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The map label for this gene is lpxH [H]

Identifier: 78046622

GI number: 78046622

Start: 1195587

End: 1196510

Strand: Reverse

Name: lpxH [H]

Synonym: XCV1066

Alternate gene names: 78046622

Gene position: 1196510-1195587 (Counterclockwise)

Preceding gene: 78046623

Following gene: 78046609

Centisome position: 23.11

GC content: 65.91

Gene sequence:

>924_bases
TTGCCCACCCACGCGCATGTCGCACGGCGCGTGCGACCCGCAGGATGTCTGAATGGCGATCGCCAGCCTGCGGCGTCGTT
GCAAGTTGGCACACCAATCGCTGCGAAGCTGCAATGCTTCTGCGGTTCCCGATTCCCGATTCCCGATTCCCGCCCCGCTC
TACCGCCGTACAATGGCGCAATGACGACCCTGTTCATTTCCGACCTGCATCTGGATCCGGCCCGGCCGGCAATCACCGAG
TTGTTTCTGGAGTTCCTGCGCACGCAGGTTCCCGGCAGCGACGCGCTCTACATCCTGGGCGATCTGTTCGAAGCCTGGAT
CGGCGACGACACCCCATCCACCGCCGCCGATGCAGTGGCGGTGGCCCTGCATGCAGTGGCAGATTCCGGGGTGCCGGTGT
TCTTCATGGCAGGCAACCGCGACTTCCTGGTAGGCGAAACCTATGCGCAGCGCGCGGGCTTCCGGATCCTGCCCGACCCC
ACCGTCATCGATCTGTACGGGCACACCACGCTGCTGATGCACGGCGATTTGCTGTGCACCGACGACACGGCCTACCAGGC
CTTCCGCGCGCAGACGCGCGACCCGGTGTTCCAGGCGCAGTTCCTGGCCCAGCCGCTGGCCGCACGCGTCGCGTTCGCGC
AGCAGGCGCGCGCTGCCAGCCAGGCGCGGCATGCAGAACTCAAGCAGGGCGACCAGTCGCGCTTCGAAACCGTCACCGAT
GTCTCGCCGGCCGAAGTGGAAGCCACCTTCGTGCGTTACGGGCTGGATCGGCTGATCCACGGCCACACCCATCGCCCTGC
CATCCACACCTTGCAAGCCGGCGGCAACACCTGCACGCGCATCGTGCTGGGCGACTGGTACGAGCAAGGATCGGTCCTGC
GCGTGGATGCCGATGGCGTGTCGCTGGAGCAGTTGGCGTTATAG

Upstream 100 bases:

>100_bases
GACTCCAGCGCGTGGCTTCGCCCCGTACCCTCACCCCCCACCCCTCTCCCGCAGGGAGAGGGAATCTTGCGCTGACGGTA
CGCGGTGAACTGACGGCAGG

Downstream 100 bases:

>100_bases
CGCGGCAGATCCACGCGCCGGCCATGGCAGGCGCAGCGACGCGGTGCTGCATTCAAGGCGCGCAGCACGATCGAAAGCGC
GCCTGACGCCACAGACACGC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPTHAHVARRVRPAGCLNGDRQPAASLQVGTPIAAKLQCFCGSRFPIPDSRPALPPYNGAMTTLFISDLHLDPARPAITE
LFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVAVALHAVADSGVPVFFMAGNRDFLVGETYAQRAGFRILPDP
TVIDLYGHTTLLMHGDLLCTDDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAASQARHAELKQGDQSRFETVTD
VSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGNTCTRIVLGDWYEQGSVLRVDADGVSLEQLAL

Sequences:

>Translated_307_residues
MPTHAHVARRVRPAGCLNGDRQPAASLQVGTPIAAKLQCFCGSRFPIPDSRPALPPYNGAMTTLFISDLHLDPARPAITE
LFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVAVALHAVADSGVPVFFMAGNRDFLVGETYAQRAGFRILPDP
TVIDLYGHTTLLMHGDLLCTDDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAASQARHAELKQGDQSRFETVTD
VSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGNTCTRIVLGDWYEQGSVLRVDADGVSLEQLAL
>Mature_306_residues
PTHAHVARRVRPAGCLNGDRQPAASLQVGTPIAAKLQCFCGSRFPIPDSRPALPPYNGAMTTLFISDLHLDPARPAITEL
FLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVAVALHAVADSGVPVFFMAGNRDFLVGETYAQRAGFRILPDPT
VIDLYGHTTLLMHGDLLCTDDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAASQARHAELKQGDQSRFETVTDV
SPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGNTCTRIVLGDWYEQGSVLRVDADGVSLEQLAL

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=242, Percent_Identity=48.7603305785124, Blast_Score=234, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.6.1.-

Molecular weight: Translated: 33301; Mature: 33170

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTHAHVARRVRPAGCLNGDRQPAASLQVGTPIAAKLQCFCGSRFPIPDSRPALPPYNGA
CCCHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCC
MTTLFISDLHLDPARPAITELFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVA
EEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
VALHAVADSGVPVFFMAGNRDFLVGETYAQRAGFRILPDPTVIDLYGHTTLLMHGDLLCT
HHHHHHHCCCCCEEEEECCCCEEECCHHHHHCCCEECCCCCEEEECCCEEEEEECCEEEC
DDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAASQARHAELKQGDQSRFETVTD
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
VSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGNTCTRIVLGDWYEQGSVLRVDADGV
CCCHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCCCEEEEEEEECCCCCCCEEEEECCCC
SLEQLAL
CHHHHCC
>Mature Secondary Structure 
PTHAHVARRVRPAGCLNGDRQPAASLQVGTPIAAKLQCFCGSRFPIPDSRPALPPYNGA
CCHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCC
MTTLFISDLHLDPARPAITELFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVA
EEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
VALHAVADSGVPVFFMAGNRDFLVGETYAQRAGFRILPDPTVIDLYGHTTLLMHGDLLCT
HHHHHHHCCCCCEEEEECCCCEEECCHHHHHCCCEECCCCCEEEECCCEEEEEECCEEEC
DDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAASQARHAELKQGDQSRFETVTD
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
VSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGNTCTRIVLGDWYEQGSVLRVDADGV
CCCHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCCCEEEEEEEECCCCCCCEEEEECCCC
SLEQLAL
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]