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The map label for this gene is blh [H]

Identifier: 78048001

GI number: 78048001

Start: 2778451

End: 2779317

Strand: Reverse

Name: blh [H]

Synonym: XCV2445

Alternate gene names: 78048001

Gene position: 2779317-2778451 (Counterclockwise)

Preceding gene: 78048004

Following gene: 78048000

Centisome position: 53.67

GC content: 63.55

Gene sequence:

>867_bases
ATGAGCGCGCCGCACGTGGCGACATTCTTCGACCCGGTGACCTTTACCGCCAGCCACGTGGTCCGAGACCCTGGCTCGTC
GGCCTGCGCCATCATCGACAGCGTGCTCGACTTCGACATGGCGTCAGGCCGAACTGCGACCGGTTCGGCTGAAGCGCTTG
CGCACTACGTGCGTGACGAGGCGTTACAGGTGCAATGGCACCTCGAAACACACGCCCATGCCGACCACCTGTCGGCTGCG
CCGTGGCTGCAGCAGCAGGTGGGCGGACAGCTCGCCATCGGCGAGCGCATCACGGCCGTGCAGCAGACCTTCGGCAACCT
TTTCAACGCCGGCAAGGAATTCAGCCGGGACGGCAGCCAGTTCGATCATCTGTTCGCCGACGGCGCAGCATTCACGATCG
GGCATCTGCACGCAGTGGCGCTGCATGTTCCCGGACATACGCCCGCGTGCATGGCTTACGTCATCGGCGATGCGCTGTTT
TCAGGCGATACGTTGTTCATGCCGGACTACGGCACGGTGCGCTGCGATTTTCCGGGCGGCTCGGCACGCCAGCTCTATCG
CTCCATCCAACGGCTGCTGAAACTGCCCGATGCCACGCGTGTCTTCGTCTGCCACGACTACAAGTCCGCAGGCCGGGCCC
ATTTCGCATGGGAAACCACGATTGGCGCGCAACGCAGCGCGAATGTGCATCTGCATGCGGGCGTTTCCGAAGCGGACTTC
GTGAAGATGCGCGAGACACGCGACGCCACGCTTCCCATGCCGCGCCTTCTGCTTCCATCGGTGCAAGTCAACATGCGCGC
CGGTCATCTGCCCACGCCGGAAGACAACGGCGTGCGTTATCTGAAGCTGCCGTTGGACGTGCTATGA

Upstream 100 bases:

>100_bases
TTCCTTACTCCTTCTCGACGCTGCCATCGTGAGTCATCCAACACGCGACACCTGCCCGGCAGCGGCCTGCGCTGTCGTGG
AAGACACCCGCTCCGGTCGC

Downstream 100 bases:

>100_bases
CGCTCCCGCACCTCGCCTGGTATTGGCCGCTGATTGGTGGGCTGATGATCGGCACCGCCTCTGGCGCGTATTTACTGCTG
GTCGGCCGCATCGCCGGCAT

Product: putative metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSAPHVATFFDPVTFTASHVVRDPGSSACAIIDSVLDFDMASGRTATGSAEALAHYVRDEALQVQWHLETHAHADHLSAA
PWLQQQVGGQLAIGERITAVQQTFGNLFNAGKEFSRDGSQFDHLFADGAAFTIGHLHAVALHVPGHTPACMAYVIGDALF
SGDTLFMPDYGTVRCDFPGGSARQLYRSIQRLLKLPDATRVFVCHDYKSAGRAHFAWETTIGAQRSANVHLHAGVSEADF
VKMRETRDATLPMPRLLLPSVQVNMRAGHLPTPEDNGVRYLKLPLDVL

Sequences:

>Translated_288_residues
MSAPHVATFFDPVTFTASHVVRDPGSSACAIIDSVLDFDMASGRTATGSAEALAHYVRDEALQVQWHLETHAHADHLSAA
PWLQQQVGGQLAIGERITAVQQTFGNLFNAGKEFSRDGSQFDHLFADGAAFTIGHLHAVALHVPGHTPACMAYVIGDALF
SGDTLFMPDYGTVRCDFPGGSARQLYRSIQRLLKLPDATRVFVCHDYKSAGRAHFAWETTIGAQRSANVHLHAGVSEADF
VKMRETRDATLPMPRLLLPSVQVNMRAGHLPTPEDNGVRYLKLPLDVL
>Mature_287_residues
SAPHVATFFDPVTFTASHVVRDPGSSACAIIDSVLDFDMASGRTATGSAEALAHYVRDEALQVQWHLETHAHADHLSAAP
WLQQQVGGQLAIGERITAVQQTFGNLFNAGKEFSRDGSQFDHLFADGAAFTIGHLHAVALHVPGHTPACMAYVIGDALFS
GDTLFMPDYGTVRCDFPGGSARQLYRSIQRLLKLPDATRVFVCHDYKSAGRAHFAWETTIGAQRSANVHLHAGVSEADFV
KMRETRDATLPMPRLLLPSVQVNMRAGHLPTPEDNGVRYLKLPLDVL

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=263, Percent_Identity=26.9961977186312, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538952, Length=271, Percent_Identity=24.3542435424354, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221330176, Length=270, Percent_Identity=28.1481481481481, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 31353; Mature: 31222

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPHVATFFDPVTFTASHVVRDPGSSACAIIDSVLDFDMASGRTATGSAEALAHYVRDE
CCCCCCCHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
ALQVQWHLETHAHADHLSAAPWLQQQVGGQLAIGERITAVQQTFGNLFNAGKEFSRDGSQ
EEEEEEEEECCCCCHHCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHCCCCCH
FDHLFADGAAFTIGHLHAVALHVPGHTPACMAYVIGDALFSGDTLFMPDYGTVRCDFPGG
HHHHHHCCCEEEEECEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCC
SARQLYRSIQRLLKLPDATRVFVCHDYKSAGRAHFAWETTIGAQRSANVHLHAGVSEADF
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEECCCCHHHH
VKMRETRDATLPMPRLLLPSVQVNMRAGHLPTPEDNGVRYLKLPLDVL
HHHHHCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
SAPHVATFFDPVTFTASHVVRDPGSSACAIIDSVLDFDMASGRTATGSAEALAHYVRDE
CCCCCCHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
ALQVQWHLETHAHADHLSAAPWLQQQVGGQLAIGERITAVQQTFGNLFNAGKEFSRDGSQ
EEEEEEEEECCCCCHHCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHCCCCCH
FDHLFADGAAFTIGHLHAVALHVPGHTPACMAYVIGDALFSGDTLFMPDYGTVRCDFPGG
HHHHHHCCCEEEEECEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCC
SARQLYRSIQRLLKLPDATRVFVCHDYKSAGRAHFAWETTIGAQRSANVHLHAGVSEADF
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEECCCCHHHH
VKMRETRDATLPMPRLLLPSVQVNMRAGHLPTPEDNGVRYLKLPLDVL
HHHHHCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]