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The map label for this gene is lip2 [H]

Identifier: 78048004

GI number: 78048004

Start: 2780431

End: 2781456

Strand: Reverse

Name: lip2 [H]

Synonym: XCV2448

Alternate gene names: 78048004

Gene position: 2781456-2780431 (Counterclockwise)

Preceding gene: 78048006

Following gene: 78048001

Centisome position: 53.71

GC content: 65.89

Gene sequence:

>1026_bases
ATGAAGACTCCCCTCGCCCTTATTGCCACCACGCTGCTGGCGGCATCGGTTGGCACTGCTGTCGCGGCCGCACCCAGCGA
CCAGCCGGCGCCATTGCGCCCGGTCGCAGACTTCCTCAAGGCGCTCAACAGCGGTGGCGGCACGCCGATCGAGCAGCTGA
GCCCCGCGCAGGCGCGTCAGGTGCTGACCAACGCCCAGGCCAATACACCCCTGCCGGCGGCTGATGTCAGCCGCAAGACC
ATCCAGGCCAACGGCAAGCTGCTGAACCTGGTGATCGTGCGGCCGCCGCATAGCACTGGCCAGGTGCTGCCGGCTTTCAT
GTTCTTCCATGGCGGCGGCTGGGTGCTGGGCGACTTCCCGACCCACGAACGCCTGATCCGCGACCTGGTCAATGCCTCCG
GCGCAGCGGCGGTCTACGTCGATTACACGCCCTCGCCGGAGGCGCACTACCCGGTGGCGATCCATCAGGCCTATGCCGCC
ACGCGTTGGGTTGCCGAACACGGCATGGAGATCGGCGTGGATGGCCAACGCCTGGCACTGGCCGGCAACAGCGTCGGTGG
CAACATGGTGGCGGCAGTGGCGCTGCAGGCCAAGGCAGCAGGCACGCCGGCACTGCGCTACAACCTGATGCTGTGGCCGG
TCACCGACGCCGCGTTCGACAATGACTCGTACCAGCGCTACCAGAGCGGCTACTTCCTCAGCCGCAACATGATGACCTGG
TTCTGGGACAACTACACCACCGACCCCAAGGCCCGCGCCGAGATCACTGCTTCGCCCCTGCGCGCTACCGCCGCCCAGCT
GGAAGGCTTGCCGCCGACCCAGATTCAGACGGCGGAGCTGGACGTATTGCGCGATGAGGGCGAAGCCTTCGGTCGCACGC
TAGATCAAGCAGGTGTCGAGGTGACCGTGACGCGCTACAACGGGCTGATCCACGATTACGGCCTGCTCAATGCGCTTCGG
GACGTACCAGCAGTCCGTGATGCGATTCGCCAAGCCGGCGATGGATTACGCGAACACCTGAAGTAA

Upstream 100 bases:

>100_bases
GGTAAAGTTTCATGGACGATTTGCGGCCTATCGTATCGCCTTGACGCGCAAAGTCACTCCTGTCGCCGGCGCCCTGCCCG
GCTTGTCCAGGAACCGCATC

Downstream 100 bases:

>100_bases
GCGCGATAGCGGAATGGCTCTGTGGCCGCCGCATCCGCAGTTGGCACGGCCGGTAGACGATGGCAAGGAACCTGTGAACT
GTCAGAAAGGAAACCGTGAC

Product: putative esterase/lipase/thioesterase family protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKTPLALIATTLLAASVGTAVAAAPSDQPAPLRPVADFLKALNSGGGTPIEQLSPAQARQVLTNAQANTPLPAADVSRKT
IQANGKLLNLVIVRPPHSTGQVLPAFMFFHGGGWVLGDFPTHERLIRDLVNASGAAAVYVDYTPSPEAHYPVAIHQAYAA
TRWVAEHGMEIGVDGQRLALAGNSVGGNMVAAVALQAKAAGTPALRYNLMLWPVTDAAFDNDSYQRYQSGYFLSRNMMTW
FWDNYTTDPKARAEITASPLRATAAQLEGLPPTQIQTAELDVLRDEGEAFGRTLDQAGVEVTVTRYNGLIHDYGLLNALR
DVPAVRDAIRQAGDGLREHLK

Sequences:

>Translated_341_residues
MKTPLALIATTLLAASVGTAVAAAPSDQPAPLRPVADFLKALNSGGGTPIEQLSPAQARQVLTNAQANTPLPAADVSRKT
IQANGKLLNLVIVRPPHSTGQVLPAFMFFHGGGWVLGDFPTHERLIRDLVNASGAAAVYVDYTPSPEAHYPVAIHQAYAA
TRWVAEHGMEIGVDGQRLALAGNSVGGNMVAAVALQAKAAGTPALRYNLMLWPVTDAAFDNDSYQRYQSGYFLSRNMMTW
FWDNYTTDPKARAEITASPLRATAAQLEGLPPTQIQTAELDVLRDEGEAFGRTLDQAGVEVTVTRYNGLIHDYGLLNALR
DVPAVRDAIRQAGDGLREHLK
>Mature_341_residues
MKTPLALIATTLLAASVGTAVAAAPSDQPAPLRPVADFLKALNSGGGTPIEQLSPAQARQVLTNAQANTPLPAADVSRKT
IQANGKLLNLVIVRPPHSTGQVLPAFMFFHGGGWVLGDFPTHERLIRDLVNASGAAAVYVDYTPSPEAHYPVAIHQAYAA
TRWVAEHGMEIGVDGQRLALAGNSVGGNMVAAVALQAKAAGTPALRYNLMLWPVTDAAFDNDSYQRYQSGYFLSRNMMTW
FWDNYTTDPKARAEITASPLRATAAQLEGLPPTQIQTAELDVLRDEGEAFGRTLDQAGVEVTVTRYNGLIHDYGLLNALR
DVPAVRDAIRQAGDGLREHLK

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=277, Percent_Identity=25.2707581227437, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI21328446, Length=121, Percent_Identity=33.8842975206612, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI68051721, Length=158, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786682, Length=239, Percent_Identity=26.3598326359833, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17567059, Length=205, Percent_Identity=25.8536585365854, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 36514; Mature: 36514

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPLALIATTLLAASVGTAVAAAPSDQPAPLRPVADFLKALNSGGGTPIEQLSPAQARQ
CCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHH
VLTNAQANTPLPAADVSRKTIQANGKLLNLVIVRPPHSTGQVLPAFMFFHGGGWVLGDFP
HHHCCCCCCCCCHHHCCHHHEECCCEEEEEEEEECCCCCCCHHHHHHEEECCCEEECCCC
THERLIRDLVNASGAAAVYVDYTPSPEAHYPVAIHQAYAATRWVAEHGMEIGVDGQRLAL
CHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCEEEE
AGNSVGGNMVAAVALQAKAAGTPALRYNLMLWPVTDAAFDNDSYQRYQSGYFLSRNMMTW
ECCCCCCCHHHHEEEHHHCCCCCEEEEEEEEEEECCCCCCCCHHHHHHCCEEEECCCEEE
FWDNYTTDPKARAEITASPLRATAAQLEGLPPTQIQTAELDVLRDEGEAFGRTLDQAGVE
EECCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCHHHHHHHHHHCCCE
VTVTRYNGLIHDYGLLNALRDVPAVRDAIRQAGDGLREHLK
EEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTPLALIATTLLAASVGTAVAAAPSDQPAPLRPVADFLKALNSGGGTPIEQLSPAQARQ
CCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHH
VLTNAQANTPLPAADVSRKTIQANGKLLNLVIVRPPHSTGQVLPAFMFFHGGGWVLGDFP
HHHCCCCCCCCCHHHCCHHHEECCCEEEEEEEEECCCCCCCHHHHHHEEECCCEEECCCC
THERLIRDLVNASGAAAVYVDYTPSPEAHYPVAIHQAYAATRWVAEHGMEIGVDGQRLAL
CHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCEEEE
AGNSVGGNMVAAVALQAKAAGTPALRYNLMLWPVTDAAFDNDSYQRYQSGYFLSRNMMTW
ECCCCCCCHHHHEEEHHHCCCCCEEEEEEEEEEECCCCCCCCHHHHHHCCEEEECCCEEE
FWDNYTTDPKARAEITASPLRATAAQLEGLPPTQIQTAELDVLRDEGEAFGRTLDQAGVE
EECCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCHHHHHHHHHHCCCE
VTVTRYNGLIHDYGLLNALRDVPAVRDAIRQAGDGLREHLK
EEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]