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The map label for this gene is hemA

Identifier: 78046532

GI number: 78046532

Start: 1106076

End: 1107374

Strand: Reverse

Name: hemA

Synonym: XCV0976

Alternate gene names: 78046532

Gene position: 1107374-1106076 (Counterclockwise)

Preceding gene: 78046553

Following gene: 78046531

Centisome position: 21.38

GC content: 67.21

Gene sequence:

>1299_bases
ATGACGTTGTGGGTGCTCGGACTGAATCACCAGACCGCACCTGTGGACCTGCGCGAACGCGCGGCGTTCGCAGGTGATGC
GCTGCCGCGCGCGCTCGAATCGCTGCGTGCGCTGCCCCAGGTAAGCGAGGCCGCGCTGTTGTCCACCTGCAACCGTACCG
AGTTGTATGCGATGGCCGACGAGGCGCACAGCCTGGTCAACTGGCTGGAAACGCACGCGCCCGGGCTGAGCGGTCATCTG
TACCAGCACCGGGAAGCCGAGGCGGTGCGCCACCTGTTCCGCGTCGCCACCGGGCTGGATTCGATGGTGCTGGGGGAACC
GCAGATTCTGGGCCAGGTGAAGGACGCCTGGGCGGTGGCGCGGGCGCACGGCGCGCTGGGCAGCGGGTTGGACCGGCTGT
TCCAACAGACCTTTTCGGTGGCCAAGCGCGCGCGTACCGACACCCGTGTCGGCGCAAATCCGGTTTCGGTCGCATCCACG
GCGGTGCGGCTGGCACAGGACTCCTTTGCCCGGCTCAACGAGTCGACGGTGTTGCTGATCGGTGCCGGCGAAACCATCGA
ACTGGCGGCCAAGCATCTGAGCGAAGGCCGCGTGCGCCGCCTGCTGATCGCCAACCGCACCCTGGCCCATGCCCAGACAC
TGGCCAGCCAGCACGGCGGCTTCGCCTTGCCGCTGACCGATCTGGAACGCCACCTGGCCGAGGCGGATGTGGTGTTTTCG
GCCACCGCTGCGCGTGAGCCGCTGGTGACCCGCGCACAGGTGGAACAGGCGTTGCGCACGCGCAAGCGCAAGCCGATGCT
GCTGTTCGACCTGGCCGTGCCGCGCGATATCGAGGCCTCGGTAGGCGAGTTGGGCGACGCCTACCTGTACACGGTGGACG
ATCTGGAACGCGCGGTCGAAGACAATCGCCGTGGCCGCCGCGAAGCGGCCGACCAGGCCGAAGCCATCATCGACCTGCAA
GTGGCGCGCTATGTCGAAACGCTGCAGGCCACTGCGCGCCAGGCACCCCTCAAACGGCTGCGCGCCTTTGGCGATAGCAC
CCGCGACGAGCTGCTGGCCAAGGCACGCCAGCAGTTGCACAACGGCAAGCCGGCCGACGAAGTGCTGGAACAGTTGGCGC
ATGCGCTGACCAACCGTTTGTTGCATCCGCCCACGGCCGCATTGCGCAATGCGGCGCTCAACAACGACCTGGAATTGACC
ACTGCGGCCGACCGGCTGTTTCCGGAAAAGCCGGGTTACCAACACCCCCCCATAGCTACCCCGATCGTGAGGACCGATGA
CGCCGACCCTGCGCCGTAA

Upstream 100 bases:

>100_bases
AAAAGAACACTCAGGATGCGAATCGGTACAGGCATCGGGGGCAACCGGGCCGTAAAATGGGGCCCTGAATGGCCGCCAGC
TTATCGCAAGCAACTGAACA

Downstream 100 bases:

>100_bases
GCTCGAAGCGCTGGCCGAGCGCCGCGAAGAACTGCAGCACCTGCTCTCCGACCCCGATGTGGTGGGCAACAACGACACGT
TCCGTACGCTCTCGCGCGAA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTLWVLGLNHQTAPVDLRERAAFAGDALPRALESLRALPQVSEAALLSTCNRTELYAMADEAHSLVNWLETHAPGLSGHL
YQHREAEAVRHLFRVATGLDSMVLGEPQILGQVKDAWAVARAHGALGSGLDRLFQQTFSVAKRARTDTRVGANPVSVAST
AVRLAQDSFARLNESTVLLIGAGETIELAAKHLSEGRVRRLLIANRTLAHAQTLASQHGGFALPLTDLERHLAEADVVFS
ATAAREPLVTRAQVEQALRTRKRKPMLLFDLAVPRDIEASVGELGDAYLYTVDDLERAVEDNRRGRREAADQAEAIIDLQ
VARYVETLQATARQAPLKRLRAFGDSTRDELLAKARQQLHNGKPADEVLEQLAHALTNRLLHPPTAALRNAALNNDLELT
TAADRLFPEKPGYQHPPIATPIVRTDDADPAP

Sequences:

>Translated_432_residues
MTLWVLGLNHQTAPVDLRERAAFAGDALPRALESLRALPQVSEAALLSTCNRTELYAMADEAHSLVNWLETHAPGLSGHL
YQHREAEAVRHLFRVATGLDSMVLGEPQILGQVKDAWAVARAHGALGSGLDRLFQQTFSVAKRARTDTRVGANPVSVAST
AVRLAQDSFARLNESTVLLIGAGETIELAAKHLSEGRVRRLLIANRTLAHAQTLASQHGGFALPLTDLERHLAEADVVFS
ATAAREPLVTRAQVEQALRTRKRKPMLLFDLAVPRDIEASVGELGDAYLYTVDDLERAVEDNRRGRREAADQAEAIIDLQ
VARYVETLQATARQAPLKRLRAFGDSTRDELLAKARQQLHNGKPADEVLEQLAHALTNRLLHPPTAALRNAALNNDLELT
TAADRLFPEKPGYQHPPIATPIVRTDDADPAP
>Mature_431_residues
TLWVLGLNHQTAPVDLRERAAFAGDALPRALESLRALPQVSEAALLSTCNRTELYAMADEAHSLVNWLETHAPGLSGHLY
QHREAEAVRHLFRVATGLDSMVLGEPQILGQVKDAWAVARAHGALGSGLDRLFQQTFSVAKRARTDTRVGANPVSVASTA
VRLAQDSFARLNESTVLLIGAGETIELAAKHLSEGRVRRLLIANRTLAHAQTLASQHGGFALPLTDLERHLAEADVVFSA
TAAREPLVTRAQVEQALRTRKRKPMLLFDLAVPRDIEASVGELGDAYLYTVDDLERAVEDNRRGRREAADQAEAIIDLQV
ARYVETLQATARQAPLKRLRAFGDSTRDELLAKARQQLHNGKPADEVLEQLAHALTNRLLHPPTAALRNAALNNDLELTT
AADRLFPEKPGYQHPPIATPIVRTDDADPAP

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=406, Percent_Identity=47.2906403940887, Blast_Score=348, Evalue=3e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_XANC5 (Q3BX06)

Other databases:

- EMBL:   AM039952
- RefSeq:   YP_362707.1
- ProteinModelPortal:   Q3BX06
- SMR:   Q3BX06
- STRING:   Q3BX06
- GeneID:   3730554
- GenomeReviews:   AM039952_GR
- KEGG:   xcv:XCV0976
- NMPDR:   fig|316273.3.peg.39
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47217; Mature: 47086

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 101-101 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLWVLGLNHQTAPVDLRERAAFAGDALPRALESLRALPQVSEAALLSTCNRTELYAMAD
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHH
EAHSLVNWLETHAPGLSGHLYQHREAEAVRHLFRVATGLDSMVLGEPQILGQVKDAWAVA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
RAHGALGSGLDRLFQQTFSVAKRARTDTRVGANPVSVASTAVRLAQDSFARLNESTVLLI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
GAGETIELAAKHLSEGRVRRLLIANRTLAHAQTLASQHGGFALPLTDLERHLAEADVVFS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHH
ATAAREPLVTRAQVEQALRTRKRKPMLLFDLAVPRDIEASVGELGDAYLYTVDDLERAVE
HHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCCEEEEEHHHHHHHHH
DNRRGRREAADQAEAIIDLQVARYVETLQATARQAPLKRLRAFGDSTRDELLAKARQQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
NGKPADEVLEQLAHALTNRLLHPPTAALRNAALNNDLELTTAADRLFPEKPGYQHPPIAT
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCC
PIVRTDDADPAP
CEEECCCCCCCC
>Mature Secondary Structure 
TLWVLGLNHQTAPVDLRERAAFAGDALPRALESLRALPQVSEAALLSTCNRTELYAMAD
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHH
EAHSLVNWLETHAPGLSGHLYQHREAEAVRHLFRVATGLDSMVLGEPQILGQVKDAWAVA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
RAHGALGSGLDRLFQQTFSVAKRARTDTRVGANPVSVASTAVRLAQDSFARLNESTVLLI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
GAGETIELAAKHLSEGRVRRLLIANRTLAHAQTLASQHGGFALPLTDLERHLAEADVVFS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHH
ATAAREPLVTRAQVEQALRTRKRKPMLLFDLAVPRDIEASVGELGDAYLYTVDDLERAVE
HHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCCEEEEEHHHHHHHHH
DNRRGRREAADQAEAIIDLQVARYVETLQATARQAPLKRLRAFGDSTRDELLAKARQQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
NGKPADEVLEQLAHALTNRLLHPPTAALRNAALNNDLELTTAADRLFPEKPGYQHPPIAT
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCC
PIVRTDDADPAP
CEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA