Click here to switch to the map view.

The map label for this gene is xdhB [H]

Identifier: 77465554

GI number: 77465554

Start: 648142

End: 650619

Strand: Direct

Name: xdhB [H]

Synonym: RSP_3555

Alternate gene names: 77465554

Gene position: 648142-650619 (Clockwise)

Preceding gene: 77465553

Following gene: 77465555

Centisome position: 68.73

GC content: 71.39

Gene sequence:

>2478_bases
ATGAGCCTCGGTCGCGCCCTGCCGCACGATGCGGCCCCGCTTCACGTCACCGGCGCTGCGCGCTATGTGGACGACTTGCC
CACCCCGCGCGGCACGCTGCATCTGGCCTTCGGCCTGTCGCCCGTGGCCCATGGCGAGATCCTGACCCTCGATCTCGACC
CGGTGCGCCGGATGCCGGGCGTGGTGCGGGTGATCGGGCCCGGCGATCTCGATCCGATGCCCGACTGCTCGCCCTCGGCC
CATGACGAGCCGCTCCTTGCAGTGGGCCGCGTGCAGTATGTGGGCCAGCCGCTCTTCCTCGTCGTGGCCGAGAGCCACCG
CGCCGCCCGCCGCGCAGCGCGCGCCGCGCGCCCCGAGATCCGGCCCCTGCCCGCGATCCTGACCGTCGAGGAGGCGCTCG
CCGCGAATGCCCGCTTCGAGGCGGGGCCCGTCGTCTGGGAGAAGGGCCGCGCGGCCGAAGCCATCGCCACAGCCCCGCAC
CGGATCGAGGGAACGATGGAGGTGGGGGGACAGGAGCATTTCTACCTCGAGGGTCAGGTGGCGCTCGCCCTGCCGCAGGA
GGCGGGCGACATGCATGTCCATTCTTCCACCCAGCATCCGACCGAGATCCAGCACAAGGTGGCCCATGCGCTGGGACTGC
CCATGAGCGCGGTGCGGGTCGAGGTGCGGCGCATGGGCGGCGGCTTCGGCGGCAAGGAGAGCCAGGGCAATGCGCTGGCC
ATCGCCTGCGCACTGGCCGCCCGCGCGACGGGGCGGCCCTGCAAGATGCGCTACGACCGCGACGACGACATGGCGATCAC
CGGCAAGCGCCACGACCTTCGGATCGACTATCGCGCGGGCTTCGATGACGAAGGGCGGCTCGCGGGCGTCGAGTTCCGCC
ATCTCTTCCGTTGCGGCTGGTCGCAGGACCTGTCGCTGCCGGTGGCGGATCGGGCGATGCTCCATGCCGACAATGCCTAT
CACCTGCCCGCGGTGCGGATCGAGAGCCACCGGCTGCGCACCCATACCCAGAGCGCCACCGCCTTCCGCGGCTTCGGCGG
CCCGCAGGGCATGATCGGGATCGAGCGGGTGATGGACCATGTGGCCCATGCGGTGGGGCGCGATCCTCTGGCGGTGCGGC
AGGCGAACTTCTACGCGCCGATGGGGCAGGTCGGGGGCGGACGTGCCGCGGATCCGGCGGGAAGGCCGGGGGCGCTGCCC
CCGGACCCCCGGGATATTTCCGCCAGAATGAAGGAGGAGGAGACGGAGGCGCGGGCGCGGCTCGGGGCGGAGGAGGTGGA
TCTGACCTCGCGCGGGGCGGAGGCGATGGAGCACGATCTGCCGCCGCCCGCGCCCGAGGGGGTGCAGACCACGCCCTATC
ACATGCCGGTCGAGGATTTCATCGGCGACGCGCTGGTGGCGGAGCTCGCCGAGCGGGCGGACTATGCCCGCCGCCGCGCC
GAGATCGGCGACTGGAACCGGCAGAGCCCGATCCTGAAGCGCGGCATCGCGCTGACGCCGGTGAAGTTCGGCATCTCCTT
CACGCTCAGCTGGCTGAACCAGGCGGGGGCGCTGGTCCATATCTATCAGGACGGCTCGGTGCATCTGAACCATGGCGGGA
CCGAAATGGGACAGGGGCTGTTCCAGAAGGTGGCGCAGGTGGCAGCGGCCGAACTGGGGCTGCCGGTCGAGGCGGTGAAG
ATCACGCCGACCGACACGGGCAAGGTGCCGAACACCTCGGCCACGGCGGCCTCGTCGGGATCGGACCTGAACGGAATGGC
GGTGCGTGCGGCCTGCGTCACGCTGCGGGATCGGCTGGCGGAGCTGGTGGCCGAGCGGCATCAGGCGCGGGCGGAGGAGG
TGCGGTTCGAGGAGGGGCGCGTGCGCGTGGGCGGCGCGGATCTCTCCTTTGCCGAAGTGGCGGCCATGGCCTATCAGGCG
CGCGTGCCCCTTTCGGCCACCGGCTACTACCGGACGCCGAAGATCGTCTGGGACCGGCTGAAGGGGCGCGGGCGGCCGTT
CTTCTACTTCGCCTACGGGGCGGCCGTGTCGGAGGTGGCGATCGACAGCCTCACCGGCGAGAACCGGATCCTGCGCGCGG
ACATCCTGCATGACACGGGCACGAGCCTCAATCCGGCGCTCGATCTGGGGCAGATCGAGGGCGGCTATGTGCAGGGCGCC
GGGTGGCTTACCACCGAGGAGCTGGTCTGGGACGCCGAGGGGCGGCTGCGGACCCATGCGCCGTCGACCTACAAGATCCC
CGCCTGTTCGGACCGGCCGCGGATCTTCAATGTGGCGCTCTGGAACCGGCCCAACCCCGAGGAGACCGTGGGCCGCTCGA
AGGCCGTGGGCGAGCCGCCCTTCATGCTCGGGATCTCGGTGCTGATGGCGCTCTCGGAGGCGGTGGCGGCCTGCGGCGAC
GGCAGCATCTATCCGGCGCTCGATGCGCCCGCGACGCCCGAGCGGATCCTTGCCGCGGTGAGGCGGCAGCGTGGCTGA

Upstream 100 bases:

>100_bases
GCGCCTCGGCCGGCTACCGTCTCGAGGCCGCGGCGGCGCTTCTCGTCCGCGCCTTCCACGATCTTCAGGGCCACCCCGTC
TCGGTGCTGGAGGTGGAGGC

Downstream 100 bases:

>100_bases
GGGCTTCGACCTCGGGGGGCTGCGGGCCGCGGTGGCCCGCCACGGACGCGTGGCGCGCGTGGTGGTGGGCGCCGTCGAGG
GCTCGGCACCCCGCGGACCC

Product: xanthine oxidase

Products: urate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 825; Mature: 824

Protein sequence:

>825_residues
MSLGRALPHDAAPLHVTGAARYVDDLPTPRGTLHLAFGLSPVAHGEILTLDLDPVRRMPGVVRVIGPGDLDPMPDCSPSA
HDEPLLAVGRVQYVGQPLFLVVAESHRAARRAARAARPEIRPLPAILTVEEALAANARFEAGPVVWEKGRAAEAIATAPH
RIEGTMEVGGQEHFYLEGQVALALPQEAGDMHVHSSTQHPTEIQHKVAHALGLPMSAVRVEVRRMGGGFGGKESQGNALA
IACALAARATGRPCKMRYDRDDDMAITGKRHDLRIDYRAGFDDEGRLAGVEFRHLFRCGWSQDLSLPVADRAMLHADNAY
HLPAVRIESHRLRTHTQSATAFRGFGGPQGMIGIERVMDHVAHAVGRDPLAVRQANFYAPMGQVGGGRAADPAGRPGALP
PDPRDISARMKEEETEARARLGAEEVDLTSRGAEAMEHDLPPPAPEGVQTTPYHMPVEDFIGDALVAELAERADYARRRA
EIGDWNRQSPILKRGIALTPVKFGISFTLSWLNQAGALVHIYQDGSVHLNHGGTEMGQGLFQKVAQVAAAELGLPVEAVK
ITPTDTGKVPNTSATAASSGSDLNGMAVRAACVTLRDRLAELVAERHQARAEEVRFEEGRVRVGGADLSFAEVAAMAYQA
RVPLSATGYYRTPKIVWDRLKGRGRPFFYFAYGAAVSEVAIDSLTGENRILRADILHDTGTSLNPALDLGQIEGGYVQGA
GWLTTEELVWDAEGRLRTHAPSTYKIPACSDRPRIFNVALWNRPNPEETVGRSKAVGEPPFMLGISVLMALSEAVAACGD
GSIYPALDAPATPERILAAVRRQRG

Sequences:

>Translated_825_residues
MSLGRALPHDAAPLHVTGAARYVDDLPTPRGTLHLAFGLSPVAHGEILTLDLDPVRRMPGVVRVIGPGDLDPMPDCSPSA
HDEPLLAVGRVQYVGQPLFLVVAESHRAARRAARAARPEIRPLPAILTVEEALAANARFEAGPVVWEKGRAAEAIATAPH
RIEGTMEVGGQEHFYLEGQVALALPQEAGDMHVHSSTQHPTEIQHKVAHALGLPMSAVRVEVRRMGGGFGGKESQGNALA
IACALAARATGRPCKMRYDRDDDMAITGKRHDLRIDYRAGFDDEGRLAGVEFRHLFRCGWSQDLSLPVADRAMLHADNAY
HLPAVRIESHRLRTHTQSATAFRGFGGPQGMIGIERVMDHVAHAVGRDPLAVRQANFYAPMGQVGGGRAADPAGRPGALP
PDPRDISARMKEEETEARARLGAEEVDLTSRGAEAMEHDLPPPAPEGVQTTPYHMPVEDFIGDALVAELAERADYARRRA
EIGDWNRQSPILKRGIALTPVKFGISFTLSWLNQAGALVHIYQDGSVHLNHGGTEMGQGLFQKVAQVAAAELGLPVEAVK
ITPTDTGKVPNTSATAASSGSDLNGMAVRAACVTLRDRLAELVAERHQARAEEVRFEEGRVRVGGADLSFAEVAAMAYQA
RVPLSATGYYRTPKIVWDRLKGRGRPFFYFAYGAAVSEVAIDSLTGENRILRADILHDTGTSLNPALDLGQIEGGYVQGA
GWLTTEELVWDAEGRLRTHAPSTYKIPACSDRPRIFNVALWNRPNPEETVGRSKAVGEPPFMLGISVLMALSEAVAACGD
GSIYPALDAPATPERILAAVRRQRG
>Mature_824_residues
SLGRALPHDAAPLHVTGAARYVDDLPTPRGTLHLAFGLSPVAHGEILTLDLDPVRRMPGVVRVIGPGDLDPMPDCSPSAH
DEPLLAVGRVQYVGQPLFLVVAESHRAARRAARAARPEIRPLPAILTVEEALAANARFEAGPVVWEKGRAAEAIATAPHR
IEGTMEVGGQEHFYLEGQVALALPQEAGDMHVHSSTQHPTEIQHKVAHALGLPMSAVRVEVRRMGGGFGGKESQGNALAI
ACALAARATGRPCKMRYDRDDDMAITGKRHDLRIDYRAGFDDEGRLAGVEFRHLFRCGWSQDLSLPVADRAMLHADNAYH
LPAVRIESHRLRTHTQSATAFRGFGGPQGMIGIERVMDHVAHAVGRDPLAVRQANFYAPMGQVGGGRAADPAGRPGALPP
DPRDISARMKEEETEARARLGAEEVDLTSRGAEAMEHDLPPPAPEGVQTTPYHMPVEDFIGDALVAELAERADYARRRAE
IGDWNRQSPILKRGIALTPVKFGISFTLSWLNQAGALVHIYQDGSVHLNHGGTEMGQGLFQKVAQVAAAELGLPVEAVKI
TPTDTGKVPNTSATAASSGSDLNGMAVRAACVTLRDRLAELVAERHQARAEEVRFEEGRVRVGGADLSFAEVAAMAYQAR
VPLSATGYYRTPKIVWDRLKGRGRPFFYFAYGAAVSEVAIDSLTGENRILRADILHDTGTSLNPALDLGQIEGGYVQGAG
WLTTEELVWDAEGRLRTHAPSTYKIPACSDRPRIFNVALWNRPNPEETVGRSKAVGEPPFMLGISVLMALSEAVAACGDG
SIYPALDAPATPERILAAVRRQRG

Specific function: Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=822, Percent_Identity=38.6861313868613, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI71773480, Length=823, Percent_Identity=34.629404617254, Blast_Score=443, Evalue=1e-124,
Organism=Escherichia coli, GI1789246, Length=821, Percent_Identity=26.4311814859927, Blast_Score=186, Evalue=7e-48,
Organism=Escherichia coli, GI1789230, Length=377, Percent_Identity=28.3819628647215, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1786478, Length=317, Percent_Identity=26.813880126183, Blast_Score=83, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17540638, Length=375, Percent_Identity=42.1333333333333, Blast_Score=272, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17539860, Length=331, Percent_Identity=35.3474320241692, Blast_Score=189, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI32566215, Length=379, Percent_Identity=29.023746701847, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI17737937, Length=378, Percent_Identity=42.3280423280423, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24647199, Length=360, Percent_Identity=36.9444444444444, Blast_Score=194, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24647195, Length=413, Percent_Identity=34.1404358353511, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24647197, Length=413, Percent_Identity=34.1404358353511, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24647193, Length=363, Percent_Identity=34.7107438016529, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24647201, Length=357, Percent_Identity=34.733893557423, Blast_Score=167, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR001041
- InterPro:   IPR017699 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2; PF01799 Fer2_2 [H]

EC number: 1.17.1.4

Molecular weight: Translated: 88850; Mature: 88719

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLGRALPHDAAPLHVTGAARYVDDLPTPRGTLHLAFGLSPVAHGEILTLDLDPVRRMPG
CCCCCCCCCCCCCEEEECHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCHHHHCCC
VVRVIGPGDLDPMPDCSPSAHDEPLLAVGRVQYVGQPLFLVVAESHRAARRAARAARPEI
EEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCC
RPLPAILTVEEALAANARFEAGPVVWEKGRAAEAIATAPHRIEGTMEVGGQEHFYLEGQV
CCCCHHEEHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCCCCCEEECCCCEEEEECCEE
ALALPQEAGDMHVHSSTQHPTEIQHKVAHALGLPMSAVRVEVRRMGGGFGGKESQGNALA
EEEECCCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEE
IACALAARATGRPCKMRYDRDDDMAITGKRHDLRIDYRAGFDDEGRLAGVEFRHLFRCGW
EEEEHHHHCCCCCEEEECCCCCCEEEECCCCEEEEEEECCCCCCCCEECHHHHHHHHCCC
SQDLSLPVADRAMLHADNAYHLPAVRIESHRLRTHTQSATAFRGFGGPQGMIGIERVMDH
CCCCCCCHHHHHHEECCCCCCCCEEEECCHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHH
VAHAVGRDPLAVRQANFYAPMGQVGGGRAADPAGRPGALPPDPRDISARMKEEETEARAR
HHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LGAEEVDLTSRGAEAMEHDLPPPAPEGVQTTPYHMPVEDFIGDALVAELAERADYARRRA
CCCHHHCCHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIGDWNRQSPILKRGIALTPVKFGISFTLSWLNQAGALVHIYQDGSVHLNHGGTEMGQGL
HCCCCCCCCHHHHCCCEECEEEHHHHHHHHHHHCCCCEEEEEECCEEEEECCCHHHHHHH
FQKVAQVAAAELGLPVEAVKITPTDTGKVPNTSATAASSGSDLNGMAVRAACVTLRDRLA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ELVAERHQARAEEVRFEEGRVRVGGADLSFAEVAAMAYQARVPLSATGYYRTPKIVWDRL
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
KGRGRPFFYFAYGAAVSEVAIDSLTGENRILRADILHDTGTSLNPALDLGQIEGGYVQGA
CCCCCEEEEEEECHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEECC
GWLTTEELVWDAEGRLRTHAPSTYKIPACSDRPRIFNVALWNRPNPEETVGRSKAVGEPP
CCEEHHHEEECCCCCEEECCCCCEECCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCCCC
FMLGISVLMALSEAVAACGDGSIYPALDAPATPERILAAVRRQRG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SLGRALPHDAAPLHVTGAARYVDDLPTPRGTLHLAFGLSPVAHGEILTLDLDPVRRMPG
CCCCCCCCCCCCEEEECHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCHHHHCCC
VVRVIGPGDLDPMPDCSPSAHDEPLLAVGRVQYVGQPLFLVVAESHRAARRAARAARPEI
EEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCC
RPLPAILTVEEALAANARFEAGPVVWEKGRAAEAIATAPHRIEGTMEVGGQEHFYLEGQV
CCCCHHEEHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCCCCCEEECCCCEEEEECCEE
ALALPQEAGDMHVHSSTQHPTEIQHKVAHALGLPMSAVRVEVRRMGGGFGGKESQGNALA
EEEECCCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEE
IACALAARATGRPCKMRYDRDDDMAITGKRHDLRIDYRAGFDDEGRLAGVEFRHLFRCGW
EEEEHHHHCCCCCEEEECCCCCCEEEECCCCEEEEEEECCCCCCCCEECHHHHHHHHCCC
SQDLSLPVADRAMLHADNAYHLPAVRIESHRLRTHTQSATAFRGFGGPQGMIGIERVMDH
CCCCCCCHHHHHHEECCCCCCCCEEEECCHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHH
VAHAVGRDPLAVRQANFYAPMGQVGGGRAADPAGRPGALPPDPRDISARMKEEETEARAR
HHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LGAEEVDLTSRGAEAMEHDLPPPAPEGVQTTPYHMPVEDFIGDALVAELAERADYARRRA
CCCHHHCCHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIGDWNRQSPILKRGIALTPVKFGISFTLSWLNQAGALVHIYQDGSVHLNHGGTEMGQGL
HCCCCCCCCHHHHCCCEECEEEHHHHHHHHHHHCCCCEEEEEECCEEEEECCCHHHHHHH
FQKVAQVAAAELGLPVEAVKITPTDTGKVPNTSATAASSGSDLNGMAVRAACVTLRDRLA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ELVAERHQARAEEVRFEEGRVRVGGADLSFAEVAAMAYQARVPLSATGYYRTPKIVWDRL
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
KGRGRPFFYFAYGAAVSEVAIDSLTGENRILRADILHDTGTSLNPALDLGQIEGGYVQGA
CCCCCEEEEEEECHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEECC
GWLTTEELVWDAEGRLRTHAPSTYKIPACSDRPRIFNVALWNRPNPEETVGRSKAVGEPP
CCEEHHHEEECCCCCEEECCCCCEECCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCCCC
FMLGISVLMALSEAVAACGDGSIYPALDAPATPERILAAVRRQRG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthine; NAD+; H2O

Specific reaction: xanthine + NAD+ + H2O = urate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]