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The map label for this gene is tdh [H]

Identifier: 78046608

GI number: 78046608

Start: 1178810

End: 1179832

Strand: Reverse

Name: tdh [H]

Synonym: XCV1052

Alternate gene names: 78046608

Gene position: 1179832-1178810 (Counterclockwise)

Preceding gene: 78046609

Following gene: 78046602

Centisome position: 22.78

GC content: 63.15

Gene sequence:

>1023_bases
ATGAAGGCGCTGGTCAAGCGCGAAGCGAACAAGGGCATCTGGCTGGAACAGGTGCCAGTGCCGACGCCCGGCCCCAACGA
GGTGCTGATCAAGCTGGAAAAGACCGCCATTTGCGGCACCGACCTGCACATCTACCTGTGGGACGAGTGGAGCCAGCGCA
CGATCAGGCCGGGCCTGACCATCGGTCATGAATTCGTCGGCCGCGTGGCCGAGCTCGGTTCGGCCGTGACCGGCTATCAG
GTCGGCCAGCGGGTGTCGGCCGAAGGCCACATCGTGTGCGGCCATTGCCGCAACTGCCGTGGCGGCCGTCCGCACCTGTG
CCCCAACACGGTCGGGATCGGTGTCAACGTCAACGGCGCTTTCGCCGAATACATGGTGATGCCGGCCAGCAACCTGTGGC
TGATCCCGGACCAGATTCCGTCCGAGCTTGCCGCGTTCTTCGACCCCTACGGCAACGCCGCGCACTGCGCGCTGGAATTC
GACGTCATCGGCGAGGACGTGCTGATCACCGGCGCCGGCCCGATCGGCATCATTGCCGCCGGCATCTGCAAGCACATCGG
TGCGCGCAATGTGGTGGTCACCGACGTCAACGATTTCCGCCTCAAGCTGGCTGCCGACATGGGGGCCACGCGCGTGGTCA
ACGTCTCCAAGACCTCGCTCAAGGACGTCATGGCCGACCTGCACATGGAAGGCTTCGACGTGGGCCTGGAAATGAGCGGC
AACCCACGTGCGTTCAACGACATGCTCGATTGCATGTACCACGGCGGCAAGATCGCCATGCTCGGCATCATGCCGCGTGG
CGCCGGTTGCGACTGGGACAAGATCATCTTCAAGGGCCTCACCGTGCAGGGCATCTACGGCCGCAAGATGTACGAGACCT
GGTACAAGATGACGCAGCTGGTGCTGTCGGGTTTTCCGCTGCACAAGGTGCTGACCCATCAGCTGCCGATCGACGATTTC
CAGAAAGGCTTCGACCTGATGGAAGAAGGCAAGGCCGGCAAGGTCGTGCTGAGCTGGAATTGA

Upstream 100 bases:

>100_bases
CATCACGTCCATTCCCGCACCGCCGCATGGCATACAGGCCGCGACGCCTATAATCGCCGGCTTACTTTCACTCAGCAGGT
TCCGCCAGATGGCGCAGACG

Downstream 100 bases:

>100_bases
TCGGCTGACACTGCAGATCTGCGAAAGGCGCCGCGAGGCGCCTTTTGCGTTTTTAAGACATGCGCTTGCTGACGAATGCT
GCGAGCGATTTTCAGGAGCT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIRPGLTIGHEFVGRVAELGSAVTGYQ
VGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGAFAEYMVMPASNLWLIPDQIPSELAAFFDPYGNAAHCALEF
DVIGEDVLITGAGPIGIIAAGICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
NPRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQLVLSGFPLHKVLTHQLPIDDF
QKGFDLMEEGKAGKVVLSWN

Sequences:

>Translated_340_residues
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIRPGLTIGHEFVGRVAELGSAVTGYQ
VGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGAFAEYMVMPASNLWLIPDQIPSELAAFFDPYGNAAHCALEF
DVIGEDVLITGAGPIGIIAAGICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
NPRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQLVLSGFPLHKVLTHQLPIDDF
QKGFDLMEEGKAGKVVLSWN
>Mature_340_residues
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIRPGLTIGHEFVGRVAELGSAVTGYQ
VGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGAFAEYMVMPASNLWLIPDQIPSELAAFFDPYGNAAHCALEF
DVIGEDVLITGAGPIGIIAAGICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
NPRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQLVLSGFPLHKVLTHQLPIDDF
QKGFDLMEEGKAGKVVLSWN

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=25.4491017964072, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=27.4932614555256, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=27.4932614555256, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4501929, Length=375, Percent_Identity=26.1333333333333, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=25.7372654155496, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=26.8817204301075, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=25.6, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI71565154, Length=378, Percent_Identity=25.3968253968254, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI156523966, Length=357, Percent_Identity=23.5294117647059, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501939, Length=351, Percent_Identity=23.6467236467236, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=63.6363636363636, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1788073, Length=316, Percent_Identity=30.6962025316456, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=27.5862068965517, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=30.2452316076294, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87082125, Length=349, Percent_Identity=29.2263610315186, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI226510992, Length=340, Percent_Identity=27.9411764705882, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI87081918, Length=321, Percent_Identity=30.5295950155763, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1790718, Length=324, Percent_Identity=27.1604938271605, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788407, Length=328, Percent_Identity=26.5243902439024, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=25.5102040816327, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786552, Length=384, Percent_Identity=25.78125, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786518, Length=254, Percent_Identity=27.1653543307087, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=333, Percent_Identity=28.8288288288288, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=217, Percent_Identity=35.4838709677419, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71988145, Length=265, Percent_Identity=28.3018867924528, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=127, Percent_Identity=35.4330708661417, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=25.5936675461741, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=126, Percent_Identity=34.1269841269841, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=324, Percent_Identity=27.4691358024691, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=324, Percent_Identity=27.1604938271605, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=28.2608695652174, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=300, Percent_Identity=28.3333333333333, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=272, Percent_Identity=29.4117647058824, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=24.5333333333333, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=27.8443113772455, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=231, Percent_Identity=30.7359307359307, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=350, Percent_Identity=26.2857142857143, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=299, Percent_Identity=26.4214046822742, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17137530, Length=339, Percent_Identity=26.2536873156342, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17737897, Length=207, Percent_Identity=32.3671497584541, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=26.525198938992, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45551930, Length=331, Percent_Identity=27.190332326284, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221457811, Length=331, Percent_Identity=27.190332326284, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550770, Length=331, Percent_Identity=27.190332326284, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37166; Mature: 37166

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIRPGLT
CCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEECEEEECCCEEEEEECCCCCCCCCCCCE
IGHEFVGRVAELGSAVTGYQVGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGA
ECHHHHHHHHHHCCHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCC
FAEYMVMPASNLWLIPDQIPSELAAFFDPYGNAAHCALEFDVIGEDVLITGAGPIGIIAA
EEEEEEECCCCEEEECCHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEEECCCHHHHHHH
GICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
HHHHHCCCCCEEEECCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECC
NPRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQL
CCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHH
VLSGFPLHKVLTHQLPIDDFQKGFDLMEEGKAGKVVLSWN
HHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIRPGLT
CCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEECEEEECCCEEEEEECCCCCCCCCCCCE
IGHEFVGRVAELGSAVTGYQVGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGA
ECHHHHHHHHHHCCHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCC
FAEYMVMPASNLWLIPDQIPSELAAFFDPYGNAAHCALEFDVIGEDVLITGAGPIGIIAA
EEEEEEECCCCEEEECCHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEEECCCHHHHHHH
GICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
HHHHHCCCCCEEEECCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECC
NPRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQL
CCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHH
VLSGFPLHKVLTHQLPIDDFQKGFDLMEEGKAGKVVLSWN
HHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA