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The map label for this gene is ilvD

Identifier: 77465088

GI number: 77465088

Start: 115149

End: 116987

Strand: Reverse

Name: ilvD

Synonym: RSP_3074

Alternate gene names: 77465088

Gene position: 116987-115149 (Counterclockwise)

Preceding gene: 77465091

Following gene: 77465086

Centisome position: 12.41

GC content: 69.44

Gene sequence:

>1839_bases
ATGCCCGCATTTCGTTCCCGCACCAGCACGCATGGCCGCAACATGGCCGGAGCCCGTGGCCTCTGGCGCGCGACCGGCGT
GAAGGACAGCGACTTCGGCAAGCCGATCATCGCCATCGTGAACAGCTTTACCCAGTTCGTGCCGGGCCACGTCCACCTCA
AGGATCTGGGCCAGCTCGTGGCGCGCGAGGTCGAGGCCGCAGGCGGCATCGCCAAGGAATTCAACACCATCGCCGTCGAT
GACGGGATCGCCATGGGCCATGACGGGATGCTCTATTCCCTGCCCTCGCGCGAGCTCATCGCGGACTCGGTCGAATACAT
GGTCAACGCCCATTGCGCCGACGCGATGGTCTGCATCTCGAACTGCGACAAGATCACCCCCGGCATGCTGATGGCCGCGA
TGCGGCTGAACATCCCCGCGGTCTTCGTCTCGGGCGGGCCGATGGAGGCGGGCAAGGTCACGCTCGGCGACGGGCGCACC
GTGAAGATGGACCTGATCGACGCGATGGTGGCCGCCGCCGACGAGAAAGTGTCCGACGACGACCTGACCCGCATCGAGCA
GGCCGCCTGCCCCACCTGCGGCTCCTGCTCGGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAGGCGCTCGGCC
TGTCGCTGCCGGGCAACGGCTCGACGCTGGCCACGCACGCCTACCGCAAGGAGCTCTTCCTCGAGGCCGGGCGCCGCGCG
GTCGAGCTCTGCCGCCGCTACTACGAGCAGGAGGACGAGGGCGTCCTGCCGCGCGCCATCGCTACCAAGGAAGCGTTCGA
GAATGCGATGGCGCTCGACATCGCGATGGGCGGCTCGACCAACACGGTGCTCCATATCCTCGCCGCCGCCCAGGAAGGCG
GCGTCGATTTCACCATGGACGACATCGACGCGCTCTCCCGCCGGGTGCCCTGCCTCTGCAAGGTCGCGCCGAACAAGGCG
GACGTGCATATCGAGGACGTGCACCGCGCGGGCGGCATCATGTCGATCCTGGGCGAGCTCGACCGCGGCGGGCTTCTGCA
CCGCGACACCCGCACCGTCCATGCGCCGACCCTCGGCGCCGCCATCGACCAGTGGGACATCGGCCGCTCCAACGCGCCCG
AGGCGCGCGAGCTGTTCCTCGCGGCGCCGGGCGGCGTGCCCACGCAGGTGGCCTTCAGCCAGTCCTCGACCTGGGACACG
CTCGACACCGACCGCGAGACCGGCGTGATCCGCTCGGTCGCGACCCCCTTCTCGAAGGACGGCGGCCTCGCGGTGCTGAA
GGGCAACCTCGCGCCCGACGGCTGCATCGTGAAAACGGCGGGCGTGGACGAGTCGATCCTCGTCTTCGCCGGGCCCGCCA
AGGTGTTCGAGAGCCAGGACGCGGCCGTCTACGGCATCCTGAACGGCGGCGTGCAGGCGGGCGACGTGGTGGTGATCCGC
TACGAGGGCCCGAAGGGCGGCCCCGGCATGCAGGAGATGCTCTATCCGACCTCCTACCTGAAGTCGAAGGGGCTGGGCAA
AGCCTGTGCGCTCATAACCGACGGGCGTTTCTCGGGCGGCACCTCGGGGCTCTCCATCGGCCATGCCTCGCCCGAGGCGG
CGTCGGGCGGCCCCATCGGCCTCGTGCGCGAGGGCGACCGGATCGAGATCGACATCCCGAACCGCACCATCACGCTGGCC
GTGCCGGAGGCCGAGCTGGCCGCCCGCCGTGCCGAGCAGGATGCGAAGGGCTGGAAGCCCGCGGGCCCGCGCAAGCGCAA
GGTCTCGCAGGCGCTGAAGGTCTATGCGCAGTTCGCCTCCTCGGCCGACAAGGGAGCCGTGCGCGTCCTGCCGGAGTGA

Upstream 100 bases:

>100_bases
GAGGCCGGTCTTTGCGCAGCTTTCCGCAAAGAAGGGTTGATTTTTCAGCACCAAAAGCGCAGTCGTCTGGCCCGAGAGTT
GCCAGCCGGAAGGTCCAGAC

Downstream 100 bases:

>100_bases
GCCTTGCCCGAGGGCTGCGCCGGCGGGATCTGATCCGAGAGCAGGGACGCATCGCCAACGTCGTTGGCGATGCCGTCCGG
CGACCTCCCCCGCCGATGCT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPAFRSRTSTHGRNMAGARGLWRATGVKDSDFGKPIIAIVNSFTQFVPGHVHLKDLGQLVAREVEAAGGIAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVTLGDGRT
VKMDLIDAMVAAADEKVSDDDLTRIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAYRKELFLEAGRRA
VELCRRYYEQEDEGVLPRAIATKEAFENAMALDIAMGGSTNTVLHILAAAQEGGVDFTMDDIDALSRRVPCLCKVAPNKA
DVHIEDVHRAGGIMSILGELDRGGLLHRDTRTVHAPTLGAAIDQWDIGRSNAPEARELFLAAPGGVPTQVAFSQSSTWDT
LDTDRETGVIRSVATPFSKDGGLAVLKGNLAPDGCIVKTAGVDESILVFAGPAKVFESQDAAVYGILNGGVQAGDVVVIR
YEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAASGGPIGLVREGDRIEIDIPNRTITLA
VPEAELAARRAEQDAKGWKPAGPRKRKVSQALKVYAQFASSADKGAVRVLPE

Sequences:

>Translated_612_residues
MPAFRSRTSTHGRNMAGARGLWRATGVKDSDFGKPIIAIVNSFTQFVPGHVHLKDLGQLVAREVEAAGGIAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVTLGDGRT
VKMDLIDAMVAAADEKVSDDDLTRIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAYRKELFLEAGRRA
VELCRRYYEQEDEGVLPRAIATKEAFENAMALDIAMGGSTNTVLHILAAAQEGGVDFTMDDIDALSRRVPCLCKVAPNKA
DVHIEDVHRAGGIMSILGELDRGGLLHRDTRTVHAPTLGAAIDQWDIGRSNAPEARELFLAAPGGVPTQVAFSQSSTWDT
LDTDRETGVIRSVATPFSKDGGLAVLKGNLAPDGCIVKTAGVDESILVFAGPAKVFESQDAAVYGILNGGVQAGDVVVIR
YEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAASGGPIGLVREGDRIEIDIPNRTITLA
VPEAELAARRAEQDAKGWKPAGPRKRKVSQALKVYAQFASSADKGAVRVLPE
>Mature_611_residues
PAFRSRTSTHGRNMAGARGLWRATGVKDSDFGKPIIAIVNSFTQFVPGHVHLKDLGQLVAREVEAAGGIAKEFNTIAVDD
GIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVTLGDGRTV
KMDLIDAMVAAADEKVSDDDLTRIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAYRKELFLEAGRRAV
ELCRRYYEQEDEGVLPRAIATKEAFENAMALDIAMGGSTNTVLHILAAAQEGGVDFTMDDIDALSRRVPCLCKVAPNKAD
VHIEDVHRAGGIMSILGELDRGGLLHRDTRTVHAPTLGAAIDQWDIGRSNAPEARELFLAAPGGVPTQVAFSQSSTWDTL
DTDRETGVIRSVATPFSKDGGLAVLKGNLAPDGCIVKTAGVDESILVFAGPAKVFESQDAAVYGILNGGVQAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAASGGPIGLVREGDRIEIDIPNRTITLAV
PEAELAARRAEQDAKGWKPAGPRKRKVSQALKVYAQFASSADKGAVRVLPE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=72.9950900163666, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=491, Percent_Identity=32.9938900203666, Blast_Score=208, Evalue=9e-55,
Organism=Escherichia coli, GI1788157, Length=541, Percent_Identity=32.1626617375231, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1786464, Length=538, Percent_Identity=31.5985130111524, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=604, Percent_Identity=37.7483443708609, Blast_Score=357, Evalue=4e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_RHOS1 (A3PRB5)

Other databases:

- EMBL:   CP000578
- RefSeq:   YP_001045653.1
- STRING:   A3PRB5
- GeneID:   4898437
- GenomeReviews:   CP000578_GR
- KEGG:   rsh:Rsph17029_3801
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BioCyc:   RSPH349101:RSPH17029_3801-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 64482; Mature: 64351

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAFRSRTSTHGRNMAGARGLWRATGVKDSDFGKPIIAIVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREVEAAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVTLGDGRTVKMDLIDAMVAAADEKVSDD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCEEEHHHHHHHHHHHCCCCCCH
DLTRIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAYRKELFLEAGRRA
HHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCHHH
VELCRRYYEQEDEGVLPRAIATKEAFENAMALDIAMGGSTNTVLHILAAAQEGGVDFTMD
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHEEEEEHHCCCCCEEEHH
DIDALSRRVPCLCKVAPNKADVHIEDVHRAGGIMSILGELDRGGLLHRDTRTVHAPTLGA
HHHHHHHCCCEEEEECCCCCCEEHHHHHHCCCHHHHHHHHCCCCEEECCCCEEECCCHHC
AIDQWDIGRSNAPEARELFLAAPGGVPTQVAFSQSSTWDTLDTDRETGVIRSVATPFSKD
CCCCCCCCCCCCCCHHEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCC
GGLAVLKGNLAPDGCIVKTAGVDESILVFAGPAKVFESQDAAVYGILNGGVQAGDVVVIR
CCEEEEECCCCCCCEEEEECCCCCEEEEEECCHHHHCCCCCEEEEEECCCCCCCCEEEEE
YEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAASGGPIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
LVREGDRIEIDIPNRTITLAVPEAELAARRAEQDAKGWKPAGPRKRKVSQALKVYAQFAS
EEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
SADKGAVRVLPE
CCCCCCEEECCC
>Mature Secondary Structure 
PAFRSRTSTHGRNMAGARGLWRATGVKDSDFGKPIIAIVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREVEAAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVTLGDGRTVKMDLIDAMVAAADEKVSDD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCEEEHHHHHHHHHHHCCCCCCH
DLTRIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAYRKELFLEAGRRA
HHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCHHH
VELCRRYYEQEDEGVLPRAIATKEAFENAMALDIAMGGSTNTVLHILAAAQEGGVDFTMD
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHEEEEEHHCCCCCEEEHH
DIDALSRRVPCLCKVAPNKADVHIEDVHRAGGIMSILGELDRGGLLHRDTRTVHAPTLGA
HHHHHHHCCCEEEEECCCCCCEEHHHHHHCCCHHHHHHHHCCCCEEECCCCEEECCCHHC
AIDQWDIGRSNAPEARELFLAAPGGVPTQVAFSQSSTWDTLDTDRETGVIRSVATPFSKD
CCCCCCCCCCCCCCHHEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCC
GGLAVLKGNLAPDGCIVKTAGVDESILVFAGPAKVFESQDAAVYGILNGGVQAGDVVVIR
CCEEEEECCCCCCCEEEEECCCCCEEEEEECCHHHHCCCCCEEEEEECCCCCCCCEEEEE
YEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAASGGPIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
LVREGDRIEIDIPNRTITLAVPEAELAARRAEQDAKGWKPAGPRKRKVSQALKVYAQFAS
EEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
SADKGAVRVLPE
CCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA