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The map label for this gene is znuA [H]

Identifier: 77465569

GI number: 77465569

Start: 666062

End: 667099

Strand: Direct

Name: znuA [H]

Synonym: RSP_3571

Alternate gene names: 77465569

Gene position: 666062-667099 (Clockwise)

Preceding gene: 77465564

Following gene: 77465570

Centisome position: 70.63

GC content: 71.19

Gene sequence:

>1038_bases
ATGCGTTATACCATATCAGTCGCTCTCGCCAGCCTGCTCGCGGGCCCGGCCCTGGCCGAAGTGCCGCGCGTGGTGACGGA
CCTGCCGCCGGTCCATTCGCTGGTGGCGCAGGTGATGGGCGATCTCGGAGAGCCGGACCTCCTGCTGGGCCAGGGAGCGG
ATCCGCATTCCTTCCAGTTGCGCCCGAGTCAGGCGCGCGCGCTGGCCAATGCCGATCTGGTGGTCTGGATCGGACCGGAG
ATGACCCGCTGGCTCGAGCGCGCGCTCGAGGGCCGCAAGGGCGAGGAGCTGCGTCTCATGCAGGTCGCGGGCACGCATCT
GCAGGACTTCGGCGAAGGCGCGGCACACGACCATGCTGGGCACGGCCATGACCATGCGGACGAGGACCACGATCACGCCG
GCGAAGGGCACGAGCACGCGGACGAGGGCCACGCCGGCGAAGCGCACGATCACGCGGACGAGGGCCACACCCACGGCGAC
GAAGCGCACGATCACGGCGAACATGAGGGCCACAGCCATACGGGCCTCGACCCCCATGCCTGGCTCGATCCCGAGAATGC
GCAGCTCTGGCTGACGGCTGTCGCGCGCGAACTGGGCCACCTCGATCCCGAGAATGCGGCGACCTACGCCGCCAATGCCG
AGGCCGCCCGGGCAGCGCTGGCCGAGCTCGACCGCGAAACGGCCGCAAGGCTGGACGAGGCGCGGAACCAGCCCTTCTAC
GTCTTCCACGATGCCTACGGCTACTTCGCCGGCCACTACGGGCTGACCGTGCAGGGCAGCGTCTCGGCAGGCGATGCGGC
CGCGCCGGGGGCGGCGCACCTCGCGGACCTGCGCGCGGAGATGGCGGGCACCCCGCGCTGCATCTTCCCGGAGGCGCAGC
ATGACGCGAAGCTCGCCCGGCAGATCGCGCAGGAGACGGGCGCGAAGGCCGGCCCGGCGCTCGATCCGTCGGGCAGCACG
CTCGAACCGGGCCCGCAGCTCTACGCGAACCTGATCCGCGGCCTCGCCGACGGCATCCTGTCCTGCGTCGCCCCTTGA

Upstream 100 bases:

>100_bases
AATGCCGCGGTGCCTCCGGTATCGGCGGTCATCCTCTCCCCCATTGACGCGTTATGATATAACGTAATACATCTGCGCCC
ATCTCAAGGAAAGGCAGACC

Downstream 100 bases:

>100_bases
TCTCGCGCGGCCTCCGGCGCAGCCTGCCCGCCTGCACCGGAGGCGCCCATGACCCTCACCCGCTTCGGAACCGCCCCTGA
CGGGCGGCCCGTCCAGCGCA

Product: ABC zinc transporter, periplasmic binding protein ZnuA

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MRYTISVALASLLAGPALAEVPRVVTDLPPVHSLVAQVMGDLGEPDLLLGQGADPHSFQLRPSQARALANADLVVWIGPE
MTRWLERALEGRKGEELRLMQVAGTHLQDFGEGAAHDHAGHGHDHADEDHDHAGEGHEHADEGHAGEAHDHADEGHTHGD
EAHDHGEHEGHSHTGLDPHAWLDPENAQLWLTAVARELGHLDPENAATYAANAEAARAALAELDRETAARLDEARNQPFY
VFHDAYGYFAGHYGLTVQGSVSAGDAAAPGAAHLADLRAEMAGTPRCIFPEAQHDAKLARQIAQETGAKAGPALDPSGST
LEPGPQLYANLIRGLADGILSCVAP

Sequences:

>Translated_345_residues
MRYTISVALASLLAGPALAEVPRVVTDLPPVHSLVAQVMGDLGEPDLLLGQGADPHSFQLRPSQARALANADLVVWIGPE
MTRWLERALEGRKGEELRLMQVAGTHLQDFGEGAAHDHAGHGHDHADEDHDHAGEGHEHADEGHAGEAHDHADEGHTHGD
EAHDHGEHEGHSHTGLDPHAWLDPENAQLWLTAVARELGHLDPENAATYAANAEAARAALAELDRETAARLDEARNQPFY
VFHDAYGYFAGHYGLTVQGSVSAGDAAAPGAAHLADLRAEMAGTPRCIFPEAQHDAKLARQIAQETGAKAGPALDPSGST
LEPGPQLYANLIRGLADGILSCVAP
>Mature_345_residues
MRYTISVALASLLAGPALAEVPRVVTDLPPVHSLVAQVMGDLGEPDLLLGQGADPHSFQLRPSQARALANADLVVWIGPE
MTRWLERALEGRKGEELRLMQVAGTHLQDFGEGAAHDHAGHGHDHADEDHDHAGEGHEHADEGHAGEAHDHADEGHTHGD
EAHDHGEHEGHSHTGLDPHAWLDPENAQLWLTAVARELGHLDPENAATYAANAEAARAALAELDRETAARLDEARNQPFY
VFHDAYGYFAGHYGLTVQGSVSAGDAAAPGAAHLADLRAEMAGTPRCIFPEAQHDAKLARQIAQETGAKAGPALDPSGST
LEPGPQLYANLIRGLADGILSCVAP

Specific function: Involved in the high-affinity zinc uptake transport system. Required for survival and normal growth under low Zn (2+) concentrations. Also required for virulence and intracellular growth in macrophages [H]

COG id: COG4531

COG function: function code P; ABC-type Zn2+ transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=321, Percent_Identity=28.3489096573209, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 36560; Mature: 36560

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYTISVALASLLAGPALAEVPRVVTDLPPVHSLVAQVMGDLGEPDLLLGQGADPHSFQL
CCEEHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCEEE
RPSQARALANADLVVWIGPEMTRWLERALEGRKGEELRLMQVAGTHLQDFGEGAAHDHAG
CHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCC
HGHDHADEDHDHAGEGHEHADEGHAGEAHDHADEGHTHGDEAHDHGEHEGHSHTGLDPHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
WLDPENAQLWLTAVARELGHLDPENAATYAANAEAARAALAELDRETAARLDEARNQPFY
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VFHDAYGYFAGHYGLTVQGSVSAGDAAAPGAAHLADLRAEMAGTPRCIFPEAQHDAKLAR
EEECCCHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHH
QIAQETGAKAGPALDPSGSTLEPGPQLYANLIRGLADGILSCVAP
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRYTISVALASLLAGPALAEVPRVVTDLPPVHSLVAQVMGDLGEPDLLLGQGADPHSFQL
CCEEHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCEEE
RPSQARALANADLVVWIGPEMTRWLERALEGRKGEELRLMQVAGTHLQDFGEGAAHDHAG
CHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCC
HGHDHADEDHDHAGEGHEHADEGHAGEAHDHADEGHTHGDEAHDHGEHEGHSHTGLDPHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
WLDPENAQLWLTAVARELGHLDPENAATYAANAEAARAALAELDRETAARLDEARNQPFY
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VFHDAYGYFAGHYGLTVQGSVSAGDAAAPGAAHLADLRAEMAGTPRCIFPEAQHDAKLAR
EEECCCHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHH
QIAQETGAKAGPALDPSGSTLEPGPQLYANLIRGLADGILSCVAP
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA