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The map label for this gene is frdA [H]

Identifier: 78044723

GI number: 78044723

Start: 52405

End: 54114

Strand: Direct

Name: frdA [H]

Synonym: CHY_0063

Alternate gene names: 78044723

Gene position: 52405-54114 (Clockwise)

Preceding gene: 78043076

Following gene: 78044013

Centisome position: 2.18

GC content: 41.11

Gene sequence:

>1710_bases
ATGCTTAAGTACGACGTACTCGTAATAGGCAGTGGAGGAGCGGGAATGCAGGCTGCTTTAGTAGCAGCTAAGTCGGGAGA
ATTAAATGTTGCTCTTATGACAAAAGTGTTTCCTACGCGTTCTGCTACTTGTTGTGCCCAAGGTGGTACTAATGCAGCTC
TTCGGAATGTTGATAAGTCTGATTCAATTGAAAAACATGCTTTTGACACTATAAAAGGAAGTGACTTTCTTGCAGACCAG
GATGCTGTAGAATTTTTTGTTAGTTTATTACCTGAAACTATTTTGGAGCTGGATTATTTTGGAGTTCCTTTTTCCCGTCT
TGAAGATGGTACAATAGCTCAGCGGCCTTTTGGGGGACAGTCTCATCCGAGAACATGCTATTCTGCAGATAAAATAGGTG
CTGTAGTTTTACACACCTTATACGAACAGTGCCTAAAAAATCAGGTAAATATTCTTACTGAGTGGTTCTTATTAGATCTT
GTAGTAGAAAACGAGCAAATTATTGGTGTTGTTGCTATGAATATGAAAACAGGAGATATTCATCCGATCCTGGCTAAAGC
TGTTGTTTTAGCGACAGGTGGGGCTGGACGCGTTTACTGGAACCGAACCACTAACCCGTTTGCCTCCACGGGCGACGGGA
TGGCTGCAGCTTTTAGAGTAGGAGTTGCTTTAAAAGATCCAGAGTTTGTACAGTTTCATCCAACCGGCTTAGCTGGAACA
GGGATCCTAATGTCTGAGGCTTGCCGGGGTGAAGGAGGATATCTCCTGAATAATAAAGGTGAACGGTTTATGCAACGTTA
TGCTCCAGAAAAAATGGAGCTTGCAACTCGTGACTTGGTTTCTCAAGCTATTGAAACTGAAATTAAAGAAGGTCGTGGAT
TTGGAGAAGGTATAAATGCTTATGTTCTGCTTGATTTACGTCACCTTGGACGGGAAAAAATCTTAGAACGTTTACCACAA
ATCCGTGAGCTTGCTATCCAGTTTGAGGGTATTGATCCTATCGAGCAGCCAATTCCTGTGCGTCCAAGTTGTCATTATAG
CATGGGTGGAATAGATGTTATAGATTACAAAACTTGTGCTACGGTTGTTAAGGGATTATATGCTGCTGGAGAATGTTCTT
GTATTTCAATCCATGGTGCAAACCGTTTGGGTGGCAATTCAACTGCCGAAGCTGTTGCTTTTGGTAAAGTTGCTGGCAAA
GCAGCGGCAGAATATGCTCAAAATGTAGGATTTTCTTCTGAGAAAAAAGTAAGTGAGTGTGCTAAGAAATGGGAAAATGA
ATACAATATTGCTGTTTCGCGGACAAATGGTCCGTCGGTTGCTTCTATTCGTAGTCGTTTAGCAGAGACAATGTGGCTTA
ATGTTGGGGTTTTTCGCAAGGAAAAAGAAATGTTGCAGGCAGCAAAAGATGTTGATGCATTAATTGAAGAGTATAAATAC
TGTGTTGTTGGTGATAAAAACAGAATTTATAATACGGCGTTTACGCAGTACATCGAATTGGGTAATATGCTTACGGTTGC
TAAGGCTATTGTTATAGGAGCGTTAAACCGCAGAGAAAGTCGTGGTTCGCATAAAAGAGAAGATTATCCGCAAAGAGATG
ATAAAAACTACTTAAAACATACAATTATTACCCTTGAAGGTTCGGAGTACAAGTTGTCGTATCGACCGGTTGTTATTACA
AAATATCAACCGGCAGAGAGGAGGTACTAA

Upstream 100 bases:

>100_bases
GCCAAAATCTATGTAGAAGATTTTCCGGCGATTGTAGCTATTGATTGTGAAGGAAACAATATCTACGAAATTGGACCAAA
AAAATATAAGAGGTGATTAA

Downstream 100 bases:

>100_bases
ATGCAAAAAGTTACTTTTAAAATAAGACGATTTGATGGGGAAAAATCATGGGTTCAGGAGTATCAATTTCCTTATCAGCC
TGGGAAAACGATTCTTTGGG

Product: fumarate reductase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MLKYDVLVIGSGGAGMQAALVAAKSGELNVALMTKVFPTRSATCCAQGGTNAALRNVDKSDSIEKHAFDTIKGSDFLADQ
DAVEFFVSLLPETILELDYFGVPFSRLEDGTIAQRPFGGQSHPRTCYSADKIGAVVLHTLYEQCLKNQVNILTEWFLLDL
VVENEQIIGVVAMNMKTGDIHPILAKAVVLATGGAGRVYWNRTTNPFASTGDGMAAAFRVGVALKDPEFVQFHPTGLAGT
GILMSEACRGEGGYLLNNKGERFMQRYAPEKMELATRDLVSQAIETEIKEGRGFGEGINAYVLLDLRHLGREKILERLPQ
IRELAIQFEGIDPIEQPIPVRPSCHYSMGGIDVIDYKTCATVVKGLYAAGECSCISIHGANRLGGNSTAEAVAFGKVAGK
AAAEYAQNVGFSSEKKVSECAKKWENEYNIAVSRTNGPSVASIRSRLAETMWLNVGVFRKEKEMLQAAKDVDALIEEYKY
CVVGDKNRIYNTAFTQYIELGNMLTVAKAIVIGALNRRESRGSHKREDYPQRDDKNYLKHTIITLEGSEYKLSYRPVVIT
KYQPAERRY

Sequences:

>Translated_569_residues
MLKYDVLVIGSGGAGMQAALVAAKSGELNVALMTKVFPTRSATCCAQGGTNAALRNVDKSDSIEKHAFDTIKGSDFLADQ
DAVEFFVSLLPETILELDYFGVPFSRLEDGTIAQRPFGGQSHPRTCYSADKIGAVVLHTLYEQCLKNQVNILTEWFLLDL
VVENEQIIGVVAMNMKTGDIHPILAKAVVLATGGAGRVYWNRTTNPFASTGDGMAAAFRVGVALKDPEFVQFHPTGLAGT
GILMSEACRGEGGYLLNNKGERFMQRYAPEKMELATRDLVSQAIETEIKEGRGFGEGINAYVLLDLRHLGREKILERLPQ
IRELAIQFEGIDPIEQPIPVRPSCHYSMGGIDVIDYKTCATVVKGLYAAGECSCISIHGANRLGGNSTAEAVAFGKVAGK
AAAEYAQNVGFSSEKKVSECAKKWENEYNIAVSRTNGPSVASIRSRLAETMWLNVGVFRKEKEMLQAAKDVDALIEEYKY
CVVGDKNRIYNTAFTQYIELGNMLTVAKAIVIGALNRRESRGSHKREDYPQRDDKNYLKHTIITLEGSEYKLSYRPVVIT
KYQPAERRY
>Mature_569_residues
MLKYDVLVIGSGGAGMQAALVAAKSGELNVALMTKVFPTRSATCCAQGGTNAALRNVDKSDSIEKHAFDTIKGSDFLADQ
DAVEFFVSLLPETILELDYFGVPFSRLEDGTIAQRPFGGQSHPRTCYSADKIGAVVLHTLYEQCLKNQVNILTEWFLLDL
VVENEQIIGVVAMNMKTGDIHPILAKAVVLATGGAGRVYWNRTTNPFASTGDGMAAAFRVGVALKDPEFVQFHPTGLAGT
GILMSEACRGEGGYLLNNKGERFMQRYAPEKMELATRDLVSQAIETEIKEGRGFGEGINAYVLLDLRHLGREKILERLPQ
IRELAIQFEGIDPIEQPIPVRPSCHYSMGGIDVIDYKTCATVVKGLYAAGECSCISIHGANRLGGNSTAEAVAFGKVAGK
AAAEYAQNVGFSSEKKVSECAKKWENEYNIAVSRTNGPSVASIRSRLAETMWLNVGVFRKEKEMLQAAKDVDALIEEYKY
CVVGDKNRIYNTAFTQYIELGNMLTVAKAIVIGALNRRESRGSHKREDYPQRDDKNYLKHTIITLEGSEYKLSYRPVVIT
KYQPAERRY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=570, Percent_Identity=40.5263157894737, Blast_Score=402, Evalue=1e-112,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=44.19795221843, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1790597, Length=555, Percent_Identity=43.4234234234234, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1788928, Length=547, Percent_Identity=34.1864716636197, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17550100, Length=589, Percent_Identity=41.0865874363328, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17505833, Length=571, Percent_Identity=40.630472854641, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71986328, Length=379, Percent_Identity=29.287598944591, Blast_Score=104, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322701, Length=577, Percent_Identity=43.3275563258232, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322416, Length=575, Percent_Identity=42.7826086956522, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322511, Length=487, Percent_Identity=26.4887063655031, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320788, Length=476, Percent_Identity=27.9411764705882, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17137288, Length=589, Percent_Identity=39.3887945670628, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655642, Length=589, Percent_Identity=39.3887945670628, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655647, Length=589, Percent_Identity=39.3887945670628, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=40.2936378466558, Blast_Score=394, Evalue=1e-110,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 62536; Mature: 62536

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKYDVLVIGSGGAGMQAALVAAKSGELNVALMTKVFPTRSATCCAQGGTNAALRNVDKS
CCEEEEEEEECCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCEECCCCCCHHHHCCCCC
DSIEKHAFDTIKGSDFLADQDAVEFFVSLLPETILELDYFGVPFSRLEDGTIAQRPFGGQ
CCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCC
SHPRTCYSADKIGAVVLHTLYEQCLKNQVNILTEWFLLDLVVENEQIIGVVAMNMKTGDI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEEECCCCCC
HPILAKAVVLATGGAGRVYWNRTTNPFASTGDGMAAAFRVGVALKDPEFVQFHPTGLAGT
HHHHHHHHHEEECCCCEEEECCCCCCCCCCCCCCEEHHEECEEECCCCEEEEECCCCCCC
GILMSEACRGEGGYLLNNKGERFMQRYAPEKMELATRDLVSQAIETEIKEGRGFGEGINA
CHHHHHHHCCCCCEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
YVLLDLRHLGREKILERLPQIRELAIQFEGIDPIEQPIPVRPSCHYSMGGIDVIDYKTCA
EEEEEHHHCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHH
TVVKGLYAAGECSCISIHGANRLGGNSTAEAVAFGKVAGKAAAEYAQNVGFSSEKKVSEC
HHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AKKWENEYNIAVSRTNGPSVASIRSRLAETMWLNVGVFRKEKEMLQAAKDVDALIEEYKY
HHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCE
CVVGDKNRIYNTAFTQYIELGNMLTVAKAIVIGALNRRESRGSHKREDYPQRDDKNYLKH
EEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCHHHEEE
TIITLEGSEYKLSYRPVVITKYQPAERRY
EEEEEECCCEEEEECCEEEEECCCHHCCC
>Mature Secondary Structure
MLKYDVLVIGSGGAGMQAALVAAKSGELNVALMTKVFPTRSATCCAQGGTNAALRNVDKS
CCEEEEEEEECCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCEECCCCCCHHHHCCCCC
DSIEKHAFDTIKGSDFLADQDAVEFFVSLLPETILELDYFGVPFSRLEDGTIAQRPFGGQ
CCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCC
SHPRTCYSADKIGAVVLHTLYEQCLKNQVNILTEWFLLDLVVENEQIIGVVAMNMKTGDI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEEECCCCCC
HPILAKAVVLATGGAGRVYWNRTTNPFASTGDGMAAAFRVGVALKDPEFVQFHPTGLAGT
HHHHHHHHHEEECCCCEEEECCCCCCCCCCCCCCEEHHEECEEECCCCEEEEECCCCCCC
GILMSEACRGEGGYLLNNKGERFMQRYAPEKMELATRDLVSQAIETEIKEGRGFGEGINA
CHHHHHHHCCCCCEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
YVLLDLRHLGREKILERLPQIRELAIQFEGIDPIEQPIPVRPSCHYSMGGIDVIDYKTCA
EEEEEHHHCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHH
TVVKGLYAAGECSCISIHGANRLGGNSTAEAVAFGKVAGKAAAEYAQNVGFSSEKKVSEC
HHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AKKWENEYNIAVSRTNGPSVASIRSRLAETMWLNVGVFRKEKEMLQAAKDVDALIEEYKY
HHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCE
CVVGDKNRIYNTAFTQYIELGNMLTVAKAIVIGALNRRESRGSHKREDYPQRDDKNYLKH
EEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCHHHEEE
TIITLEGSEYKLSYRPVVITKYQPAERRY
EEEEEECCCEEEEECCEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA