Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 77465064

GI number: 77465064

Start: 87403

End: 88419

Strand: Direct

Name: moaA [H]

Synonym: RSP_3050

Alternate gene names: 77465064

Gene position: 87403-88419 (Clockwise)

Preceding gene: 77465063

Following gene: 77465065

Centisome position: 9.27

GC content: 69.52

Gene sequence:

>1017_bases
ATGCTTCATGATCCCCTTGTCCCGCTCAGCGACAGTTTCGGCCGCACGGTCACCTACCTGCGCGTCTCGGTCACCGACCG
CTGCGACCTGCGCTGCACCTACTGCATGTCCGAACACACGAGCTTCATGCCGAAGCGCGAGCTCCTGACGCTGGAAGAGC
TCGACCGGCTGGTGAGCGCCTTCGTCGATCTGGGCGTGCGCAAGCTGCGCGTCACCGGGGGCGAGCCGCTCGTGCGGCGC
GGCATCATGACCTTCTTTCAGGCGATGGGGCGCCATGTGCGCTCGGGCGCGCTGAAGGAGCTTACGCTCACCACGAACGG
CACGCTGCTCGCCCGCCATGCGGCCGAACTGGCCGACTGCGGCGTGAAGCGGGTCAATGTCTCGCTCGACACGCTCGATC
CCGCGAAATACGGCCGGATCACCCGCTGGGGCCGGCTGGAGAATGTGCTGGGGGGCATCGCCGCGGCGCAGGCCGCGGGC
CTCCGGGTCAAGATCAACACGGTGGCGCTGCGCGGGCAGAATGACGACGAGCTCTTCCGTCTCGTGGACTGGTGCGCCGA
GCAGGGCTGCGATCTCACCTTCATCGAGGTCATGCCGATGGGCGAATTCGGGGTCGAGGACCGGCTCTCGCAGTTCTGGC
CGCTGAGCGAGCTGCGCGCCGAACTCGAGACCCGCTACCGGCTCGCCGACACGGCGCTCTCGACCGGCGGCCCCGCCTCC
TATGTCCGGGTCGCGGAGACCGGCCAGACGATCGGCTTCATCCGCCCGCTCAGCCACAATTTCTGCGCCACCTGCAACCG
CGTGCGCCTGAGCTGCCGGGGCGAGCTCTACACCTGCCTCGGCACCGAAGGGTCGAGCGACCTGCGCCCGGCGCTCCGCG
ACGGCGAGGCGGGGCTCGGGCTCTATGCGGCCATTCAGACCGCGCTGCGCCTGAAACCTGCGGGCCACGCCTTCGGCTAC
CTCGCGGGCGGCGTGCAGGGCGCGATGGCGCGCGGCATGAACCACACCGGCGGCTGA

Upstream 100 bases:

>100_bases
GCGACCGGCTCCACTGGTACCGGTTCGCCTGCGGGCGGGGCTGATCCCGTGATCGCCCTGCCCGCCTTTCTTCCGCCCGC
CGATCCCCAAGGATGTCGCC

Downstream 100 bases:

>100_bases
TCGGAGAGGGGCGGCAGGCGGGGCGGACCCGGCCCGCCCTTTACCGGCGCTTTCCGACCCACGCTGTCCGCCTGCTGGAG
CCCGCGTGGCAGCGCGCGCA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLHDPLVPLSDSFGRTVTYLRVSVTDRCDLRCTYCMSEHTSFMPKRELLTLEELDRLVSAFVDLGVRKLRVTGGEPLVRR
GIMTFFQAMGRHVRSGALKELTLTTNGTLLARHAAELADCGVKRVNVSLDTLDPAKYGRITRWGRLENVLGGIAAAQAAG
LRVKINTVALRGQNDDELFRLVDWCAEQGCDLTFIEVMPMGEFGVEDRLSQFWPLSELRAELETRYRLADTALSTGGPAS
YVRVAETGQTIGFIRPLSHNFCATCNRVRLSCRGELYTCLGTEGSSDLRPALRDGEAGLGLYAAIQTALRLKPAGHAFGY
LAGGVQGAMARGMNHTGG

Sequences:

>Translated_338_residues
MLHDPLVPLSDSFGRTVTYLRVSVTDRCDLRCTYCMSEHTSFMPKRELLTLEELDRLVSAFVDLGVRKLRVTGGEPLVRR
GIMTFFQAMGRHVRSGALKELTLTTNGTLLARHAAELADCGVKRVNVSLDTLDPAKYGRITRWGRLENVLGGIAAAQAAG
LRVKINTVALRGQNDDELFRLVDWCAEQGCDLTFIEVMPMGEFGVEDRLSQFWPLSELRAELETRYRLADTALSTGGPAS
YVRVAETGQTIGFIRPLSHNFCATCNRVRLSCRGELYTCLGTEGSSDLRPALRDGEAGLGLYAAIQTALRLKPAGHAFGY
LAGGVQGAMARGMNHTGG
>Mature_338_residues
MLHDPLVPLSDSFGRTVTYLRVSVTDRCDLRCTYCMSEHTSFMPKRELLTLEELDRLVSAFVDLGVRKLRVTGGEPLVRR
GIMTFFQAMGRHVRSGALKELTLTTNGTLLARHAAELADCGVKRVNVSLDTLDPAKYGRITRWGRLENVLGGIAAAQAAG
LRVKINTVALRGQNDDELFRLVDWCAEQGCDLTFIEVMPMGEFGVEDRLSQFWPLSELRAELETRYRLADTALSTGGPAS
YVRVAETGQTIGFIRPLSHNFCATCNRVRLSCRGELYTCLGTEGSSDLRPALRDGEAGLGLYAAIQTALRLKPAGHAFGY
LAGGVQGAMARGMNHTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=313, Percent_Identity=36.4217252396166, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI116734668, Length=313, Percent_Identity=36.4217252396166, Blast_Score=177, Evalue=9e-45,
Organism=Escherichia coli, GI1786999, Length=311, Percent_Identity=37.620578778135, Blast_Score=191, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=316, Percent_Identity=35.7594936708861, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32566329, Length=316, Percent_Identity=35.7594936708861, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17561210, Length=317, Percent_Identity=35.6466876971609, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574490, Length=317, Percent_Identity=38.801261829653, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI28574488, Length=317, Percent_Identity=38.801261829653, Blast_Score=187, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36974; Mature: 36974

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHDPLVPLSDSFGRTVTYLRVSVTDRCDLRCTYCMSEHTSFMPKRELLTLEELDRLVSA
CCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHH
FVDLGVRKLRVTGGEPLVRRGIMTFFQAMGRHVRSGALKELTLTTNGTLLARHAAELADC
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHC
GVKRVNVSLDTLDPAKYGRITRWGRLENVLGGIAAAQAAGLRVKINTVALRGQNDDELFR
CCEEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHH
LVDWCAEQGCDLTFIEVMPMGEFGVEDRLSQFWPLSELRAELETRYRLADTALSTGGPAS
HHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
YVRVAETGQTIGFIRPLSHNFCATCNRVRLSCRGELYTCLGTEGSSDLRPALRDGEAGLG
EEEEECCCCEEEEECCCCCCHHHHHHHEEEEECCCEEEEECCCCCCCCCHHHHCCCCCCH
LYAAIQTALRLKPAGHAFGYLAGGVQGAMARGMNHTGG
HHHHHHHHHHCCCCCCHHHHHHCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MLHDPLVPLSDSFGRTVTYLRVSVTDRCDLRCTYCMSEHTSFMPKRELLTLEELDRLVSA
CCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHH
FVDLGVRKLRVTGGEPLVRRGIMTFFQAMGRHVRSGALKELTLTTNGTLLARHAAELADC
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHC
GVKRVNVSLDTLDPAKYGRITRWGRLENVLGGIAAAQAAGLRVKINTVALRGQNDDELFR
CCEEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHH
LVDWCAEQGCDLTFIEVMPMGEFGVEDRLSQFWPLSELRAELETRYRLADTALSTGGPAS
HHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
YVRVAETGQTIGFIRPLSHNFCATCNRVRLSCRGELYTCLGTEGSSDLRPALRDGEAGLG
EEEEECCCCEEEEECCCCCCHHHHHHHEEEEECCCEEEEECCCCCCCCCHHHHCCCCCCH
LYAAIQTALRLKPAGHAFGYLAGGVQGAMARGMNHTGG
HHHHHHHHHHCCCCCCHHHHHHCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA