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The map label for this gene is accC1 [H]

Identifier: 78044884

GI number: 78044884

Start: 811050

End: 812603

Strand: Direct

Name: accC1 [H]

Synonym: CHY_0918

Alternate gene names: 78044884

Gene position: 811050-812603 (Clockwise)

Preceding gene: 78042975

Following gene: 78043991

Centisome position: 33.77

GC content: 47.94

Gene sequence:

>1554_bases
GTGCAGGAAAAAATCTTAATAGCCAATCGGGGTGAAATTGCCCTAAGAATAATCCGGGCTTGCAAAGAACTGGGAATAAC
TTCGGCGGTGGTTTATACCCCGGCAGATAAAGATAGCCTTCCGGTGAAAATGGCCGATGAAGCTTACCCCTTAAAAGAAA
ATAAGAGTTACTTAAATATTGAGGAAATAATCAATACCGCATTAAAAAACCAGGTTACCGCAATTCATCCCGGTTACGGC
TTTCTTGCGGAAAACTCTAAGTTCGCTAAAAGCTGCCTGGATGCCGGGATAAAATTTATCGGGCCTTCGGCCAAAGCTAT
TGAACTTATGGGGGATAAAGCGGTAGCCAGGGAAATCATGAAAAAAGCCGGCGTTCCGGTAATTCCCGGGTCCGATGGCG
AGATTGATGATTTCCGGGAAGCCCTGAAGGTTGCCGATGAAATTGGCTACCCGGTAATTGTCAAAGCTGCCGGCGGAGGC
GGGGGCCGGGGGATGCGGATTGTTCACACTCCCAAGGAATTGGAAGAAGCGATTCAATCCGCGGCCCGGGAAGCCGCGTC
AACCTTTGGTAATTCCAAATTATATTTAGAGAAGTATCTTCAGGACTGCCGGCACGTGGAGTTTCAAATTTTAGCCGACC
AGTACGGGAACGCGGTTTATTTGGGAGAGCGGGACTGCTCCCTGCAGCGGCGCAACCAAAAGGTAATCGAAGAAGGACCG
TGCCACGTCTTAACGGAAAGAATGCGGAAAAAAATGGGCGAACTGGCGGTGCGCTCCGCCATGGCCGTTCATTACGCCGG
GGCCGGAACGGTGGAATTTTTGCTGGATGATCGGGGAAACTTTTATTTTATTGAAATGAATACCCGGATACAGGTGGAAC
ATCCGGTAACCGAAATGATTACCGGCATAGATATCGTCAAGGAACAAATAAAAATCGGCCTCGGAGAAAGGTTAAGCATT
ACCCAGAAAGATGTGAAAATTTACGGACACGCTATTGAGTGCCGGGTAAATGCGGAAGACCCGATATCGTTTATTCCTAC
CCCGGGGGAAATAAAAAAATTAATGCTGCCCCAGGGGCCTTTTGTCCGGGTGGATACGGCAGTTTACGAAGGTTATACCA
TACCGCCTTACTATGATTCGATGATTGCCAAGTTAATTGTCTGGGGAAGAAATCGGGAAGAAGCGATTATCAGGATGAAA
CGAGCGCTGGAGGAGTTTGTAATTGGCGGTGTTACCACCAACTTACCTTTTTTACGCAAGGTGATGGATAATGCCTTTTA
CCGCCGGGGTGAGGTTTATACCAACTTTATCAAACGCCGGATGGAACCTTTAACCGAAGAAGACCTGGAAACCTACCGGG
ATAAACAGATATTTGGTGCCGAAGGGGAGCAAGAACAACCTTTAGAGGAAATAATTGCTGCGGTAGCTGCCGCCTTTGCG
GCCGATCAGACTTCAAAGAAAGAAACGCGGGAGCAGCATTTAACGTTATCTCCCTGGAAAATCGGAGGCCTTTTGGAACA
AATGCAGCGTCGGCTTTTTAGAGGAGGTGTATAA

Upstream 100 bases:

>100_bases
TGATTAAAGCCCTTCTGGCTGTAAGTACCAAGAGAGAATCAAGACCCATGAAGAAGCACGGAAATATTCCCTTTTAACAA
CCCCCGGGGAGGTGATAGGG

Downstream 100 bases:

>100_bases
GATGGTAAAAAAATTTAAAATCCGGGTAAACGGCCGGGAATACGAGATAGAGGTGGAAGAAATCCACACCGAAGGTTGGG
GAGTTTTACCAAATACCCGG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MQEKILIANRGEIALRIIRACKELGITSAVVYTPADKDSLPVKMADEAYPLKENKSYLNIEEIINTALKNQVTAIHPGYG
FLAENSKFAKSCLDAGIKFIGPSAKAIELMGDKAVAREIMKKAGVPVIPGSDGEIDDFREALKVADEIGYPVIVKAAGGG
GGRGMRIVHTPKELEEAIQSAAREAASTFGNSKLYLEKYLQDCRHVEFQILADQYGNAVYLGERDCSLQRRNQKVIEEGP
CHVLTERMRKKMGELAVRSAMAVHYAGAGTVEFLLDDRGNFYFIEMNTRIQVEHPVTEMITGIDIVKEQIKIGLGERLSI
TQKDVKIYGHAIECRVNAEDPISFIPTPGEIKKLMLPQGPFVRVDTAVYEGYTIPPYYDSMIAKLIVWGRNREEAIIRMK
RALEEFVIGGVTTNLPFLRKVMDNAFYRRGEVYTNFIKRRMEPLTEEDLETYRDKQIFGAEGEQEQPLEEIIAAVAAAFA
ADQTSKKETREQHLTLSPWKIGGLLEQMQRRLFRGGV

Sequences:

>Translated_517_residues
MQEKILIANRGEIALRIIRACKELGITSAVVYTPADKDSLPVKMADEAYPLKENKSYLNIEEIINTALKNQVTAIHPGYG
FLAENSKFAKSCLDAGIKFIGPSAKAIELMGDKAVAREIMKKAGVPVIPGSDGEIDDFREALKVADEIGYPVIVKAAGGG
GGRGMRIVHTPKELEEAIQSAAREAASTFGNSKLYLEKYLQDCRHVEFQILADQYGNAVYLGERDCSLQRRNQKVIEEGP
CHVLTERMRKKMGELAVRSAMAVHYAGAGTVEFLLDDRGNFYFIEMNTRIQVEHPVTEMITGIDIVKEQIKIGLGERLSI
TQKDVKIYGHAIECRVNAEDPISFIPTPGEIKKLMLPQGPFVRVDTAVYEGYTIPPYYDSMIAKLIVWGRNREEAIIRMK
RALEEFVIGGVTTNLPFLRKVMDNAFYRRGEVYTNFIKRRMEPLTEEDLETYRDKQIFGAEGEQEQPLEEIIAAVAAAFA
ADQTSKKETREQHLTLSPWKIGGLLEQMQRRLFRGGV
>Mature_517_residues
MQEKILIANRGEIALRIIRACKELGITSAVVYTPADKDSLPVKMADEAYPLKENKSYLNIEEIINTALKNQVTAIHPGYG
FLAENSKFAKSCLDAGIKFIGPSAKAIELMGDKAVAREIMKKAGVPVIPGSDGEIDDFREALKVADEIGYPVIVKAAGGG
GGRGMRIVHTPKELEEAIQSAAREAASTFGNSKLYLEKYLQDCRHVEFQILADQYGNAVYLGERDCSLQRRNQKVIEEGP
CHVLTERMRKKMGELAVRSAMAVHYAGAGTVEFLLDDRGNFYFIEMNTRIQVEHPVTEMITGIDIVKEQIKIGLGERLSI
TQKDVKIYGHAIECRVNAEDPISFIPTPGEIKKLMLPQGPFVRVDTAVYEGYTIPPYYDSMIAKLIVWGRNREEAIIRMK
RALEEFVIGGVTTNLPFLRKVMDNAFYRRGEVYTNFIKRRMEPLTEEDLETYRDKQIFGAEGEQEQPLEEIIAAVAAAFA
ADQTSKKETREQHLTLSPWKIGGLLEQMQRRLFRGGV

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=48.0984340044743, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=49.4331065759637, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=49.4331065759637, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=49.4331065759637, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=46.7706013363029, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=46.7706013363029, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=46.7706013363029, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI38679960, Length=522, Percent_Identity=31.8007662835249, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI38679977, Length=522, Percent_Identity=31.8007662835249, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI38679967, Length=522, Percent_Identity=31.8007662835249, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI38679974, Length=522, Percent_Identity=31.8007662835249, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679971, Length=522, Percent_Identity=31.8007662835249, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI134142062, Length=501, Percent_Identity=31.936127744511, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI18105007, Length=476, Percent_Identity=21.4285714285714, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=53.0337078651685, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1786216, Length=239, Percent_Identity=25.9414225941423, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=489, Percent_Identity=46.4212678936605, Blast_Score=420, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=48.7528344671202, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=47.0982142857143, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71997163, Length=447, Percent_Identity=31.3199105145414, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI133931226, Length=545, Percent_Identity=28.9908256880734, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=447, Percent_Identity=31.3199105145414, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI193204318, Length=192, Percent_Identity=23.9583333333333, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=42.9530201342282, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.1901565995526, Blast_Score=353, Evalue=5e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.0850111856823, Blast_Score=345, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=31.0492505353319, Blast_Score=220, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=556, Percent_Identity=29.8561151079137, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6322569, Length=327, Percent_Identity=23.2415902140673, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=47.5446428571429, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281363050, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=442, Percent_Identity=48.4162895927602, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=412, Percent_Identity=47.3300970873786, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI161076409, Length=494, Percent_Identity=31.5789473684211, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586458, Length=494, Percent_Identity=31.5789473684211, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI161076407, Length=494, Percent_Identity=31.5789473684211, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586460, Length=494, Percent_Identity=31.5789473684211, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI45555749, Length=429, Percent_Identity=21.9114219114219, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24642586, Length=429, Percent_Identity=21.9114219114219, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 57900; Mature: 57900

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKILIANRGEIALRIIRACKELGITSAVVYTPADKDSLPVKMADEAYPLKENKSYLNI
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCEECH
EEIINTALKNQVTAIHPGYGFLAENSKFAKSCLDAGIKFIGPSAKAIELMGDKAVAREIM
HHHHHHHHHCCCEEECCCCCEEECCCHHHHHHHHCCHHCCCCCCHHHHHHCCHHHHHHHH
KKAGVPVIPGSDGEIDDFREALKVADEIGYPVIVKAAGGGGGRGMRIVHTPKELEEAIQS
HHCCCCEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHHHHHH
AAREAASTFGNSKLYLEKYLQDCRHVEFQILADQYGNAVYLGERDCSLQRRNQKVIEEGP
HHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEHHCCCEEEECCCCCHHHHHHHHHHHCCC
CHVLTERMRKKMGELAVRSAMAVHYAGAGTVEFLLDDRGNFYFIEMNTRIQVEHPVTEMI
HHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCEEEEEECCEEEECCCHHHHH
TGIDIVKEQIKIGLGERLSITQKDVKIYGHAIECRVNAEDPISFIPTPGEIKKLMLPQGP
HHHHHHHHHHHHCCCCCCCCCHHHHEEEEEEEEEEECCCCCCEECCCCHHHHHHHCCCCC
FVRVDTAVYEGYTIPPYYDSMIAKLIVWGRNREEAIIRMKRALEEFVIGGVTTNLPFLRK
EEEEEHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VMDNAFYRRGEVYTNFIKRRMEPLTEEDLETYRDKQIFGAEGEQEQPLEEIIAAVAAAFA
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHH
ADQTSKKETREQHLTLSPWKIGGLLEQMQRRLFRGGV
HCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQEKILIANRGEIALRIIRACKELGITSAVVYTPADKDSLPVKMADEAYPLKENKSYLNI
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCEECH
EEIINTALKNQVTAIHPGYGFLAENSKFAKSCLDAGIKFIGPSAKAIELMGDKAVAREIM
HHHHHHHHHCCCEEECCCCCEEECCCHHHHHHHHCCHHCCCCCCHHHHHHCCHHHHHHHH
KKAGVPVIPGSDGEIDDFREALKVADEIGYPVIVKAAGGGGGRGMRIVHTPKELEEAIQS
HHCCCCEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHHHHHH
AAREAASTFGNSKLYLEKYLQDCRHVEFQILADQYGNAVYLGERDCSLQRRNQKVIEEGP
HHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEHHCCCEEEECCCCCHHHHHHHHHHHCCC
CHVLTERMRKKMGELAVRSAMAVHYAGAGTVEFLLDDRGNFYFIEMNTRIQVEHPVTEMI
HHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCEEEEEECCEEEECCCHHHHH
TGIDIVKEQIKIGLGERLSITQKDVKIYGHAIECRVNAEDPISFIPTPGEIKKLMLPQGP
HHHHHHHHHHHHCCCCCCCCCHHHHEEEEEEEEEEECCCCCCEECCCCHHHHHHHCCCCC
FVRVDTAVYEGYTIPPYYDSMIAKLIVWGRNREEAIIRMKRALEEFVIGGVTTNLPFLRK
EEEEEHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VMDNAFYRRGEVYTNFIKRRMEPLTEEDLETYRDKQIFGAEGEQEQPLEEIIAAVAAAFA
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHH
ADQTSKKETREQHLTLSPWKIGGLLEQMQRRLFRGGV
HCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]