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The map label for this gene is coaBC [H]

Identifier: 77461761

GI number: 77461761

Start: 6209174

End: 6210397

Strand: Direct

Name: coaBC [H]

Synonym: Pfl01_5540

Alternate gene names: 77461761

Gene position: 6209174-6210397 (Clockwise)

Preceding gene: 77461759

Following gene: 77461762

Centisome position: 96.44

GC content: 64.13

Gene sequence:

>1224_bases
ATGAAAGGCAGACCTATGCAGCGGCTGTATCGGAAACGCATCGTTCTGGGCGTCGGCGGCGGCATTGCTGCCTACAAGAG
CGCCGACCTTGTGCGCCGCCTGATCGACCAGGGCGCCGAAGTGCGCGTGGTCATGACCCGCGGCGGCAGCGAATTCATCA
CCCCGCTGACCATGCAGGCCCTGTCCGGCCACCCGGTTCACCTGGACTTGCTCGACCCGGCTGCTGAAGCCGCAATGGGC
CACATCGAACTGGCCAAATGGGCCGATTTGGTGCTGATCGCCCCGGCGACCGCCGACTTGTTGGCCCGTCTGGCCCAAGG
CATTGCCAACGACCTGCTGACCACGCTGGTGCTGGCCACCGATGCTATCGTCGCGGTCGCTCCGGCCATGAACCAGGCCA
TGTGGCGCGACCCGGCGACCCAGGCCAACCTGCAACTCCTTGAAAGTCGCGGCCTGAAGACCTTCGGCCCGGCCTCCGGC
AGCCAGGCCTGCGGCGACGTCGGCATGGGCCGGATGATGGAAGCCACCGATCTGGCGCAGTGCGCGGCAGACTGCTTCCA
GCGTCAGGCACTGACCGGCAAGCACGTGGTGATCACCGCCGGCCCGACCCAGGAAAACATCGACCCGGTGCGCTACATCA
CCAACCACAGCTCCGGGAAAATGGGCTTTGCCCTCGCCGAAGCCGCGGTGGAAGCCGGCGCCCGTGTGACCCTGATCAGC
GGCCCGGTGCACCTGCCGACGCCAGATCGCGTCACGCGCATCGATGTGGTCAGCGCCCGCGACATGCTGGCGGCGTGCGA
ATCAGCCATCCCGTGCGATGTGTTCATCGCCTCGGCCGCGGTGGCGGACTACCGTCCGGAAGTCGTTGCCCCGCAAAAAC
TCAAGAAAGACCCTACAAGCGGCGACGGCTTCGTCCTGCAAATGGTGCGTAACCCGGACATCCTGGCCACCATAGCGACC
CGTCCCGACCGTCCGTTCAGTGTGGGCTTCGCCGCCGAGACCGAACACCTGCTCGACTACGCTGCACGCAAGCTGAAAGA
CAAGAATCTCGATTTGATCGTCGCCAACGACGTGGCCAATCCGAGCATCGGTTTCAACAGCGAAGAAAACGCCTGCAGCG
TGATCGACCGTGAGCTTCACGCCACCGTTTTCGCCCAGACCAGCAAGAGCAAGATCGCTCGCCAACTGGTCACTTTTATC
GCCGAACGTCTGAACCAGGTTTAA

Upstream 100 bases:

>100_bases
CGCCGCTGTTCCGTAGCGGTCGCTGTGATATCGTAGCCCATCTTTTTTGCGGGCGAATTCACTCTGGGGAGGGGGTTTCG
CCACGTATGTCACCAACGAA

Downstream 100 bases:

>100_bases
TTTACATGCACGCTTTGCAAGCCAAGATCCTCGACCCACGCATCGGTACCGAATTCCCGCTGCCGCAATACGCCACACCG
GGCTCCGCCGGCCTCGACCT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKGRPMQRLYRKRIVLGVGGGIAAYKSADLVRRLIDQGAEVRVVMTRGGSEFITPLTMQALSGHPVHLDLLDPAAEAAMG
HIELAKWADLVLIAPATADLLARLAQGIANDLLTTLVLATDAIVAVAPAMNQAMWRDPATQANLQLLESRGLKTFGPASG
SQACGDVGMGRMMEATDLAQCAADCFQRQALTGKHVVITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLIS
GPVHLPTPDRVTRIDVVSARDMLAACESAIPCDVFIASAAVADYRPEVVAPQKLKKDPTSGDGFVLQMVRNPDILATIAT
RPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRELHATVFAQTSKSKIARQLVTFI
AERLNQV

Sequences:

>Translated_407_residues
MKGRPMQRLYRKRIVLGVGGGIAAYKSADLVRRLIDQGAEVRVVMTRGGSEFITPLTMQALSGHPVHLDLLDPAAEAAMG
HIELAKWADLVLIAPATADLLARLAQGIANDLLTTLVLATDAIVAVAPAMNQAMWRDPATQANLQLLESRGLKTFGPASG
SQACGDVGMGRMMEATDLAQCAADCFQRQALTGKHVVITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLIS
GPVHLPTPDRVTRIDVVSARDMLAACESAIPCDVFIASAAVADYRPEVVAPQKLKKDPTSGDGFVLQMVRNPDILATIAT
RPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRELHATVFAQTSKSKIARQLVTFI
AERLNQV
>Mature_407_residues
MKGRPMQRLYRKRIVLGVGGGIAAYKSADLVRRLIDQGAEVRVVMTRGGSEFITPLTMQALSGHPVHLDLLDPAAEAAMG
HIELAKWADLVLIAPATADLLARLAQGIANDLLTTLVLATDAIVAVAPAMNQAMWRDPATQANLQLLESRGLKTFGPASG
SQACGDVGMGRMMEATDLAQCAADCFQRQALTGKHVVITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLIS
GPVHLPTPDRVTRIDVVSARDMLAACESAIPCDVFIASAAVADYRPEVVAPQKLKKDPTSGDGFVLQMVRNPDILATIAT
RPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRELHATVFAQTSKSKIARQLVTFI
AERLNQV

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=173, Percent_Identity=34.1040462427746, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082301, Length=367, Percent_Identity=59.4005449591281, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17560194, Length=174, Percent_Identity=31.0344827586207, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=206, Percent_Identity=28.6407766990291, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43464; Mature: 43464

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGRPMQRLYRKRIVLGVGGGIAAYKSADLVRRLIDQGAEVRVVMTRGGSEFITPLTMQA
CCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LSGHPVHLDLLDPAAEAAMGHIELAKWADLVLIAPATADLLARLAQGIANDLLTTLVLAT
CCCCCEEEEECCHHHHHHHCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
DAIVAVAPAMNQAMWRDPATQANLQLLESRGLKTFGPASGSQACGDVGMGRMMEATDLAQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHH
CAADCFQRQALTGKHVVITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLIS
HHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHCCCEEEEEE
GPVHLPTPDRVTRIDVVSARDMLAACESAIPCDVFIASAAVADYRPEVVAPQKLKKDPTS
CCEECCCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCC
GDGFVLQMVRNPDILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVAN
CCCEEEEEECCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
PSIGFNSEENACSVIDRELHATVFAQTSKSKIARQLVTFIAERLNQV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGRPMQRLYRKRIVLGVGGGIAAYKSADLVRRLIDQGAEVRVVMTRGGSEFITPLTMQA
CCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LSGHPVHLDLLDPAAEAAMGHIELAKWADLVLIAPATADLLARLAQGIANDLLTTLVLAT
CCCCCEEEEECCHHHHHHHCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
DAIVAVAPAMNQAMWRDPATQANLQLLESRGLKTFGPASGSQACGDVGMGRMMEATDLAQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHH
CAADCFQRQALTGKHVVITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLIS
HHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHCCCEEEEEE
GPVHLPTPDRVTRIDVVSARDMLAACESAIPCDVFIASAAVADYRPEVVAPQKLKKDPTS
CCEECCCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCC
GDGFVLQMVRNPDILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVAN
CCCEEEEEECCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
PSIGFNSEENACSVIDRELHATVFAQTSKSKIARQLVTFIAERLNQV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]