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The map label for this gene is clpP

Identifier: 78043074

GI number: 78043074

Start: 280446

End: 281033

Strand: Direct

Name: clpP

Synonym: CHY_0325

Alternate gene names: 78043074

Gene position: 280446-281033 (Clockwise)

Preceding gene: 78044834

Following gene: 78043800

Centisome position: 11.68

GC content: 44.56

Gene sequence:

>588_bases
ATGAGCTATCTTGTTCCCATTGTAATAGAACAAACCAGCCGGGGAGAAAGAAGTTACGATATTTGGTCAAGGTTATTAAA
AGACCGCACAATATTTATTGGAGGACCTATAGACGACCATGTGGCAAATTTAGTGATAGCACAAATGCTTTTCTTGGAAG
CGGAAGACCCGGAAAAAGATATTCACCTGTATATTAACTCTCCCGGCGGAGTAATAACCGCAGGAATGGCCATATACGAT
ACAATGCAGTATATTAAACCGGATGTTTCTACCATTTGCATAGGTCAGGCGGCAAGTATGGGTGCCTTTCTGTTAGCGGC
CGGGGCCAAGGGTAAGCGTTTTTCTCTGCCCTATGCCCGGATTATGATCCACCAGCCTTTGGGTGGAGTGCAGGGGCAAG
CGACCGATATTGATATTCACGCGCGCGAGATATTAAGAATGAGAGATATGTTAAATGAATTATTAACCAAACATACCGGA
CAGCCGAAAGAGAAAATTGAACGGGATACCGAGCGCGACTTCTTTATGTCGGCTGCCGAAGCTAAAGAATACGGAATCAT
CGATGAGGTGATTACCGTTCGCAAATAA

Upstream 100 bases:

>100_bases
GATGGATGATCTTGCCTATTCCATTGTTCGCCGAAAAACGATTGACTTTTTGGTTGAAAATGCTAAAGCTGTTTAATTAA
ACAGATAAGGGGGTTTGGTT

Downstream 100 bases:

>100_bases
TTTTTGAGGTGATGAAATGTTTGATAAAAATCAGCTAAAGTGTTCCTTTTGCGGTAAGCATCAGGACCAGGTGCGAAAGC
TCGTGGCTGGACCAGGAGTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSYLVPIVIEQTSRGERSYDIWSRLLKDRTIFIGGPIDDHVANLVIAQMLFLEAEDPEKDIHLYINSPGGVITAGMAIYD
TMQYIKPDVSTICIGQAASMGAFLLAAGAKGKRFSLPYARIMIHQPLGGVQGQATDIDIHAREILRMRDMLNELLTKHTG
QPKEKIERDTERDFFMSAAEAKEYGIIDEVITVRK

Sequences:

>Translated_195_residues
MSYLVPIVIEQTSRGERSYDIWSRLLKDRTIFIGGPIDDHVANLVIAQMLFLEAEDPEKDIHLYINSPGGVITAGMAIYD
TMQYIKPDVSTICIGQAASMGAFLLAAGAKGKRFSLPYARIMIHQPLGGVQGQATDIDIHAREILRMRDMLNELLTKHTG
QPKEKIERDTERDFFMSAAEAKEYGIIDEVITVRK
>Mature_194_residues
SYLVPIVIEQTSRGERSYDIWSRLLKDRTIFIGGPIDDHVANLVIAQMLFLEAEDPEKDIHLYINSPGGVITAGMAIYDT
MQYIKPDVSTICIGQAASMGAFLLAAGAKGKRFSLPYARIMIHQPLGGVQGQATDIDIHAREILRMRDMLNELLTKHTGQ
PKEKIERDTERDFFMSAAEAKEYGIIDEVITVRK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=61.1702127659574, Blast_Score=245, Evalue=2e-65,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=75, Blast_Score=313, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=53.7234042553192, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=60.1063829787234, Blast_Score=242, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_CARHZ (Q3AF96)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359188.1
- ProteinModelPortal:   Q3AF96
- SMR:   Q3AF96
- STRING:   Q3AF96
- MEROPS:   S14.001
- GeneID:   3726391
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0325
- NMPDR:   fig|246194.3.peg.446
- TIGR:   CHY_0325
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   PRK00277
- BioCyc:   CHYD246194:CHY_0325-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21841; Mature: 21709

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 99-99 ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLVPIVIEQTSRGERSYDIWSRLLKDRTIFIGGPIDDHVANLVIAQMLFLEAEDPEKD
CCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCE
IHLYINSPGGVITAGMAIYDTMQYIKPDVSTICIGQAASMGAFLLAAGAKGKRFSLPYAR
EEEEECCCCCEEEHHHHHHHHHHHHCCCCCEEEECCHHHHHHEEEECCCCCCEEECCHHE
IMIHQPLGGVQGQATDIDIHAREILRMRDMLNELLTKHTGQPKEKIERDTERDFFMSAAE
EEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AKEYGIIDEVITVRK
HHHCCCHHHHHHCCC
>Mature Secondary Structure 
SYLVPIVIEQTSRGERSYDIWSRLLKDRTIFIGGPIDDHVANLVIAQMLFLEAEDPEKD
CCEEEEEEECCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCE
IHLYINSPGGVITAGMAIYDTMQYIKPDVSTICIGQAASMGAFLLAAGAKGKRFSLPYAR
EEEEECCCCCEEEHHHHHHHHHHHHCCCCCEEEECCHHHHHHEEEECCCCCCEEECCHHE
IMIHQPLGGVQGQATDIDIHAREILRMRDMLNELLTKHTGQPKEKIERDTERDFFMSAAE
EEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AKEYGIIDEVITVRK
HHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA