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The map label for this gene is xdhA [H]

Identifier: 77465553

GI number: 77465553

Start: 646688

End: 648145

Strand: Direct

Name: xdhA [H]

Synonym: RSP_3554

Alternate gene names: 77465553

Gene position: 646688-648145 (Clockwise)

Preceding gene: 77465551

Following gene: 77465554

Centisome position: 68.58

GC content: 72.7

Gene sequence:

>1458_bases
ATGACGGAGATCGCGTTCATCCTGAACGGAACGCCCCTCAGCGTCGCGGCGGAGCCCACCCGGACGCTGCTCGACTTCCT
GCGCGAGGACCGCGGGCTCACCGGCACCAAGGAGGGCTGCAACGAGGGCGACTGCGGCGCCTGCACGGTGATGGTGACCG
ACGAGACCGGGCCCCGCGCGCTGAACGCCTGCCTCCTGTTCCTGCCCCAGCTTCAGGGCAAGGAGGTCCGGACTGTCGAG
GGCCTCGCCGCGCCCGACGGCCGCCTCCATCCGGTGCAACAGGCGCTGATCGACCATCACGGCTCGCAATGCGGCTTCTG
CACCCCGGGCTTCGTCATGTCGATGGCCGCGGCCCATGCCACCGGCTGCCGCGACCATGACGATACGCTCGCGGGCAACC
TCTGCCGCTGCACGGGCTATGCTCCCATCGTCCGCGCCGCCCGCGCCGCCGAGGAGGCGCCTCCGCCCGACTGGCTGCCC
TCTTTCACTCTGCCTCAAATATCCTCGGGGGGGACCGTGAGCGGCGAGAGCCCCTCCCCCGGAGGGGCGGCCGCGAACGC
CCGCCCCGCGGGCGGGCCCGGGGGGGCAGACAGCCCCCCCGCAGCCGGTTGCCGCCCGACCAGCCTCGAGGAGCTCGCGC
GGCTTTACGAGGCCCATCCCGAGGCCACGCTGATCGCAGGCGCCACCGACGTGGGCCTCTGGGTCACCAAGGATCTGCGC
GACCTGTCGATGCCCCTCTTCCTCGGCGCCATCCCCGAGTTGCGCCGCATCGAGGAGGCGGCGGGCAGTCTGCGTGTCGG
GGCCATGGTCACCATCTCGGACCTGCGCGCGGCACTTGCCCCCCGCCTGCCGGGCCTCGCGGACCTGCTGCGCCGCTTCG
CCAGCGTGCAGATCCGCAACGCGGCCACCCTCGGCGGCAATATCGCCAACGGCTCGCCCATCGGCGACACGCCGCCTGCG
CTGATCGCGCTCGGCGCCACGCTGCACCTGCGCCGGGGCGAGACCCGCCGCGACCTGCCGCTCGAGGAGTTCTTCCTCGA
TTACCGCAAGCAGGACCGGCGCCCGGGCGAGTTCGTCGAGGCGGTCACGATCCCCACCGAGGCACCGGGGCTGCGCTGCT
ACAAGCTCTCGAAACGGTTCGATCAGGACATTTCGGCGGTCTGCGGCTGTTTCAACATCTCGGTCGAGGCGGGCCGCGTC
GCGGCGGCCCGCCTGGCCTTCGGCGGCATGGCCGGGATCCCGAAGCGCGCGGCGGCGGTCGAGGCGGCGCTTCTGGGCCG
CCCCTGGACCCTCGCCACGATCGAGGCGGCCCGCCCGGCCTTCGCCGAGGATTTCACCCCGCTCTCCGACATGCGCGCCT
CGGCCGGCTACCGTCTCGAGGCCGCGGCGGCGCTTCTCGTCCGCGCCTTCCACGATCTTCAGGGCCACCCCGTCTCGGTG
CTGGAGGTGGAGGCATGA

Upstream 100 bases:

>100_bases
GGCAGGCTTTGATGGGTCCGAATTGTCGCAGGCCGCTTTACGCCGCATCGGGTGGCCTGCACCGGCGCAGCCGGACCCAC
AGAAGGCGGCAGGTTTTCAC

Downstream 100 bases:

>100_bases
GCCTCGGTCGCGCCCTGCCGCACGATGCGGCCCCGCTTCACGTCACCGGCGCTGCGCGCTATGTGGACGACTTGCCCACC
CCGCGCGGCACGCTGCATCT

Product: xanthine dehydrogenase, small subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTEIAFILNGTPLSVAAEPTRTLLDFLREDRGLTGTKEGCNEGDCGACTVMVTDETGPRALNACLLFLPQLQGKEVRTVE
GLAAPDGRLHPVQQALIDHHGSQCGFCTPGFVMSMAAAHATGCRDHDDTLAGNLCRCTGYAPIVRAARAAEEAPPPDWLP
SFTLPQISSGGTVSGESPSPGGAAANARPAGGPGGADSPPAAGCRPTSLEELARLYEAHPEATLIAGATDVGLWVTKDLR
DLSMPLFLGAIPELRRIEEAAGSLRVGAMVTISDLRAALAPRLPGLADLLRRFASVQIRNAATLGGNIANGSPIGDTPPA
LIALGATLHLRRGETRRDLPLEEFFLDYRKQDRRPGEFVEAVTIPTEAPGLRCYKLSKRFDQDISAVCGCFNISVEAGRV
AAARLAFGGMAGIPKRAAAVEAALLGRPWTLATIEAARPAFAEDFTPLSDMRASAGYRLEAAAALLVRAFHDLQGHPVSV
LEVEA

Sequences:

>Translated_485_residues
MTEIAFILNGTPLSVAAEPTRTLLDFLREDRGLTGTKEGCNEGDCGACTVMVTDETGPRALNACLLFLPQLQGKEVRTVE
GLAAPDGRLHPVQQALIDHHGSQCGFCTPGFVMSMAAAHATGCRDHDDTLAGNLCRCTGYAPIVRAARAAEEAPPPDWLP
SFTLPQISSGGTVSGESPSPGGAAANARPAGGPGGADSPPAAGCRPTSLEELARLYEAHPEATLIAGATDVGLWVTKDLR
DLSMPLFLGAIPELRRIEEAAGSLRVGAMVTISDLRAALAPRLPGLADLLRRFASVQIRNAATLGGNIANGSPIGDTPPA
LIALGATLHLRRGETRRDLPLEEFFLDYRKQDRRPGEFVEAVTIPTEAPGLRCYKLSKRFDQDISAVCGCFNISVEAGRV
AAARLAFGGMAGIPKRAAAVEAALLGRPWTLATIEAARPAFAEDFTPLSDMRASAGYRLEAAAALLVRAFHDLQGHPVSV
LEVEA
>Mature_484_residues
TEIAFILNGTPLSVAAEPTRTLLDFLREDRGLTGTKEGCNEGDCGACTVMVTDETGPRALNACLLFLPQLQGKEVRTVEG
LAAPDGRLHPVQQALIDHHGSQCGFCTPGFVMSMAAAHATGCRDHDDTLAGNLCRCTGYAPIVRAARAAEEAPPPDWLPS
FTLPQISSGGTVSGESPSPGGAAANARPAGGPGGADSPPAAGCRPTSLEELARLYEAHPEATLIAGATDVGLWVTKDLRD
LSMPLFLGAIPELRRIEEAAGSLRVGAMVTISDLRAALAPRLPGLADLLRRFASVQIRNAATLGGNIANGSPIGDTPPAL
IALGATLHLRRGETRRDLPLEEFFLDYRKQDRRPGEFVEAVTIPTEAPGLRCYKLSKRFDQDISAVCGCFNISVEAGRVA
AARLAFGGMAGIPKRAAAVEAALLGRPWTLATIEAARPAFAEDFTPLSDMRASAGYRLEAAAALLVRAFHDLQGHPVSVL
EVEA

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=492, Percent_Identity=30.6910569105691, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI71773480, Length=509, Percent_Identity=29.2730844793713, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1786480, Length=166, Percent_Identity=39.1566265060241, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789232, Length=156, Percent_Identity=44.2307692307692, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1789231, Length=266, Percent_Identity=30.4511278195489, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17540638, Length=545, Percent_Identity=30.0917431192661, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI32566215, Length=544, Percent_Identity=26.4705882352941, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17539860, Length=473, Percent_Identity=26.8498942917548, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17737937, Length=531, Percent_Identity=32.7683615819209, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24647199, Length=511, Percent_Identity=26.4187866927593, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24647197, Length=513, Percent_Identity=30.6042884990253, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24647195, Length=337, Percent_Identity=34.4213649851632, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24647201, Length=507, Percent_Identity=27.0216962524655, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24647193, Length=505, Percent_Identity=27.3267326732673, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR017606
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 50948; Mature: 50816

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIAFILNGTPLSVAAEPTRTLLDFLREDRGLTGTKEGCNEGDCGACTVMVTDETGPRA
CCEEEEEECCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
LNACLLFLPQLQGKEVRTVEGLAAPDGRLHPVQQALIDHHGSQCGFCTPGFVMSMAAAHA
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
TGCRDHDDTLAGNLCRCTGYAPIVRAARAAEEAPPPDWLPSFTLPQISSGGTVSGESPSP
CCCCCCCHHHHCCHHEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGAAANARPAGGPGGADSPPAAGCRPTSLEELARLYEAHPEATLIAGATDVGLWVTKDLR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCEEEECCHH
DLSMPLFLGAIPELRRIEEAAGSLRVGAMVTISDLRAALAPRLPGLADLLRRFASVQIRN
HHCCHHHHHCCHHHHHHHHHHCCEEECEEEEHHHHHHHHCCCCCCHHHHHHHHHHEEECC
AATLGGNIANGSPIGDTPPALIALGATLHLRRGETRRDLPLEEFFLDYRKQDRRPGEFVE
HHCCCCCCCCCCCCCCCCHHHHEECCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHEE
AVTIPTEAPGLRCYKLSKRFDQDISAVCGCFNISVEAGRVAAARLAFGGMAGIPKRAAAV
EEECCCCCCCCEEEHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCCCCHHHHHH
EAALLGRPWTLATIEAARPAFAEDFTPLSDMRASAGYRLEAAAALLVRAFHDLQGHPVSV
HHHHHCCCCEEEEEHHCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEE
LEVEA
EEECC
>Mature Secondary Structure 
TEIAFILNGTPLSVAAEPTRTLLDFLREDRGLTGTKEGCNEGDCGACTVMVTDETGPRA
CEEEEEECCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
LNACLLFLPQLQGKEVRTVEGLAAPDGRLHPVQQALIDHHGSQCGFCTPGFVMSMAAAHA
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
TGCRDHDDTLAGNLCRCTGYAPIVRAARAAEEAPPPDWLPSFTLPQISSGGTVSGESPSP
CCCCCCCHHHHCCHHEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGAAANARPAGGPGGADSPPAAGCRPTSLEELARLYEAHPEATLIAGATDVGLWVTKDLR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCEEEECCHH
DLSMPLFLGAIPELRRIEEAAGSLRVGAMVTISDLRAALAPRLPGLADLLRRFASVQIRN
HHCCHHHHHCCHHHHHHHHHHCCEEECEEEEHHHHHHHHCCCCCCHHHHHHHHHHEEECC
AATLGGNIANGSPIGDTPPALIALGATLHLRRGETRRDLPLEEFFLDYRKQDRRPGEFVE
HHCCCCCCCCCCCCCCCCHHHHEECCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHEE
AVTIPTEAPGLRCYKLSKRFDQDISAVCGCFNISVEAGRVAAARLAFGGMAGIPKRAAAV
EEECCCCCCCCEEEHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCCCCHHHHHH
EAALLGRPWTLATIEAARPAFAEDFTPLSDMRASAGYRLEAAAALLVRAFHDLQGHPVSV
HHHHHCCCCEEEEEHHCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEE
LEVEA
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]