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The map label for this gene is pgi

Identifier: 78043246

GI number: 78043246

Start: 206121

End: 207515

Strand: Direct

Name: pgi

Synonym: CHY_0239

Alternate gene names: 78043246

Gene position: 206121-207515 (Clockwise)

Preceding gene: 78042881

Following gene: 78042788

Centisome position: 8.58

GC content: 45.52

Gene sequence:

>1395_bases
ATGGCGTTAAAAATTGACTTTAATAATGTCTTTCATCCATATCTGCAAAAGGAAAGGTTAGGGGAAGCGGATATTGATGG
TTATAAAGAAAAATTTACCTCTGCCCTTGTAAGCTTACGGGAGAAAAAAGAAAAAGGGGAATTGGGCTTCTTTCACCTGC
CGTATCTTCCGGAAGAAGAAATAGCTGAAATTGAAAAAACCGCCCGGGAGGTCCGGGAAAAATTTAAGTATTTTGTAGTC
TTGGGGATTGGCGGTTCTGCCTTAGGGCCTCTGGCGGTTCATACGGCATTAAACAATTTACGGTACAACGAGCTTTCCGA
GGAGCTTAGGGGTGGACCGAAATTTTATGTAGAAGATAACATTGACCCGGAGCGGATGGCTTCGCTTTTAAAGGTAATTG
AACCGGAAAAGACCGTTTTTAACGTTATTACCAAATCGGGGGCAACGGCCGAAACCTTATCCCAGTTATTAATAGTTACG
GAGGTACTAAAGAAAAAGGTTGGAAAGCGGTTTACTGAACACTTGATTTTTACTACCGATCCGGAAAAAGGAAGTTTAAG
GGCGCTTGCCCGGGAACTCGGGGTAAAAACCTTTGCCATTCCTCCTAACGTAGGCGGCCGTTTTTCCGAGTTGACACCTG
TGGGGCTATTACCGGCAGCGGTTACCGGTATTAACATCCGGGAGCTTTTAGCAGGAGCCCGGGAAATGGCGGAAAGGTGC
GAACGGGAAAACCTTTGGGAAAATCCGGCGGGTTTAGCGGCTGCCATTCACGTTTTGCTCTTGGAGCGGGGAAAAAATAT
GGCGGTTATGATGCCGTATGCCGACAGCTTAAAATATATGGCCGATTGGTACGCTCAATTACTCGGGGAAAGTATCGGTA
AAAGGTTAAACCGCCGGGGAGAAGAGGTTTTTGTAGGACAAACTCCGGTTAAAGCCCTGGGGGTCACCGATCAGCATTCT
CAGGTCCAGCTTTATACCGAAGGACCCTTTGATAAACTCCTGATTTTCTTGGAAGTAGAACGTTACCGGAATAGGGTGGT
GATTCCTCCGGATTTTCCGCAGTATGCTGAACTAAAGTTCTTGGGCGGACATACTTTAAACGAGCTTATTATAGCGGAGA
AAAAAGCTACCGAATTTGCTCTTTTGAAAGCGAGAAGACCAAACTATACCGTAATTTTCCCGGAGGTAAATCCCTATACG
GTGGGCGAGCTTCTCTATTTCTTAGAGGCGAAAATTGCTTTTATGGGAGAATATCTTGATATTAATGCTTTTGACCAGCC
CGGGGTGGAGGAAGGAAAAAAGGCCACCTATGCGCTCCTGGGTCGGGAAGGGTTTGAAGAGAAACGGCAGGAAGTTTTAA
AGGTAAAAAAAGAACCGCGGTTTATTCTGGAATAA

Upstream 100 bases:

>100_bases
TCTTTTCCTATCACTATTTTAGCATATACTTTCTTTAAAATACCAAAAATTTGGGGTAAAATAATCCTGATATACAAATT
TTAAGCACTGGAGGGGTATA

Downstream 100 bases:

>100_bases
GAGGAGTGCCAAACTCCAACCTCCAGCATCCCGCCTCCAGAAGAGTTGGCCCGCTTTAAAAATTCTCCCTTATAAACCGA
TACAACTCATAAAAATCCCC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MALKIDFNNVFHPYLQKERLGEADIDGYKEKFTSALVSLREKKEKGELGFFHLPYLPEEEIAEIEKTAREVREKFKYFVV
LGIGGSALGPLAVHTALNNLRYNELSEELRGGPKFYVEDNIDPERMASLLKVIEPEKTVFNVITKSGATAETLSQLLIVT
EVLKKKVGKRFTEHLIFTTDPEKGSLRALARELGVKTFAIPPNVGGRFSELTPVGLLPAAVTGINIRELLAGAREMAERC
ERENLWENPAGLAAAIHVLLLERGKNMAVMMPYADSLKYMADWYAQLLGESIGKRLNRRGEEVFVGQTPVKALGVTDQHS
QVQLYTEGPFDKLLIFLEVERYRNRVVIPPDFPQYAELKFLGGHTLNELIIAEKKATEFALLKARRPNYTVIFPEVNPYT
VGELLYFLEAKIAFMGEYLDINAFDQPGVEEGKKATYALLGREGFEEKRQEVLKVKKEPRFILE

Sequences:

>Translated_464_residues
MALKIDFNNVFHPYLQKERLGEADIDGYKEKFTSALVSLREKKEKGELGFFHLPYLPEEEIAEIEKTAREVREKFKYFVV
LGIGGSALGPLAVHTALNNLRYNELSEELRGGPKFYVEDNIDPERMASLLKVIEPEKTVFNVITKSGATAETLSQLLIVT
EVLKKKVGKRFTEHLIFTTDPEKGSLRALARELGVKTFAIPPNVGGRFSELTPVGLLPAAVTGINIRELLAGAREMAERC
ERENLWENPAGLAAAIHVLLLERGKNMAVMMPYADSLKYMADWYAQLLGESIGKRLNRRGEEVFVGQTPVKALGVTDQHS
QVQLYTEGPFDKLLIFLEVERYRNRVVIPPDFPQYAELKFLGGHTLNELIIAEKKATEFALLKARRPNYTVIFPEVNPYT
VGELLYFLEAKIAFMGEYLDINAFDQPGVEEGKKATYALLGREGFEEKRQEVLKVKKEPRFILE
>Mature_463_residues
ALKIDFNNVFHPYLQKERLGEADIDGYKEKFTSALVSLREKKEKGELGFFHLPYLPEEEIAEIEKTAREVREKFKYFVVL
GIGGSALGPLAVHTALNNLRYNELSEELRGGPKFYVEDNIDPERMASLLKVIEPEKTVFNVITKSGATAETLSQLLIVTE
VLKKKVGKRFTEHLIFTTDPEKGSLRALARELGVKTFAIPPNVGGRFSELTPVGLLPAAVTGINIRELLAGAREMAERCE
RENLWENPAGLAAAIHVLLLERGKNMAVMMPYADSLKYMADWYAQLLGESIGKRLNRRGEEVFVGQTPVKALGVTDQHSQ
VQLYTEGPFDKLLIFLEVERYRNRVVIPPDFPQYAELKFLGGHTLNELIIAEKKATEFALLKARRPNYTVIFPEVNPYTV
GELLYFLEAKIAFMGEYLDINAFDQPGVEEGKKATYALLGREGFEEKRQEVLKVKKEPRFILE

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=390, Percent_Identity=28.2051282051282, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI296080693, Length=380, Percent_Identity=27.3684210526316, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1790457, Length=379, Percent_Identity=27.4406332453826, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71996708, Length=406, Percent_Identity=27.3399014778325, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71996703, Length=406, Percent_Identity=27.3399014778325, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319673, Length=377, Percent_Identity=26.790450928382, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651916, Length=392, Percent_Identity=27.2959183673469, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24651914, Length=392, Percent_Identity=27.2959183673469, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17737445, Length=392, Percent_Identity=27.2959183673469, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CARHZ (Q3AFH3)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359111.1
- STRING:   Q3AFH3
- GeneID:   3728629
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0239
- NMPDR:   fig|246194.3.peg.215
- TIGR:   CHY_0239
- eggNOG:   COG0166
- HOGENOM:   HBG615843
- OMA:   LLPAWLN
- ProtClustDB:   PRK00973
- BioCyc:   CHYD246194:CHY_0239-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 52456; Mature: 52325

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 290-290 ACT_SITE 319-319 ACT_SITE 433-433

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKIDFNNVFHPYLQKERLGEADIDGYKEKFTSALVSLREKKEKGELGFFHLPYLPEEE
CEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHH
IAEIEKTAREVREKFKYFVVLGIGGSALGPLAVHTALNNLRYNELSEELRGGPKFYVEDN
HHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEEECCC
IDPERMASLLKVIEPEKTVFNVITKSGATAETLSQLLIVTEVLKKKVGKRFTEHLIFTTD
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECC
PEKGSLRALARELGVKTFAIPPNVGGRFSELTPVGLLPAAVTGINIRELLAGAREMAERC
CCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
ERENLWENPAGLAAAIHVLLLERGKNMAVMMPYADSLKYMADWYAQLLGESIGKRLNRRG
HHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EEVFVGQTPVKALGVTDQHSQVQLYTEGPFDKLLIFLEVERYRNRVVIPPDFPQYAELKF
CEEEECCCCHHHCCCCCCCCEEEEEECCCHHHEEEEEEEHHHCCEEEECCCCCCHHCEEE
LGGHTLNELIIAEKKATEFALLKARRPNYTVIFPEVNPYTVGELLYFLEAKIAFMGEYLD
ECCCCHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEE
INAFDQPGVEEGKKATYALLGREGFEEKRQEVLKVKKEPRFILE
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ALKIDFNNVFHPYLQKERLGEADIDGYKEKFTSALVSLREKKEKGELGFFHLPYLPEEE
EEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHH
IAEIEKTAREVREKFKYFVVLGIGGSALGPLAVHTALNNLRYNELSEELRGGPKFYVEDN
HHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEEECCC
IDPERMASLLKVIEPEKTVFNVITKSGATAETLSQLLIVTEVLKKKVGKRFTEHLIFTTD
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECC
PEKGSLRALARELGVKTFAIPPNVGGRFSELTPVGLLPAAVTGINIRELLAGAREMAERC
CCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
ERENLWENPAGLAAAIHVLLLERGKNMAVMMPYADSLKYMADWYAQLLGESIGKRLNRRG
HHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EEVFVGQTPVKALGVTDQHSQVQLYTEGPFDKLLIFLEVERYRNRVVIPPDFPQYAELKF
CEEEECCCCHHHCCCCCCCCEEEEEECCCHHHEEEEEEEHHHCCEEEECCCCCCHHCEEE
LGGHTLNELIIAEKKATEFALLKARRPNYTVIFPEVNPYTVGELLYFLEAKIAFMGEYLD
ECCCCHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEE
INAFDQPGVEEGKKATYALLGREGFEEKRQEVLKVKKEPRFILE
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA