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The map label for this gene is tesB [H]

Identifier: 78046835

GI number: 78046835

Start: 1435524

End: 1436195

Strand: Reverse

Name: tesB [H]

Synonym: XCV1279

Alternate gene names: 78046835

Gene position: 1436195-1435524 (Counterclockwise)

Preceding gene: 78046836

Following gene: 78046834

Centisome position: 27.73

GC content: 63.54

Gene sequence:

>672_bases
TTGTCCGCCACCGCCGAACCCGTCGTCTCCGAACTGATCAGCCTGCTGTCGCTGGAGCGTCTGGAAGACAACCTGTTCCG
TGGCCAGAGCCGCGACATCGGCACCAAATACGTGTTCGGCGGGCAGGTGCTGGGCCAGGCGTTATCGGCAGCGCAGGCCA
CGGTCGAAAACGGCCGCCAGGCGCATTCGCTGCATGCGTATTTCCTGCGTGCCGGCAATATCGACCACCCCATCGTCTAC
GACGTCGACCGCACCCGCGATGGCGGCAGTTTCTCGGTGCGCCGGGTTACCGCGATCCAGCATGGCAAGGTGATCTTTTT
CTGCGCAGCTTCGTTTCAGGAGCGCGAAGATGGCGCCGAGCATCAGTCGGCGATGCCGGTGGTGCCGCCACCGGAAGACA
TCGAACCGGCCGCACCGCTGGCACCGGAAGTGTTGGCCAAGCTACCGGCCAAGGTGCAGCGTTGGCTGTCGCGCGGCGGC
CCGTTCGAATTTCGCCATGTCTTTCCGCGCGACGAACTCAAGCCGCCCAAGCGTCCGCCGTTCCAGCAGATGTGGCTGCG
CCTGAACGATCCCATCGGCGACGATGTGGGCCTGCATCAAGCGCTGCTTGCGTACGCGTCGGATTTTCAGTTGCTCGGTA
CCTCGACATTTCCGCACGGCATCAGCTATTAG

Upstream 100 bases:

>100_bases
TGGCCTGGTGGCGCGCCTGCAAAAGGCCTGAGCCCTGCCTCGCGGCGCCCATTGGGCGGGCCGGTATACTCGCGTTCCGT
CGCATGTCCAGGCCAGCCCC

Downstream 100 bases:

>100_bases
ACGCCGAACGTGCAGATGGCCTCGCTCGATCATGCCCTGTGGTTCCATCGCCCATTCCGTACCGACGACTGGCTGCTGTA
CTCGCTCGACAGCCCCACCG

Product: putative acyl-CoA thioesterase (fragment)

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALSAAQATVENGRQAHSLHAYFLRAGNIDHPIVY
DVDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEREDGAEHQSAMPVVPPPEDIEPAAPLAPEVLAKLPAKVQRWLSRGG
PFEFRHVFPRDELKPPKRPPFQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISY

Sequences:

>Translated_223_residues
MSATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALSAAQATVENGRQAHSLHAYFLRAGNIDHPIVY
DVDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEREDGAEHQSAMPVVPPPEDIEPAAPLAPEVLAKLPAKVQRWLSRGG
PFEFRHVFPRDELKPPKRPPFQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISY
>Mature_222_residues
SATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALSAAQATVENGRQAHSLHAYFLRAGNIDHPIVYD
VDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEREDGAEHQSAMPVVPPPEDIEPAAPLAPEVLAKLPAKVQRWLSRGGP
FEFRHVFPRDELKPPKRPPFQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISY

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=216, Percent_Identity=40.7407407407407, Blast_Score=162, Evalue=2e-40,
Organism=Escherichia coli, GI1786657, Length=205, Percent_Identity=46.8292682926829, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71988741, Length=221, Percent_Identity=39.8190045248869, Blast_Score=154, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17558508, Length=254, Percent_Identity=35.8267716535433, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17531889, Length=205, Percent_Identity=33.6585365853659, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115532456, Length=205, Percent_Identity=33.6585365853659, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17531885, Length=205, Percent_Identity=33.6585365853659, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI212645202, Length=193, Percent_Identity=31.6062176165803, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71982224, Length=231, Percent_Identity=29.004329004329, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322480, Length=199, Percent_Identity=27.6381909547739, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 24668; Mature: 24537

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALSAAQATVENGRQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCHH
AHSLHAYFLRAGNIDHPIVYDVDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEREDGAE
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHHHCCHH
HQSAMPVVPPPEDIEPAAPLAPEVLAKLPAKVQRWLSRGGPFEFRHVFPRDELKPPKRPP
HHCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHCCCCCCEEECCCCHHCCCCCCCC
FQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISY
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
SATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALSAAQATVENGRQ
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCHH
AHSLHAYFLRAGNIDHPIVYDVDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEREDGAE
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHHHCCHH
HQSAMPVVPPPEDIEPAAPLAPEVLAKLPAKVQRWLSRGGPFEFRHVFPRDELKPPKRPP
HHCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHCCCCCCEEECCCCHHCCCCCCCC
FQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISY
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]