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The map label for this gene is tmk

Identifier: 78044441

GI number: 78044441

Start: 40882

End: 41493

Strand: Direct

Name: tmk

Synonym: CHY_0050

Alternate gene names: 78044441

Gene position: 40882-41493 (Clockwise)

Preceding gene: 78045175

Following gene: 78043743

Centisome position: 1.7

GC content: 45.42

Gene sequence:

>612_bases
ATGCGCGGTAAATTTATTACCATTGAAGGGGTGGAAGGGTCAGGAAAAACCACCCAGATACAATATATTGCTCGGTATCT
TACAGAAAAAAATATACCCCACATTATCACCCGGGAGCCCGGTGGTACTGCTTTGGGTAAAAAAATACGGGAACTTTTAT
TAAACCCCTCCTACCCGGTGGTACCGGAAGCAGAAATTCTTTTATACCTGGCTGACCGGGCCCAGCATGTGGGGGAAAAG
ATAATTCCCCATTTGGACAAAGGGGTATGGGTAATTTCCGACCGGTATTTTGATTCCACGTTGGCTTATCAGGGTTACGG
CCGGGGATTTGACCTAACCCTTCTAAAAAGTTTCATAGCTTTTGCTACCAAAGGTTTAATTCCTGATTTAACAGTATTAA
TTGACCTTCCTCCGGAAGTAGGATTATCCCGGGTTAAAGGCCGGGGGGAATATGACCGTTTGGAGCGGGAGACTTTGGAG
TTTCACCAAAGGGTAAGGGAAGGCTTTTTACAACTTGCCAGAGATCAGCGTTTTCGAGTGGTGGATGGCCGGAAAAAGCC
CGAGGAAATTTTTTGGGAAATCAAAGGGTTTTTGGAGGGGCTAAATGGATAA

Upstream 100 bases:

>100_bases
AAGAAATTACTAAAGAAGCAGTGGAGTATTTAGAGTATCATTTAAACTTGGGAGTAAAGGTAACCGGGATATATGATGGC
AGGATAAAGGTGGTAAGGTA

Downstream 100 bases:

>100_bases
TCTAATTATAGAAGCTTTAAATCAGGATAAGCTAAGTCATGCGTATTTATTAACTTCACCGGTTCTTGAGGCGGTAGTGG
ATTTTGCCCGAAGGACCGCC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MRGKFITIEGVEGSGKTTQIQYIARYLTEKNIPHIITREPGGTALGKKIRELLLNPSYPVVPEAEILLYLADRAQHVGEK
IIPHLDKGVWVISDRYFDSTLAYQGYGRGFDLTLLKSFIAFATKGLIPDLTVLIDLPPEVGLSRVKGRGEYDRLERETLE
FHQRVREGFLQLARDQRFRVVDGRKKPEEIFWEIKGFLEGLNG

Sequences:

>Translated_203_residues
MRGKFITIEGVEGSGKTTQIQYIARYLTEKNIPHIITREPGGTALGKKIRELLLNPSYPVVPEAEILLYLADRAQHVGEK
IIPHLDKGVWVISDRYFDSTLAYQGYGRGFDLTLLKSFIAFATKGLIPDLTVLIDLPPEVGLSRVKGRGEYDRLERETLE
FHQRVREGFLQLARDQRFRVVDGRKKPEEIFWEIKGFLEGLNG
>Mature_203_residues
MRGKFITIEGVEGSGKTTQIQYIARYLTEKNIPHIITREPGGTALGKKIRELLLNPSYPVVPEAEILLYLADRAQHVGEK
IIPHLDKGVWVISDRYFDSTLAYQGYGRGFDLTLLKSFIAFATKGLIPDLTVLIDLPPEVGLSRVKGRGEYDRLERETLE
FHQRVREGFLQLARDQRFRVVDGRKKPEEIFWEIKGFLEGLNG

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=201, Percent_Identity=40.7960199004975, Blast_Score=144, Evalue=3e-36,
Organism=Drosophila melanogaster, GI28573735, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CARHZ (Q3AG12)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_358922.1
- HSSP:   P65248
- ProteinModelPortal:   Q3AG12
- SMR:   Q3AG12
- STRING:   Q3AG12
- GeneID:   3727559
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0050
- NMPDR:   fig|246194.3.peg.148
- TIGR:   CHY_0050
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- BioCyc:   CHYD246194:CHY_0050-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23156; Mature: 23156

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKFITIEGVEGSGKTTQIQYIARYLTEKNIPHIITREPGGTALGKKIRELLLNPSYPV
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCC
VPEAEILLYLADRAQHVGEKIIPHLDKGVWVISDRYFDSTLAYQGYGRGFDLTLLKSFIA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHCHHHHCCCCCCCCHHHHHHHHHH
FATKGLIPDLTVLIDLPPEVGLSRVKGRGEYDRLERETLEFHQRVREGFLQLARDQRFRV
HHHHCCCCCEEEEEECCCHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VDGRKKPEEIFWEIKGFLEGLNG
ECCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRGKFITIEGVEGSGKTTQIQYIARYLTEKNIPHIITREPGGTALGKKIRELLLNPSYPV
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCC
VPEAEILLYLADRAQHVGEKIIPHLDKGVWVISDRYFDSTLAYQGYGRGFDLTLLKSFIA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHCHHHHCCCCCCCCHHHHHHHHHH
FATKGLIPDLTVLIDLPPEVGLSRVKGRGEYDRLERETLEFHQRVREGFLQLARDQRFRV
HHHHCCCCCEEEEEECCCHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VDGRKKPEEIFWEIKGFLEGLNG
ECCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA