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The map label for this gene is tklB [H]

Identifier: 77465274

GI number: 77465274

Start: 324492

End: 326465

Strand: Direct

Name: tklB [H]

Synonym: RSP_3268

Alternate gene names: 77465274

Gene position: 324492-326465 (Clockwise)

Preceding gene: 77465273

Following gene: 77465275

Centisome position: 34.41

GC content: 70.06

Gene sequence:

>1974_bases
ATGAAGGACATTGGAGCCGCGCAGGAGACGCGGATGGCGAACGCCATCCGGGCCCTCGCGATGGATGCGGTGGAGAAGGC
CAAGTCGGGCCATCCCGGGATGCCGATGGGGATGGCGGACGTGGCGACCGTCCTCTTCAACCGCTTTCTCACGGTCGATC
CTTCGGCGCCCAAATGGCCCGACCGCGACCGGTTCGTGCTGTCGGCGGGGCATGGCTCGATGCTGCTCTATGCCATCCAT
CATCTGCTGGGCTATGCCGATATGGACATGGATCAGATCCGGTCCTTCCGCCAGCTCGGCGCGCGGACGGCGGGCCACCC
GGAATACGGCCATGCCGAGGGGATCGAGGTCACGACCGGGCCGCTCGGTCAGGGGATCGCGACCGCGGTGGGCATGGCGC
TGGCCGAGCGCATGAAGAACGCGCGCTATGGCGATGATCTGGTGGACCATTTCACCTATGTCATCGCGGGTGACGGCTGC
CTGATGGAGGGCATCTCGCACGAGGCCATCGACATGGCGGGTCATCTGGGCCTCGGCCGGCTGATCGTGCTGTGGGACGA
CAACCGCATCACCATCGACGGCGACACGGGCATCTCGACCTCGACCGACCAGAAGGCGCGGTTCGCCGCCTCGGGCTGGC
ATGTGCTGGCCTGCGACGGTCATGCGCCCGAGGAGATCGCCGCCGCCATCGAGGCCGCACGGCGCGACCCCCGGCCCTCG
ATGATCGCCTGCCGCACGGTGATCGGCTACGGCGCGCCGAACAAGCAGGGCGGCCACGATGTCCATGGCGCGCCGCTGGG
CGCGGCCGAGATCGCGGCGGCGCGCGAGCGGCTCGGCTGGGACCATCCGCCCTTCGAGATCCCCGCGGATCTCTACGAGG
CCTGGGGCCGGATCGCCGCCCGCGGCGCCGACGCCCGCGCGGCCTGGGAAACACGCCTTCAGGCGAGCCCCCTCCGCGCC
GCCTTCGAGACGGCGGAGGCGGCCGACACCTCGGCGCTGCCGCCGGCCATCGCGGCCTACAAGGCGCGGCTCTCGGCCGA
GGCGCCCAAGGTCGCGACCCGCAAGGCCTCGGAAATGGCGCTGGGTGTGGTCAACGAGGCGCTGCCCTTCGCGGTCGGCG
GCTCGGCCGACCTGACGGGCTCGAACCTGACCCGCTCGAAGGGCATGGTCTCGGTCGCGCCGGGCGCCTTCGCGGGCAGC
TATATCCATTACGGCATCCGCGAGCACGGCATGGCCGCCGCGATGAACGGGATCGCGCTGCATGGCGGCCTGCGCCCCTA
CGGCGGCACCTTCATGGCCTTCGCCGACTATTGCCGGCCCTCGATCCGGCTCTCGGCGCTGATGGGCGTGCCGGTGACCT
ATGTCATGACGCACGATTCCATCGGGCTCGGCGAGGATGGGCCCACGCACCAGCCGGTCGAGCATCTGGCGAGCCTGCGG
GCGATCCCGAACCTTGCGGTGATCCGGCCTGCGGATGCGGTCGAGACCGCCGAGGCCTGGGAGATCGCCATGACGGCGAC
ATCCACGCCCACGCTTCTGGTGCTGTCGCGCCAGAACCTGCCCACGGTGCGGACCGAACATCGGGACGAGAACCTGACCG
CGCGCGGCGCCTATCTCCTGCGGGATCCGGGCGAGCGACAGGTGACGCTGATCGCGACCGGCTCGGAGCTGGAGCTGGCG
CTGGCCGCGGCGGATCTTCTGGCCGCGGAAGGCATCGCCGCCGCCGTGGTCTCGGCGCCCTGCTTCGAGCTCTTCGCCGC
GCAGCCGGCGGACTACCGGGCGACGGTTCTGGGACGGGCCCCGCGTGTGGGATGCGAGGCGGCGCTGCGGCAGGGGTGGG
ATCTCTTCCTCGGACCGCAGGACGGGTTCGTGGGCATGACGGGCTTCGGCGCTTCGGCGCCCGCGCCCGCACTCTATCAA
CATTTCAACATCACCGCTGAAGCCATTGTCAAATCGGCAAAAGAACGGATCTGA

Upstream 100 bases:

>100_bases
CGCGCCGCGCGCGGGCCTGAGGCGCGACAGACAGACGGAGAGGGGGCCGCGGATCGAGCCGCGGCCCGGCAACCGGGACG
CACAGCGAAGGATGAGAGCC

Downstream 100 bases:

>100_bases
GGGAAGAAGGATGACAATCAGGGTTGCCATCAACGGCTTCGGCCGTATCGGCCGCAACGTGCTGCGGGCCATCGTGGAGT
CGGGGCGCACCGATATCGAG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MKDIGAAQETRMANAIRALAMDAVEKAKSGHPGMPMGMADVATVLFNRFLTVDPSAPKWPDRDRFVLSAGHGSMLLYAIH
HLLGYADMDMDQIRSFRQLGARTAGHPEYGHAEGIEVTTGPLGQGIATAVGMALAERMKNARYGDDLVDHFTYVIAGDGC
LMEGISHEAIDMAGHLGLGRLIVLWDDNRITIDGDTGISTSTDQKARFAASGWHVLACDGHAPEEIAAAIEAARRDPRPS
MIACRTVIGYGAPNKQGGHDVHGAPLGAAEIAAARERLGWDHPPFEIPADLYEAWGRIAARGADARAAWETRLQASPLRA
AFETAEAADTSALPPAIAAYKARLSAEAPKVATRKASEMALGVVNEALPFAVGGSADLTGSNLTRSKGMVSVAPGAFAGS
YIHYGIREHGMAAAMNGIALHGGLRPYGGTFMAFADYCRPSIRLSALMGVPVTYVMTHDSIGLGEDGPTHQPVEHLASLR
AIPNLAVIRPADAVETAEAWEIAMTATSTPTLLVLSRQNLPTVRTEHRDENLTARGAYLLRDPGERQVTLIATGSELELA
LAAADLLAAEGIAAAVVSAPCFELFAAQPADYRATVLGRAPRVGCEAALRQGWDLFLGPQDGFVGMTGFGASAPAPALYQ
HFNITAEAIVKSAKERI

Sequences:

>Translated_657_residues
MKDIGAAQETRMANAIRALAMDAVEKAKSGHPGMPMGMADVATVLFNRFLTVDPSAPKWPDRDRFVLSAGHGSMLLYAIH
HLLGYADMDMDQIRSFRQLGARTAGHPEYGHAEGIEVTTGPLGQGIATAVGMALAERMKNARYGDDLVDHFTYVIAGDGC
LMEGISHEAIDMAGHLGLGRLIVLWDDNRITIDGDTGISTSTDQKARFAASGWHVLACDGHAPEEIAAAIEAARRDPRPS
MIACRTVIGYGAPNKQGGHDVHGAPLGAAEIAAARERLGWDHPPFEIPADLYEAWGRIAARGADARAAWETRLQASPLRA
AFETAEAADTSALPPAIAAYKARLSAEAPKVATRKASEMALGVVNEALPFAVGGSADLTGSNLTRSKGMVSVAPGAFAGS
YIHYGIREHGMAAAMNGIALHGGLRPYGGTFMAFADYCRPSIRLSALMGVPVTYVMTHDSIGLGEDGPTHQPVEHLASLR
AIPNLAVIRPADAVETAEAWEIAMTATSTPTLLVLSRQNLPTVRTEHRDENLTARGAYLLRDPGERQVTLIATGSELELA
LAAADLLAAEGIAAAVVSAPCFELFAAQPADYRATVLGRAPRVGCEAALRQGWDLFLGPQDGFVGMTGFGASAPAPALYQ
HFNITAEAIVKSAKERI
>Mature_657_residues
MKDIGAAQETRMANAIRALAMDAVEKAKSGHPGMPMGMADVATVLFNRFLTVDPSAPKWPDRDRFVLSAGHGSMLLYAIH
HLLGYADMDMDQIRSFRQLGARTAGHPEYGHAEGIEVTTGPLGQGIATAVGMALAERMKNARYGDDLVDHFTYVIAGDGC
LMEGISHEAIDMAGHLGLGRLIVLWDDNRITIDGDTGISTSTDQKARFAASGWHVLACDGHAPEEIAAAIEAARRDPRPS
MIACRTVIGYGAPNKQGGHDVHGAPLGAAEIAAARERLGWDHPPFEIPADLYEAWGRIAARGADARAAWETRLQASPLRA
AFETAEAADTSALPPAIAAYKARLSAEAPKVATRKASEMALGVVNEALPFAVGGSADLTGSNLTRSKGMVSVAPGAFAGS
YIHYGIREHGMAAAMNGIALHGGLRPYGGTFMAFADYCRPSIRLSALMGVPVTYVMTHDSIGLGEDGPTHQPVEHLASLR
AIPNLAVIRPADAVETAEAWEIAMTATSTPTLLVLSRQNLPTVRTEHRDENLTARGAYLLRDPGERQVTLIATGSELELA
LAAADLLAAEGIAAAVVSAPCFELFAAQPADYRATVLGRAPRVGCEAALRQGWDLFLGPQDGFVGMTGFGASAPAPALYQ
HFNITAEAIVKSAKERI

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=590, Percent_Identity=28.135593220339, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI4507521, Length=590, Percent_Identity=28.135593220339, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI133778974, Length=608, Percent_Identity=26.9736842105263, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI225637459, Length=596, Percent_Identity=24.3288590604027, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI225637461, Length=568, Percent_Identity=24.1197183098592, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI225637463, Length=565, Percent_Identity=24.2477876106195, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=50.6042296072508, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1788808, Length=659, Percent_Identity=50.6828528072838, Blast_Score=619, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI17539652, Length=600, Percent_Identity=28.1666666666667, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325331, Length=661, Percent_Identity=44.0242057488654, Blast_Score=506, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319593, Length=662, Percent_Identity=41.238670694864, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45551847, Length=593, Percent_Identity=29.1736930860034, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45550715, Length=593, Percent_Identity=29.1736930860034, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24666278, Length=583, Percent_Identity=26.9296740994854, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24645119, Length=562, Percent_Identity=29.1814946619217, Blast_Score=162, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 69426; Mature: 69426

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDIGAAQETRMANAIRALAMDAVEKAKSGHPGMPMGMADVATVLFNRFLTVDPSAPKWP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCC
DRDRFVLSAGHGSMLLYAIHHLLGYADMDMDQIRSFRQLGARTAGHPEYGHAEGIEVTTG
CCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGQGIATAVGMALAERMKNARYGDDLVDHFTYVIAGDGCLMEGISHEAIDMAGHLGLGR
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCHHHHCCCHHHHHHHCCCCCCE
LIVLWDDNRITIDGDTGISTSTDQKARFAASGWHVLACDGHAPEEIAAAIEAARRDPRPS
EEEEECCCEEEECCCCCCCCCCCCHHHEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCC
MIACRTVIGYGAPNKQGGHDVHGAPLGAAEIAAARERLGWDHPPFEIPADLYEAWGRIAA
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RGADARAAWETRLQASPLRAAFETAEAADTSALPPAIAAYKARLSAEAPKVATRKASEMA
CCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
LGVVNEALPFAVGGSADLTGSNLTRSKGMVSVAPGAFAGSYIHYGIREHGMAAAMNGIAL
HHHHHHHCCEEECCCCCCCCCCCHHCCCEEEECCCCHHCHHHHHCHHHCCHHHHHCCEEE
HGGLRPYGGTFMAFADYCRPSIRLSALMGVPVTYVMTHDSIGLGEDGPTHQPVEHLASLR
ECCCCCCCCHHHHHHHHCCCCCEEHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHH
AIPNLAVIRPADAVETAEAWEIAMTATSTPTLLVLSRQNLPTVRTEHRDENLTARGAYLL
CCCCEEEECCCHHHHHHHHEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCEECCEEEE
RDPGERQVTLIATGSELELALAAADLLAAEGIAAAVVSAPCFELFAAQPADYRATVLGRA
ECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
PRVGCEAALRQGWDLFLGPQDGFVGMTGFGASAPAPALYQHFNITAEAIVKSAKERI
CCCHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKDIGAAQETRMANAIRALAMDAVEKAKSGHPGMPMGMADVATVLFNRFLTVDPSAPKWP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCC
DRDRFVLSAGHGSMLLYAIHHLLGYADMDMDQIRSFRQLGARTAGHPEYGHAEGIEVTTG
CCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGQGIATAVGMALAERMKNARYGDDLVDHFTYVIAGDGCLMEGISHEAIDMAGHLGLGR
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCHHHHCCCHHHHHHHCCCCCCE
LIVLWDDNRITIDGDTGISTSTDQKARFAASGWHVLACDGHAPEEIAAAIEAARRDPRPS
EEEEECCCEEEECCCCCCCCCCCCHHHEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCC
MIACRTVIGYGAPNKQGGHDVHGAPLGAAEIAAARERLGWDHPPFEIPADLYEAWGRIAA
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RGADARAAWETRLQASPLRAAFETAEAADTSALPPAIAAYKARLSAEAPKVATRKASEMA
CCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
LGVVNEALPFAVGGSADLTGSNLTRSKGMVSVAPGAFAGSYIHYGIREHGMAAAMNGIAL
HHHHHHHCCEEECCCCCCCCCCCHHCCCEEEECCCCHHCHHHHHCHHHCCHHHHHCCEEE
HGGLRPYGGTFMAFADYCRPSIRLSALMGVPVTYVMTHDSIGLGEDGPTHQPVEHLASLR
ECCCCCCCCHHHHHHHHCCCCCEEHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHH
AIPNLAVIRPADAVETAEAWEIAMTATSTPTLLVLSRQNLPTVRTEHRDENLTARGAYLL
CCCCEEEECCCHHHHHHHHEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCEECCEEEE
RDPGERQVTLIATGSELELALAAADLLAAEGIAAAVVSAPCFELFAAQPADYRATVLGRA
ECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
PRVGCEAALRQGWDLFLGPQDGFVGMTGFGASAPAPALYQHFNITAEAIVKSAKERI
CCCHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1939098 [H]