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The map label for this gene is zitB [H]

Identifier: 77465119

GI number: 77465119

Start: 151439

End: 152263

Strand: Reverse

Name: zitB [H]

Synonym: RSP_3106

Alternate gene names: 77465119

Gene position: 152263-151439 (Counterclockwise)

Preceding gene: 77465120

Following gene: 77465118

Centisome position: 16.15

GC content: 69.58

Gene sequence:

>825_bases
ATGATGGTGATCGAGATCGCGGCGGGCACGCTCTACGGCTCGATGGCGCTCGTGGCCGACGGATGGCACATGTCCACCCA
TGCCGCCGCCCTGCTCATTACGGCGCTGGCCTATCTGCTGGCCCGCCGCCATGCGCGCGACCGGCGCTTCACCTTCGGGA
CCGGCAAGTTCGGCGACCTCGCAGGGTTTGCCAGCGCGGTGGTGCTGGCAGTCGTGGCGCTCCTCATCGGCTGGGAGAGC
GCGATGCGCCTCCTCGATCCTGTGCCGATCGACTTCGGGCAGGCCACGGTGGTCGCGGTGATCGGGCTTCTGGTGAACCT
CGGCTCGGCGGCTCTGCTGCACGAGGGGCACGATCATGGGCACGGGCTCGATCATGGGCATGGACACGGACACGGACACC
ATGCGCAGGACAACAACCTGCGCGCGGCCTATCTGCATGTGCTGGCAGACGCGCTGACCTCGGTCCTCGCCATCGCGGCG
CTCATCGGGGGGCGTATCGGCGGCTGGGTCTGGCTCGACCCGCTGATCGGCCTTCTCGGCGCTCTGGTGATCGCACGGTG
GTCGCTGGGCCTGCTGCGCAGCGCGGGCGGCGTGCTGGTCGACTTCATCCCCGAGGAGGAGGAGCTGCCCGCCGAGATCC
GCGCGGCGCTCGAGACCGGCTGCGACCGGATCACCGATCTCCACGTCTGGCAGCTCGGGCCCGGCCATCATGGCGCCATC
GTGGCGCTGCGGTCCGGGGATCCCCGGCCTCCCGACCATTATCGCGGCAAGCTCAGCCATCTGCACGAGATCTCGCACCT
GACGCTCGAGGTGCGGCCCGCCTGA

Upstream 100 bases:

>100_bases
GACCAGGTTCATGGTCACGACCATGACCATGTCTTCCTCGGCGCCCGCCATGCGCGCAACGAGCGCCGCACCTGGGCCGT
GATCGCCCTTCACCTCGGCC

Downstream 100 bases:

>100_bases
TGGCGCCGATGGGCGCAGGCCTGGCGGGCCGGCCTTCCCCGACAGGGGCCCGACAGCAAAGTTGGAGTTGCGAAATCGGA
GCCGGGGATCATATTGGTAG

Product: cation efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MMVIEIAAGTLYGSMALVADGWHMSTHAAALLITALAYLLARRHARDRRFTFGTGKFGDLAGFASAVVLAVVALLIGWES
AMRLLDPVPIDFGQATVVAVIGLLVNLGSAALLHEGHDHGHGLDHGHGHGHGHHAQDNNLRAAYLHVLADALTSVLAIAA
LIGGRIGGWVWLDPLIGLLGALVIARWSLGLLRSAGGVLVDFIPEEEELPAEIRAALETGCDRITDLHVWQLGPGHHGAI
VALRSGDPRPPDHYRGKLSHLHEISHLTLEVRPA

Sequences:

>Translated_274_residues
MMVIEIAAGTLYGSMALVADGWHMSTHAAALLITALAYLLARRHARDRRFTFGTGKFGDLAGFASAVVLAVVALLIGWES
AMRLLDPVPIDFGQATVVAVIGLLVNLGSAALLHEGHDHGHGLDHGHGHGHGHHAQDNNLRAAYLHVLADALTSVLAIAA
LIGGRIGGWVWLDPLIGLLGALVIARWSLGLLRSAGGVLVDFIPEEEELPAEIRAALETGCDRITDLHVWQLGPGHHGAI
VALRSGDPRPPDHYRGKLSHLHEISHLTLEVRPA
>Mature_274_residues
MMVIEIAAGTLYGSMALVADGWHMSTHAAALLITALAYLLARRHARDRRFTFGTGKFGDLAGFASAVVLAVVALLIGWES
AMRLLDPVPIDFGQATVVAVIGLLVNLGSAALLHEGHDHGHGLDHGHGHGHGHHAQDNNLRAAYLHVLADALTSVLAIAA
LIGGRIGGWVWLDPLIGLLGALVIARWSLGLLRSAGGVLVDFIPEEEELPAEIRAALETGCDRITDLHVWQLGPGHHGAI
VALRSGDPRPPDHYRGKLSHLHEISHLTLEVRPA

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=266, Percent_Identity=32.3308270676692, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI222080086, Length=280, Percent_Identity=26.0714285714286, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40255009, Length=280, Percent_Identity=26.0714285714286, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI52352805, Length=237, Percent_Identity=25.7383966244726, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI21359890, Length=282, Percent_Identity=24.822695035461, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786966, Length=239, Percent_Identity=35.5648535564854, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32564488, Length=282, Percent_Identity=31.2056737588652, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193210990, Length=282, Percent_Identity=26.9503546099291, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24645863, Length=302, Percent_Identity=24.1721854304636, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24656728, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656724, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656720, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656715, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357035, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 29122; Mature: 29122

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVIEIAAGTLYGSMALVADGWHMSTHAAALLITALAYLLARRHARDRRFTFGTGKFGDL
CEEEEEECCHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
AGFASAVVLAVVALLIGWESAMRLLDPVPIDFGQATVVAVIGLLVNLGSAALLHEGHDHG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCC
HGLDHGHGHGHGHHAQDNNLRAAYLHVLADALTSVLAIAALIGGRIGGWVWLDPLIGLLG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ALVIARWSLGLLRSAGGVLVDFIPEEEELPAEIRAALETGCDRITDLHVWQLGPGHHGAI
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCEE
VALRSGDPRPPDHYRGKLSHLHEISHLTLEVRPA
EEECCCCCCCCHHHHHHHHHHHHHHHEEEEEECC
>Mature Secondary Structure
MMVIEIAAGTLYGSMALVADGWHMSTHAAALLITALAYLLARRHARDRRFTFGTGKFGDL
CEEEEEECCHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
AGFASAVVLAVVALLIGWESAMRLLDPVPIDFGQATVVAVIGLLVNLGSAALLHEGHDHG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCC
HGLDHGHGHGHGHHAQDNNLRAAYLHVLADALTSVLAIAALIGGRIGGWVWLDPLIGLLG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ALVIARWSLGLLRSAGGVLVDFIPEEEELPAEIRAALETGCDRITDLHVWQLGPGHHGAI
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCEE
VALRSGDPRPPDHYRGKLSHLHEISHLTLEVRPA
EEECCCCCCCCHHHHHHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]