCAGCAGCAAGCC
GGCGAAGTGGCACGGGTCAAGAAGTTCGAATCCGGCGTGATCACCGAGCCGTTCACCGTCAGCCCCGACACGACCATCGG
CGAAGTGCTGGCACTGACGCGCGCGCGCAACATCTCCGGCGTGCCGGTGGTGGATGGCAGCGAACTGGTCGGTATCGTCA
CCAGCCGCGACATGCGCTTCGAAAAGAAGCTCGACGATCCGGTCCGGCACATCATGACCAAGAAGGACCGCCTGATTACC
GTGCGCGAAGGCGCCAGCGATGAGGAAGTGCTCGAGCTGCTGCATCGCAACCGGATCGAAAAGGTCCTGGTGGTCAACGA
CAGCTTCGAGCTGCGCGGCCTGATCACGGTCAAGGACATCCAGAAGAAGACCGACAACCCCAATGCCGCCAAGGACAGCG
CCAAGCGTTTGCTGGTGGGCGCGGCGGTGGGCGTGGGCGGCGATACCGAGCAGCGCATCGAGCTGCTTGCCGCAGCCGGC
GTGGACGTGGTGATTGTCGATACCGCGCATGGCCATTCGCAGGGCGTGATCGATCGCGTGGCTTGGGTCAAGAAGACCTA
TCCGCAGTTGCAGGTGATCGGCGGCAACATCGTCACCGGCGATGCGGCATTGGCGTTGATGGATGCCGGTGCGGACGCGG
TCAAGGTCGGCGTGGGCCCGGGTTCGATCTGCACCACGCGAGTGGTTGCCGGCGTGGGCGTGCCGCAGATCACTGCGGTG
GACATGGTGGCCGAAGCGCTGCAGGACCGCATCCCCTTGATTGCCGATGGCGGCATCCGCTATTCCGGCGACATCGGCAA
GGCGCTGGTGGCCGGTGCCTCGACGGTGATGGTCGGCGGCCTGTTGGCCGGTACCGAAGAAGCGCCGGGCGAGGTCGAAC
TGTTCCAGGGCCGCAGCTACAAGAGCTACCGCGGCATGGGTAGCCTGGGTGCGATGGAAAAGGGGTCCAAGGACCGCTAC
TTCCAGGATGCCTCCGATGCCGACAAGCTGGTTCCCGAAGGCATCGAGGGCCGCGTGCCGTATCGCGGGCCGGTCGGCGG
CATCATCCATCAGCTCATCGGTGGCCTGCGCGCGACCATGGGCTACGTGGGCTGCGCCACCATCGAAGACATGCGGACCA
AGCCCAAGTTCGTCAAGATCACTGGCGCCGGCCAGCGCGAAAGCCACGTGCACGACGTGCAGATCATCAAAGAGCCGCCG
AACTATCGCGCCGGCTAA

Upstream 100 bases:

>100_bases
AACGGCGGACGGTGCAGGGCGCGCTGTTGCGAATCCCGACTCCCCCATCCTGGCCCCAATGCGTTAAAATGCCGCGCTTC
CCCAAAACTCGGGTCCGCCG

Downstream 100 bases:

>100_bases
CCGGGAATGGGGAATCGCGAATCGGGAATCGTAAGAGCCCGCCGCCTCCTCATCCGATAGCGGTCGGCGCTGCGTTTGCT
GTTTCGATTCCCTCATCCCG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPQQQA
GEVARVKKFESGVITEPFTVSPDTTIGEVLALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKVLVVNDSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATIEDMRTKPKFVKITGAGQRESHVHDVQIIKEPP
NYRAG

Sequences:

>Translated_485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPQQQA
GEVARVKKFESGVITEPFTVSPDTTIGEVLALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKVLVVNDSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATIEDMRTKPKFVKITGAGQRESHVHDVQIIKEPP
NYRAG
>Mature_485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPQQQA
GEVARVKKFESGVITEPFTVSPDTTIGEVLALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKVLVVNDSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATIEDMRTKPKFVKITGAGQRESHVHDVQIIKEPP
NYRAG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=485, Percent_Identity=44.5360824742268, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=485, Percent_Identity=44.5360824742268, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI34328930, Length=485, Percent_Identity=44.5360824742268, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI156616279, Length=485, Percent_Identity=44.5360824742268, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=43.4782608695652, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=44.5147679324894, Blast_Score=354, Evalue=9e-98,
Organism=Homo sapiens, GI217035148, Length=485, Percent_Identity=43.9175257731959, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI217035150, Length=485, Percent_Identity=41.4432989690722, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=38.6178861788618, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=38.6178861788618, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=38.6178861788618, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=38.6178861788618, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI156104880, Length=261, Percent_Identity=36.3984674329502, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=63.0390143737166, Blast_Score=570, Evalue=1e-164,
Organism=Escherichia coli, GI1786293, Length=267, Percent_Identity=34.0823970037453, Blast_Score=149, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=503, Percent_Identity=39.5626242544732, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI71994389, Length=421, Percent_Identity=42.0427553444181, Blast_Score=291, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI17560440, Length=255, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=40.041067761807, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=40.1656314699793, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=40.1656314699793, Blast_Score=322, Evalue=6e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=40.2366863905325, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=141, Percent_Identity=36.8794326241135, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=42.2037422037422, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=42.2037422037422, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=43.0523917995444, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51685; Mature: 51685

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVA
CEEEEEEEEEECCCEECCCCEEECCCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHHHHH
MAQLGGIGIIHKNLTPQQQAGEVARVKKFESGVITEPFTVSPDTTIGEVLALTRARNISG
HHHHCCEEEEECCCCCHHHHCHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHCCCCC
VPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLITVREGASDEEVLELLHRNRIE
CEEECCCCEEEEEECCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCC
KVLVVNDSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
EEEEECCCEEEEEEEEEHHHHHHCCCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHHCC
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGP
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEECCCCEEEEECCC
GSICTTRVVAGVGVPQITAVDMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHCCHHHHHHH
LLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRYFQDASDADKLVPEGIEGRVP
EEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
YRGPVGGIIHQLIGGLRATMGYVGCATIEDMRTKPKFVKITGAGQRESHVHDVQIIKEPP
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCC
NYRAG
CCCCC
>Mature Secondary Structure
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVA
CEEEEEEEEEECCCEECCCCEEECCCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHHHHH
MAQLGGIGIIHKNLTPQQQAGEVARVKKFESGVITEPFTVSPDTTIGEVLALTRARNISG
HHHHCCEEEEECCCCCHHHHCHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHCCCCC
VPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLITVREGASDEEVLELLHRNRIE
CEEECCCCEEEEEECCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCC
KVLVVNDSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
EEEEECCCEEEEEEEEEHHHHHHCCCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHHCC
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGP
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEECCCCEEEEECCC
GSICTTRVVAGVGVPQITAVDMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHCCHHHHHHH
LLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRYFQDASDADKLVPEGIEGRVP
EEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
YRGPVGGIIHQLIGGLRATMGYVGCATIEDMRTKPKFVKITGAGQRESHVHDVQIIKEPP
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCC
NYRAG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA