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The map label for this gene is frdB1 [H]

Identifier: 78044013

GI number: 78044013

Start: 54115

End: 55068

Strand: Direct

Name: frdB1 [H]

Synonym: CHY_0064

Alternate gene names: 78044013

Gene position: 54115-55068 (Clockwise)

Preceding gene: 78044723

Following gene: 78043435

Centisome position: 2.25

GC content: 40.36

Gene sequence:

>954_bases
ATGCAAAAAGTTACTTTTAAAATAAGACGATTTGATGGGGAAAAATCATGGGTTCAGGAGTATCAATTTCCTTATCAGCC
TGGGAAAACGATTCTTTGGGCATTATCTTATATAAAAGAGTCTATTGACCCAACGTTAACCTTTACCGCATCCTGCCGCC
ATGCTGTTTGTGGTGCGTGTGCAGTGCGGGTTAATGGGCAGGCGGTGTTGGCCTGCGAAACTTTGTTGGATAAGATGTTA
GACCGTTGGGAAACTGATACTTTGCTAATTGAGCCTCTGCAGAATTTTAAAGTAATTCGCGACTTAGTGGTAGATTGGGA
AACAAAAGTGGAACGACTAGCAAGGGTAAAACCATGGTTGATACCTCGCGACGAATTTAGCAAAGAAACAGGCTGTCGGC
AAACGCCTGAGGAATTCAAAAAAATTAATAAAAATTCCGACTGTATTTTATGTGGTTGCTGTGCATCGGAGTGTAATAAA
CTTAGCAATAACGACAGTGATTTTCTTGAACCTTTTATCTTCTCTAAAGCCCAAAAATTTATCGCTGATTCTCGCGATAA
AGACCCGCTTTCGCGTATAAGTACTGCCATTAATAATGGAGCCTGGAAATGCATGCATTGTCAGGAATGTGTCACCAAGT
GTCCGAAAGGCTTATCTCCGGCTGATGATATTTCTTTCATTCGTCAGTTTGCAATAGCTAATGGGATTAGAAATAATCCT
GGTACCCGTCATGCTAAATCATTTTTGGACGATATTCAAAAAACCGGCCGGTTAAATGAGGCGTTGATGTTTATTAAAAC
TGAAGGATTGTTAGGATCATTAGGTAGCATCCCAGTGGCTTTGCGCTTGGTAAGAAAGGGGAAACTACGCTTGAAGCATG
TGTTGGCCAAACCTATAAAAGAAATCGAACAGGTCCGCACAATAATTAAGGTTATTACGAAAGATAAAAAATAG

Upstream 100 bases:

>100_bases
CTTAAAACATACAATTATTACCCTTGAAGGTTCGGAGTACAAGTTGTCGTATCGACCGGTTGTTATTACAAAATATCAAC
CGGCAGAGAGGAGGTACTAA

Downstream 100 bases:

>100_bases
TTAGGAAAAATTGAATGAAAATGTCCAAAGCAGATGTTTGCAAAATCAATTAAAGAGATATAAGCAGGCTTGTAAAATAT
TAAAATAACAACGAGAAAAC

Product: fumarate reductase, iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MQKVTFKIRRFDGEKSWVQEYQFPYQPGKTILWALSYIKESIDPTLTFTASCRHAVCGACAVRVNGQAVLACETLLDKML
DRWETDTLLIEPLQNFKVIRDLVVDWETKVERLARVKPWLIPRDEFSKETGCRQTPEEFKKINKNSDCILCGCCASECNK
LSNNDSDFLEPFIFSKAQKFIADSRDKDPLSRISTAINNGAWKCMHCQECVTKCPKGLSPADDISFIRQFAIANGIRNNP
GTRHAKSFLDDIQKTGRLNEALMFIKTEGLLGSLGSIPVALRLVRKGKLRLKHVLAKPIKEIEQVRTIIKVITKDKK

Sequences:

>Translated_317_residues
MQKVTFKIRRFDGEKSWVQEYQFPYQPGKTILWALSYIKESIDPTLTFTASCRHAVCGACAVRVNGQAVLACETLLDKML
DRWETDTLLIEPLQNFKVIRDLVVDWETKVERLARVKPWLIPRDEFSKETGCRQTPEEFKKINKNSDCILCGCCASECNK
LSNNDSDFLEPFIFSKAQKFIADSRDKDPLSRISTAINNGAWKCMHCQECVTKCPKGLSPADDISFIRQFAIANGIRNNP
GTRHAKSFLDDIQKTGRLNEALMFIKTEGLLGSLGSIPVALRLVRKGKLRLKHVLAKPIKEIEQVRTIIKVITKDKK
>Mature_317_residues
MQKVTFKIRRFDGEKSWVQEYQFPYQPGKTILWALSYIKESIDPTLTFTASCRHAVCGACAVRVNGQAVLACETLLDKML
DRWETDTLLIEPLQNFKVIRDLVVDWETKVERLARVKPWLIPRDEFSKETGCRQTPEEFKKINKNSDCILCGCCASECNK
LSNNDSDFLEPFIFSKAQKFIADSRDKDPLSRISTAINNGAWKCMHCQECVTKCPKGLSPADDISFIRQFAIANGIRNNP
GTRHAKSFLDDIQKTGRLNEALMFIKTEGLLGSLGSIPVALRLVRKGKLRLKHVLAKPIKEIEQVRTIIKVITKDKK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=32.7586206896552, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1790596, Length=228, Percent_Identity=33.7719298245614, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=30.9322033898305, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17533915, Length=244, Percent_Identity=32.7868852459016, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=33.1896551724138, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17137106, Length=247, Percent_Identity=31.9838056680162, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24643156, Length=244, Percent_Identity=32.3770491803279, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 36056; Mature: 36056

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00518 ZF_RING_1 ; PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVTFKIRRFDGEKSWVQEYQFPYQPGKTILWALSYIKESIDPTLTFTASCRHAVCGAC
CCCEEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
AVRVNGQAVLACETLLDKMLDRWETDTLLIEPLQNFKVIRDLVVDWETKVERLARVKPWL
HEEECCCEEHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IPRDEFSKETGCRQTPEEFKKINKNSDCILCGCCASECNKLSNNDSDFLEPFIFSKAQKF
CCCHHHHHHCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHH
IADSRDKDPLSRISTAINNGAWKCMHCQECVTKCPKGLSPADDISFIRQFAIANGIRNNP
HHCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTRHAKSFLDDIQKTGRLNEALMFIKTEGLLGSLGSIPVALRLVRKGKLRLKHVLAKPIK
CHHHHHHHHHHHHHHCCHHHHHHHEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIEQVRTIIKVITKDKK
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQKVTFKIRRFDGEKSWVQEYQFPYQPGKTILWALSYIKESIDPTLTFTASCRHAVCGAC
CCCEEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
AVRVNGQAVLACETLLDKMLDRWETDTLLIEPLQNFKVIRDLVVDWETKVERLARVKPWL
HEEECCCEEHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IPRDEFSKETGCRQTPEEFKKINKNSDCILCGCCASECNKLSNNDSDFLEPFIFSKAQKF
CCCHHHHHHCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHH
IADSRDKDPLSRISTAINNGAWKCMHCQECVTKCPKGLSPADDISFIRQFAIANGIRNNP
HHCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTRHAKSFLDDIQKTGRLNEALMFIKTEGLLGSLGSIPVALRLVRKGKLRLKHVLAKPIK
CHHHHHHHHHHHHHHCCHHHHHHHEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIEQVRTIIKVITKDKK
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]