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The map label for this gene is pccB [H]

Identifier: 78042975

GI number: 78042975

Start: 809485

End: 811026

Strand: Direct

Name: pccB [H]

Synonym: CHY_0917

Alternate gene names: 78042975

Gene position: 809485-811026 (Clockwise)

Preceding gene: 78043708

Following gene: 78044884

Centisome position: 33.71

GC content: 50.71

Gene sequence:

>1542_bases
ATGGAGAATAAGTTACAGGAACTTAACCGGAAAAGACAGGAATCCCTTTTGGGGGGCGGCGAAAAAAGGATAAAACGGCA
GCACGAAGCAGGCAAACTTACAGCACGGGAAAGGATTAACCTTTTGTTGGATCCGGGAAGTTTCGTCGAATTGGATATGT
TTGTGCGGGGAGAACAGGGAGAGTTTGCCAAGAGCGACATGGAAAACTACGGGGAAGGGGTGGTAACCGGCTTTGGTACC
ATCAATGGGCGCACGGTTTACCTCTTTTCCCAGGATTTTACCGTTTACGGCGGATCACTGGGGGAACTCCATTCGGCCAA
GATCTGTAAGGTAATGGACTTAGCCATGAAAGCGGGAGTTCCCTTTATCGGGCTTAACGACTCCGGCGGAGCCAGGATTC
AGGAAGGGGTATATTCCTTGAGTGCCTACGGAAATATTTTTTACCGGAATACCCTGGCTTCGGGAGTTATCCCGCAGATT
TCGGTGATTATGGGGCCGTGTGCCGGGGGAGCGGTTTATTCGCCGGCAATAACCGATTTTATTTTCATGGTTGATAAAAC
CAGCCAGATGTTTATTACCGGCCCCCAGGTCATTAAATCGGTTACCGGTGAAGAAGTAAGTCCCGAAGAGCTCGGCGGTG
CTATGACCCATAACCACATAAGCGGCGTTGCCCATTTTGTGGGGGAAAACGAAGAAATCACCCTGAGTATGGTGCGAAAG
CTTTTAGAGTACCTTCCCCAGAACAACATGGAAGAACCGCCGGTTAAGGCTCCGCTACCGCCAAAATATTCGACCGAAGA
GCTCCTGGATATAGTTCCGGAAGATCCCAACCGGCAGTACGATGTCCGGGAGGTAATTTTACGCATTGTCGATGACAGCG
AATTTTTTGAAGTGCATAAGTATTTTGCGGAAAATGCGGTGGTGGGTTTTGCCCGCCTATCCGGAAGGGTAGTGGGTATT
GTGGCCAACCAGCCCAAGTATTTAGCGGGGACTTTGGACATCAATGCTTCCGATAAAATTGCCCGGTTTGTGCGTTTTTG
CGATTGCTTTAATATTCCGCTTCTAACCTTTGTGGATGTACCGGGCTTTTTGCCGGGAATCAATCAGGAGTACGGTGGAA
TTATCCGGCACGGAGCCAAGATACTGTATGCTTATTCCGAAGCTACCGTTCCCAAGCTTACGGTAATCCTGCGGAAAGCT
TACGGTGGGGCTTATGTGGCCATGTGCAGTCGTTCTCTGGGAGCCGATGCGGCTTTTGCCTGGCCGACCGCGGAAATCGC
GGTGATGGGCCCTGACGGTGCTGCCAATATTATTTTCCGGGATGAGATCGCCCAGGCGGAAGACCCGGCCAAGGTGCGGG
CGGAAAAAACGGCGATGTACCGGGAAAAGTTCTGCAATCCCTATGTCGCGGCTGCCAAAGGGATGATCGATGATGTGATT
GATCCCAGGGAGACCCGGGACCGTTTGATTAAAGCCCTTCTGGCTGTAAGTACCAAGAGAGAATCAAGACCCATGAAGAA
GCACGGAAATATTCCCTTTTAA

Upstream 100 bases:

>100_bases
GATGAAAAACCGCGCCCTGGAGCTCACGGGAAAAAAATTGCCTTTATCCATCCGAAATCAACTAACAGTGTTTTAATAGA
ACTTTGTGAGGTGGTGGACG

Downstream 100 bases:

>100_bases
CAACCCCCGGGGAGGTGATAGGGGTGCAGGAAAAAATCTTAATAGCCAATCGGGGTGAAATTGCCCTAAGAATAATCCGG
GCTTGCAAAGAACTGGGAAT

Product: propionyl-CoA carboxylase subunit B

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MENKLQELNRKRQESLLGGGEKRIKRQHEAGKLTARERINLLLDPGSFVELDMFVRGEQGEFAKSDMENYGEGVVTGFGT
INGRTVYLFSQDFTVYGGSLGELHSAKICKVMDLAMKAGVPFIGLNDSGGARIQEGVYSLSAYGNIFYRNTLASGVIPQI
SVIMGPCAGGAVYSPAITDFIFMVDKTSQMFITGPQVIKSVTGEEVSPEELGGAMTHNHISGVAHFVGENEEITLSMVRK
LLEYLPQNNMEEPPVKAPLPPKYSTEELLDIVPEDPNRQYDVREVILRIVDDSEFFEVHKYFAENAVVGFARLSGRVVGI
VANQPKYLAGTLDINASDKIARFVRFCDCFNIPLLTFVDVPGFLPGINQEYGGIIRHGAKILYAYSEATVPKLTVILRKA
YGGAYVAMCSRSLGADAAFAWPTAEIAVMGPDGAANIIFRDEIAQAEDPAKVRAEKTAMYREKFCNPYVAAAKGMIDDVI
DPRETRDRLIKALLAVSTKRESRPMKKHGNIPF

Sequences:

>Translated_513_residues
MENKLQELNRKRQESLLGGGEKRIKRQHEAGKLTARERINLLLDPGSFVELDMFVRGEQGEFAKSDMENYGEGVVTGFGT
INGRTVYLFSQDFTVYGGSLGELHSAKICKVMDLAMKAGVPFIGLNDSGGARIQEGVYSLSAYGNIFYRNTLASGVIPQI
SVIMGPCAGGAVYSPAITDFIFMVDKTSQMFITGPQVIKSVTGEEVSPEELGGAMTHNHISGVAHFVGENEEITLSMVRK
LLEYLPQNNMEEPPVKAPLPPKYSTEELLDIVPEDPNRQYDVREVILRIVDDSEFFEVHKYFAENAVVGFARLSGRVVGI
VANQPKYLAGTLDINASDKIARFVRFCDCFNIPLLTFVDVPGFLPGINQEYGGIIRHGAKILYAYSEATVPKLTVILRKA
YGGAYVAMCSRSLGADAAFAWPTAEIAVMGPDGAANIIFRDEIAQAEDPAKVRAEKTAMYREKFCNPYVAAAKGMIDDVI
DPRETRDRLIKALLAVSTKRESRPMKKHGNIPF
>Mature_513_residues
MENKLQELNRKRQESLLGGGEKRIKRQHEAGKLTARERINLLLDPGSFVELDMFVRGEQGEFAKSDMENYGEGVVTGFGT
INGRTVYLFSQDFTVYGGSLGELHSAKICKVMDLAMKAGVPFIGLNDSGGARIQEGVYSLSAYGNIFYRNTLASGVIPQI
SVIMGPCAGGAVYSPAITDFIFMVDKTSQMFITGPQVIKSVTGEEVSPEELGGAMTHNHISGVAHFVGENEEITLSMVRK
LLEYLPQNNMEEPPVKAPLPPKYSTEELLDIVPEDPNRQYDVREVILRIVDDSEFFEVHKYFAENAVVGFARLSGRVVGI
VANQPKYLAGTLDINASDKIARFVRFCDCFNIPLLTFVDVPGFLPGINQEYGGIIRHGAKILYAYSEATVPKLTVILRKA
YGGAYVAMCSRSLGADAAFAWPTAEIAVMGPDGAANIIFRDEIAQAEDPAKVRAEKTAMYREKFCNPYVAAAKGMIDDVI
DPRETRDRLIKALLAVSTKRESRPMKKHGNIPF

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=515, Percent_Identity=58.252427184466, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI295821216, Length=535, Percent_Identity=56.0747663551402, Blast_Score=580, Evalue=1e-166,
Organism=Homo sapiens, GI11545863, Length=500, Percent_Identity=35.8, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI134142062, Length=391, Percent_Identity=25.8312020460358, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788655, Length=246, Percent_Identity=27.6422764227642, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=55.4027504911591, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=55.4027504911591, Blast_Score=569, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17552936, Length=525, Percent_Identity=35.8095238095238, Blast_Score=284, Evalue=9e-77,
Organism=Drosophila melanogaster, GI24586065, Length=532, Percent_Identity=37.218045112782, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56419; Mature: 56419

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKLQELNRKRQESLLGGGEKRIKRQHEAGKLTARERINLLLDPGSFVELDMFVRGEQG
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHCCCEEEECCCCEEEEEEEEECCCC
EFAKSDMENYGEGVVTGFGTINGRTVYLFSQDFTVYGGSLGELHSAKICKVMDLAMKAGV
CHHHHHHHHHCCEEEEEEECCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHCCC
PFIGLNDSGGARIQEGVYSLSAYGNIFYRNTLASGVIPQISVIMGPCAGGAVYSPAITDF
CEEEECCCCCCHHHHHHHHHHHHCCEEEHHHHHHCCCCEEHHEECCCCCCCCCCHHHHHH
IFMVDKTSQMFITGPQVIKSVTGEEVSPEELGGAMTHNHISGVAHFVGENEEITLSMVRK
EEEEECCCCEEEECHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHH
LLEYLPQNNMEEPPVKAPLPPKYSTEELLDIVPEDPNRQYDVREVILRIVDDSEFFEVHK
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
YFAENAVVGFARLSGRVVGIVANQPKYLAGTLDINASDKIARFVRFCDCFNIPLLTFVDV
HHHHHHHEEEEECCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHCCC
PGFLPGINQEYGGIIRHGAKILYAYSEATVPKLTVILRKAYGGAYVAMCSRSLGADAAFA
CCCCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEHHHHHCCCCCEEE
WPTAEIAVMGPDGAANIIFRDEIAQAEDPAKVRAEKTAMYREKFCNPYVAAAKGMIDDVI
CCCCEEEEECCCCCCEEEECCCHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
DPRETRDRLIKALLAVSTKRESRPMKKHGNIPF
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure
MENKLQELNRKRQESLLGGGEKRIKRQHEAGKLTARERINLLLDPGSFVELDMFVRGEQG
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHCCCEEEECCCCEEEEEEEEECCCC
EFAKSDMENYGEGVVTGFGTINGRTVYLFSQDFTVYGGSLGELHSAKICKVMDLAMKAGV
CHHHHHHHHHCCEEEEEEECCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHCCC
PFIGLNDSGGARIQEGVYSLSAYGNIFYRNTLASGVIPQISVIMGPCAGGAVYSPAITDF
CEEEECCCCCCHHHHHHHHHHHHCCEEEHHHHHHCCCCEEHHEECCCCCCCCCCHHHHHH
IFMVDKTSQMFITGPQVIKSVTGEEVSPEELGGAMTHNHISGVAHFVGENEEITLSMVRK
EEEEECCCCEEEECHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHH
LLEYLPQNNMEEPPVKAPLPPKYSTEELLDIVPEDPNRQYDVREVILRIVDDSEFFEVHK
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
YFAENAVVGFARLSGRVVGIVANQPKYLAGTLDINASDKIARFVRFCDCFNIPLLTFVDV
HHHHHHHEEEEECCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHCCC
PGFLPGINQEYGGIIRHGAKILYAYSEATVPKLTVILRKAYGGAYVAMCSRSLGADAAFA
CCCCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEHHHHHCCCCCEEE
WPTAEIAVMGPDGAANIIFRDEIAQAEDPAKVRAEKTAMYREKFCNPYVAAAKGMIDDVI
CCCCEEEEECCCCCCEEEECCCHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
DPRETRDRLIKALLAVSTKRESRPMKKHGNIPF
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]