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The map label for this gene is hgdA [H]

Identifier: 78043965

GI number: 78043965

Start: 752857

End: 754071

Strand: Direct

Name: hgdA [H]

Synonym: CHY_0847

Alternate gene names: 78043965

Gene position: 752857-754071 (Clockwise)

Preceding gene: 78043556

Following gene: 78043944

Centisome position: 31.35

GC content: 44.36

Gene sequence:

>1215_bases
ATGGCTAAAAAAATCTTTAAGCCTCTTAAGGCTTCAGAGAAAATAAATAAAATTTTAAAAAATCATTATTTAAAAGCAAA
GTATTTGCCAACGCTTGGAAAATTTTTTGGTTATAAAACCGCCTGGATTACCAGCGGAGCTCCGGTGGAACTACTGCGGG
CCTTTGGTATAGAGCCGGTTTATCCGGAGAATTACGGTGCCATTTGCGGTGCCCGCAAGGTTTCGCCGAGTCTTTGCCAG
GTAGCGGAAAACAGGGGTTATTCTCTCGATTTGTGTTCTTATGCCAAGAGTAATCTCGGAAGTATCTGGAATCCGAAAGA
AAGTCCATTTAACGGCTTACCCCGGCCGGATTTACTGGTGGTTTGCAACAACATTTGCGGGACGGTTTTAAAGTGGTACG
AAACTTTAAGCCGGGAATTTAATATTCCCCTTTTTATCATTGATACCCCTTTTATCACCGGTGAACCCCAACCCTGGCAA
ATCCAGTATGTGGCCAAACAGATAGAAAAACTGGCGATTGAACTGGAAAAATTTTTCCGGAAAAAGTTGGATTTAAACCG
TTTGGAAAAAGTAATTCTCCTTGCCAATGAGACGGTGGATTTATGGAAGGGGATAAGAAATTTTGCCAAAAATAAACCTT
CGCCGGTAAACGTTACCGATTTATTTATTAATCTGGGGCCAATGGTGGTTTTAAGGGGTACCGAAGTTGCCCGGGATTTT
TACGAGGAAGTTTACCGGGAAGTGGAAGAAAGGTACAAAGCCGGGGTTCCGGCGGTAGAGGGAGAAAAATACCGTTTAGT
CTGGGACAACATTCCCATCTGGTACGGACTGTACCGTTTTTACGGTTATTTTGCCGAAAGGGGAGCGGTTTTTGTTACCG
ATTCCTATACCGGTGGCTGGGCGGTCAACATAAAAAAGGGTCCTCCCTTTTATGCATTAGCCGAGACCTATGCCGGCGTC
TTTTTAAATCGGGATTTAGAATTTCGCAAAAATCAGTTGCAATCTTTCATTGAGGAATTTTCTGCCGATGGCTTTGTCAT
GCACTCCAATCGTTCGTGCAAAGCTTATTCTTTTGTGCAGGAGGAAATCCGGCGCCAAATCATGAGGTCACTAGGAGTGC
CGGGGTTAATAGTGGATGCCGATATGACCGACAGCCGGCTTTATTCCGAAGAAACGGTTTTAAACCGGGTCCAGGCTTTC
CTGGAGAGCCTGTAG

Upstream 100 bases:

>100_bases
AGGGAGTTCCGGTTTTAGTTTTAGAGGTGGAAGGCGGAGAAATCGGCGAGCAAAATAAAACTCGCCTCCAGGCCTTCCGG
GAAAGCGTGGGTGGAGTGTA

Downstream 100 bases:

>100_bases
AGAAAAAGGGGGAGGGAGATTTTGTATCTTGGAGTTGATATTGGTTCGCTTACGACCAAGGTTGTCTTAATTGACCGGGG
AAAAAATCTTATTGCTTATC

Product: (R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha

Products: NA

Alternate protein names: 3-hydroxybenzoyl-CoA reductase subunit beta [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKKIFKPLKASEKINKILKNHYLKAKYLPTLGKFFGYKTAWITSGAPVELLRAFGIEPVYPENYGAICGARKVSPSLCQ
VAENRGYSLDLCSYAKSNLGSIWNPKESPFNGLPRPDLLVVCNNICGTVLKWYETLSREFNIPLFIIDTPFITGEPQPWQ
IQYVAKQIEKLAIELEKFFRKKLDLNRLEKVILLANETVDLWKGIRNFAKNKPSPVNVTDLFINLGPMVVLRGTEVARDF
YEEVYREVEERYKAGVPAVEGEKYRLVWDNIPIWYGLYRFYGYFAERGAVFVTDSYTGGWAVNIKKGPPFYALAETYAGV
FLNRDLEFRKNQLQSFIEEFSADGFVMHSNRSCKAYSFVQEEIRRQIMRSLGVPGLIVDADMTDSRLYSEETVLNRVQAF
LESL

Sequences:

>Translated_404_residues
MAKKIFKPLKASEKINKILKNHYLKAKYLPTLGKFFGYKTAWITSGAPVELLRAFGIEPVYPENYGAICGARKVSPSLCQ
VAENRGYSLDLCSYAKSNLGSIWNPKESPFNGLPRPDLLVVCNNICGTVLKWYETLSREFNIPLFIIDTPFITGEPQPWQ
IQYVAKQIEKLAIELEKFFRKKLDLNRLEKVILLANETVDLWKGIRNFAKNKPSPVNVTDLFINLGPMVVLRGTEVARDF
YEEVYREVEERYKAGVPAVEGEKYRLVWDNIPIWYGLYRFYGYFAERGAVFVTDSYTGGWAVNIKKGPPFYALAETYAGV
FLNRDLEFRKNQLQSFIEEFSADGFVMHSNRSCKAYSFVQEEIRRQIMRSLGVPGLIVDADMTDSRLYSEETVLNRVQAF
LESL
>Mature_403_residues
AKKIFKPLKASEKINKILKNHYLKAKYLPTLGKFFGYKTAWITSGAPVELLRAFGIEPVYPENYGAICGARKVSPSLCQV
AENRGYSLDLCSYAKSNLGSIWNPKESPFNGLPRPDLLVVCNNICGTVLKWYETLSREFNIPLFIIDTPFITGEPQPWQI
QYVAKQIEKLAIELEKFFRKKLDLNRLEKVILLANETVDLWKGIRNFAKNKPSPVNVTDLFINLGPMVVLRGTEVARDFY
EEVYREVEERYKAGVPAVEGEKYRLVWDNIPIWYGLYRFYGYFAERGAVFVTDSYTGGWAVNIKKGPPFYALAETYAGVF
LNRDLEFRKNQLQSFIEEFSADGFVMHSNRSCKAYSFVQEEIRRQIMRSLGVPGLIVDADMTDSRLYSEETVLNRVQAFL
ESL

Specific function: Catalyzes the anaerobic reduction of benzoyl-CoA and 3- hydroxybenzoyl-CoA to form cyclohexa-1,5-diene-1-carbonyl-CoA and 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA, respectively. The enzyme also reduces other benzoyl-CoA analogs with small substituents

COG id: COG1775

COG function: function code E; Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011955
- InterPro:   IPR010327 [H]

Pfam domain/function: PF06050 HGD-D [H]

EC number: =1.3.99.15 [H]

Molecular weight: Translated: 46365; Mature: 46234

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKIFKPLKASEKINKILKNHYLKAKYLPTLGKFFGYKTAWITSGAPVELLRAFGIEPV
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCCCC
YPENYGAICGARKVSPSLCQVAENRGYSLDLCSYAKSNLGSIWNPKESPFNGLPRPDLLV
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
VCNNICGTVLKWYETLSREFNIPLFIIDTPFITGEPQPWQIQYVAKQIEKLAIELEKFFR
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
KKLDLNRLEKVILLANETVDLWKGIRNFAKNKPSPVNVTDLFINLGPMVVLRGTEVARDF
HHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHEECCCEEEEECHHHHHHH
YEEVYREVEERYKAGVPAVEGEKYRLVWDNIPIWYGLYRFYGYFAERGAVFVTDSYTGGW
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCE
AVNIKKGPPFYALAETYAGVFLNRDLEFRKNQLQSFIEEFSADGFVMHSNRSCKAYSFVQ
EEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
EEIRRQIMRSLGVPGLIVDADMTDSRLYSEETVLNRVQAFLESL
HHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKKIFKPLKASEKINKILKNHYLKAKYLPTLGKFFGYKTAWITSGAPVELLRAFGIEPV
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCCCC
YPENYGAICGARKVSPSLCQVAENRGYSLDLCSYAKSNLGSIWNPKESPFNGLPRPDLLV
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
VCNNICGTVLKWYETLSREFNIPLFIIDTPFITGEPQPWQIQYVAKQIEKLAIELEKFFR
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
KKLDLNRLEKVILLANETVDLWKGIRNFAKNKPSPVNVTDLFINLGPMVVLRGTEVARDF
HHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHEECCCEEEEECHHHHHHH
YEEVYREVEERYKAGVPAVEGEKYRLVWDNIPIWYGLYRFYGYFAERGAVFVTDSYTGGW
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCE
AVNIKKGPPFYALAETYAGVFLNRDLEFRKNQLQSFIEEFSADGFVMHSNRSCKAYSFVQ
EEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
EEIRRQIMRSLGVPGLIVDADMTDSRLYSEETVLNRVQAFLESL
HHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9746358; 11208796 [H]