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The map label for this gene is moeA [C]

Identifier: 78043077

GI number: 78043077

Start: 707619

End: 708848

Strand: Direct

Name: moeA [C]

Synonym: CHY_0798

Alternate gene names: 78043077

Gene position: 707619-708848 (Clockwise)

Preceding gene: 78043695

Following gene: 78045151

Centisome position: 29.47

GC content: 44.63

Gene sequence:

>1230_bases
ATGAAAGAACTTTTAAATTTAATTACTCCAGAAGAAGCATTAAAGCTCTTAAAAAGTAATTTTAAAGTGTCGTTAAAAGC
TACTGAAATAGAACTTTCCCAGGCTTTTGGCAAAATTTTAGCAGAGCCGGTAAAAGCCCTGGAAAATATACCTCCATTTT
CTCGCTCTACGGTTGATGGTTATGCGGTTTTTGCGGAAGACACTTTTGGCGCAACGGAAACTTTTCCTGTACTATTAAAG
CTAAAAGGCGAAATAGGAATGGGGGAGGTTCCGGAATTTGCTCTGGGACCCGGGGAAGCGGTGCGAATTTTTACCGGTGG
GGCCCTGCCGGAAGGTGCCGATAGTGTAGTGATGGTCGAGCATACCGAACTGTTTGACTCCGAAACTGTTTCGGTTTTAA
AACCGGTGGCACCGGGAGAAAATGTTATTGCCGCGGGAGAGGATTTTAAAGAAGGGGAAGTGGTTTTGGAAAAGGGGACG
AGAATTCGTCCTCAGGAACTTGGGGTTTTGGCTGCGCTGGGTTACAGCAAGGTTACCGTTTATAATTCTTTAAAAGTAGG
AATTATTTCTACCGGTGATGAACTGGTTCCGGTGGAAACCAAGTTAAAACCGGGACAAATTCGGGATACCAATGCCTATC
TTTTGGTGGGACGAATTCTTGATTTAGGGATGCAACCGGTGTATTTTGGCATAGTTCCCGATAGATTTGAAGAGCTAATT
AAAGCAATTAAGAAAGCCCTCCTGGAAACCGATATCGTTCTTTTATCCGGCGGCACTTCCATGGGGGTAAAGGATATGGT
AGTGGATGCTATAAATAGCCTGGGGACTCCCGGGGTTTTATTCCATGGTCTTGCCATAAAGCCCGGAAAACCCACCATAG
GCGGAGGTATCAACGGCAAACCTATTCTCGGTCTTCCCGGCCATCCCGCTTCTGCTTTAATGGTTTTTGAGCGAATTGGT
GTACCCTTTTTGCGCTATCTTTCCGGGTTAAAAAGTAGCTATCAGCCCCGGGTAAAAGCCACCTTAACTTTAAATCTTCC
TTCCAAAACCGGTCAGGAAGATTTATACCGGGTAATGTTAACCCAGAAAGAACAGGGCTATTTAGCCACTCCAATTTTAG
GCAAGTCGGGATTAATAAATACCTTAACCCGGGCTGATGGTTATGTAATGGTGCCGTTAGATATTGAAGGGCTGCATGCC
GGGGAAGAAGTGGAAGTTATTTTGTTTTAG

Upstream 100 bases:

>100_bases
TTAAATGTTCCGCCCAAAAAAATTGGTGATGCTGCTAATGAACTAAAAATAAAAATTTCAGCCTGTCAGTTAGGCTGTTT
TAAATAAACGGTGACATCTT

Downstream 100 bases:

>100_bases
GGGGTTTAGAGAAATTGGCCTTTTATTTAAACCAGGTACCTTTTGAAGAGGCATGGGAAAATTTCGAAAGCGAACTTTTA
AATGTTAATTTTTTTCATCC

Product: putative molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKELLNLITPEEALKLLKSNFKVSLKATEIELSQAFGKILAEPVKALENIPPFSRSTVDGYAVFAEDTFGATETFPVLLK
LKGEIGMGEVPEFALGPGEAVRIFTGGALPEGADSVVMVEHTELFDSETVSVLKPVAPGENVIAAGEDFKEGEVVLEKGT
RIRPQELGVLAALGYSKVTVYNSLKVGIISTGDELVPVETKLKPGQIRDTNAYLLVGRILDLGMQPVYFGIVPDRFEELI
KAIKKALLETDIVLLSGGTSMGVKDMVVDAINSLGTPGVLFHGLAIKPGKPTIGGGINGKPILGLPGHPASALMVFERIG
VPFLRYLSGLKSSYQPRVKATLTLNLPSKTGQEDLYRVMLTQKEQGYLATPILGKSGLINTLTRADGYVMVPLDIEGLHA
GEEVEVILF

Sequences:

>Translated_409_residues
MKELLNLITPEEALKLLKSNFKVSLKATEIELSQAFGKILAEPVKALENIPPFSRSTVDGYAVFAEDTFGATETFPVLLK
LKGEIGMGEVPEFALGPGEAVRIFTGGALPEGADSVVMVEHTELFDSETVSVLKPVAPGENVIAAGEDFKEGEVVLEKGT
RIRPQELGVLAALGYSKVTVYNSLKVGIISTGDELVPVETKLKPGQIRDTNAYLLVGRILDLGMQPVYFGIVPDRFEELI
KAIKKALLETDIVLLSGGTSMGVKDMVVDAINSLGTPGVLFHGLAIKPGKPTIGGGINGKPILGLPGHPASALMVFERIG
VPFLRYLSGLKSSYQPRVKATLTLNLPSKTGQEDLYRVMLTQKEQGYLATPILGKSGLINTLTRADGYVMVPLDIEGLHA
GEEVEVILF
>Mature_409_residues
MKELLNLITPEEALKLLKSNFKVSLKATEIELSQAFGKILAEPVKALENIPPFSRSTVDGYAVFAEDTFGATETFPVLLK
LKGEIGMGEVPEFALGPGEAVRIFTGGALPEGADSVVMVEHTELFDSETVSVLKPVAPGENVIAAGEDFKEGEVVLEKGT
RIRPQELGVLAALGYSKVTVYNSLKVGIISTGDELVPVETKLKPGQIRDTNAYLLVGRILDLGMQPVYFGIVPDRFEELI
KAIKKALLETDIVLLSGGTSMGVKDMVVDAINSLGTPGVLFHGLAIKPGKPTIGGGINGKPILGLPGHPASALMVFERIG
VPFLRYLSGLKSSYQPRVKATLTLNLPSKTGQEDLYRVMLTQKEQGYLATPILGKSGLINTLTRADGYVMVPLDIEGLHA
GEEVEVILF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=399, Percent_Identity=35.0877192982456, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI66932975, Length=399, Percent_Identity=35.0877192982456, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1787049, Length=398, Percent_Identity=33.9195979899498, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25147659, Length=351, Percent_Identity=33.048433048433, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=344, Percent_Identity=26.1627906976744, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136978, Length=325, Percent_Identity=29.8461538461538, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24638841, Length=325, Percent_Identity=29.8461538461538, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43781; Mature: 43781

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELLNLITPEEALKLLKSNFKVSLKATEIELSQAFGKILAEPVKALENIPPFSRSTVDG
CHHHHHHCCHHHHHHHHHCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
YAVFAEDTFGATETFPVLLKLKGEIGMGEVPEFALGPGEAVRIFTGGALPEGADSVVMVE
EEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEE
HTELFDSETVSVLKPVAPGENVIAAGEDFKEGEVVLEKGTRIRPQELGVLAALGYSKVTV
EHHHCCCCCHHHHCCCCCCCCEEECCCCCCCCCEEEECCCCCCHHHCCEEEECCCCEEEE
YNSLKVGIISTGDELVPVETKLKPGQIRDTNAYLLVGRILDLGMQPVYFGIVPDRFEELI
EECEEEEEEECCCCEEEEECCCCCCCEECCCCEEEEEHHHHCCCCCEEEECCHHHHHHHH
KAIKKALLETDIVLLSGGTSMGVKDMVVDAINSLGTPGVLFHGLAIKPGKPTIGGGINGK
HHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCC
PILGLPGHPASALMVFERIGVPFLRYLSGLKSSYQPRVKATLTLNLPSKTGQEDLYRVML
EEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHH
TQKEQGYLATPILGKSGLINTLTRADGYVMVPLDIEGLHAGEEVEVILF
CCCCCCEEECCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCEEEEEEC
>Mature Secondary Structure
MKELLNLITPEEALKLLKSNFKVSLKATEIELSQAFGKILAEPVKALENIPPFSRSTVDG
CHHHHHHCCHHHHHHHHHCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
YAVFAEDTFGATETFPVLLKLKGEIGMGEVPEFALGPGEAVRIFTGGALPEGADSVVMVE
EEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEE
HTELFDSETVSVLKPVAPGENVIAAGEDFKEGEVVLEKGTRIRPQELGVLAALGYSKVTV
EHHHCCCCCHHHHCCCCCCCCEEECCCCCCCCCEEEECCCCCCHHHCCEEEECCCCEEEE
YNSLKVGIISTGDELVPVETKLKPGQIRDTNAYLLVGRILDLGMQPVYFGIVPDRFEELI
EECEEEEEEECCCCEEEEECCCCCCCEECCCCEEEEEHHHHCCCCCEEEECCHHHHHHHH
KAIKKALLETDIVLLSGGTSMGVKDMVVDAINSLGTPGVLFHGLAIKPGKPTIGGGINGK
HHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCC
PILGLPGHPASALMVFERIGVPFLRYLSGLKSSYQPRVKATLTLNLPSKTGQEDLYRVML
EEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHH
TQKEQGYLATPILGKSGLINTLTRADGYVMVPLDIEGLHAGEEVEVILF
CCCCCCEEECCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]