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The map label for this gene is htrA [H]

Identifier: 78044916

GI number: 78044916

Start: 567075

End: 568205

Strand: Direct

Name: htrA [H]

Synonym: CHY_0655

Alternate gene names: 78044916

Gene position: 567075-568205 (Clockwise)

Preceding gene: 78045197

Following gene: 78043700

Centisome position: 23.61

GC content: 49.34

Gene sequence:

>1131_bases
ATGTACCAGTACCGTATGGATGAGCCGAGAGGACACCGGCCTTCGTGGTTTACGGTAATAGTGGTGGCGGTAATTGCCGG
TTTAATTGGGAGCATGGCGGGGATTTATGCCTATCCCAAACTTTTTCCCGCGAAGAATACGAAGATAGAATATACACTAC
CCCAGACTCCCGAAGTAAAAACCGCCGAATACAGCTATACGCCGGTGGTGGCGGTGGCCAAGAAGGTATCACCGGCGGTG
GTGGGGATATCCAATATTGCGCCGGGGGGCTTTTTTGGCCTGGGAGGGCTTGAAGAAAAAAGCTCCGGATCTGGCTTTAT
CATTTCTCCCGATGGCTACATCGTTACCAACAACCACGTGGTAGAAGGAGCATATGAGCTGTATGTGAGTTTGGCCGATG
GCCGGCAGATGAAGGCCAAAATCATCGGTACCGACCCGCGGGCGGACCTGGCGGTGATAAAGGTAAATGCCAAAAATTTA
CCGGTAGTAACCCTGGGTCATTCCAGCACTTTGCAGGTAGGAGAGCTGGCCATTGCCATCGGAAACCCTCTGGGTAAAGA
ATTTGCCCGAAGTGTCACCGTCGGGGTGATAAGTGCCCTTAATAGAACGTTAACTTATGAATCGGGAGAAAAAAGTCTTA
GGCTGATTCAGACCGATGCGGCTATTAACCCTGGCAATTCCGGTGGACCTCTCTGCAACGCCAAAGGGGAAGTGGTAGGG
ATAAATTCGGCCAAAATTTCCATTCCGGGCTTTGAGGGAATGGGCTTTGCCATCCCGATCGATGAGGCAAAACCGATTAT
TGAGCAGCTAATTAACAAGGGTTACGTTACCCGGCCGTGGCTGGGCATTGCCGGTGCGGAAATTTCCGAACAGGAAGCCC
AGTATTACGATATACCCCAGGGAATTTACATTGAAGGGGTTGTCGAAGGTGGACCGGCGGATAAAGCCGGTATTCAGGCT
AAAGATATTATTACCGCCATTAACGGTACGAAAATTACCACCATGGCGGAACTAACCGATGAACTGTTTAAACACAAGCC
GGGAGAAAAAATAAAAGTAGAAGTATACCGGCTAAAGGAAGGCAAAAAATATACCTTAGAAGTAACCTTGGGCGAAAAAC
CAAGAGAATAA

Upstream 100 bases:

>100_bases
TTCTTAAACTTGCCGCCGGGTGCTACCATTGTGGCCACCGGTGTATTAATATATATTTTGGTAGTATCAGGGAAAAAACT
TGGGCAAAGGGGGAAGTAAG

Downstream 100 bases:

>100_bases
CGCTGGAGGGACGGTTCTGAGAACCACCACTTTCGACGATGAATAGAAAATGGTGGCTGTAAGTACCGTCCCTGGAGGAG
GTATTTTAGTGGAGATTCTG

Product: serine protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MYQYRMDEPRGHRPSWFTVIVVAVIAGLIGSMAGIYAYPKLFPAKNTKIEYTLPQTPEVKTAEYSYTPVVAVAKKVSPAV
VGISNIAPGGFFGLGGLEEKSSGSGFIISPDGYIVTNNHVVEGAYELYVSLADGRQMKAKIIGTDPRADLAVIKVNAKNL
PVVTLGHSSTLQVGELAIAIGNPLGKEFARSVTVGVISALNRTLTYESGEKSLRLIQTDAAINPGNSGGPLCNAKGEVVG
INSAKISIPGFEGMGFAIPIDEAKPIIEQLINKGYVTRPWLGIAGAEISEQEAQYYDIPQGIYIEGVVEGGPADKAGIQA
KDIITAINGTKITTMAELTDELFKHKPGEKIKVEVYRLKEGKKYTLEVTLGEKPRE

Sequences:

>Translated_376_residues
MYQYRMDEPRGHRPSWFTVIVVAVIAGLIGSMAGIYAYPKLFPAKNTKIEYTLPQTPEVKTAEYSYTPVVAVAKKVSPAV
VGISNIAPGGFFGLGGLEEKSSGSGFIISPDGYIVTNNHVVEGAYELYVSLADGRQMKAKIIGTDPRADLAVIKVNAKNL
PVVTLGHSSTLQVGELAIAIGNPLGKEFARSVTVGVISALNRTLTYESGEKSLRLIQTDAAINPGNSGGPLCNAKGEVVG
INSAKISIPGFEGMGFAIPIDEAKPIIEQLINKGYVTRPWLGIAGAEISEQEAQYYDIPQGIYIEGVVEGGPADKAGIQA
KDIITAINGTKITTMAELTDELFKHKPGEKIKVEVYRLKEGKKYTLEVTLGEKPRE
>Mature_376_residues
MYQYRMDEPRGHRPSWFTVIVVAVIAGLIGSMAGIYAYPKLFPAKNTKIEYTLPQTPEVKTAEYSYTPVVAVAKKVSPAV
VGISNIAPGGFFGLGGLEEKSSGSGFIISPDGYIVTNNHVVEGAYELYVSLADGRQMKAKIIGTDPRADLAVIKVNAKNL
PVVTLGHSSTLQVGELAIAIGNPLGKEFARSVTVGVISALNRTLTYESGEKSLRLIQTDAAINPGNSGGPLCNAKGEVVG
INSAKISIPGFEGMGFAIPIDEAKPIIEQLINKGYVTRPWLGIAGAEISEQEAQYYDIPQGIYIEGVVEGGPADKAGIQA
KDIITAINGTKITTMAELTDELFKHKPGEKIKVEVYRLKEGKKYTLEVTLGEKPRE

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=322, Percent_Identity=36.0248447204969, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4506141, Length=303, Percent_Identity=35.6435643564356, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI24308541, Length=318, Percent_Identity=34.5911949685535, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI7019477, Length=325, Percent_Identity=33.2307692307692, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789629, Length=274, Percent_Identity=41.2408759124088, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1786356, Length=280, Percent_Identity=41.4285714285714, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789630, Length=371, Percent_Identity=35.5795148247978, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646839, Length=264, Percent_Identity=37.8787878787879, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40226; Mature: 40226

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQYRMDEPRGHRPSWFTVIVVAVIAGLIGSMAGIYAYPKLFPAKNTKIEYTLPQTPEVK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCE
TAEYSYTPVVAVAKKVSPAVVGISNIAPGGFFGLGGLEEKSSGSGFIISPDGYIVTNNHV
ECCCCCCHHHHHHHHCCCEEEEECCCCCCCEECCCCCCCCCCCCEEEECCCCEEEECCEE
VEGAYELYVSLADGRQMKAKIIGTDPRADLAVIKVNAKNLPVVTLGHSSTLQVGELAIAI
ECCEEEEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCEEECEEEEEE
GNPLGKEFARSVTVGVISALNRTLTYESGEKSLRLIQTDAAINPGNSGGPLCNAKGEVVG
CCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCEECCCCCEEE
INSAKISIPGFEGMGFAIPIDEAKPIIEQLINKGYVTRPWLGIAGAEISEQEAQYYDIPQ
ECCCEEECCCCCCCEEEEECCCHHHHHHHHHHCCCEECCCCEECCCCCCCCCCCEEECCC
GIYIEGVVEGGPADKAGIQAKDIITAINGTKITTMAELTDELFKHKPGEKIKVEVYRLKE
CEEEEEEECCCCCCCCCCCHHHEEEEECCCEEEHHHHHHHHHHHCCCCCEEEEEEEEECC
GKKYTLEVTLGEKPRE
CCEEEEEEEECCCCCC
>Mature Secondary Structure
MYQYRMDEPRGHRPSWFTVIVVAVIAGLIGSMAGIYAYPKLFPAKNTKIEYTLPQTPEVK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCE
TAEYSYTPVVAVAKKVSPAVVGISNIAPGGFFGLGGLEEKSSGSGFIISPDGYIVTNNHV
ECCCCCCHHHHHHHHCCCEEEEECCCCCCCEECCCCCCCCCCCCEEEECCCCEEEECCEE
VEGAYELYVSLADGRQMKAKIIGTDPRADLAVIKVNAKNLPVVTLGHSSTLQVGELAIAI
ECCEEEEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCEEECEEEEEE
GNPLGKEFARSVTVGVISALNRTLTYESGEKSLRLIQTDAAINPGNSGGPLCNAKGEVVG
CCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCEECCCCCEEE
INSAKISIPGFEGMGFAIPIDEAKPIIEQLINKGYVTRPWLGIAGAEISEQEAQYYDIPQ
ECCCEEECCCCCCCEEEEECCCHHHHHHHHHHCCCEECCCCEECCCCCCCCCCCEEECCC
GIYIEGVVEGGPADKAGIQAKDIITAINGTKITTMAELTDELFKHKPGEKIKVEVYRLKE
CEEEEEEECCCCCCCCCCCHHHEEEEECCCEEEHHHHHHHHHHHCCCCCEEEEEEEEECC
GKKYTLEVTLGEKPRE
CCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10692364; 11133960; 11555295 [H]