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The map label for this gene is trx1 [H]

Identifier: 78042898

GI number: 78042898

Start: 480592

End: 480915

Strand: Direct

Name: trx1 [H]

Synonym: CHY_0553

Alternate gene names: 78042898

Gene position: 480592-480915 (Clockwise)

Preceding gene: 78043614

Following gene: 78044881

Centisome position: 20.01

GC content: 41.05

Gene sequence:

>324_bases
ATGGTTTTAAAGTTTACCGATGCCAATTTTGAAGATGAAGTAATTAATTCCGATATGCCGGTATTAGTAGATTTTTGGGC
GGAGTGGTGTGGTCCGTGCCGGATGATTGCCCCCATCATCGAAAGACTGGCGATTGATTATCTCGGTCAGGTTAAAGTTG
GCAAGCTAAATGTTGATGAAAACCGGGAAACGGCTATTGCTCTTGGAATCATGAGCATTCCTACGGTAATGATTTTTAAA
GATGGAAAGGTGCTTGATACCATTATCGGTTATCAGCCGGAAAACGTCTTTCGCGAGAAAATAGAAAAAGCGTTAAAAAA
GTAG

Upstream 100 bases:

>100_bases
TTATCTTGAAAAAGCTGGTTTAAAGCTACTGCAGAAGATGAACGTAAGTGCAGCTCACTGGGGTATAATAGGGATAAAAG
AATAAAAGGAGGAGGTCTTT

Downstream 100 bases:

>100_bases
GTTAAAAACGTAATTGAGAAAAGGGAGAATCTTAAGGTGTTTGCCAAAAAACAAGCGGTAATAATTTACGAGCGGTGCAA
AAACTGTGAAGTTTGTGAAC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MVLKFTDANFEDEVINSDMPVLVDFWAEWCGPCRMIAPIIERLAIDYLGQVKVGKLNVDENRETAIALGIMSIPTVMIFK
DGKVLDTIIGYQPENVFREKIEKALKK

Sequences:

>Translated_107_residues
MVLKFTDANFEDEVINSDMPVLVDFWAEWCGPCRMIAPIIERLAIDYLGQVKVGKLNVDENRETAIALGIMSIPTVMIFK
DGKVLDTIIGYQPENVFREKIEKALKK
>Mature_107_residues
MVLKFTDANFEDEVINSDMPVLVDFWAEWCGPCRMIAPIIERLAIDYLGQVKVGKLNVDENRETAIALGIMSIPTVMIFK
DGKVLDTIIGYQPENVFREKIEKALKK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=99, Percent_Identity=37.3737373737374, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=44.2307692307692, Blast_Score=106, Evalue=3e-25,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=44.6808510638298, Blast_Score=95, Evalue=9e-22,
Organism=Escherichia coli, GI87081747, Length=108, Percent_Identity=34.2592592592593, Blast_Score=73, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=98, Percent_Identity=39.7959183673469, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=37.037037037037, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=70, Percent_Identity=44.2857142857143, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=81, Percent_Identity=38.2716049382716, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=96, Percent_Identity=40.625, Blast_Score=80, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=97, Percent_Identity=39.1752577319588, Blast_Score=74, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=92, Percent_Identity=32.6086956521739, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=37, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=37.6470588235294, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=46.0526315789474, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21358065, Length=99, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24639068, Length=81, Percent_Identity=34.5679012345679, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921434, Length=82, Percent_Identity=36.5853658536585, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12161; Mature: 12161

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLKFTDANFEDEVINSDMPVLVDFWAEWCGPCRMIAPIIERLAIDYLGQVKVGKLNVDE
CEEEECCCCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCC
NRETAIALGIMSIPTVMIFKDGKVLDTIIGYQPENVFREKIEKALKK
CCCHHHEEEHHHCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLKFTDANFEDEVINSDMPVLVDFWAEWCGPCRMIAPIIERLAIDYLGQVKVGKLNVDE
CEEEECCCCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCC
NRETAIALGIMSIPTVMIFKDGKVLDTIIGYQPENVFREKIEKALKK
CCCHHHEEEHHHCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]