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The map label for this gene is moeA [C]

Identifier: 78045151

GI number: 78045151

Start: 708863

End: 710767

Strand: Direct

Name: moeA [C]

Synonym: CHY_0799

Alternate gene names: 78045151

Gene position: 708863-710767 (Clockwise)

Preceding gene: 78043077

Following gene: 78043212

Centisome position: 29.52

GC content: 42.99

Gene sequence:

>1905_bases
TTGGCCTTTTATTTAAACCAGGTACCTTTTGAAGAGGCATGGGAAAATTTCGAAAGCGAACTTTTAAATGTTAATTTTTT
TCATCCCCGGGAAGAAGAAATTGAAACCGTTTTGGCGGTGGGACGGATAACTTGTGAGCCGGTTCTGGCCAAGCGTTCCA
ATCCTCATTTCAATGCCTCGGCGGTGGATGGTTTTGCCGTCAAGGCTAAAGACACCTTTTATGCCCGGGAGACAAGTCCA
ATTTTATTAAAAATCGGTGAGTCATGTATAAGGGTTGATACCGGAGACCTTATCCCCGAAGGATTTGATGCGGTAATTAT
GGTGGAAGATGTCCTTTATCCAGAACCTGGAGTGATTTCGGTAATTAAACCGGTAACTCCCGGAACAAATATCCGTTTTC
TTGGGGAAGACTTTAATGAGGAGGAAGTTTTGCTACCGGCTTTTGCCAAGGTGAAGCCTGCTGACATTGGGGCCCTTCTG
GCGGGCGGAGTAAAGACGCTTAAAGTGTTAAAAAAATTAAAAGCTCTTTTTATTCCTACCGGCGATGAAATAATCCCGTT
TACAGAAACGCCAGAGCCCGGGCAAATTCCCGATACCAACTCTTCCTTTATTAAAGCTGTTCTTGCCGAATACGGGTACG
AAACTTCCATTCATCCTATTGTCAAAGATGATCCGGAGCTTTTGTATAAGACGGTAAAGGATAATTTAGAGAAATACGAC
GTAATAATTATTAATGCCGGCTCTTCGGCCGGACGGGACGATTATGCTGCTAAAGTGATTGAACGTTTGGGGCGGGTTTT
AGTCCATGGCCTTGCTACCAAACCCGGTAAGCCAACCGTTTTAGGAATTGCCGGAAATAAACCGGTAATCGGACTTCCTG
GTTTTCCCTTATCGGCTTATTTGGTCTGTGAAATAATCTTAAAACCTCTGGCGGAAAAGTATTACAAAAATAAGTTTCAC
GACTATGGCAAAATTAAAGCAACCTTAACTAAAACTTTGATATCTACCACCGGAGTAGATGATTTTGTCTGGGGAAAAGT
GAGCCGGGTAGCCGGCAGGTATTGTTTTACACCCTTATCGCGCGGAGCCAGTGTCAGCTCCACTCTTTTAAAAGCCAATG
CTTTACTCAGGATTCCTCGCTTTTCCGAAGGGTATAAAGAGGGAATGGAAATCGAAGTAACCCTTAAAGAACCACCGGCG
GAAGTGGACCAATACCTGACCGTTACCGGAAGTCATGATCTTTTACTGGACCTTATAGATTCTTTCTTACGGGAAAAATA
CGGAATTAAACTTAGTTCTTCACATGTTGGAAGCTTAAACGGTATTGTGGCAATTGAAAAAAATTACGCTAAGCTTGCCG
GAGTGCATTTATTAGATCCGGCAACGGGGGATTATAATCAAAGTTATGTGGAAAAAAGGCTAAAAGGTTATGTTCTTATA
AATTTAAGTTTGCGGGAACAGGGTTTAATCGTTGCCCGGGGAAACCCCAGGAAAATTTCCGGTCTTGCCGATTTAGTAAA
ACCCGGGGTTACCTTTGTCAACCGGCAAAAAGGCTCCGGAACCCGGGTGTTTTTGGATTACCTGTTAAATAAAGAAAACA
TCAACCCCCGTCAGATTTCCGGATATGACCGGGAAGAATACACCCATCTGGCGGTAGCGGCGAAAGTAAAAAATGGTCTT
GCCGATTGCGGGATGGGAATTTTTGCTGCTGCTAAAATCTTTGACCTGGATTTTATTCCGTTAGGAGAAGAACGGTATGA
CCTTTTGCTGCGGGAAGATACTTTGGAAGATCCGCAGGTTAAGAAATTGTTAGAGGTAATAACCAGTGAAGAATTTAAAA
AAGAAGTAGAAAGAATAGGCGGATATAAAACTACGTTAACAGGACAAATTGTGGGGAAAGGATAG

Upstream 100 bases:

>100_bases
TAACCCGGGCTGATGGTTATGTAATGGTGCCGTTAGATATTGAAGGGCTGCATGCCGGGGAAGAAGTGGAAGTTATTTTG
TTTTAGGGGGTTTAGAGAAA

Downstream 100 bases:

>100_bases
GATTATGGAGATAGTAAATAAAAGAAACATTATTCGTTATTTTGACGGACGCCTGGAAGAAAAAGAAGATTTACTGGTGG
ATGAAGCGCCTCTTACCATT

Product: putative molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MAFYLNQVPFEEAWENFESELLNVNFFHPREEEIETVLAVGRITCEPVLAKRSNPHFNASAVDGFAVKAKDTFYARETSP
ILLKIGESCIRVDTGDLIPEGFDAVIMVEDVLYPEPGVISVIKPVTPGTNIRFLGEDFNEEEVLLPAFAKVKPADIGALL
AGGVKTLKVLKKLKALFIPTGDEIIPFTETPEPGQIPDTNSSFIKAVLAEYGYETSIHPIVKDDPELLYKTVKDNLEKYD
VIIINAGSSAGRDDYAAKVIERLGRVLVHGLATKPGKPTVLGIAGNKPVIGLPGFPLSAYLVCEIILKPLAEKYYKNKFH
DYGKIKATLTKTLISTTGVDDFVWGKVSRVAGRYCFTPLSRGASVSSTLLKANALLRIPRFSEGYKEGMEIEVTLKEPPA
EVDQYLTVTGSHDLLLDLIDSFLREKYGIKLSSSHVGSLNGIVAIEKNYAKLAGVHLLDPATGDYNQSYVEKRLKGYVLI
NLSLREQGLIVARGNPRKISGLADLVKPGVTFVNRQKGSGTRVFLDYLLNKENINPRQISGYDREEYTHLAVAAKVKNGL
ADCGMGIFAAAKIFDLDFIPLGEERYDLLLREDTLEDPQVKKLLEVITSEEFKKEVERIGGYKTTLTGQIVGKG

Sequences:

>Translated_634_residues
MAFYLNQVPFEEAWENFESELLNVNFFHPREEEIETVLAVGRITCEPVLAKRSNPHFNASAVDGFAVKAKDTFYARETSP
ILLKIGESCIRVDTGDLIPEGFDAVIMVEDVLYPEPGVISVIKPVTPGTNIRFLGEDFNEEEVLLPAFAKVKPADIGALL
AGGVKTLKVLKKLKALFIPTGDEIIPFTETPEPGQIPDTNSSFIKAVLAEYGYETSIHPIVKDDPELLYKTVKDNLEKYD
VIIINAGSSAGRDDYAAKVIERLGRVLVHGLATKPGKPTVLGIAGNKPVIGLPGFPLSAYLVCEIILKPLAEKYYKNKFH
DYGKIKATLTKTLISTTGVDDFVWGKVSRVAGRYCFTPLSRGASVSSTLLKANALLRIPRFSEGYKEGMEIEVTLKEPPA
EVDQYLTVTGSHDLLLDLIDSFLREKYGIKLSSSHVGSLNGIVAIEKNYAKLAGVHLLDPATGDYNQSYVEKRLKGYVLI
NLSLREQGLIVARGNPRKISGLADLVKPGVTFVNRQKGSGTRVFLDYLLNKENINPRQISGYDREEYTHLAVAAKVKNGL
ADCGMGIFAAAKIFDLDFIPLGEERYDLLLREDTLEDPQVKKLLEVITSEEFKKEVERIGGYKTTLTGQIVGKG
>Mature_633_residues
AFYLNQVPFEEAWENFESELLNVNFFHPREEEIETVLAVGRITCEPVLAKRSNPHFNASAVDGFAVKAKDTFYARETSPI
LLKIGESCIRVDTGDLIPEGFDAVIMVEDVLYPEPGVISVIKPVTPGTNIRFLGEDFNEEEVLLPAFAKVKPADIGALLA
GGVKTLKVLKKLKALFIPTGDEIIPFTETPEPGQIPDTNSSFIKAVLAEYGYETSIHPIVKDDPELLYKTVKDNLEKYDV
IIINAGSSAGRDDYAAKVIERLGRVLVHGLATKPGKPTVLGIAGNKPVIGLPGFPLSAYLVCEIILKPLAEKYYKNKFHD
YGKIKATLTKTLISTTGVDDFVWGKVSRVAGRYCFTPLSRGASVSSTLLKANALLRIPRFSEGYKEGMEIEVTLKEPPAE
VDQYLTVTGSHDLLLDLIDSFLREKYGIKLSSSHVGSLNGIVAIEKNYAKLAGVHLLDPATGDYNQSYVEKRLKGYVLIN
LSLREQGLIVARGNPRKISGLADLVKPGVTFVNRQKGSGTRVFLDYLLNKENINPRQISGYDREEYTHLAVAAKVKNGLA
DCGMGIFAAAKIFDLDFIPLGEERYDLLLREDTLEDPQVKKLLEVITSEEFKKEVERIGGYKTTLTGQIVGKG

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=390, Percent_Identity=29.7435897435897, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI10880983, Length=390, Percent_Identity=29.7435897435897, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1787049, Length=333, Percent_Identity=31.8318318318318, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25147659, Length=319, Percent_Identity=31.6614420062696, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=377, Percent_Identity=22.2811671087533, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136978, Length=271, Percent_Identity=26.5682656826568, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24638841, Length=271, Percent_Identity=26.5682656826568, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 69847; Mature: 69716

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFYLNQVPFEEAWENFESELLNVNFFHPREEEIETVLAVGRITCEPVLAKRSNPHFNAS
CEEECCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCC
AVDGFAVKAKDTFYARETSPILLKIGESCIRVDTGDLIPEGFDAVIMVEDVLYPEPGVIS
CCCCEEEEECCCEEECCCCCEEEEECCHHEEECCCCCCCCCCCEEEEEEECCCCCCCEEE
VIKPVTPGTNIRFLGEDFNEEEVLLPAFAKVKPADIGALLAGGVKTLKVLKKLKALFIPT
EEECCCCCCCEEEECCCCCCCCEEECHHHCCCCCHHHHHHHCHHHHHHHHHHHHHEECCC
GDEIIPFTETPEPGQIPDTNSSFIKAVLAEYGYETSIHPIVKDDPELLYKTVKDNLEKYD
CCCEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEE
VIIINAGSSAGRDDYAAKVIERLGRVLVHGLATKPGKPTVLGIAGNKPVIGLPGFPLSAY
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCHHHH
LVCEIILKPLAEKYYKNKFHDYGKIKATLTKTLISTTGVDDFVWGKVSRVAGRYCFTPLS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHCCHHC
RGASVSSTLLKANALLRIPRFSEGYKEGMEIEVTLKEPPAEVDQYLTVTGSHDLLLDLID
CCCCHHHHHHHHHHEEECCCCCCHHHCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHH
SFLREKYGIKLSSSHVGSLNGIVAIEKNYAKLAGVHLLDPATGDYNQSYVEKRLKGYVLI
HHHHHHHCCEECCCCCCCCCCEEEEECCHHHHCCEEEECCCCCCCCHHHHHHHHCEEEEE
NLSLREQGLIVARGNPRKISGLADLVKPGVTFVNRQKGSGTRVFLDYLLNKENINPRQIS
EEEECCCCEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCEEHEEHHHCCCCCCCCCCC
GYDREEYTHLAVAAKVKNGLADCGMGIFAAAKIFDLDFIPLGEERYDLLLREDTLEDPQV
CCCHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHEECEEEECCCHHHHEEEECCCCCCHHH
KKLLEVITSEEFKKEVERIGGYKTTLTGQIVGKG
HHHHHHHCCHHHHHHHHHHCCEEEEEEEEEEECC
>Mature Secondary Structure 
AFYLNQVPFEEAWENFESELLNVNFFHPREEEIETVLAVGRITCEPVLAKRSNPHFNAS
EEECCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCC
AVDGFAVKAKDTFYARETSPILLKIGESCIRVDTGDLIPEGFDAVIMVEDVLYPEPGVIS
CCCCEEEEECCCEEECCCCCEEEEECCHHEEECCCCCCCCCCCEEEEEEECCCCCCCEEE
VIKPVTPGTNIRFLGEDFNEEEVLLPAFAKVKPADIGALLAGGVKTLKVLKKLKALFIPT
EEECCCCCCCEEEECCCCCCCCEEECHHHCCCCCHHHHHHHCHHHHHHHHHHHHHEECCC
GDEIIPFTETPEPGQIPDTNSSFIKAVLAEYGYETSIHPIVKDDPELLYKTVKDNLEKYD
CCCEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEE
VIIINAGSSAGRDDYAAKVIERLGRVLVHGLATKPGKPTVLGIAGNKPVIGLPGFPLSAY
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCHHHH
LVCEIILKPLAEKYYKNKFHDYGKIKATLTKTLISTTGVDDFVWGKVSRVAGRYCFTPLS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHCCHHC
RGASVSSTLLKANALLRIPRFSEGYKEGMEIEVTLKEPPAEVDQYLTVTGSHDLLLDLID
CCCCHHHHHHHHHHEEECCCCCCHHHCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHH
SFLREKYGIKLSSSHVGSLNGIVAIEKNYAKLAGVHLLDPATGDYNQSYVEKRLKGYVLI
HHHHHHHCCEECCCCCCCCCCEEEEECCHHHHCCEEEECCCCCCCCHHHHHHHHCEEEEE
NLSLREQGLIVARGNPRKISGLADLVKPGVTFVNRQKGSGTRVFLDYLLNKENINPRQIS
EEEECCCCEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCEEHEEHHHCCCCCCCCCCC
GYDREEYTHLAVAAKVKNGLADCGMGIFAAAKIFDLDFIPLGEERYDLLLREDTLEDPQV
CCCHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHEECEEEECCCHHHHEEEECCCCCCHHH
KKLLEVITSEEFKKEVERIGGYKTTLTGQIVGKG
HHHHHHHCCHHHHHHHHHHCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]