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The map label for this gene is coxM [H]

Identifier: 78043119

GI number: 78043119

Start: 603389

End: 604249

Strand: Direct

Name: coxM [H]

Synonym: CHY_0690

Alternate gene names: 78043119

Gene position: 603389-604249 (Clockwise)

Preceding gene: 78042715

Following gene: 78043859

Centisome position: 25.13

GC content: 48.55

Gene sequence:

>861_bases
ATGCAAAAGGTTGATTATTTTCGACCCGAAACCATAGAGGAAGCCCTGGAGCTTTTAGCCGCTGGTCGGGAAGAGTATAA
AATTCTCGCTGGCGGTACCGACCTGGTGCTTCATTTACGGGAGAGGAAAGTTAGTCCTAAGGCTTTGGTGGATATCACTC
ATATTTCTGCTCTTCGGGGCATTAGAGAAGAACAAGGAAAAATTATTATTAAAGCGGCAACAACCTTTACGGAAGTTGCC
ACCTCCTCAATTGTTTTAGAAAAAATCCCGGCCCTTGCCGATGCCTGTAAAGTTGTGGGCTCACCGCAAATTCGCAATCA
AGGGACCATTGGGGGCAATATAGTAAACGCCTCTCCAGCCGCCGATTCGGTACCGGCGTTGGTGCTGTTTGATGGGGTAG
CCAAACTTAAAAGTAAAAGGGGTACCCGGGAGATTTTACTTACCGAGCTTCTCAAGGGAGCCGGAAAAACAGCAATTGAA
CCGGATGAGTTGTTAGAAGAGGTTATTTTAACGCCGTATCCAGGAAGTGTCAGCGGTTTTTACAAACTCGGGCGACGGAA
TGCCCTGGCGATATCGCGGATTTCTGGAGCGGTGGAGCTTGTTTTTGCCGGCAGCAAAATTGAAAAGGCAAGAGTGGCCC
TGGGTTCGGTTGCTCCCAATCCCTTTCGGGCAGCAGAATTAGAACAGTTTTTAAGCGGTCGGGAATTTAACGAAGAAACT
AAAGAAGAGCTTATCGTTCTTGCCAAAAAGTTGGTGGCGGATAAGCTTGGCAGTCGTGCATCGGCGCCCTACAAACGCGA
AGCGATTGCCGGAGTTATGCGGGAAATTTTAAATCTCATTGAACAGCGCCGGGGGAGGTAG

Upstream 100 bases:

>100_bases
CTTTGACCACCAGTCCCAAGTGGAAAATTACCGACCAGGGTTTAATTGATGTTAATAGTTTTGCCATCATTCCGCCGGTT
AAGTAAGGAGGGGCACTTAT

Downstream 100 bases:

>100_bases
CGGCCGTGGAGATGAAAAAGCTTTCCCTTACTGTTAACGGAAAATTAATTGAAAGGGAAGTACCAACCAACATCCGCCTT
CTCGATTTCCTTAGAGATTA

Product: carbon monoxide dehydrogenase medium subunit

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase FAD-subunit; NAH [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MQKVDYFRPETIEEALELLAAGREEYKILAGGTDLVLHLRERKVSPKALVDITHISALRGIREEQGKIIIKAATTFTEVA
TSSIVLEKIPALADACKVVGSPQIRNQGTIGGNIVNASPAADSVPALVLFDGVAKLKSKRGTREILLTELLKGAGKTAIE
PDELLEEVILTPYPGSVSGFYKLGRRNALAISRISGAVELVFAGSKIEKARVALGSVAPNPFRAAELEQFLSGREFNEET
KEELIVLAKKLVADKLGSRASAPYKREAIAGVMREILNLIEQRRGR

Sequences:

>Translated_286_residues
MQKVDYFRPETIEEALELLAAGREEYKILAGGTDLVLHLRERKVSPKALVDITHISALRGIREEQGKIIIKAATTFTEVA
TSSIVLEKIPALADACKVVGSPQIRNQGTIGGNIVNASPAADSVPALVLFDGVAKLKSKRGTREILLTELLKGAGKTAIE
PDELLEEVILTPYPGSVSGFYKLGRRNALAISRISGAVELVFAGSKIEKARVALGSVAPNPFRAAELEQFLSGREFNEET
KEELIVLAKKLVADKLGSRASAPYKREAIAGVMREILNLIEQRRGR
>Mature_286_residues
MQKVDYFRPETIEEALELLAAGREEYKILAGGTDLVLHLRERKVSPKALVDITHISALRGIREEQGKIIIKAATTFTEVA
TSSIVLEKIPALADACKVVGSPQIRNQGTIGGNIVNASPAADSVPALVLFDGVAKLKSKRGTREILLTELLKGAGKTAIE
PDELLEEVILTPYPGSVSGFYKLGRRNALAISRISGAVELVFAGSKIEKARVALGSVAPNPFRAAELEQFLSGREFNEET
KEELIVLAKKLVADKLGSRASAPYKREAIAGVMREILNLIEQRRGR

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1319

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=278, Percent_Identity=25.1798561151079, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789231, Length=276, Percent_Identity=32.2463768115942, Blast_Score=146, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17737937, Length=281, Percent_Identity=25.2669039145907, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 30963; Mature: 30963

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVDYFRPETIEEALELLAAGREEYKILAGGTDLVLHLRERKVSPKALVDITHISALRG
CCCCCCCCCHHHHHHHHHHHCCCHHEEEEECCHHHHHEEHHHCCCCHHHHHHHHHHHHHH
IREEQGKIIIKAATTFTEVATSSIVLEKIPALADACKVVGSPQIRNQGTIGGNIVNASPA
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCC
ADSVPALVLFDGVAKLKSKRGTREILLTELLKGAGKTAIEPDELLEEVILTPYPGSVSGF
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHH
YKLGRRNALAISRISGAVELVFAGSKIEKARVALGSVAPNPFRAAELEQFLSGREFNEET
HHHCCCCHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHH
KEELIVLAKKLVADKLGSRASAPYKREAIAGVMREILNLIEQRRGR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKVDYFRPETIEEALELLAAGREEYKILAGGTDLVLHLRERKVSPKALVDITHISALRG
CCCCCCCCCHHHHHHHHHHHCCCHHEEEEECCHHHHHEEHHHCCCCHHHHHHHHHHHHHH
IREEQGKIIIKAATTFTEVATSSIVLEKIPALADACKVVGSPQIRNQGTIGGNIVNASPA
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCC
ADSVPALVLFDGVAKLKSKRGTREILLTELLKGAGKTAIEPDELLEEVILTPYPGSVSGF
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHH
YKLGRRNALAISRISGAVELVFAGSKIEKARVALGSVAPNPFRAAELEQFLSGREFNEET
HHHCCCCHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHH
KEELIVLAKKLVADKLGSRASAPYKREAIAGVMREILNLIEQRRGR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA