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The map label for this gene is hgdC [H]

Identifier: 78043944

GI number: 78043944

Start: 754093

End: 754857

Strand: Direct

Name: hgdC [H]

Synonym: CHY_0848

Alternate gene names: 78043944

Gene position: 754093-754857 (Clockwise)

Preceding gene: 78043965

Following gene: 78044162

Centisome position: 31.4

GC content: 49.02

Gene sequence:

>765_bases
TTGTATCTTGGAGTTGATATTGGTTCGCTTACGACCAAGGTTGTCTTAATTGACCGGGGAAAAAATCTTATTGCTTATCG
TTACAGTAAAACCGGACCTGCCGGAAAGGAAACGGCCGAGCGGTTAATTCAAGAGGTTTTGATAAAAGCGAATATTTCCC
GGGACGATATTCAGGGAATAGTTGCTACCGGTTACGGCAGGGTTCTCTTTTCCGGAAAGGAGTTTTCGGAGATAACCTGT
CAGGCCCGGGGGATTGGGCATTTATACCCGGAGGCAAAAACGATTATCGATATTGGTGGCCAGGATAGCAAAGTAATTTC
TCTGGGAAAAAACGGAAAGGTACTGGACTTTGCCATGAACGATAAATGTGCTGCTGGCACCGGACGTTTTTTGGAGGTGA
TGAGTCAGGCCCTTGAAGTTCGTCTGGAAGAGATAGGGGAACTTGCCGAAAAGAGCCAGGAGGCAGCTAAGATATCTTCG
GTTTGTACCGTTTTTGCCGAATCGGAAGTGATATCCAATTTATCCCGGGGGCAGAGCCGGGAAGCGGTAGCACGGGGAAT
TTGTGAGGCGGTGGCGGCCCGAACGGCTATACTGGCGCAAAAAGTGGGGGTGGTAGAACCGGTGGTTTTTACCGGAGGGG
TGGCCAAAAATACTGGAGTTGTGGCGGCTTTGGAGCGAAAGCTTGGGGTTAAGTTATTAATTCCGGAAGATTCCACGATT
ACCGCAGCTCTGGGGGCGGCTTTATTAGCCGCTGAAAATTCTTAA

Upstream 100 bases:

>100_bases
TGCCGATATGACCGACAGCCGGCTTTATTCCGAAGAAACGGTTTTAAACCGGGTCCAGGCTTTCCTGGAGAGCCTGTAGA
GAAAAAGGGGGAGGGAGATT

Downstream 100 bases:

>100_bases
AGAGGAAAATTCGGGAATTTCAAGGGGTTAGCTTTAAAATTGCCGAAAGGAAATCATGAACTTGATTATTCAACACGAGT
ATTATAAAAAGCTGCAGGAA

Product: (R)-2-hydroxyglutaryl-CoA dehydratase activator

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MYLGVDIGSLTTKVVLIDRGKNLIAYRYSKTGPAGKETAERLIQEVLIKANISRDDIQGIVATGYGRVLFSGKEFSEITC
QARGIGHLYPEAKTIIDIGGQDSKVISLGKNGKVLDFAMNDKCAAGTGRFLEVMSQALEVRLEEIGELAEKSQEAAKISS
VCTVFAESEVISNLSRGQSREAVARGICEAVAARTAILAQKVGVVEPVVFTGGVAKNTGVVAALERKLGVKLLIPEDSTI
TAALGAALLAAENS

Sequences:

>Translated_254_residues
MYLGVDIGSLTTKVVLIDRGKNLIAYRYSKTGPAGKETAERLIQEVLIKANISRDDIQGIVATGYGRVLFSGKEFSEITC
QARGIGHLYPEAKTIIDIGGQDSKVISLGKNGKVLDFAMNDKCAAGTGRFLEVMSQALEVRLEEIGELAEKSQEAAKISS
VCTVFAESEVISNLSRGQSREAVARGICEAVAARTAILAQKVGVVEPVVFTGGVAKNTGVVAALERKLGVKLLIPEDSTI
TAALGAALLAAENS
>Mature_254_residues
MYLGVDIGSLTTKVVLIDRGKNLIAYRYSKTGPAGKETAERLIQEVLIKANISRDDIQGIVATGYGRVLFSGKEFSEITC
QARGIGHLYPEAKTIIDIGGQDSKVISLGKNGKVLDFAMNDKCAAGTGRFLEVMSQALEVRLEEIGELAEKSQEAAKISS
VCTVFAESEVISNLSRGQSREAVARGICEAVAARTAILAQKVGVVEPVVFTGGVAKNTGVVAALERKLGVKLLIPEDSTI
TAALGAALLAAENS

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=249, Percent_Identity=39.7590361445783, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 26770; Mature: 26770

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLGVDIGSLTTKVVLIDRGKNLIAYRYSKTGPAGKETAERLIQEVLIKANISRDDIQGI
CEEECEECCCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHCEE
VATGYGRVLFSGKEFSEITCQARGIGHLYPEAKTIIDIGGQDSKVISLGKNGKVLDFAMN
EECCCCEEEECCCCCCHHEEECCCCCCCCCCCCEEEEECCCCCEEEEECCCCCEEEEECC
DKCAAGTGRFLEVMSQALEVRLEEIGELAEKSQEAAKISSVCTVFAESEVISNLSRGQSR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EAVARGICEAVAARTAILAQKVGVVEPVVFTGGVAKNTGVVAALERKLGVKLLIPEDSTI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHEEEHHHCCEEEEECCCCCH
TAALGAALLAAENS
HHHHHHHHHHCCCC
>Mature Secondary Structure
MYLGVDIGSLTTKVVLIDRGKNLIAYRYSKTGPAGKETAERLIQEVLIKANISRDDIQGI
CEEECEECCCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHCEE
VATGYGRVLFSGKEFSEITCQARGIGHLYPEAKTIIDIGGQDSKVISLGKNGKVLDFAMN
EECCCCEEEECCCCCCHHEEECCCCCCCCCCCCEEEEECCCCCEEEEECCCCCEEEEECC
DKCAAGTGRFLEVMSQALEVRLEEIGELAEKSQEAAKISSVCTVFAESEVISNLSRGQSR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EAVARGICEAVAARTAILAQKVGVVEPVVFTGGVAKNTGVVAALERKLGVKLLIPEDSTI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHEEEHHHCCEEEEECCCCCH
TAALGAALLAAENS
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]