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The map label for this gene is qor [C]

Identifier: 78046597

GI number: 78046597

Start: 1167822

End: 1168457

Strand: Reverse

Name: qor [C]

Synonym: XCV1041

Alternate gene names: 78046597

Gene position: 1168457-1167822 (Counterclockwise)

Preceding gene: 78046601

Following gene: 78046596

Centisome position: 22.56

GC content: 64.78

Gene sequence:

>636_bases
ATGAAAGCTGTCGCCCTCACCCGCCATCTTCCGATCGACGATCCCGAATCGCTGCTTGATATGGAACTTCCGACACCTGC
GGCGCCGTCGGGGTATGACTTATTGGTGCGGGTGGAAGCGATCTCGGTGAACCCGGTCGATACGAAGGTGCGCGCGCCCA
CGCCGCAACCGCTGCACGCGCCGAAGATCCTGGGTTACGACGCCGCCGGGGTGATCGAGGCGGTTGGCCCGGAGGTCACC
GCCTTTGCGGTCGGCGACGAGGTCTACTACGCCGGCGATATCGGGCGGCCGGGCAGCAATGCGCAGTACCAGCTGGTGGA
CGCCCGCATTGCCGGATGCAAACCGACCTCGCTCAGCTTCGCGCAGGCGGCCGCGTTGCCGCTGACCACTCTGACGGCAT
GGGAGCTGCTGTTCCAGCGCATGCCCTTTTCGTTCGACGGTGCACGCAATCGCGGCAGGCATCTGCTGATCATCGGCGGC
GCTGGTGGCGTGGGCTCCATCGCGATCCAACTGGCGCGGCATGCCGGATTCACGGTGATTGCCACCGCATCGCGTCCTGA
GAGCATCGAGTGGGTTCGCCAAATGGGTGCGCATCACGTGATCGATCATCACCAACCGCTGCAGCCGCAACTGTAG

Upstream 100 bases:

>100_bases
TGGTGAACGCCAGGCCCCGTCCGAGCTGAATTGTGGGGTCGGTGATTGCGGGCGACTTGCTCCACAACGCACCCTGAACC
TCCCGCTCTGGAGCGCTCCA

Downstream 100 bases:

>100_bases
GCGCTGGGGCTGGACACGGTGGACGCGGCGCTCAATCTGGCCGACACCGACCGCTACTGGCAGCCACTGGGCGAAGTGCT
GGCGCCGCAGGGCCATGTGG

Product: putative oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKAVALTRHLPIDDPESLLDMELPTPAAPSGYDLLVRVEAISVNPVDTKVRAPTPQPLHAPKILGYDAAGVIEAVGPEVT
AFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSFAQAAALPLTTLTAWELLFQRMPFSFDGARNRGRHLLIIGG
AGGVGSIAIQLARHAGFTVIATASRPESIEWVRQMGAHHVIDHHQPLQPQL

Sequences:

>Translated_211_residues
MKAVALTRHLPIDDPESLLDMELPTPAAPSGYDLLVRVEAISVNPVDTKVRAPTPQPLHAPKILGYDAAGVIEAVGPEVT
AFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSFAQAAALPLTTLTAWELLFQRMPFSFDGARNRGRHLLIIGG
AGGVGSIAIQLARHAGFTVIATASRPESIEWVRQMGAHHVIDHHQPLQPQL
>Mature_211_residues
MKAVALTRHLPIDDPESLLDMELPTPAAPSGYDLLVRVEAISVNPVDTKVRAPTPQPLHAPKILGYDAAGVIEAVGPEVT
AFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSFAQAAALPLTTLTAWELLFQRMPFSFDGARNRGRHLLIIGG
AGGVGSIAIQLARHAGFTVIATASRPESIEWVRQMGAHHVIDHHQPLQPQL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239676, Length=208, Percent_Identity=35.5769230769231, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI194239674, Length=208, Percent_Identity=35.5769230769231, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI13236495, Length=208, Percent_Identity=35.5769230769231, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI47519420, Length=199, Percent_Identity=33.6683417085427, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI28557745, Length=210, Percent_Identity=29.5238095238095, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI22538446, Length=193, Percent_Identity=31.0880829015544, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI22538444, Length=193, Percent_Identity=31.0880829015544, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=191, Percent_Identity=32.9842931937173, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71987554, Length=181, Percent_Identity=33.7016574585635, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17507255, Length=171, Percent_Identity=36.2573099415205, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324195, Length=232, Percent_Identity=29.7413793103448, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 22506; Mature: 22506

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVALTRHLPIDDPESLLDMELPTPAAPSGYDLLVRVEAISVNPVDTKVRAPTPQPLHA
CCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCCCCCCC
PKILGYDAAGVIEAVGPEVTAFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSF
CEEECCCCHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCH
AQAAALPLTTLTAWELLFQRMPFSFDGARNRGRHLLIIGGAGGVGSIAIQLARHAGFTVI
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEE
ATASRPESIEWVRQMGAHHVIDHHQPLQPQL
EECCCCCHHHHHHHCCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MKAVALTRHLPIDDPESLLDMELPTPAAPSGYDLLVRVEAISVNPVDTKVRAPTPQPLHA
CCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCCCCCCC
PKILGYDAAGVIEAVGPEVTAFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSF
CEEECCCCHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCH
AQAAALPLTTLTAWELLFQRMPFSFDGARNRGRHLLIIGGAGGVGSIAIQLARHAGFTVI
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEE
ATASRPESIEWVRQMGAHHVIDHHQPLQPQL
EECCCCCHHHHHHHCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA