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The map label for this gene is moeA [H]

Identifier: 77465063

GI number: 77465063

Start: 86114

End: 87346

Strand: Direct

Name: moeA [H]

Synonym: RSP_3049

Alternate gene names: 77465063

Gene position: 86114-87346 (Clockwise)

Preceding gene: 77465062

Following gene: 77465064

Centisome position: 9.13

GC content: 75.99

Gene sequence:

>1233_bases
GTGTCCGCCGAGACCACGCCTCCGCCGCTGCTCGACATCGAAGCCGCAACCCGGCTCGCCCGCGCGCTCGTCTCTCCGAT
CGCCGAGGCCGAGACCGTGCCGCTGGCGCAGGCGTCGGGCCGGGTCGCCGCGCGCAGGATCTCGGCGCCGCGGGCCCTGC
CTGCCGCCGACCGCTCCGCCATGGACGGGTTCGCCCTGCGCGCGGGCGATCCGGGCGAGGGCGGCACACTGCCCGTGGCG
GGCACCATTGCCGCCGGAGAGCCGCGCCGCGCCCTGTCCGAGGGCGCGAGCCTCCGCATCTTCACCGGGGCCCTCCTGCC
CGAGGGTGCCGATGCCGTCGTGCCCCTCGAGGACTGCATCGAGGAGGGCGGCCGCCTCCGCCTCCGCCATCCCGCAAAGG
CCGGCGACCATGTCCGCCGCGCCGGCAGCGAGCAGCCCGAAGGGGGCACGCTCCTGCGGTCCGGCGCGCGGGTCCGTCCG
CAGCATGTGGGTCTGCTGGCCGCGAACGGGATCGGCGCGCTGGCCGTCGTGCGCCGTCCGCGTCTGGGCATCCTGTCGAC
CGGCGACGAACTCGGCCGGGACGGGCAGGGGCCCGAGGGCATCCCGGACAGCAATCGCCCCATGCTGATCGCCCTGGCCG
AGGCCGCCGGCGCCGAGGTCGAGGATCTGGGGATCCTCCCCGACGACCGCGACGCCCTCGTGGCGCGGCTGCAGGCGCTC
GGCGGGCGTCACGATCTGCTGGTGACGTCCGGCGCCGTCTCGATGGGCGGTCGCGACCATCTGCGCCCCGCACTCGAAGC
GGCGGGCGGCACGGTCGAGGGCTGGCGCGTGGCGCTGAAGCCGGGCAAGCCCGTGCTGTTCGGCCGCCTCGGCCCGACCG
CCGTCACCGCGCTGCCCGGCCATCCGCTCGCGGCCTTCGTCACCTTCCATCTCTTCGTCGCGGCCCAGATCGCGCAGATG
CTGCGCTTGCCCTGGACGCCCCTCTTCACCGAGCCCGCGCGGTCCGGCTTCGACGGCCTCCGCAAGCCGGGCCGTGCCGA
GGTCGTGCCGGTGCGGATGGGCCACGGTCAGGTGCAGGGCGTGCCGATCCTGCGCCGGCTGGGCGAGGGCGGCTCCGGCT
CGCTCTATCCCCTGGCCGAGGCGGACGGTCTCGCTCTCGTTCCGTCCCACCTCGACCGCATTCGCACCGGCGACCGGCTC
CACTGGTACCGGTTCGCCTGCGGGCGGGGCTGA

Upstream 100 bases:

>100_bases
CCGCCTCACCTTCCCGGCCCGCACCCGCTGCCGGGCCGGGACTTCTGACATCACCCGCTTCGGTGGCGACAGCCGCCGCC
GCACCCGAGGAGACAAGCCG

Downstream 100 bases:

>100_bases
TCCCGTGATCGCCCTGCCCGCCTTTCTTCCGCCCGCCGATCCCCAAGGATGTCGCCATGCTTCATGATCCCCTTGTCCCG
CTCAGCGACAGTTTCGGCCG

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSAETTPPPLLDIEAATRLARALVSPIAEAETVPLAQASGRVAARRISAPRALPAADRSAMDGFALRAGDPGEGGTLPVA
GTIAAGEPRRALSEGASLRIFTGALLPEGADAVVPLEDCIEEGGRLRLRHPAKAGDHVRRAGSEQPEGGTLLRSGARVRP
QHVGLLAANGIGALAVVRRPRLGILSTGDELGRDGQGPEGIPDSNRPMLIALAEAAGAEVEDLGILPDDRDALVARLQAL
GGRHDLLVTSGAVSMGGRDHLRPALEAAGGTVEGWRVALKPGKPVLFGRLGPTAVTALPGHPLAAFVTFHLFVAAQIAQM
LRLPWTPLFTEPARSGFDGLRKPGRAEVVPVRMGHGQVQGVPILRRLGEGGSGSLYPLAEADGLALVPSHLDRIRTGDRL
HWYRFACGRG

Sequences:

>Translated_410_residues
MSAETTPPPLLDIEAATRLARALVSPIAEAETVPLAQASGRVAARRISAPRALPAADRSAMDGFALRAGDPGEGGTLPVA
GTIAAGEPRRALSEGASLRIFTGALLPEGADAVVPLEDCIEEGGRLRLRHPAKAGDHVRRAGSEQPEGGTLLRSGARVRP
QHVGLLAANGIGALAVVRRPRLGILSTGDELGRDGQGPEGIPDSNRPMLIALAEAAGAEVEDLGILPDDRDALVARLQAL
GGRHDLLVTSGAVSMGGRDHLRPALEAAGGTVEGWRVALKPGKPVLFGRLGPTAVTALPGHPLAAFVTFHLFVAAQIAQM
LRLPWTPLFTEPARSGFDGLRKPGRAEVVPVRMGHGQVQGVPILRRLGEGGSGSLYPLAEADGLALVPSHLDRIRTGDRL
HWYRFACGRG
>Mature_409_residues
SAETTPPPLLDIEAATRLARALVSPIAEAETVPLAQASGRVAARRISAPRALPAADRSAMDGFALRAGDPGEGGTLPVAG
TIAAGEPRRALSEGASLRIFTGALLPEGADAVVPLEDCIEEGGRLRLRHPAKAGDHVRRAGSEQPEGGTLLRSGARVRPQ
HVGLLAANGIGALAVVRRPRLGILSTGDELGRDGQGPEGIPDSNRPMLIALAEAAGAEVEDLGILPDDRDALVARLQALG
GRHDLLVTSGAVSMGGRDHLRPALEAAGGTVEGWRVALKPGKPVLFGRLGPTAVTALPGHPLAAFVTFHLFVAAQIAQML
RLPWTPLFTEPARSGFDGLRKPGRAEVVPVRMGHGQVQGVPILRRLGEGGSGSLYPLAEADGLALVPSHLDRIRTGDRLH
WYRFACGRG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=399, Percent_Identity=31.8295739348371, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI10880983, Length=399, Percent_Identity=31.8295739348371, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1787049, Length=314, Percent_Identity=35.9872611464968, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=301, Percent_Identity=32.5581395348837, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=288, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136978, Length=329, Percent_Identity=31.0030395136778, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24638841, Length=329, Percent_Identity=31.0030395136778, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42653; Mature: 42521

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAETTPPPLLDIEAATRLARALVSPIAEAETVPLAQASGRVAARRISAPRALPAADRSA
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHCCCCCCCCCCHHH
MDGFALRAGDPGEGGTLPVAGTIAAGEPRRALSEGASLRIFTGALLPEGADAVVPLEDCI
CCCEEEECCCCCCCCCEEEEEEEECCCCHHHHHCCCEEEEEEEECCCCCCCCEECHHHHH
EEGGRLRLRHPAKAGDHVRRAGSEQPEGGTLLRSGARVRPQHVGLLAANGIGALAVVRRP
HCCCEEEEECCCCCCHHHHHCCCCCCCCCCEECCCCCCCHHHEEEEEECCCCEEEEECCC
RLGILSTGDELGRDGQGPEGIPDSNRPMLIALAEAAGAEVEDLGILPDDRDALVARLQAL
CCCEEECCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCCCCCHHHHHHHHHHH
GGRHDLLVTSGAVSMGGRDHLRPALEAAGGTVEGWRVALKPGKPVLFGRLGPTAVTALPG
CCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEEEECCCCCEEEECCC
HPLAAFVTFHLFVAAQIAQMLRLPWTPLFTEPARSGFDGLRKPGRAEVVPVRMGHGQVQG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHCCCCCCEEEEEECCCCCCCC
VPILRRLGEGGSGSLYPLAEADGLALVPSHLDRIRTGDRLHWYRFACGRG
CHHHHHHCCCCCCCEEEECCCCCCEECHHHHHHHCCCCCEEEEEEECCCC
>Mature Secondary Structure 
SAETTPPPLLDIEAATRLARALVSPIAEAETVPLAQASGRVAARRISAPRALPAADRSA
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHCCCCCCCCCCHHH
MDGFALRAGDPGEGGTLPVAGTIAAGEPRRALSEGASLRIFTGALLPEGADAVVPLEDCI
CCCEEEECCCCCCCCCEEEEEEEECCCCHHHHHCCCEEEEEEEECCCCCCCCEECHHHHH
EEGGRLRLRHPAKAGDHVRRAGSEQPEGGTLLRSGARVRPQHVGLLAANGIGALAVVRRP
HCCCEEEEECCCCCCHHHHHCCCCCCCCCCEECCCCCCCHHHEEEEEECCCCEEEEECCC
RLGILSTGDELGRDGQGPEGIPDSNRPMLIALAEAAGAEVEDLGILPDDRDALVARLQAL
CCCEEECCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCCCCCHHHHHHHHHHH
GGRHDLLVTSGAVSMGGRDHLRPALEAAGGTVEGWRVALKPGKPVLFGRLGPTAVTALPG
CCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEEEECCCCCEEEECCC
HPLAAFVTFHLFVAAQIAQMLRLPWTPLFTEPARSGFDGLRKPGRAEVVPVRMGHGQVQG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHCCCCCCEEEEEECCCCCCCC
VPILRRLGEGGSGSLYPLAEADGLALVPSHLDRIRTGDRLHWYRFACGRG
CHHHHHHCCCCCCCEEEECCCCCCEECHHHHHHHCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]