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The map label for this gene is lytS [H]

Identifier: 78043390

GI number: 78043390

Start: 569788

End: 571071

Strand: Direct

Name: lytS [H]

Synonym: CHY_0657

Alternate gene names: 78043390

Gene position: 569788-571071 (Clockwise)

Preceding gene: 78043700

Following gene: 78044195

Centisome position: 23.73

GC content: 44.63

Gene sequence:

>1284_bases
ATGACAGCTTTTGAAGGGTTTTTTGAATTTTATGTTTTTTTTCCGGAAGGCTTAAAGCTTTTACTGCCCGTTATTCTCCT
GTTTTTAATTAATTTTTTTGGAGTATATGTAGCCAGCTACTTTTTTCGCACTTTCCGGGTGATTACTTTAAAAAAAGAAG
AGCAGGACCAATTAAATCCTCTCATGCTGGCCAATGAAGCTTTGCCGATTATCAAGCAGGGATTAAATGTGGAGACCGCC
GGAAAAATTGCCGAAATAATTCAGCGGATTAGCGACATGGAAGCGGTAGCAATTACGGACCGGGAAAAAGTGCTGGCGTA
TGTGGGGGTTGGTTGTGAACGGCATAAGATAGGGGACCCTATCCGGACCTTTGCCACCAAAGAAGCCATCCGCACCGGGG
AGCTTAAAATAATTGACCACAGTTTAAAATACATTTGTTCGGTAAAAGACTGCGACTGCCCCCTCCAGGCGGCGGTGGTT
GTTCCTTTGAAAATTCGCGGGCAGGTGGTGGGTACAATAAAGCTTTACCAGACGAAAAAAGGCGAGATGCCGGCCCAAAC
CGTAAAACTTGCGATGGGGATTGCCCAGATCTTAAACCTGCAAATGGAAATAGCCGAGCTTGACCGCCAGGCGCAAATGG
TGACCAAAGCCCAGTTAGAAGCGCTGCAGGCCAAGATAAATCCGCACTTTCTTTTTAATACCTTAAATACCATCATTATG
TTTAACCGGACCAACCCGGAATTAGCCCGAAAGCTTCTAATTCATCTGGCAAAATTTTTCCGGCAAACTTTAAAAAAACA
GGGGATGTTTGGCACGTTAAAGGAAGAGCTTGATTACGTCAATACTTATTTAGTTCTGGAAAAAGCCCGGTTTCGGCAAA
AGCTTAGAATTATAAGGGATATTGACCGGGAATTACTGAATTACCAGTTTCCGGTATTAACATTACAACCACTTGTGGAA
AATGCGGTTAAACACGGTATTACCCCTAAAGAATCCCAGGGTACGGTTTTAATCCGGATTAAGAGGGATGGGGAAAAAAT
TAACGTGGAAATAAAGGATGATGGAGTGGGAATTTCTCCCAGTATGGTTGGCCGGGTTTTGGAACCGGGATTTGGTTCGG
GAAACGGGGTCGGGATGTCCAACGTTCACGAACGTTTGCTCAGTTTGTACGGCCGGGAGGCGGGCCTTAAAATAGAGTCG
AAGTTAGGGGTGGGGACTACCGTGAGTTTTTCCATTCCGGCGTTAAAAGTTGAAGAAGAAGGGGAGAGGGAAAATGAAAA
TTAG

Upstream 100 bases:

>100_bases
TATTTATTTTTTTAAATTTTAAATTATAATAATATTAAGAAAATTTTGACGGGGTGGGAGTTTGGAACCCTTACTAAAGC
TTTTTCTTTTAGCGGTGATA

Downstream 100 bases:

>100_bases
GACGCTCATTGTGGATGATGAGTATCCTGCCCGGCAGGAACTGCGTTTTTTGTTAGCGGAGATTCCGGAAATTGAAGTGG
TGGGGGAGGCGGCAACGGCC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTAFEGFFEFYVFFPEGLKLLLPVILLFLINFFGVYVASYFFRTFRVITLKKEEQDQLNPLMLANEALPIIKQGLNVETA
GKIAEIIQRISDMEAVAITDREKVLAYVGVGCERHKIGDPIRTFATKEAIRTGELKIIDHSLKYICSVKDCDCPLQAAVV
VPLKIRGQVVGTIKLYQTKKGEMPAQTVKLAMGIAQILNLQMEIAELDRQAQMVTKAQLEALQAKINPHFLFNTLNTIIM
FNRTNPELARKLLIHLAKFFRQTLKKQGMFGTLKEELDYVNTYLVLEKARFRQKLRIIRDIDRELLNYQFPVLTLQPLVE
NAVKHGITPKESQGTVLIRIKRDGEKINVEIKDDGVGISPSMVGRVLEPGFGSGNGVGMSNVHERLLSLYGREAGLKIES
KLGVGTTVSFSIPALKVEEEGERENEN

Sequences:

>Translated_427_residues
MTAFEGFFEFYVFFPEGLKLLLPVILLFLINFFGVYVASYFFRTFRVITLKKEEQDQLNPLMLANEALPIIKQGLNVETA
GKIAEIIQRISDMEAVAITDREKVLAYVGVGCERHKIGDPIRTFATKEAIRTGELKIIDHSLKYICSVKDCDCPLQAAVV
VPLKIRGQVVGTIKLYQTKKGEMPAQTVKLAMGIAQILNLQMEIAELDRQAQMVTKAQLEALQAKINPHFLFNTLNTIIM
FNRTNPELARKLLIHLAKFFRQTLKKQGMFGTLKEELDYVNTYLVLEKARFRQKLRIIRDIDRELLNYQFPVLTLQPLVE
NAVKHGITPKESQGTVLIRIKRDGEKINVEIKDDGVGISPSMVGRVLEPGFGSGNGVGMSNVHERLLSLYGREAGLKIES
KLGVGTTVSFSIPALKVEEEGERENEN
>Mature_426_residues
TAFEGFFEFYVFFPEGLKLLLPVILLFLINFFGVYVASYFFRTFRVITLKKEEQDQLNPLMLANEALPIIKQGLNVETAG
KIAEIIQRISDMEAVAITDREKVLAYVGVGCERHKIGDPIRTFATKEAIRTGELKIIDHSLKYICSVKDCDCPLQAAVVV
PLKIRGQVVGTIKLYQTKKGEMPAQTVKLAMGIAQILNLQMEIAELDRQAQMVTKAQLEALQAKINPHFLFNTLNTIIMF
NRTNPELARKLLIHLAKFFRQTLKKQGMFGTLKEELDYVNTYLVLEKARFRQKLRIIRDIDRELLNYQFPVLTLQPLVEN
AVKHGITPKESQGTVLIRIKRDGEKINVEIKDDGVGISPSMVGRVLEPGFGSGNGVGMSNVHERLLSLYGREAGLKIESK
LGVGTTVSFSIPALKVEEEGERENEN

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=346, Percent_Identity=37.8612716763006, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1788723, Length=355, Percent_Identity=37.7464788732394, Blast_Score=228, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48114; Mature: 47983

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFEGFFEFYVFFPEGLKLLLPVILLFLINFFGVYVASYFFRTFRVITLKKEEQDQLNP
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCCCC
LMLANEALPIIKQGLNVETAGKIAEIIQRISDMEAVAITDREKVLAYVGVGCERHKIGDP
EEEECCCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHHCCCH
IRTFATKEAIRTGELKIIDHSLKYICSVKDCDCPLQAAVVVPLKIRGQVVGTIKLYQTKK
HHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCCCEEEEEEEEECCEEEEEEEEEECCC
GEMPAQTVKLAMGIAQILNLQMEIAELDRQAQMVTKAQLEALQAKINPHFLFNTLNTIIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEE
FNRTNPELARKLLIHLAKFFRQTLKKQGMFGTLKEELDYVNTYLVLEKARFRQKLRIIRD
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDRELLNYQFPVLTLQPLVENAVKHGITPKESQGTVLIRIKRDGEKINVEIKDDGVGISP
HHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCH
SMVGRVLEPGFGSGNGVGMSNVHERLLSLYGREAGLKIESKLGVGTTVSFSIPALKVEEE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEECCEEEECCC
GERENEN
CCCCCCC
>Mature Secondary Structure 
TAFEGFFEFYVFFPEGLKLLLPVILLFLINFFGVYVASYFFRTFRVITLKKEEQDQLNP
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCCCC
LMLANEALPIIKQGLNVETAGKIAEIIQRISDMEAVAITDREKVLAYVGVGCERHKIGDP
EEEECCCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHHCCCH
IRTFATKEAIRTGELKIIDHSLKYICSVKDCDCPLQAAVVVPLKIRGQVVGTIKLYQTKK
HHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCCCEEEEEEEEECCEEEEEEEEEECCC
GEMPAQTVKLAMGIAQILNLQMEIAELDRQAQMVTKAQLEALQAKINPHFLFNTLNTIIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEE
FNRTNPELARKLLIHLAKFFRQTLKKQGMFGTLKEELDYVNTYLVLEKARFRQKLRIIRD
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDRELLNYQFPVLTLQPLVENAVKHGITPKESQGTVLIRIKRDGEKINVEIKDDGVGISP
HHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCH
SMVGRVLEPGFGSGNGVGMSNVHERLLSLYGREAGLKIESKLGVGTTVSFSIPALKVEEE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEECCEEEECCC
GERENEN
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]