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The map label for this gene is gcvT

Identifier: 78042904

GI number: 78042904

Start: 423982

End: 425064

Strand: Direct

Name: gcvT

Synonym: CHY_0489

Alternate gene names: 78042904

Gene position: 423982-425064 (Clockwise)

Preceding gene: 78044862

Following gene: 78044435

Centisome position: 17.65

GC content: 44.6

Gene sequence:

>1083_bases
ATGGAGAACTTGAAAAGGACGCCGCTTTATGAGGAACATATTAAGCTTGGTGCGAAAATGGTTCCCTTTGGCGGATGGGA
GATGCCGGTCCAGTATACCGGTATTTTAGAAGAACATATGGCCGTTCGGACCGATGTAGGCATGTTTGATGTTTCCCACA
TGGGGGAAATAGAAATTACCGGAAAGCAAGCGGAACGGTTTGTTAATTACCTTATCACCAATGATGTTTCCCGCCTTAAT
TCCGGCGACGTAATTTACACTACTATGTGCTATCCCGATGGAGGTACCGTTGACGACCTTTTGGCTTATAAGTATTCGAC
CGAACGGTATTTGTTGGTGGTAAACGCAGCCAATAAAGATAAAGATTTAGCTCATATTCTCCAATACAGGTGGGACGATG
TTACTGTTACCGATTTATCCGACGAAACCGCCGAAATTGCTTTGCAGGGTCCAAGAGCCCAGGAGATTTTGCAGAAGTTA
ACCGCTTTTGATTTAAATCAAATTAAATATTTTGGTTTTGCCGAAATTGAGGTTGCAGGCGTTCCCTGTCTTGTTAGCCG
CACCGGATATACCGGTGAAGATGGCTTTGAAATTTATTTTGCTCCAAATTTGGCTACAAAAATCTGGAATGAACTCTTAA
ATCTTGGTGTCAAGCCGGCAGGTCTTGGTGCCCGGGATACGTTAAGATTTGAAGCCTGTCTTCCTTTATACGGCCATGAA
CTTTCCGCCGAAATCACACCCTTAGAAGCCGGACTGGGCTGGGCCGTTAAGTTTAATAAGGAAGATTTTATAGGAAAAGA
AGCTTTACTTGCCCAAAAAAATGCCGGGCTTAAAAGAAAAATTGTTGGTTTGGAAATGATCGGAGCAGGAATTCCACGCC
AAGGCTACGAAATAGTATTTAACCAAAGGGGAGTAGGTTTTGTCACCTCCGGTACCTTTGCACCGTTCCTCAAGAAAAAC
CTGGCAATGGCTATGGTGGATCTTGAGGCGGCGGAAATTGGTACCGAGGTGGACGTAATCATTCGGGGGAAGGGCGTGCG
TGCCCGCGTAATTTCAAGACCATTTTATAAAAGGGGGAAATAA

Upstream 100 bases:

>100_bases
GGACAGAGGCTAAAGCAGTTTGTTTTAGCTATCTGTCTTTTTTGTTTTTCTTGGGATGAAAAAAGTGTTGCTGTTAAAAC
TATTAAAAAGGGGTGATGGG

Downstream 100 bases:

>100_bases
GCATGAGTGTGGTACCTAAGGATTTAAAGTACAGCCGTGAGCATGAGTGGATTAAGGTAGATGGCAATATCGGTATTATC
GGTATTACCGATTTTGCCCA

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MENLKRTPLYEEHIKLGAKMVPFGGWEMPVQYTGILEEHMAVRTDVGMFDVSHMGEIEITGKQAERFVNYLITNDVSRLN
SGDVIYTTMCYPDGGTVDDLLAYKYSTERYLLVVNAANKDKDLAHILQYRWDDVTVTDLSDETAEIALQGPRAQEILQKL
TAFDLNQIKYFGFAEIEVAGVPCLVSRTGYTGEDGFEIYFAPNLATKIWNELLNLGVKPAGLGARDTLRFEACLPLYGHE
LSAEITPLEAGLGWAVKFNKEDFIGKEALLAQKNAGLKRKIVGLEMIGAGIPRQGYEIVFNQRGVGFVTSGTFAPFLKKN
LAMAMVDLEAAEIGTEVDVIIRGKGVRARVISRPFYKRGK

Sequences:

>Translated_360_residues
MENLKRTPLYEEHIKLGAKMVPFGGWEMPVQYTGILEEHMAVRTDVGMFDVSHMGEIEITGKQAERFVNYLITNDVSRLN
SGDVIYTTMCYPDGGTVDDLLAYKYSTERYLLVVNAANKDKDLAHILQYRWDDVTVTDLSDETAEIALQGPRAQEILQKL
TAFDLNQIKYFGFAEIEVAGVPCLVSRTGYTGEDGFEIYFAPNLATKIWNELLNLGVKPAGLGARDTLRFEACLPLYGHE
LSAEITPLEAGLGWAVKFNKEDFIGKEALLAQKNAGLKRKIVGLEMIGAGIPRQGYEIVFNQRGVGFVTSGTFAPFLKKN
LAMAMVDLEAAEIGTEVDVIIRGKGVRARVISRPFYKRGK
>Mature_360_residues
MENLKRTPLYEEHIKLGAKMVPFGGWEMPVQYTGILEEHMAVRTDVGMFDVSHMGEIEITGKQAERFVNYLITNDVSRLN
SGDVIYTTMCYPDGGTVDDLLAYKYSTERYLLVVNAANKDKDLAHILQYRWDDVTVTDLSDETAEIALQGPRAQEILQKL
TAFDLNQIKYFGFAEIEVAGVPCLVSRTGYTGEDGFEIYFAPNLATKIWNELLNLGVKPAGLGARDTLRFEACLPLYGHE
LSAEITPLEAGLGWAVKFNKEDFIGKEALLAQKNAGLKRKIVGLEMIGAGIPRQGYEIVFNQRGVGFVTSGTFAPFLKKN
LAMAMVDLEAAEIGTEVDVIIRGKGVRARVISRPFYKRGK

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=371, Percent_Identity=38.544474393531, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI257796258, Length=351, Percent_Identity=38.7464387464387, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=36.4383561643836, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI24797151, Length=329, Percent_Identity=31.0030395136778, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI257796256, Length=316, Percent_Identity=36.7088607594937, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=28.3950617283951, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=28.3950617283951, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI194306651, Length=385, Percent_Identity=24.4155844155844, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789272, Length=370, Percent_Identity=39.7297297297297, Blast_Score=250, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17560118, Length=369, Percent_Identity=37.3983739837398, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71994045, Length=347, Percent_Identity=25.6484149855908, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71994052, Length=347, Percent_Identity=25.6484149855908, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32563613, Length=358, Percent_Identity=25.1396648044693, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320222, Length=372, Percent_Identity=34.4086021505376, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20129441, Length=371, Percent_Identity=36.9272237196765, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI28571104, Length=270, Percent_Identity=29.6296296296296, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20130091, Length=439, Percent_Identity=23.6902050113895, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_CARHZ (Q3AET7)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359347.1
- HSSP:   P27248
- ProteinModelPortal:   Q3AET7
- SMR:   Q3AET7
- STRING:   Q3AET7
- GeneID:   3727042
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0489
- NMPDR:   fig|246194.3.peg.974
- TIGR:   CHY_0489
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   NDISKPP
- BioCyc:   CHYD246194:CHY_0489-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 40037; Mature: 40037

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLKRTPLYEEHIKLGAKMVPFGGWEMPVQYTGILEEHMAVRTDVGMFDVSHMGEIEIT
CCCCCCCCCHHHHHHCCCEEECCCCCCCCEEEECHHHHHHHHHCCCCEEECCCCCEEEEE
GKQAERFVNYLITNDVSRLNSGDVIYTTMCYPDGGTVDDLLAYKYSTERYLLVVNAANKD
CHHHHHHHHHHHHCCHHHCCCCCEEEEEEEECCCCCHHHHHHEEECCCEEEEEEECCCCC
KDLAHILQYRWDDVTVTDLSDETAEIALQGPRAQEILQKLTAFDLNQIKYFGFAEIEVAG
HHHHHHHHHCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECEEEEEEEC
VPCLVSRTGYTGEDGFEIYFAPNLATKIWNELLNLGVKPAGLGARDTLRFEACLPLYGHE
CCEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCC
LSAEITPLEAGLGWAVKFNKEDFIGKEALLAQKNAGLKRKIVGLEMIGAGIPRQGYEIVF
CCCEEEEECCCCEEEEEECCHHHCCHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCEEEE
NQRGVGFVTSGTFAPFLKKNLAMAMVDLEAAEIGTEVDVIIRGKGVRARVISRPFYKRGK
ECCCCEEEECCCHHHHHHHCCEEEEEEEHHHHCCCEEEEEEECCCCEEEECCCCHHCCCC
>Mature Secondary Structure
MENLKRTPLYEEHIKLGAKMVPFGGWEMPVQYTGILEEHMAVRTDVGMFDVSHMGEIEIT
CCCCCCCCCHHHHHHCCCEEECCCCCCCCEEEECHHHHHHHHHCCCCEEECCCCCEEEEE
GKQAERFVNYLITNDVSRLNSGDVIYTTMCYPDGGTVDDLLAYKYSTERYLLVVNAANKD
CHHHHHHHHHHHHCCHHHCCCCCEEEEEEEECCCCCHHHHHHEEECCCEEEEEEECCCCC
KDLAHILQYRWDDVTVTDLSDETAEIALQGPRAQEILQKLTAFDLNQIKYFGFAEIEVAG
HHHHHHHHHCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECEEEEEEEC
VPCLVSRTGYTGEDGFEIYFAPNLATKIWNELLNLGVKPAGLGARDTLRFEACLPLYGHE
CCEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCC
LSAEITPLEAGLGWAVKFNKEDFIGKEALLAQKNAGLKRKIVGLEMIGAGIPRQGYEIVF
CCCEEEEECCCCEEEEEECCHHHCCHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCEEEE
NQRGVGFVTSGTFAPFLKKNLAMAMVDLEAAEIGTEVDVIIRGKGVRARVISRPFYKRGK
ECCCCEEEECCCHHHHHHHCCEEEEEEEHHHHCCCEEEEEEECCCCEEEECCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA