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The map label for this gene is bioC [H]

Identifier: 78045954

GI number: 78045954

Start: 451447

End: 452331

Strand: Reverse

Name: bioC [H]

Synonym: XCV0398

Alternate gene names: 78045954

Gene position: 452331-451447 (Counterclockwise)

Preceding gene: 78045955

Following gene: 78045953

Centisome position: 8.73

GC content: 69.6

Gene sequence:

>885_bases
ATGACCAGTACTTTCGATCCCCGCCACGTCCGGCGCGCGTTTGCGCGTGCCGCCAGCACCTATACCGCCGCCGCCGCGCT
TCAACGCGAAGCGGAAGCCCGCCTGCTCGAATCGCTCGACTACCTGGGCGAGCATGTGCCCAAGGTGGTGCTGGATGTCG
GCGCCGGCCCCGGCCATGCCAGCGCTGCAATCAAGAAGCGCTGGCCCAAGGCACAGGTGATCGCGCTGGATCAGGCCATG
CCGATGCTTCGCCAGGCGCGCAAGGCCGCAGGCTGGTGGAAGCCGTTCACGCAGGTGTGTGCCGATGCGCGCGCGCTACC
GGTCGCCGACGGCAGCGTGGATGTGATCTTCAGCAATCTGTGCCTGCAGTGGGTGGAAGACCTGCCGGCCGTGTTCGCCG
GTTTCCGTCGCGCGCTGCGCCCGGGCGGGTTGCTGCTGTGCTCCACCTTCGGCCCGGAAACGCTGATCGAATTGCGCGAG
GCCTTTGCGCAGACCGACCCGGCCCCGCACGTCAGCCGCTTTCCGCCGATCGCCCAATTCGGCGATGCCCTGCTGATGTC
CGGGTTCCGCGACCCGGTGCTGGACCGCGACCTGTTCACCCTGACCTACAACGACCTGCCCGCACTGATGCGCGAGCTGC
GTGCGATGGGGGCAACCAATGCGCTCAGCAACCGCCGGGCCACCCTGACCGGACGCGGTCGCTTCGCGGCCGCCAGCGCG
GCCTACGAACCGCTGCGGCGACCGGACGGCACCCTGCCCAGCTCCTGGGAAGTGATCTACGCCCATGCCTGGGCACCGGC
GCCGGGCGCGCCCATCCGCGAACACGGGCATGAGGTCGCCAGCGTGCCGGTCAGCGCCATCCCGATCCGCCGCCGCATCG
ACTGA

Upstream 100 bases:

>100_bases
GTTGATCGATGGCGGCAGCTATCCCGGCACGTTCTAGCGCGGCGCCTTGCACGCCCGATCGATTCCCTCCGCCCCTGCCA
GGGGCGACAATAGCCTTGCC

Downstream 100 bases:

>100_bases
ACGGCGGTACAGAACGCCGGTCCGCGCGCATCCACTGCCGGTGAGACACAGCGTATTGCGCCCATGCCACTGCTCAGCGG
TCAGGCTCGGCGGTGACAGT

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTSTFDPRHVRRAFARAASTYTAAAALQREAEARLLESLDYLGEHVPKVVLDVGAGPGHASAAIKKRWPKAQVIALDQAM
PMLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNLCLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELRE
AFAQTDPAPHVSRFPPIAQFGDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID

Sequences:

>Translated_294_residues
MTSTFDPRHVRRAFARAASTYTAAAALQREAEARLLESLDYLGEHVPKVVLDVGAGPGHASAAIKKRWPKAQVIALDQAM
PMLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNLCLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELRE
AFAQTDPAPHVSRFPPIAQFGDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID
>Mature_293_residues
TSTFDPRHVRRAFARAASTYTAAAALQREAEARLLESLDYLGEHVPKVVLDVGAGPGHASAAIKKRWPKAQVIALDQAMP
MLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNLCLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELREA
FAQTDPAPHVSRFPPIAQFGDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASAA
YEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=244, Percent_Identity=29.0983606557377, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI86792933, Length=151, Percent_Identity=33.7748344370861, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786994, Length=222, Percent_Identity=30.6306306306306, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17535003, Length=268, Percent_Identity=24.2537313432836, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922210, Length=232, Percent_Identity=31.8965517241379, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 32094; Mature: 31963

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTFDPRHVRRAFARAASTYTAAAALQREAEARLLESLDYLGEHVPKVVLDVGAGPGHA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SAAIKKRWPKAQVIALDQAMPMLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNL
HHHHHHCCCCHHEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHH
CLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELREAFAQTDPAPHVSRFPPIAQF
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
GDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCHHHHHH
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHCCCHHHHCCHHHCCCHHCCC
>Mature Secondary Structure 
TSTFDPRHVRRAFARAASTYTAAAALQREAEARLLESLDYLGEHVPKVVLDVGAGPGHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SAAIKKRWPKAQVIALDQAMPMLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNL
HHHHHHCCCCHHEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHH
CLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELREAFAQTDPAPHVSRFPPIAQF
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
GDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCHHHHHH
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHCCCHHHHCCHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]