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The map label for this gene is hbd1 [H]

Identifier: 78044398

GI number: 78044398

Start: 1150035

End: 1150889

Strand: Direct

Name: hbd1 [H]

Synonym: CHY_1292

Alternate gene names: 78044398

Gene position: 1150035-1150889 (Clockwise)

Preceding gene: 78044218

Following gene: 78043648

Centisome position: 47.89

GC content: 38.71

Gene sequence:

>855_bases
TTGAAGTCTGTTTTGGTTTTAGGGGCAGGAACTATGGGTTCGGGTATTGCTCAAGTATTTGCTCAAGCGGGTTTTAAGGT
ATTTTTAAGGGATATAGAAATAAATTTAGTGGAAAAAGGCTTAACTACTATTAATAAAAATTTAGAGCGGTTAGTAAATA
AAGGTAAATTAACTTTAGAAGATAAACAGGAAATAATAGGGCGAATTAAAGGAATTGTAAATATTGAGGAAGCGCAAAAT
GTTGACTTGGTAGTTGAGGGTATTGTTGAGAATATTGAGGTAAAAAAGAAAGTATTTGCAGAATTAGATGAGATATTTCC
CGCAAATACTATTTTTGCGACAAATACCTCAAGTCTGAGCATAACCGACCTTGCTGCTGTTACAAAAAGGCCGGAAAAGG
TTATAGGAATGCATTTCTTCAATCCGGTACCGGTAATGCAGTTAGTTGAGGTTATTAAAGGTGTAGCTACATCTGAAGAA
ACTTACCAGACAATTTGTGATTTAGTAAGGCAGCTAGGTAAGACCCCGGTAACGGTAAACGAAGCCCCGGGTTTTGTAGT
AAACCGGTTGCTTATCCCCATGATTAATGAGGCTGCCTATTTACTAATGGAAGGTGTGGCTACGGCAGAAGATATTGATA
CTGCAATGCGGTTGGGAGCTAACCATCCTATGGGCCCACTGGCCTTGGCAGATCTAATTGGTCTTGATGTTTGCTTGGCA
ATAATGGAAACTCTTCATAAAGAGTTTGGTGACGACAAGTACCGTCCTTGTCCATTATTAAGAAAGATGGTTCGTGCTGG
CCATTTAGGTCGAAAAACCCAACGGGGATTTTATCAGTATACGAATGAAAATTAA

Upstream 100 bases:

>100_bases
TTTAATCTTCGCAAAGGCACGCCAAGTTATCAAGAACCCTTAACCTAATTTTTCGGCTCGGGTTCTATGGTAATTTAAAT
TATACGAGGAGGGAAAAATA

Downstream 100 bases:

>100_bases
AATAAAAATTTTTTCTTTTGGCAGTACCTCTTCCGTAAGTTGGGGGCAGGTACTGCCAATACGTGTTTATTCATGAGATA
TAAAATTTTGAGGAGGGTTA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKSVLVLGAGTMGSGIAQVFAQAGFKVFLRDIEINLVEKGLTTINKNLERLVNKGKLTLEDKQEIIGRIKGIVNIEEAQN
VDLVVEGIVENIEVKKKVFAELDEIFPANTIFATNTSSLSITDLAAVTKRPEKVIGMHFFNPVPVMQLVEVIKGVATSEE
TYQTICDLVRQLGKTPVTVNEAPGFVVNRLLIPMINEAAYLLMEGVATAEDIDTAMRLGANHPMGPLALADLIGLDVCLA
IMETLHKEFGDDKYRPCPLLRKMVRAGHLGRKTQRGFYQYTNEN

Sequences:

>Translated_284_residues
MKSVLVLGAGTMGSGIAQVFAQAGFKVFLRDIEINLVEKGLTTINKNLERLVNKGKLTLEDKQEIIGRIKGIVNIEEAQN
VDLVVEGIVENIEVKKKVFAELDEIFPANTIFATNTSSLSITDLAAVTKRPEKVIGMHFFNPVPVMQLVEVIKGVATSEE
TYQTICDLVRQLGKTPVTVNEAPGFVVNRLLIPMINEAAYLLMEGVATAEDIDTAMRLGANHPMGPLALADLIGLDVCLA
IMETLHKEFGDDKYRPCPLLRKMVRAGHLGRKTQRGFYQYTNEN
>Mature_284_residues
MKSVLVLGAGTMGSGIAQVFAQAGFKVFLRDIEINLVEKGLTTINKNLERLVNKGKLTLEDKQEIIGRIKGIVNIEEAQN
VDLVVEGIVENIEVKKKVFAELDEIFPANTIFATNTSSLSITDLAAVTKRPEKVIGMHFFNPVPVMQLVEVIKGVATSEE
TYQTICDLVRQLGKTPVTVNEAPGFVVNRLLIPMINEAAYLLMEGVATAEDIDTAMRLGANHPMGPLALADLIGLDVCLA
IMETLHKEFGDDKYRPCPLLRKMVRAGHLGRKTQRGFYQYTNEN

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=44.7916666666667, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=42.2950819672131, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI20127408, Length=281, Percent_Identity=38.0782918149466, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=34.8122866894198, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=34.8122866894198, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=33.9055793991416, Blast_Score=115, Evalue=4e-26,
Organism=Escherichia coli, GI1787661, Length=285, Percent_Identity=42.8070175438597, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788682, Length=259, Percent_Identity=37.4517374517375, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=35.2059925093633, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=41.6083916083916, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=41.4634146341463, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=40.0696864111498, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17508953, Length=280, Percent_Identity=38.9285714285714, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25144276, Length=278, Percent_Identity=39.2086330935252, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17508951, Length=280, Percent_Identity=38.9285714285714, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17558304, Length=278, Percent_Identity=37.7697841726619, Blast_Score=180, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=35, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71985930, Length=285, Percent_Identity=34.7368421052632, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI193203623, Length=204, Percent_Identity=25.9803921568627, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=204, Percent_Identity=25.9803921568627, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=35.6643356643357, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=35.6643356643357, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=35.6643356643357, Blast_Score=183, Evalue=9e-47,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=30.9322033898305, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI20129993, Length=222, Percent_Identity=27.4774774774775, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31253; Mature: 31253

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVLVLGAGTMGSGIAQVFAQAGFKVFLRDIEINLVEKGLTTINKNLERLVNKGKLTLE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DKQEIIGRIKGIVNIEEAQNVDLVVEGIVENIEVKKKVFAELDEIFPANTIFATNTSSLS
HHHHHHHHHHHCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
ITDLAAVTKRPEKVIGMHFFNPVPVMQLVEVIKGVATSEETYQTICDLVRQLGKTPVTVN
HHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEC
EAPGFVVNRLLIPMINEAAYLLMEGVATAEDIDTAMRLGANHPMGPLALADLIGLDVCLA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
IMETLHKEFGDDKYRPCPLLRKMVRAGHLGRKTQRGFYQYTNEN
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHCCHHHCCCCC
>Mature Secondary Structure
MKSVLVLGAGTMGSGIAQVFAQAGFKVFLRDIEINLVEKGLTTINKNLERLVNKGKLTLE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DKQEIIGRIKGIVNIEEAQNVDLVVEGIVENIEVKKKVFAELDEIFPANTIFATNTSSLS
HHHHHHHHHHHCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
ITDLAAVTKRPEKVIGMHFFNPVPVMQLVEVIKGVATSEETYQTICDLVRQLGKTPVTVN
HHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEC
EAPGFVVNRLLIPMINEAAYLLMEGVATAEDIDTAMRLGANHPMGPLALADLIGLDVCLA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
IMETLHKEFGDDKYRPCPLLRKMVRAGHLGRKTQRGFYQYTNEN
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA