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The map label for this gene is phoR [H]

Identifier: 78043258

GI number: 78043258

Start: 77959

End: 79416

Strand: Direct

Name: phoR [H]

Synonym: CHY_0091

Alternate gene names: 78043258

Gene position: 77959-79416 (Clockwise)

Preceding gene: 78042731

Following gene: 78045188

Centisome position: 3.25

GC content: 39.23

Gene sequence:

>1458_bases
GTGTCTTTAAAGTTTCGGCTTATTCTGTCTTACTTGGCAATGTTAGTGATACCTATTTTATTATCGGCGGTAGCCAGCTT
TTTAGTGGGTTTAATTTATATTGGAGACGCCGGCCAGGCTTTTAATCTTCCCCATGGGCCTAAAGCCTTTCGGGAAGTTT
TTCGCGAGCGCCAGGAGACAATTAATGAAGTTAAAATAAATATCTTAAAACAGCCGGAAAAGGCTTTAAGTAAAAGTTTC
TGGGCCGCTGAGGAGAAAAAACTGGTAAATCACCAAACTTATCTTGTGGTTAAAAAAGGAAAGGATTTAATTTATGCGTC
AGAGCTTATGCGGGAACAAAAGCTTTTAGAGAAATTACCTGCCTTTGGGAATCCTGAAGAAGAAGGGGCAATAAAGGCGC
CGGATGGGAAACGTTATTTATTAAAACAGGTTGATTTTTACTTTAGTGATAAGACTCCGGGAAGTATTTATTTTATTACC
GATGTCGAAAATGTCCGTAAAATCTTGACTCGCTTTAGCATTACCATGCTGGTAGTTTTTCTTTTAATTCTGGTAGCTAC
AAACGGTACTTTAACTTTTCTTGTTTCCCGCAGTATTTTAAAACCTCTTTCCCAGCTTAAACAGGCTTCGGAGCAGATAA
AAAATGGCAATCTTGATTTTACGGTTAAAAACAGTGCCAAAGATGAGATTGGAGAGCTTTTTGTTGCTTTTGAGGAGATG
CGAAAAAGGCTTAAGGAGTCCGAAGAATTAAAAAAACAATACGAAGAAAATCGCAAGGAACTAATAGCCAACATTTCCCA
CGATTTAAAAACACCGATTACTGCGATAAAAGGTTATGTAGAAGGGATCCGGGATGGGGTGGCGGACAGTCCGGAAAAGT
TATCCCGGTATGTTGATACCATTTACCGTAAAATTTTAGAAGTGGATGGACTTATCGATGAGCTGTTTCTTTTTTCCAAG
CTGGATTTAAAAAAGCTACCTTTTAATTTTGAAAAAGTTAATTTAAACCGTTACTTAAGCGATGTGGCCGAGGAGTTGGA
GTTTGATTTAAGAAAGAAGGGGATTGAGCTTAAACTTCATCTGCCTTGCCAGCAAGTTTTTGTTTGGGCTGACCGCGAAA
AACTAAAGCGAGTTATCAACAACATTGTGGATAATTCCGTTAAATTTATGGATAAAGAAAATTCGCAAGTGGTTATTAAT
GTTAAAGATGAGGAAAAGAGGGTTATTATAGAAATAGCTGATAATGGCCGGGGAATACCGCTTGACGCAATACCGAAAAT
TTTTGAGCGTTTTTACCGGGTAGATTCAGCCCGTACAGGAACTTCCGGCTCGGGGCTGGGACTCTCAATTGCTGCTAAGA
TTATTGAAGAGCACGGTGGGGAAATTTGGGCCAATAGTGTTTTAAATGAGGGAACCACGATAAGTTTTACCTTGAAAAAA
CTGGGGGAAGGCGCATGA

Upstream 100 bases:

>100_bases
CTTCGGCGGTGGGAATCTTCTTTGGGATATATCCGGCAAGAAAAGCAGCTAAGTTAGATCCGATTGAATCCTTAAGGTAT
GAGTAAAGGAGGTGCGGCCG

Downstream 100 bases:

>100_bases
AAAAGGTGCTTATTATCGAAGATGACCGGAGTATTGCGGAACTTGAGCGAGATTATTTGGAAGTGGCGGGGTTTTTGGTG
GAGATTGCAGTTAATGGTGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSLKFRLILSYLAMLVIPILLSAVASFLVGLIYIGDAGQAFNLPHGPKAFREVFRERQETINEVKINILKQPEKALSKSF
WAAEEKKLVNHQTYLVVKKGKDLIYASELMREQKLLEKLPAFGNPEEEGAIKAPDGKRYLLKQVDFYFSDKTPGSIYFIT
DVENVRKILTRFSITMLVVFLLILVATNGTLTFLVSRSILKPLSQLKQASEQIKNGNLDFTVKNSAKDEIGELFVAFEEM
RKRLKESEELKKQYEENRKELIANISHDLKTPITAIKGYVEGIRDGVADSPEKLSRYVDTIYRKILEVDGLIDELFLFSK
LDLKKLPFNFEKVNLNRYLSDVAEELEFDLRKKGIELKLHLPCQQVFVWADREKLKRVINNIVDNSVKFMDKENSQVVIN
VKDEEKRVIIEIADNGRGIPLDAIPKIFERFYRVDSARTGTSGSGLGLSIAAKIIEEHGGEIWANSVLNEGTTISFTLKK
LGEGA

Sequences:

>Translated_485_residues
MSLKFRLILSYLAMLVIPILLSAVASFLVGLIYIGDAGQAFNLPHGPKAFREVFRERQETINEVKINILKQPEKALSKSF
WAAEEKKLVNHQTYLVVKKGKDLIYASELMREQKLLEKLPAFGNPEEEGAIKAPDGKRYLLKQVDFYFSDKTPGSIYFIT
DVENVRKILTRFSITMLVVFLLILVATNGTLTFLVSRSILKPLSQLKQASEQIKNGNLDFTVKNSAKDEIGELFVAFEEM
RKRLKESEELKKQYEENRKELIANISHDLKTPITAIKGYVEGIRDGVADSPEKLSRYVDTIYRKILEVDGLIDELFLFSK
LDLKKLPFNFEKVNLNRYLSDVAEELEFDLRKKGIELKLHLPCQQVFVWADREKLKRVINNIVDNSVKFMDKENSQVVIN
VKDEEKRVIIEIADNGRGIPLDAIPKIFERFYRVDSARTGTSGSGLGLSIAAKIIEEHGGEIWANSVLNEGTTISFTLKK
LGEGA
>Mature_484_residues
SLKFRLILSYLAMLVIPILLSAVASFLVGLIYIGDAGQAFNLPHGPKAFREVFRERQETINEVKINILKQPEKALSKSFW
AAEEKKLVNHQTYLVVKKGKDLIYASELMREQKLLEKLPAFGNPEEEGAIKAPDGKRYLLKQVDFYFSDKTPGSIYFITD
VENVRKILTRFSITMLVVFLLILVATNGTLTFLVSRSILKPLSQLKQASEQIKNGNLDFTVKNSAKDEIGELFVAFEEMR
KRLKESEELKKQYEENRKELIANISHDLKTPITAIKGYVEGIRDGVADSPEKLSRYVDTIYRKILEVDGLIDELFLFSKL
DLKKLPFNFEKVNLNRYLSDVAEELEFDLRKKGIELKLHLPCQQVFVWADREKLKRVINNIVDNSVKFMDKENSQVVINV
KDEEKRVIIEIADNGRGIPLDAIPKIFERFYRVDSARTGTSGSGLGLSIAAKIIEEHGGEIWANSVLNEGTTISFTLKKL
GEGA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=29.2253521126761, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=26.9387755102041, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790861, Length=302, Percent_Identity=25.8278145695364, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=28.6919831223629, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788549, Length=266, Percent_Identity=27.8195488721804, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789808, Length=296, Percent_Identity=27.7027027027027, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789149, Length=337, Percent_Identity=25.2225519287834, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=27.0916334661355, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87081816, Length=351, Percent_Identity=22.2222222222222, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=340, Percent_Identity=23.8235294117647, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=24.5283018867925, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787894, Length=334, Percent_Identity=23.0538922155689, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=25.8064516129032, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=301, Percent_Identity=25.2491694352159, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=24.0174672489083, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=24.8322147651007, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=22.7091633466135, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=327, Percent_Identity=24.1590214067278, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=25.7261410788382, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=201, Percent_Identity=26.3681592039801, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55140; Mature: 55009

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKFRLILSYLAMLVIPILLSAVASFLVGLIYIGDAGQAFNLPHGPKAFREVFRERQET
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
INEVKINILKQPEKALSKSFWAAEEKKLVNHQTYLVVKKGKDLIYASELMREQKLLEKLP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
AFGNPEEEGAIKAPDGKRYLLKQVDFYFSDKTPGSIYFITDVENVRKILTRFSITMLVVF
CCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
LLILVATNGTLTFLVSRSILKPLSQLKQASEQIKNGNLDFTVKNSAKDEIGELFVAFEEM
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
RKRLKESEELKKQYEENRKELIANISHDLKTPITAIKGYVEGIRDGVADSPEKLSRYVDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IYRKILEVDGLIDELFLFSKLDLKKLPFNFEKVNLNRYLSDVAEELEFDLRKKGIELKLH
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCEEEEE
LPCQQVFVWADREKLKRVINNIVDNSVKFMDKENSQVVINVKDEEKRVIIEIADNGRGIP
CCHHHHHEECCHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCC
LDAIPKIFERFYRVDSARTGTSGSGLGLSIAAKIIEEHGGEIWANSVLNEGTTISFTLKK
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEHHH
LGEGA
CCCCC
>Mature Secondary Structure 
SLKFRLILSYLAMLVIPILLSAVASFLVGLIYIGDAGQAFNLPHGPKAFREVFRERQET
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
INEVKINILKQPEKALSKSFWAAEEKKLVNHQTYLVVKKGKDLIYASELMREQKLLEKLP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
AFGNPEEEGAIKAPDGKRYLLKQVDFYFSDKTPGSIYFITDVENVRKILTRFSITMLVVF
CCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
LLILVATNGTLTFLVSRSILKPLSQLKQASEQIKNGNLDFTVKNSAKDEIGELFVAFEEM
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
RKRLKESEELKKQYEENRKELIANISHDLKTPITAIKGYVEGIRDGVADSPEKLSRYVDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IYRKILEVDGLIDELFLFSKLDLKKLPFNFEKVNLNRYLSDVAEELEFDLRKKGIELKLH
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCEEEEE
LPCQQVFVWADREKLKRVINNIVDNSVKFMDKENSQVVINVKDEEKRVIIEIADNGRGIP
CCHHHHHEECCHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCC
LDAIPKIFERFYRVDSARTGTSGSGLGLSIAAKIIEEHGGEIWANSVLNEGTTISFTLKK
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEHHH
LGEGA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]