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The map label for this gene is kbl [C]

Identifier: 78046602

GI number: 78046602

Start: 1171904

End: 1173112

Strand: Reverse

Name: kbl [C]

Synonym: XCV1046

Alternate gene names: 78046602

Gene position: 1173112-1171904 (Counterclockwise)

Preceding gene: 78046608

Following gene: 78046601

Centisome position: 22.65

GC content: 64.1

Gene sequence:

>1209_bases
ATGACCACCGCTCCCGCCGCGCTGACTGCCCATTACGCCGCCGAACTGGATGCCATCCAGGCCCAAGGCCTGTTCAAGTC
CGAGCGCATCATCACCGGTCCGCAGTCGGCCGAGATCACCCTGGCCGATGGCCGCCGCGTGCTGAACTTCTGTGCCAACA
ACTATCTGGGCCTGGCCGACCACCCGGACATCATCCAGGCCGCCAAGGACGCGCTGGACAGCCACGGCTTCGGCATGGCC
TCGGTACGCTTCATCTGCGGCACCCAGGACCTGCACAAGCAACTGGAACGCAGCATCGCCGAGTTCTTCGGCACCGAAGA
CACCATCCTCTACGCGGCCTGTTTCGATGCCAATGGCGGCCTGTTCGAACCGCTGCTGGGCGAGCACGACGCCATCATTT
CCGACGCGCTCAACCATGCCTCCATCATCGATGGTGTGCGCCTGTGCAAGGCCAAGCGCTTCCGCTACGCCAACTGCGAC
ATGGCCGATCTGGAGGCGCAGCTGCAGGCCGCCGACGCCGCCGGTTGCAAGACCAAGCTGATCACCAGCGACGGCGTGTT
CTCGATGGACGGCTTCATCGCCCCGCTCGACGAAATCACTGCCCTGGCCCGCAAGTACAACGCGCTGGTGCATATCGACG
AATGCCACGCCACCGGCTTCCTCGGCGCCACCGGCCGCGGCTCGGCCGAAGTCAAGGGCGTACTGGACCAGATCGATATT
TTCACCGGCACCCTGGGCAAGGCCATGGGCGGCGCACTCGGCGGCTTCACCACCGCAAAGCGCGAAGTGATCGAGTTGCT
GCGCCAGCGTTCGCGCCCCTACCTGTTCTCCAATTCATTGCCGCCGCACGTGGTGGCTGCCGGCATCAAGGCCTTCGACA
TGCTGGATGCCGCGGGCGAGCTGCGCACGCAGCTGGTCGAAAACACCACCTATTTCCGCGCCCGCATGACCGCCGCCGGT
TTCGACGTCAAGCCGGGCGTGCATCCGATCAGCCCGGTGATGCTGTACGACGCACCGCTGGCGCAAAAATTCGCCGAGCG
CTTGCTGGAAGAAGGCATCTACGCCATCGGCTTTTTCTTTCCGGTGGTTCCGAAAGGCCAGGCGCGCATTCGCACCCAGA
TCAGCGCAGCGCATACGCGCGAGCACCTGGATCATGCGATCGAAGCGTTCATCAAGATCGGGCGCGAACTCAAGGTCATC
GACGCCTGA

Upstream 100 bases:

>100_bases
GAAATGACATCAGCGCCGCCTCTTATGCCGATTTTGCATGACGTAGTGGTATGCCACCGTGATCGTTAAAATTGCGCTTC
TTTCTGCCACTGCGACCGCC

Downstream 100 bases:

>100_bases
GCATGCGCACGGTGCTGCGCCAACGGCTGCTGCTGGCGGCGCAGACCGATGCGCAGGCGCAGCTGCGCGACGGCCATTGG
GAGACACGCTGCCTGCATTG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRRVLNFCANNYLGLADHPDIIQAAKDALDSHGFGMA
SVRFICGTQDLHKQLERSIAEFFGTEDTILYAACFDANGGLFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCD
MADLEAQLQAADAAGCKTKLITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDI
FTGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFDMLDAAGELRTQLVENTTYFRARMTAAG
FDVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFFPVVPKGQARIRTQISAAHTREHLDHAIEAFIKIGRELKVI
DA

Sequences:

>Translated_402_residues
MTTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRRVLNFCANNYLGLADHPDIIQAAKDALDSHGFGMA
SVRFICGTQDLHKQLERSIAEFFGTEDTILYAACFDANGGLFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCD
MADLEAQLQAADAAGCKTKLITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDI
FTGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFDMLDAAGELRTQLVENTTYFRARMTAAG
FDVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFFPVVPKGQARIRTQISAAHTREHLDHAIEAFIKIGRELKVI
DA
>Mature_401_residues
TTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRRVLNFCANNYLGLADHPDIIQAAKDALDSHGFGMAS
VRFICGTQDLHKQLERSIAEFFGTEDTILYAACFDANGGLFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCDM
ADLEAQLQAADAAGCKTKLITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDIF
TGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFDMLDAAGELRTQLVENTTYFRARMTAAGF
DVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFFPVVPKGQARIRTQISAAHTREHLDHAIEAFIKIGRELKVID
A

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=395, Percent_Identity=55.6962025316456, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI284448556, Length=421, Percent_Identity=52.2565320665083, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=32.5648414985591, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=32.5648414985591, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=32.5648414985591, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=35.5013550135501, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=34.5945945945946, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI4502025, Length=368, Percent_Identity=31.7934782608696, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI40316939, Length=368, Percent_Identity=31.7934782608696, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI5454084, Length=262, Percent_Identity=31.2977099236641, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1790046, Length=386, Percent_Identity=65.0259067357513, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=31.25, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71994529, Length=403, Percent_Identity=57.0719602977667, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI32566772, Length=367, Percent_Identity=32.1525885558583, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17560914, Length=366, Percent_Identity=31.6939890710383, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17560912, Length=366, Percent_Identity=31.6939890710383, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71982617, Length=273, Percent_Identity=26.7399267399267, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71982625, Length=273, Percent_Identity=26.7399267399267, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=421, Percent_Identity=31.353919239905, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320267, Length=369, Percent_Identity=31.4363143631436, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=29.5880149812734, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24662918, Length=398, Percent_Identity=59.5477386934673, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17137420, Length=365, Percent_Identity=31.2328767123288, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17136286, Length=372, Percent_Identity=33.6021505376344, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24653280, Length=322, Percent_Identity=28.8819875776398, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653276, Length=322, Percent_Identity=28.8819875776398, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653278, Length=322, Percent_Identity=28.8819875776398, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43428; Mature: 43297

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRRVLNFCANNYLGLAD
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCHHHHHHHHCCCCCCCC
HPDIIQAAKDALDSHGFGMASVRFICGTQDLHKQLERSIAEFFGTEDTILYAACFDANGG
CCHHHHHHHHHHHCCCCCHHHEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
LFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCDMADLEAQLQAADAAGCKTKL
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEE
ITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDI
EECCCCEECCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
FTGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFDMLDAAGE
HHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
LRTQLVENTTYFRARMTAAGFDVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFF
HHHHHHHCCHHHHEEHEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEHHHH
PVVPKGQARIRTQISAAHTREHLDHAIEAFIKIGRELKVIDA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure 
TTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRRVLNFCANNYLGLAD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCHHHHHHHHCCCCCCCC
HPDIIQAAKDALDSHGFGMASVRFICGTQDLHKQLERSIAEFFGTEDTILYAACFDANGG
CCHHHHHHHHHHHCCCCCHHHEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
LFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCDMADLEAQLQAADAAGCKTKL
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEE
ITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDI
EECCCCEECCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
FTGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFDMLDAAGE
HHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
LRTQLVENTTYFRARMTAAGFDVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFF
HHHHHHHCCHHHHEEHEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEHHHH
PVVPKGQARIRTQISAAHTREHLDHAIEAFIKIGRELKVIDA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]