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The map label for this gene is aphA [H]

Identifier: 77461851

GI number: 77461851

Start: 6306421

End: 6307446

Strand: Direct

Name: aphA [H]

Synonym: Pfl01_5631

Alternate gene names: 77461851

Gene position: 6306421-6307446 (Clockwise)

Preceding gene: 77461850

Following gene: 77461852

Centisome position: 97.95

GC content: 62.28

Gene sequence:

>1026_bases
ATGCTGACGATCTACTCTGACGATCACCACCTGCACCATGGCCGCTGCGAATTGATCGACGGGCAACTCAAGCCTTGCTT
CGAGATGCCGTCGCGCGCCGACCACGTGCTGCAACGGGTAAAAAATCAAAACCTCGGCCCGGTCGAGGCACCGAAGGATT
TCGGCCTCGGGCCGATCGAGCGCATTCACAGCCGCGACTACCTCGACTTTTTCAAAGGCGCGTGGGCACGCTGGACCGAG
TTCAACACCGACGGCGACTTGCTGCCTTACACCTGGCCGGCGCGCACCTTGCGTCAGGTCAAGCCGACCAGCCTGCACGG
CCAGCTCGGCTATTACAGCTTCGACGGAGGCGCGCCGATCACCGCCGGCACCTGGCAAGCGGCGTACAGCGCGGCGCAAG
TGGCGCTGACCGCACAAGCGGAAATCCAGCGCGGCGCCCGCGGTGCCTTCGCCCTGTGCCGTCCACCGGGACACCACGCT
GCCGGTGATTTGATGGGCGGTTATTGCTACCTCAACAACGCCGCCATCGCCGCGCAGGCATTCCTCGATCAGGGCCACAA
GAAGGTCGCGATCCTCGACGTCGACTACCACCACGGCAATGGCACCCAATCGATTTTCTACGAGCGCAGCGACGTGCTGT
TCACCTCGATCCATGGCCACCCGGAAGCGGAATTCCCGTTCTTCCTCGGCTACGAAGACGAACGCGGGGAAGGCGCCGGG
GAAGGCTTCAACTTCAACTATCCGCTGCCAGCCGGTTCCGGCTGGGATATCTGGAGTGCGGCACTGGATCAGGCCTGCCA
GGAGATCGACAACTACGGCGCCGACATCATCGTCGTGTCGCTGGGTGTGGACACCTTCAAGGACGATCCGATTTCGCAGT
TCAAGCTCGACAGCCCGGACTACCTGGCCATGGGCAAGCGCATCGCGGCCCTCGGCAAACCGACCCTGTTCGTCATGGAA
GGTGGCTACGCGGTGGAAGAAATCGGCATCAACGCGGTGAACGTGCTTGAAGGTTTCGAACAATGA

Upstream 100 bases:

>100_bases
TGGCCACATCGATCCCCTTTTGGCCTCTCTGGCCGTTCTCCGATTCGGCTCACGCCGCAACACTGTGATCAACCGAATCA
GCCCCTGCGGAGAACAACAA

Downstream 100 bases:

>100_bases
GCAGACTCAAGCAATTCATCGCGCCGGCGTTGTGCGCGGCGCTGCTGAGCGGCGCCGCACACGCCGAAGAACGCACCCTG
CGCGTCTACAACTGGTTCGA

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MLTIYSDDHHLHHGRCELIDGQLKPCFEMPSRADHVLQRVKNQNLGPVEAPKDFGLGPIERIHSRDYLDFFKGAWARWTE
FNTDGDLLPYTWPARTLRQVKPTSLHGQLGYYSFDGGAPITAGTWQAAYSAAQVALTAQAEIQRGARGAFALCRPPGHHA
AGDLMGGYCYLNNAAIAAQAFLDQGHKKVAILDVDYHHGNGTQSIFYERSDVLFTSIHGHPEAEFPFFLGYEDERGEGAG
EGFNFNYPLPAGSGWDIWSAALDQACQEIDNYGADIIVVSLGVDTFKDDPISQFKLDSPDYLAMGKRIAALGKPTLFVME
GGYAVEEIGINAVNVLEGFEQ

Sequences:

>Translated_341_residues
MLTIYSDDHHLHHGRCELIDGQLKPCFEMPSRADHVLQRVKNQNLGPVEAPKDFGLGPIERIHSRDYLDFFKGAWARWTE
FNTDGDLLPYTWPARTLRQVKPTSLHGQLGYYSFDGGAPITAGTWQAAYSAAQVALTAQAEIQRGARGAFALCRPPGHHA
AGDLMGGYCYLNNAAIAAQAFLDQGHKKVAILDVDYHHGNGTQSIFYERSDVLFTSIHGHPEAEFPFFLGYEDERGEGAG
EGFNFNYPLPAGSGWDIWSAALDQACQEIDNYGADIIVVSLGVDTFKDDPISQFKLDSPDYLAMGKRIAALGKPTLFVME
GGYAVEEIGINAVNVLEGFEQ
>Mature_341_residues
MLTIYSDDHHLHHGRCELIDGQLKPCFEMPSRADHVLQRVKNQNLGPVEAPKDFGLGPIERIHSRDYLDFFKGAWARWTE
FNTDGDLLPYTWPARTLRQVKPTSLHGQLGYYSFDGGAPITAGTWQAAYSAAQVALTAQAEIQRGARGAFALCRPPGHHA
AGDLMGGYCYLNNAAIAAQAFLDQGHKKVAILDVDYHHGNGTQSIFYERSDVLFTSIHGHPEAEFPFFLGYEDERGEGAG
EGFNFNYPLPAGSGWDIWSAALDQACQEIDNYGADIIVVSLGVDTFKDDPISQFKLDSPDYLAMGKRIAALGKPTLFVME
GGYAVEEIGINAVNVLEGFEQ

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795202, Length=254, Percent_Identity=28.3464566929134, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI30795204, Length=254, Percent_Identity=28.3464566929134, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI17158039, Length=215, Percent_Identity=30.2325581395349, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI148539870, Length=211, Percent_Identity=32.7014218009479, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI169234807, Length=211, Percent_Identity=32.7014218009479, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI153085395, Length=234, Percent_Identity=31.1965811965812, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI13128864, Length=244, Percent_Identity=29.9180327868852, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI20070354, Length=213, Percent_Identity=30.9859154929577, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI62750347, Length=236, Percent_Identity=29.2372881355932, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI62750349, Length=236, Percent_Identity=29.2372881355932, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI13128860, Length=175, Percent_Identity=27.4285714285714, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI226529806, Length=129, Percent_Identity=36.4341085271318, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI13128862, Length=276, Percent_Identity=23.9130434782609, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI8923769, Length=230, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI293336691, Length=206, Percent_Identity=23.3009708737864, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=234, Percent_Identity=35.8974358974359, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193206283, Length=234, Percent_Identity=35.8974358974359, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17540332, Length=234, Percent_Identity=35.8974358974359, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193209491, Length=301, Percent_Identity=26.9102990033223, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17534739, Length=329, Percent_Identity=24.9240121580547, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537347, Length=226, Percent_Identity=27.4336283185841, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25154020, Length=212, Percent_Identity=31.1320754716981, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI25154022, Length=212, Percent_Identity=31.1320754716981, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508561, Length=286, Percent_Identity=24.1258741258741, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17561978, Length=276, Percent_Identity=22.8260869565217, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324307, Length=208, Percent_Identity=33.6538461538462, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323999, Length=254, Percent_Identity=25.1968503937008, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321244, Length=207, Percent_Identity=26.5700483091787, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281360899, Length=244, Percent_Identity=35.655737704918, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24642144, Length=244, Percent_Identity=35.655737704918, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24642142, Length=244, Percent_Identity=35.655737704918, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24642146, Length=244, Percent_Identity=35.655737704918, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24641720, Length=225, Percent_Identity=32, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281360799, Length=236, Percent_Identity=30.9322033898305, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281360801, Length=236, Percent_Identity=30.9322033898305, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24657891, Length=244, Percent_Identity=24.1803278688525, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644244, Length=173, Percent_Identity=30.0578034682081, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37531; Mature: 37531

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIYSDDHHLHHGRCELIDGQLKPCFEMPSRADHVLQRVKNQNLGPVEAPKDFGLGPIE
CEEEECCCCCEECCEEEEECCCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
RIHSRDYLDFFKGAWARWTEFNTDGDLLPYTWPARTLRQVKPTSLHGQLGYYSFDGGAPI
HHHCCHHHHHHHCCHHEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCCCCC
TAGTWQAAYSAAQVALTAQAEIQRGARGAFALCRPPGHHAAGDLMGGYCYLNNAAIAAQA
CCCCHHHHHHHHHEEEEEHHHHHCCCCCCEEEECCCCCCCCHHCCCCEEEECCCHHHHHH
FLDQGHKKVAILDVDYHHGNGTQSIFYERSDVLFTSIHGHPEAEFPFFLGYEDERGEGAG
HHHCCCCEEEEEEEEEECCCCCCEEEEECCCEEEEEECCCCCCCCCEEECCCCCCCCCCC
EGFNFNYPLPAGSGWDIWSAALDQACQEIDNYGADIIVVSLGVDTFKDDPISQFKLDSPD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEECCCCC
YLAMGKRIAALGKPTLFVMEGGYAVEEIGINAVNVLEGFEQ
HHHHHHHHHHCCCCEEEEEECCEEEEHHCCCHHHHHHHCCC
>Mature Secondary Structure
MLTIYSDDHHLHHGRCELIDGQLKPCFEMPSRADHVLQRVKNQNLGPVEAPKDFGLGPIE
CEEEECCCCCEECCEEEEECCCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
RIHSRDYLDFFKGAWARWTEFNTDGDLLPYTWPARTLRQVKPTSLHGQLGYYSFDGGAPI
HHHCCHHHHHHHCCHHEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCCCCC
TAGTWQAAYSAAQVALTAQAEIQRGARGAFALCRPPGHHAAGDLMGGYCYLNNAAIAAQA
CCCCHHHHHHHHHEEEEEHHHHHCCCCCCEEEECCCCCCCCHHCCCCEEEECCCHHHHHH
FLDQGHKKVAILDVDYHHGNGTQSIFYERSDVLFTSIHGHPEAEFPFFLGYEDERGEGAG
HHHCCCCEEEEEEEEEECCCCCCEEEEECCCEEEEEECCCCCCCCCEEECCCCCCCCCCC
EGFNFNYPLPAGSGWDIWSAALDQACQEIDNYGADIIVVSLGVDTFKDDPISQFKLDSPD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEECCCCC
YLAMGKRIAALGKPTLFVMEGGYAVEEIGINAVNVLEGFEQ
HHHHHHHHHHCCCCEEEEEECCEEEEHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]